DE60042710D1 - Verwendung von 1- 4-(5-cyanoindol-3-yl)butyl -4-(2-carbamoylbenzofuran-5-yl)piperazin und dessem physiologisch akzeptablen Salzen - Google Patents

Verwendung von 1- 4-(5-cyanoindol-3-yl)butyl -4-(2-carbamoylbenzofuran-5-yl)piperazin und dessem physiologisch akzeptablen Salzen

Info

Publication number: DE60042710D1
Authority: DE; Germany
Prior art keywords: carbamoylbenzofuran; cyanoindol; piperazine; butyl; acceptable salts
Prior art date: 1999-05-27
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE60042710T

Other languages

English (en)

Inventor

Gerd Bartoszyk

Christoph Seyfried

Amsterdam Christoph Van

Henning Boettcher

Ewen Sedman

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Merck Patent GmbH

Original Assignee

Merck Patent GmbH

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-05-27

Filing date

2000-05-16

Publication date

2009-09-17

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8238153&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE60042710(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2000-05-16 Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH

2009-09-17 Application granted granted Critical

2009-09-17 Publication of DE60042710D1 publication Critical patent/DE60042710D1/de

2020-05-17 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
- A—HUMAN NECESSITIES
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- A61P3/06—Antihyperlipidemics
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics

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Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Reproductive Health (AREA)
Psychiatry (AREA)
Endocrinology (AREA)
Pain & Pain Management (AREA)
Hematology (AREA)
Diabetes (AREA)
Rheumatology (AREA)
Gynecology & Obstetrics (AREA)
Obesity (AREA)
Hospice & Palliative Care (AREA)
Addiction (AREA)
Oncology (AREA)
Pregnancy & Childbirth (AREA)
Child & Adolescent Psychology (AREA)
Nutrition Science (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Communicable Diseases (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

DE60042710T 1999-05-27 2000-05-16 Verwendung von 1- 4-(5-cyanoindol-3-yl)butyl -4-(2-carbamoylbenzofuran-5-yl)piperazin und dessem physiologisch akzeptablen Salzen Expired - Lifetime DE60042710D1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP99109295		1999-05-27

Publications (1)

Publication Number	Publication Date
DE60042710D1 true DE60042710D1 (de)	2009-09-17

Family

ID=8238153

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
DE60030338T Expired - Lifetime DE60030338T2 (de)	1999-05-27	2000-05-16	Verwendung von 1- 4-(5-cyanoindol-3-yl)butyl -4-(2-carbamoylbenzofuran-5-yl)piperazin und deren physiologisch akzeptablen Salzen
DE60042710T Expired - Lifetime DE60042710D1 (de)	1999-05-27	2000-05-16	Verwendung von 1- 4-(5-cyanoindol-3-yl)butyl -4-(2-carbamoylbenzofuran-5-yl)piperazin und dessem physiologisch akzeptablen Salzen
DE60009697T Expired - Lifetime DE60009697T2 (de)	1999-05-27	2000-05-16	Verwendung von 1-[4-(5-cyanoindol-3yl)butyl]-4-(2-carbamoylbenzofuran-5-yl)piperazin und dessen physiologisch akzeptablen salzen zur behandlung von bipolaren krankheiten und manie

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DE60030338T Expired - Lifetime DE60030338T2 (de)	1999-05-27	2000-05-16	Verwendung von 1- 4-(5-cyanoindol-3-yl)butyl -4-(2-carbamoylbenzofuran-5-yl)piperazin und deren physiologisch akzeptablen Salzen

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DE60009697T Expired - Lifetime DE60009697T2 (de)	1999-05-27	2000-05-16	Verwendung von 1-[4-(5-cyanoindol-3yl)butyl]-4-(2-carbamoylbenzofuran-5-yl)piperazin und dessen physiologisch akzeptablen salzen zur behandlung von bipolaren krankheiten und manie

Country Status (31)

Country	Link
US (4)	US6900212B1 (de)
EP (3)	EP1410800B1 (de)
JP (2)	JP4884588B2 (de)
KR (1)	KR100683367B1 (de)
CN (3)	CN1198618C (de)
AR (1)	AR024112A1 (de)
AT (3)	ATE263564T1 (de)
AU (1)	AU771778B2 (de)
BR (1)	BR0010948A (de)
CA (3)	CA2615271C (de)
CY (2)	CY1105750T1 (de)
CZ (1)	CZ295623B6 (de)
DE (3)	DE60030338T2 (de)
DK (3)	DK1736158T3 (de)
ES (3)	ES2219342T3 (de)
HK (1)	HK1048444B (de)
HU (1)	HU229059B1 (de)
IL (2)	IL146707A0 (de)
MX (1)	MXPA01012172A (de)
MY (1)	MY135627A (de)
NO (2)	NO322120B1 (de)
PL (3)	PL200490B1 (de)
PT (3)	PT1736158E (de)
RU (1)	RU2237477C2 (de)
SI (2)	SI1410800T1 (de)
SK (1)	SK287851B6 (de)
TR (1)	TR200103361T2 (de)
TW (1)	TW518218B (de)
UA (1)	UA74337C2 (de)
WO (1)	WO2000072832A2 (de)
ZA (1)	ZA200110485B (de)

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TW518218B (en) *	1999-05-27	2003-01-21	Merck Patent Gmbh	Pharmaceutical compositions comprising 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoylbenzofuran-5-yl)piperazine or its physiologically acceptable salts for use in the treatment of sub-type anxiety disorders
UA76130C2 (en) *	2000-11-20	2006-07-17	Merck Patent Gmbh	Use of compounds combining properties of selective inhibitors of serotonin re-uptake and agonists of 5-ht1a receptor for treatment of irritable bowel syndrome
DE10112151A1 (de)	2001-03-14	2002-09-19	Merck Patent Gmbh	Substituierte Benzofuran-2-carbonsäureamide
UA76758C2 (uk) *	2001-06-19	2006-09-15	Мерк Патент Гмбх	Поліморфні форми гідрохлориду 1-'4-(5-ціаноіндол-3-іл)бутил-4-(2-карбамоїлбензофуран-5-іл)піперазину
DE10217006A1 (de) *	2002-04-16	2003-11-06	Merck Patent Gmbh	Substituierte Indole
DE10305739A1 (de)	2003-02-11	2004-08-19	Merck Patent Gmbh	Benzofuranderivate
US20040192730A1 (en) *	2003-03-13	2004-09-30	Dynogen Pharmaceuticals, Inc.	Methods of using compounds with combined 5-HT1A and SSRI activities as-needed to treat sexual dysfunction
EP1732610A2 (de)	2004-03-26	2006-12-20	Baylor University	Gezielte inhibitoren der serotonin-wiederaufname
CN101460470B (zh)	2006-05-30	2011-05-18	阿斯利康(瑞典)有限公司	作为dgat1抑制剂的1,3,4-二唑衍生物
KR20100099738A (ko)	2007-12-20	2010-09-13	아스트라제네카 아베	Ｄｇａｔ1 억제제로서의 카르바모일 화합물 190
EP2443096A1 (de)	2009-06-19	2012-04-25	AstraZeneca AB	Pyrazincarboxamide als dgat1-hemmer
CN102762201B (zh)	2009-11-06	2013-12-18	爱思开生物制药株式会社	注意力缺陷/多动症的治疗方法
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US9610274B2 (en)	2010-06-30	2017-04-04	Sk Biopharmaceuticals Co., Ltd.	Methods for treating bipolar disorder
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TWI577377B (zh) *	2010-09-16	2017-04-11	Ｖｉｉｖ醫療保健公司	醫藥組合物
WO2012131706A1 (en)	2011-03-20	2012-10-04	Cadila Healthcare Limited	Amorphous form of vilazodone hydrochloride and process for its preparation
CN102949364A (zh) *	2011-08-30	2013-03-06	天津药物研究院	一种含有效成分盐酸维拉佐酮的缓释片
WO2013185209A1 (en)	2012-06-13	2013-12-19	Apotex Technologies Inc.	Forms of vilazodone and processes for the preparation thereof
CN102860993A (zh) *	2012-10-16	2013-01-09	北京诚创思达医药科技有限公司	一种盐酸维拉唑酮快速释放片剂及其制备方法
WO2014064715A2 (en)	2012-10-22	2014-05-01	Cadila Healthcare Limited	Amorphous form of vilazodone hydrochloride and process for preparing thereof
CN102977083A (zh) *	2012-12-17	2013-03-20	南京海纳医药科技有限公司	1-[4-(5-氰基吲哚-3-基)丁基]-4-(2-氨甲酰-苯并呋喃-5-基)-哌嗪盐酸盐的新晶型xⅶ及其制备方法
SI3228313T1 (sl)	2013-01-22	2019-12-31	Vistagen Therapeutics, Inc.	Odmerne oblike in terapevtske uporabe L-4-klorokinurenina
EP2824104A1 (de)	2013-07-12	2015-01-14	Sandoz AG	Verfahren zur Herstellung von Form III von Vilazodonhydrochlorid
KR20240068766A (ko) *	2015-05-22	2024-05-17	비스타젠 쎄라퓨틱스, 인크.	L-４-클로로키누레닌의 치료적 용도

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TW518218B (en) *	1999-05-27	2003-01-21	Merck Patent Gmbh	Pharmaceutical compositions comprising 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoylbenzofuran-5-yl)piperazine or its physiologically acceptable salts for use in the treatment of sub-type anxiety disorders
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1999
- 1999-11-15 TW TW088119882A patent/TW518218B/zh not_active IP Right Cessation
2000
- 2000-05-16 CA CA2615271A patent/CA2615271C/en not_active Expired - Fee Related
- 2000-05-16 IL IL14670700A patent/IL146707A0/xx active IP Right Grant
- 2000-05-16 DK DK06017231T patent/DK1736158T3/da active
- 2000-05-16 UA UA2001128861A patent/UA74337C2/uk unknown
- 2000-05-16 DE DE60030338T patent/DE60030338T2/de not_active Expired - Lifetime
- 2000-05-16 PL PL383006A patent/PL200490B1/pl unknown
- 2000-05-16 AT AT00935031T patent/ATE263564T1/de active
- 2000-05-16 EP EP04001441A patent/EP1410800B1/de not_active Expired - Lifetime
- 2000-05-16 DE DE60042710T patent/DE60042710D1/de not_active Expired - Lifetime
- 2000-05-16 CN CNB008081352A patent/CN1198618C/zh not_active Expired - Fee Related
- 2000-05-16 MX MXPA01012172A patent/MXPA01012172A/es active IP Right Grant
- 2000-05-16 CZ CZ20014226A patent/CZ295623B6/cs not_active IP Right Cessation
- 2000-05-16 DK DK00935031T patent/DK1185272T3/da active
- 2000-05-16 ES ES00935031T patent/ES2219342T3/es not_active Expired - Lifetime
- 2000-05-16 AT AT04001441T patent/ATE337008T1/de active
- 2000-05-16 SK SK1646-2001A patent/SK287851B6/sk not_active IP Right Cessation
- 2000-05-16 PT PT06017231T patent/PT1736158E/pt unknown
- 2000-05-16 AT AT06017231T patent/ATE438399T1/de active
- 2000-05-16 WO PCT/EP2000/004376 patent/WO2000072832A2/en not_active Ceased
- 2000-05-16 CA CA002372668A patent/CA2372668C/en not_active Expired - Fee Related
- 2000-05-16 AU AU50663/00A patent/AU771778B2/en not_active Ceased
- 2000-05-16 ES ES06017231T patent/ES2330774T3/es not_active Expired - Lifetime
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- 2000-05-16 SI SI200030902T patent/SI1410800T1/sl unknown
- 2000-05-16 KR KR1020017015141A patent/KR100683367B1/ko not_active Expired - Fee Related
- 2000-05-16 SI SI200030423T patent/SI1185272T1/xx unknown
- 2000-05-16 JP JP2000620944A patent/JP4884588B2/ja not_active Expired - Fee Related
- 2000-05-16 CN CN200910113677A patent/CN101869565A/zh active Pending
- 2000-05-16 EP EP06017231A patent/EP1736158B1/de not_active Expired - Lifetime
- 2000-05-16 CA CA2694866A patent/CA2694866A1/en not_active Abandoned
- 2000-05-16 TR TR2001/03361T patent/TR200103361T2/xx unknown
- 2000-05-16 PT PT00935031T patent/PT1185272E/pt unknown
- 2000-05-16 PL PL352373A patent/PL199516B1/pl unknown
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- 2000-05-16 PT PT04001441T patent/PT1410800E/pt unknown
- 2000-05-16 DK DK04001441T patent/DK1410800T3/da active
- 2000-05-16 BR BR0010948-7A patent/BR0010948A/pt not_active Application Discontinuation
- 2000-05-16 EP EP00935031A patent/EP1185272B1/de not_active Expired - Lifetime
- 2000-05-16 US US09/979,922 patent/US6900212B1/en not_active Expired - Lifetime
- 2000-05-16 HU HU0201275A patent/HU229059B1/hu not_active IP Right Cessation
- 2000-05-16 DE DE60009697T patent/DE60009697T2/de not_active Expired - Lifetime
- 2000-05-16 ES ES04001441T patent/ES2271707T3/es not_active Expired - Lifetime
- 2000-05-16 CN CNA2005100544177A patent/CN1679577A/zh active Pending
- 2000-05-16 PL PL383406A patent/PL199650B1/pl unknown
- 2000-05-25 MY MYPI20002314A patent/MY135627A/en unknown
- 2000-05-26 AR ARP000102575A patent/AR024112A1/es unknown
2001
- 2001-11-22 IL IL146707A patent/IL146707A/en not_active IP Right Cessation
- 2001-11-26 NO NO20015746A patent/NO322120B1/no not_active IP Right Cessation
- 2001-12-20 ZA ZA200110485A patent/ZA200110485B/en unknown
2004
- 2004-11-23 US US10/994,226 patent/US7371756B2/en not_active Expired - Lifetime
2006
- 2006-04-06 NO NO20061562A patent/NO324230B1/no not_active IP Right Cessation
- 2006-11-02 CY CY20061101575T patent/CY1105750T1/el unknown
2007
- 2007-11-28 US US11/946,149 patent/US7642261B2/en not_active Expired - Fee Related
2009
- 2009-10-14 CY CY20091101063T patent/CY1109472T1/el unknown
- 2009-11-17 US US12/620,049 patent/US20100063062A1/en not_active Abandoned
2011
- 2011-02-10 JP JP2011027903A patent/JP2011148799A/ja active Pending

Also Published As

Publication number	Publication date
DK1410800T3 (da)	2006-12-27
PL352373A1 (en)	2003-08-25
CN1198618C (zh)	2005-04-27
EP1736158A2 (de)	2006-12-27
US20050113386A1 (en)	2005-05-26
US6900212B1 (en)	2005-05-31
CA2615271A1 (en)	2000-12-07
NO322120B1 (no)	2006-08-14
US20100063062A1 (en)	2010-03-11
AR024112A1 (es)	2002-09-04
ATE263564T1 (de)	2004-04-15
EP1185272B1 (de)	2004-04-07
JP2003500441A (ja)	2003-01-07
EP1736158B1 (de)	2009-08-05
SK16462001A3 (sk)	2002-02-05
PT1185272E (pt)	2004-08-31
SI1410800T1 (sl)	2007-02-28
WO2000072832A2 (en)	2000-12-07
PL199516B1 (pl)	2008-09-30
ZA200110485B (en)	2003-06-30
CA2372668A1 (en)	2000-12-07
DE60030338D1 (de)	2006-10-05
AU771778B2 (en)	2004-04-01
JP2011148799A (ja)	2011-08-04
CA2372668C (en)	2009-11-03
UA74337C2 (uk)	2005-12-15
DK1185272T3 (da)	2004-08-09
ES2271707T3 (es)	2007-04-16
SK287851B6 (sk)	2012-01-04
RU2237477C2 (ru)	2004-10-10
DE60009697T2 (de)	2005-04-14
NO324230B1 (no)	2007-09-10
WO2000072832A3 (en)	2001-12-20
ATE337008T1 (de)	2006-09-15
EP1410800A1 (de)	2004-04-21
KR20020008847A (ko)	2002-01-31
NO20061562L (no)	2001-11-26
TW518218B (en)	2003-01-21
PT1410800E (pt)	2007-01-31
ATE438399T1 (de)	2009-08-15
CN1679577A (zh)	2005-10-12
TR200103361T2 (tr)	2002-05-21
HK1048444B (zh)	2005-12-09
DK1736158T3 (da)	2009-11-02
US20080119484A1 (en)	2008-05-22
AU5066300A (en)	2000-12-18
CA2615271C (en)	2011-02-15
CN101869565A (zh)	2010-10-27
BR0010948A (pt)	2002-04-23
ES2330774T3 (es)	2009-12-15
PT1736158E (pt)	2009-11-11
NO20015746D0 (no)	2001-11-26
CY1105750T1 (el)	2010-12-22
IL146707A (en)	2007-06-03
CA2694866A1 (en)	2000-12-07
EP1736158A3 (de)	2007-01-03
US7371756B2 (en)	2008-05-13
PL200490B1 (pl)	2009-01-30
HU229059B1 (en)	2013-07-29
SI1185272T1 (en)	2004-12-31
DE60030338T2 (de)	2007-08-16
MXPA01012172A (es)	2002-07-22
EP1410800B1 (de)	2006-08-23
CZ295623B6 (cs)	2005-09-14
NO20015746L (no)	2001-11-26
CZ20014226A3 (cs)	2002-03-13
PL199650B1 (pl)	2008-10-31
HK1048444A1 (en)	2003-04-04
DE60009697D1 (de)	2004-05-13
HUP0201275A2 (en)	2002-08-28
KR100683367B1 (ko)	2007-02-15
US7642261B2 (en)	2010-01-05
CN1361692A (zh)	2002-07-31
CY1109472T1 (el)	2012-05-23
HUP0201275A3 (en)	2004-04-28
MY135627A (en)	2008-05-30
EP1185272A2 (de)	2002-03-13
ES2219342T3 (es)	2004-12-01
JP4884588B2 (ja)	2012-02-29
IL146707A0 (en)	2002-07-25

Publication	Publication Date	Title
ATE438399T1 (de)	2009-08-15	Verwendung von 1- 4-(5-cyanoindol-3-yl)butyl -4- (2-carbamoylbenzofuran-5-yl)piperazin und dessem physiologisch akzeptablen salzen
DE60040234D1 (de)	2008-10-23	Automatische erstellung von dokumenten mittels anordnungselement und inhaltselementen
DE60113865D1 (de)	2006-02-16	Piperazin derivate
IS6477A (is)	2002-07-19	Afleiður piperazíns og piperadíns
DE60223841D1 (de)	2008-01-10	Medizinische verwendung von gsk3-hemmenden oxindolderivaten
DE60208351D1 (de)	2006-02-02	Glukopyranosyloxybenzylbenzolderivate und deren medizinische verwendung
DK1198453T3 (da)	2003-07-21	N-(indolcarbonyl-)piperazinderivater
ATE267183T1 (de)	2004-06-15	Piperazine und piperidine derivate
DE50012379D1 (de)	2006-05-04	Verwendung von nanoskaligen antischuppenwirkstoffen
ATE301703T1 (de)	2005-08-15	Verwendung von zusammensetzungen zur textilpflege
NO984380L (no)	1999-03-25	Nye piperazin og piperidinforbindelser
DK1283838T3 (da)	2004-03-22	Piperazin- og piperidinforbindelser
PT1446399E (pt)	2005-09-30	Derivados de piperazina tendo actividade antagonista de sst1
DE60001725D1 (de)	2003-04-24	Verwendung des saredutant und seiner pharmazeutisch akzeptablen salze zur behandlung von schwere depression
DE60000343D1 (de)	2002-09-26	Stabilisierung von isothiazolonen
DE60217870D1 (de)	2007-03-15	Verwendung von 2- 5-(4-fluorphenyl)-3-pyridylmethylaminomethyl-chroman und seiner physiologisch annehmbaren salze
DE60125374D1 (de)	2007-02-01	Bisacrylamid enthaltende dentalmassen und deren verwendung
DE60210696D1 (de)	2006-05-24	Optisch aktive 4-(tert-Butoxycarbonyl)piperazin Derivate und Verfahren zu ihrer Herstellung
DE60037197D1 (de)	2008-01-03	Verwendung funktioneller oraler präparate
PT1131308E (pt)	2004-10-29	Novos compostos de piperazina e piperidina
SE9801673D0 (sv)	1998-05-13	New medical use of substituted quinolines
SE9802551D0 (sv)	1998-07-15	New medical use of substituted quinolines

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