DE60100625D1 - Verwndung von verbindungen mit 5-ht1a aktivität zur behandlung von krankheiten der äusseren retina - Google Patents

Verwndung von verbindungen mit 5-ht1a aktivität zur behandlung von krankheiten der äusseren retina

Info

Publication number: DE60100625D1
Authority: DE; Germany
Prior art keywords: compounds; treating diseases; external retina; ht1a activity; ht1a
Prior art date: 2000-03-17
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE60100625T

Other languages

English (en)

Other versions

DE60100625T2 (de

Inventor

J Collier

A Kapin

R Hellberg

R Dean

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Alcon Inc

Original Assignee

Alcon Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-03-17

Filing date

2001-02-23

Publication date

2003-09-25

2001-02-23 Application filed by Alcon Inc filed Critical Alcon Inc

2003-09-25 Application granted granted Critical

2003-09-25 Publication of DE60100625D1 publication Critical patent/DE60100625D1/de

2004-02-26 Publication of DE60100625T2 publication Critical patent/DE60100625T2/de

2021-02-24 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
- A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Epidemiology (AREA)
Ophthalmology & Optometry (AREA)
Vascular Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Plural Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Crystals, And After-Treatments Of Crystals (AREA)
Liquid Crystal Substances (AREA)
Indole Compounds (AREA)

DE60100625T 2000-03-17 2001-02-23 Verwndung von verbindungen mit 5-ht1a aktivität zur behandlung von krankheiten der äusseren retina Expired - Lifetime DE60100625T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US19027900P	2000-03-17	2000-03-17
US190279P		2000-03-17
PCT/US2001/005700 WO2001070222A2 (en)	2000-03-17	2001-02-23	Compounds with 5-ht1a activity useful for treating disorders of the outer retina

Publications (2)

Publication Number	Publication Date
DE60100625D1 true DE60100625D1 (de)	2003-09-25
DE60100625T2 DE60100625T2 (de)	2004-02-26

Family

ID=22700682

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE60100625T Expired - Lifetime DE60100625T2 (de)	2000-03-17	2001-02-23	Verwndung von verbindungen mit 5-ht1a aktivität zur behandlung von krankheiten der äusseren retina

Country Status (18)

Country	Link
EP (3)	EP1263434A1 (de)
JP (5)	JP2003527423A (de)
KR (3)	KR20030016239A (de)
CN (2)	CN1418100A (de)
AR (1)	AR028258A1 (de)
AT (1)	ATE247507T1 (de)
AU (5)	AU2001238552A1 (de)
BR (3)	BR0109193A (de)
CA (3)	CA2400637A1 (de)
DE (1)	DE60100625T2 (de)
DK (1)	DK1263504T3 (de)
ES (1)	ES2204848T3 (de)
MX (3)	MXPA02009071A (de)
PL (1)	PL203709B1 (de)
PT (1)	PT1263504E (de)
TW (1)	TWI268777B (de)
WO (3)	WO2001070223A1 (de)
ZA (1)	ZA200206350B (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
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US6960579B1 (en)	1998-05-19	2005-11-01	Alcon Manufacturing, Ltd.	Serotonergic 5HT7 receptor compounds for treating ocular and CNS disorders
WO2001070223A1 (en) *	2000-03-17	2001-09-27	Alcon, Inc.	Compounds with 5-ht2 and 5-ht1a agonist activity for treating glaucoma
US20030207890A1 (en)	2001-02-23	2003-11-06	Collier Robert J	Compounds with 5-ht1a activity useful for treating disorders of the outer retina
TW593302B (en) *	2001-12-20	2004-06-21	Alcon Inc	Novel benzodifuranimidazoline and benzofuranimidazoline derivatives and their use for the treatment of glaucoma
EP1581209A4 (de)	2002-12-13	2009-03-11	Alcon Inc	Neue benzopyran-analoga und ihre verwendung zur behandlung von glaukom
JP2004262812A (ja) *	2003-02-28	2004-09-24	Rohto Pharmaceut Co Ltd	眼圧低下剤
KR101139744B1 (ko) *	2003-04-25	2012-04-26	미쓰비시 타나베 파마 코퍼레이션	알킬렌 디옥시벤젠 유도체 함유 경구 투여용 조성물
WO2005053688A1 (en)	2003-11-26	2005-06-16	Alcon, Inc.	Substituted furo[2,3-g] indazoles for the treatment of glaucoma
US7338972B1 (en)	2003-12-15	2008-03-04	Alcon, Inc.	Substituted 1-alkylamino-1H-indazoles for the treatment of glaucoma
TW200520760A (en)	2003-12-15	2005-07-01	Alcon Inc	Substituted [1,4] oxazino [2,3-g] indazoles for the treatment of glaucoma
US7129257B1 (en)	2003-12-15	2006-10-31	Alcon, Inc.	Pyrazolo[3,4- e]benzoxazoles for the treatment of glaucoma
US20050244463A1 (en)	2004-04-30	2005-11-03	Allergan, Inc.	Sustained release intraocular implants and methods for treating ocular vasculopathies
EP2248524A3 (de)	2004-08-25	2011-03-09	Takeda Pharmaceutical Company Limited	Mittel zur prävention/behandlung von stressbedingter harninkontinenz und vorsorgeuntersuchungsverfahren dafür
WO2006062839A1 (en)	2004-12-08	2006-06-15	Alcon, Inc.	Use of dioxindoindazoles and dioxoloindazoles for treating glaucoma
US8158617B2 (en)	2006-05-16	2012-04-17	Takeda Pharmaceutical Company Limited	Fused heterocyclic compound and use thereof
WO2008024846A2 (en) *	2006-08-25	2008-02-28	Allergan, Inc.	Brimonidine and timolol compositions
EP2896624B1 (de)	2007-03-28	2016-07-13	Atir Holding S.A.	Heterotricyclische Verbindungen als Serotonerge und/oder Dopaminerge Mittel und Anwendungen davon
EP2216023A4 (de)	2007-11-15	2013-03-13	Takeda Pharmaceutical	Kondensiertes pyridinderivat und seine verwendung
TW201010727A (en) *	2008-09-03	2010-03-16	Alcon Res Ltd	Pharmaceutical composition having relatively low ionic strength
BR112012010983A2 (pt)	2009-11-09	2016-04-12	Allergan Inc	composições e métodos para a estimulação do crescimento de cabelos
JPWO2011071136A1 (ja)	2009-12-11	2013-04-22	アステラス製薬株式会社	線維筋痛症治療剤
CN109602691A (zh)	2013-02-15	2019-04-12	阿勒根公司	持续药物递送植入物
WO2018064465A1 (en)	2016-09-29	2018-04-05	The Regents Of The University Of California	Compounds for increasing neural plasticity
WO2019131902A1 (ja)	2017-12-27	2019-07-04	武田薬品工業株式会社	腹圧性尿失禁および便失禁の治療薬
AU2020229779B9 (en)	2019-02-27	2025-09-18	The Regents Of The University Of California	Azepino-indoles and other heterocycles for treating brain disorders
CN113840600A (zh)	2019-02-27	2021-12-24	加利福尼亚大学董事会	用于治疗脑疾病的n-取代吲哚和其他杂环化合物
WO2023114313A1 (en)	2021-12-15	2023-06-22	Delix Therapeutics, Inc.	Phenoxy and benzyloxy substituted psychoplastogens and uses thereof
LT4452267T (lt) *	2021-12-23	2025-06-10	Cilcare Dev	4-fenil-tetrahidropiridino dariniai, skirti klausos ligų gydymui

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH02262518A (ja) *	1989-04-03	1990-10-25	Kaken Pharmaceut Co Ltd	眼圧調整剤
JP2824863B2 (ja) *	1989-07-12	1998-11-18	エーザイ株式会社	α▲下１▼―ブロッカー点眼剤
TW270114B (de) *	1993-10-22	1996-02-11	Hoffmann La Roche
US5521183A (en) *	1994-08-30	1996-05-28	Allergan	Use of 5-HT ligands as anti-pruritic agents
US5998467A (en) *	1995-10-25	1999-12-07	Mitsubishi Chemical Corporation	Medicine for oculopathy
JP3958391B2 (ja) *	1995-10-25	2007-08-15	三菱化学株式会社	眼疾患用薬剤
AU4249297A (en) *	1996-10-31	1998-05-22	Alcon Laboratories, Inc.	Opthalmological compositions containing serotonin 5-ht1a receptor agonist and their use in the treatment of glaucoma
DE19751949A1 (de) *	1997-11-24	1999-05-27	Bayer Ag	Verwendung von substituierten Aminomethyl-Chromanen zur Verhinderung der neuronalen Degeneration und zur Förderung der neuronalen Regeneration
GB9819033D0 (en) *	1998-09-01	1998-10-28	Cerebrus Ltd	Chemical compounds VI
WO2001070223A1 (en) *	2000-03-17	2001-09-27	Alcon, Inc.	Compounds with 5-ht2 and 5-ht1a agonist activity for treating glaucoma

2001
- 2001-02-20 WO PCT/US2001/005432 patent/WO2001070223A1/en not_active Ceased
- 2001-02-20 CA CA002400637A patent/CA2400637A1/en not_active Abandoned
- 2001-02-20 MX MXPA02009071A patent/MXPA02009071A/es unknown
- 2001-02-20 KR KR1020027012169A patent/KR20030016239A/ko not_active Withdrawn
- 2001-02-20 BR BR0109193-0A patent/BR0109193A/pt not_active Application Discontinuation
- 2001-02-20 JP JP2001568421A patent/JP2003527423A/ja active Pending
- 2001-02-20 EP EP01911005A patent/EP1263434A1/de not_active Withdrawn
- 2001-02-20 AU AU2001238552A patent/AU2001238552A1/en not_active Abandoned
- 2001-02-23 EP EP01914447A patent/EP1267878A2/de not_active Withdrawn
- 2001-02-23 AU AU2001239836A patent/AU2001239836A1/en not_active Abandoned
- 2001-02-23 CA CA002399985A patent/CA2399985A1/en not_active Abandoned
- 2001-02-23 WO PCT/US2001/005740 patent/WO2001070230A2/en not_active Ceased
- 2001-02-23 DE DE60100625T patent/DE60100625T2/de not_active Expired - Lifetime
- 2001-02-23 PL PL358306A patent/PL203709B1/pl not_active IP Right Cessation
- 2001-02-23 PT PT01918208T patent/PT1263504E/pt unknown
- 2001-02-23 BR BR0109211-1A patent/BR0109211A/pt not_active Application Discontinuation
- 2001-02-23 AT AT01918208T patent/ATE247507T1/de active
- 2001-02-23 AU AU4531001A patent/AU4531001A/xx active Pending
- 2001-02-23 CN CN01806620A patent/CN1418100A/zh active Pending
- 2001-02-23 CA CA2400639A patent/CA2400639C/en not_active Expired - Fee Related
- 2001-02-23 CN CNB018067646A patent/CN1198605C/zh not_active Expired - Fee Related
- 2001-02-23 MX MXPA02009073A patent/MXPA02009073A/es unknown
- 2001-02-23 DK DK01918208T patent/DK1263504T3/da active
- 2001-02-23 KR KR1020027012170A patent/KR100749191B1/ko not_active Expired - Fee Related
- 2001-02-23 JP JP2001568420A patent/JP4789231B2/ja not_active Expired - Fee Related
- 2001-02-23 AU AU2001245310A patent/AU2001245310B2/en not_active Ceased
- 2001-02-23 ES ES01918208T patent/ES2204848T3/es not_active Expired - Lifetime
- 2001-02-23 MX MXPA02009072A patent/MXPA02009072A/es active IP Right Grant
- 2001-02-23 KR KR1020027012171A patent/KR20030009390A/ko not_active Withdrawn
- 2001-02-23 JP JP2001568428A patent/JP2003527427A/ja not_active Withdrawn
- 2001-02-23 EP EP01918208A patent/EP1263504B1/de not_active Expired - Lifetime
- 2001-02-23 BR BR0109230-8A patent/BR0109230A/pt not_active Application Discontinuation
- 2001-02-23 WO PCT/US2001/005700 patent/WO2001070222A2/en not_active Ceased
- 2001-03-15 AR ARP010101211A patent/AR028258A1/es not_active Application Discontinuation
- 2001-03-16 TW TW090106235A patent/TWI268777B/zh not_active IP Right Cessation
2002
- 2002-08-08 ZA ZA200206350A patent/ZA200206350B/en unknown
2005
- 2005-06-15 AU AU2005202600A patent/AU2005202600B2/en not_active Ceased
2010
- 2010-11-24 JP JP2010261857A patent/JP2011037901A/ja not_active Withdrawn
2011
- 2011-05-13 JP JP2011108785A patent/JP2011153158A/ja not_active Withdrawn

Also Published As

Publication number	Publication date
WO2001070222A3 (en)	2002-07-25
PT1263504E (pt)	2003-12-31
PL358306A1 (en)	2004-08-09
JP2003527423A (ja)	2003-09-16
ZA200206350B (en)	2003-08-08
CA2399985A1 (en)	2001-09-27
BR0109230A (pt)	2003-06-03
KR20030009390A (ko)	2003-01-29
AU4531001A (en)	2001-10-03
CN1418121A (zh)	2003-05-14
CN1418100A (zh)	2003-05-14
AU2005202600B2 (en)	2008-07-31
DE60100625T2 (de)	2004-02-26
ES2204848T3 (es)	2004-05-01
AU2001239836A1 (en)	2001-10-03
PL203709B1 (pl)	2009-11-30
KR20030016239A (ko)	2003-02-26
AU2001245310B2 (en)	2005-03-17
AU2005202600A1 (en)	2005-07-07
MXPA02009073A (es)	2003-03-12
EP1263434A1 (de)	2002-12-11
EP1263504A2 (de)	2002-12-11
CA2400639C (en)	2011-08-16
CA2400637A1 (en)	2001-09-27
AR028258A1 (es)	2003-04-30
TWI268777B (en)	2006-12-21
KR100749191B1 (ko)	2007-08-13
WO2001070230A3 (en)	2002-04-25
WO2001070222A2 (en)	2001-09-27
AU2001238552A1 (en)	2001-10-03
BR0109211A (pt)	2003-02-11
KR20020082885A (ko)	2002-10-31
DK1263504T3 (da)	2003-12-08
EP1263504B1 (de)	2003-08-20
ATE247507T1 (de)	2003-09-15
JP2003527422A (ja)	2003-09-16
JP2003527427A (ja)	2003-09-16
JP2011037901A (ja)	2011-02-24
JP4789231B2 (ja)	2011-10-12
HK1051504A1 (en)	2003-08-08
WO2001070223A1 (en)	2001-09-27
EP1267878A2 (de)	2003-01-02
MXPA02009071A (es)	2003-05-23
CN1198605C (zh)	2005-04-27
WO2001070230A2 (en)	2001-09-27
CA2400639A1 (en)	2001-09-27
JP2011153158A (ja)	2011-08-11
BR0109193A (pt)	2003-05-27
MXPA02009072A (es)	2003-03-12

Publication	Publication Date	Title
DE60100625D1 (de)	2003-09-25	Verwndung von verbindungen mit 5-ht1a aktivität zur behandlung von krankheiten der äusseren retina
ATE308997T1 (de)	2005-11-15	Mittel zur behandlung von erkrankungen der speiseröhre
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ATE390407T1 (de)	2008-04-15	Phenethanolamin-derivate zur behandlung von atemwegserkrankungen
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ATE472325T1 (de)	2010-07-15	Intrakorporale medikamente zur photodynamischen behandlung von erkrankungen
ATE292134T1 (de)	2005-04-15	Neue oxabispidin-verbindungen zur behandlung von herzarrhythmien
DE69918687D1 (de)	2004-08-19	4-phenylpiperidine zur behandlung von prutitischen hauterkrankungen
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ATE289196T1 (de)	2005-03-15	Verwendung von pleuromutilinderivaten zur transdermalen behandlung bakterieller erkrankungen
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Legal Events

Date	Code	Title	Description
2004-09-16	8364	No opposition during term of opposition