DE60039074D1 - Verfahren zur herstellung von insulinvorläufern und von analogen von insulinvorläufern - Google Patents

Verfahren zur herstellung von insulinvorläufern und von analogen von insulinvorläufern

Info

Publication number: DE60039074D1
Authority: DE; Germany
Prior art keywords: insulin; processors; analogs; precursors; production
Prior art date: 1999-12-29
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE60039074T

Other languages

English (en)

Inventor

Thomas B Rglum Kjeldsen

Svend Ludvigsen

Niels Christian Kaarsholm

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Novo Nordisk AS

Original Assignee

Novo Nordisk AS

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-12-29

Filing date

2000-12-04

Publication date

2008-07-10

2000-12-04 Application filed by Novo Nordisk AS filed Critical Novo Nordisk AS

2008-07-10 Application granted granted Critical

2008-07-10 Publication of DE60039074D1 publication Critical patent/DE60039074D1/de

2020-12-05 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 12
102000004877 Insulin Human genes 0.000 title abstract 6
108090001061 Insulin Proteins 0.000 title abstract 6
229940125396 insulin Drugs 0.000 title abstract 6
239000002243 precursor Substances 0.000 abstract 6
102000040430 polynucleotide Human genes 0.000 abstract 2
108091033319 polynucleotide Proteins 0.000 abstract 2
239000002157 polynucleotide Substances 0.000 abstract 2
VOUAQYXWVJDEQY-QENPJCQMSA-N 33017-11-7 Chemical compound OC(=O)CC[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O)CCC1 VOUAQYXWVJDEQY-QENPJCQMSA-N 0.000 abstract 1
108010075254 C-Peptide Proteins 0.000 abstract 1
240000004808 Saccharomyces cerevisiae Species 0.000 abstract 1
125000000539 amino acid group Chemical group 0.000 abstract 1
239000013598 vector Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
Gastroenterology & Hepatology (AREA)
Endocrinology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Toxicology (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Diabetes (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DE60039074T 1999-12-29 2000-12-04 Verfahren zur herstellung von insulinvorläufern und von analogen von insulinvorläufern Expired - Lifetime DE60039074D1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DKPA199901868		1999-12-29
DKPA200000440		2000-03-17
PCT/DK2000/000665 WO2001049742A1 (en)	1999-12-29	2000-12-04	Method for making insulin precursors and insulin precursor analogs

Publications (1)

Publication Number	Publication Date
DE60039074D1 true DE60039074D1 (de)	2008-07-10

Family

ID=26066172

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE60039074T Expired - Lifetime DE60039074D1 (de)	1999-12-29	2000-12-04	Verfahren zur herstellung von insulinvorläufern und von analogen von insulinvorläufern

Country Status (13)

Country	Link
EP (1)	EP1246845B1 (de)
JP (1)	JP4773023B2 (de)
KR (1)	KR20030004317A (de)
CN (1)	CN100432104C (de)
AT (1)	ATE397017T1 (de)
AU (1)	AU1850601A (de)
BR (1)	BR0016867A (de)
CA (1)	CA2392840C (de)
DE (1)	DE60039074D1 (de)
ES (1)	ES2307544T3 (de)
HU (1)	HUP0203475A3 (de)
RU (1)	RU2283846C2 (de)
WO (1)	WO2001049742A1 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7105314B2 (en)	2001-04-02	2006-09-12	Novo Nordisk A/S	Method for making human insulin precursors
DE60233722D1 (de) *	2001-04-02	2009-10-29	Novo Nordisk As	Insulinvorstufen und verfahren zu deren herstellung
ATE464390T1 (de)	2001-11-19	2010-04-15	Novo Nordisk As	Verfahren zur herstellung von insulinverbindungen
WO2004085472A1 (en) *	2003-03-27	2004-10-07	Novo Nordisk A/S	Method for making human insulin precursors and human insulin
JP5697831B2 (ja) *	2003-12-03	2015-04-08	ノヴォノルディスクアー／エス	単鎖インシュリン
CN100460508C (zh) *	2004-11-03	2009-02-11	马延高	人胰岛素基因在甲醇酵母中的分泌表达方法
EP2178909B1 (de)	2007-08-13	2015-10-21	Novo Nordisk A/S	Insulinanaloga mit schneller wirkung
CA2695970A1 (en)	2007-08-15	2009-02-19	Novo Nordisk A\S	Insulin analogues with an acyl and aklylene glycol moiety
CN101784563B (zh)	2007-08-15	2015-02-04	诺沃-诺迪斯克有限公司	具有包括含亚烷基二醇的氨基酸的重复单位的酰基部分的胰岛素
ES2563553T3 (es)	2008-04-01	2016-03-15	Novo Nordisk A/S	Conjugados de insulina-albúmina
EP2585483A1 (de)	2010-06-23	2013-05-01	Novo Nordisk A/S	Humane insulinanaloga mit zusätzlichen disulfid-bindungen
BR112012033107A2 (pt)	2010-06-23	2016-10-11	Novo Nordisk As	derivados de insulina contendo ligações dissulfeto adicionais.
JP5973427B2 (ja)	2010-06-23	2016-08-23	ノヴォノルディスクアー／エス	追加のジスルフィド結合を含有するインスリン類似体
US9260503B2 (en)	2011-06-15	2016-02-16	Novo Nordisk A/S	Multi-substituted insulins
EP2784085A4 (de) *	2011-12-15	2015-07-08	Shanghai Hengrui Pharm Co Ltd	Menschliches insulin-analog und acyliertes derivat daraus
EP3004156A1 (de)	2013-06-07	2016-04-13	Novo Nordisk A/S	Verfahren zur herstellung von reifen insulinpolypeptiden
CN105087724B (zh) *	2014-05-04	2019-12-03	重庆派金生物科技有限公司	酵母重组表达门冬胰岛素的制备方法
CN107417787B (zh) *	2016-05-23	2020-11-17	江苏恒瑞医药股份有限公司	一种人松弛素2类似物的制备方法
CN107446039B (zh) *	2016-05-31	2021-11-12	江苏恒瑞医药股份有限公司	一种人胰岛素类似物前体及其制备方法
CN106699872B (zh) *	2016-12-27	2019-12-24	江南大学	一种提高胰岛素前体产量的方法
EP3668892A1 (de)	2017-08-17	2020-06-24	Novo Nordisk A/S	Neuartige acylierte insulinanaloga und verwendungen dafür
CN108148114B (zh) *	2017-12-08	2020-05-15	珠海冀百康生物科技有限公司	一种提高重组小分子蛋白表达量的串联前导肽及方法
CN108929370B (zh) *	2018-07-15	2021-06-25	渤海大学	三种具有ace抑制活性的鸡蛋源活性肽
JP7439062B2 (ja)	2018-09-19	2024-02-27	ノヴォ・ノルディスク・リサーチ・センター・オックスフォード・リミテッド	グルコース感受性インスリンおよびその使用
CN113773392B (zh) *	2020-06-09	2023-04-07	宁波鲲鹏生物科技有限公司	一种甘精胰岛素的制备方法
WO2022090448A1 (en)	2020-10-30	2022-05-05	Novo Nordisk A/S	Novel acylating reagents
WO2023144240A1 (en)	2022-01-26	2023-08-03	Novo Nordisk Research Centre Oxford Limited	Glucose sensitive insulin derivatives and uses thereof
WO2025099208A1 (en)	2023-11-10	2025-05-15	Intervet International B.V.	Recombinant insulin precursor

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK58285D0 (da) *	1984-05-30	1985-02-08	Novo Industri As	Peptider samt fremstilling og anvendelse deraf
AU1272295A (en) *	1993-12-17	1995-07-03	Novo Nordisk A/S	Proinsulin-like compounds
KR0150565B1 (ko) *	1995-02-15	1998-08-17	김정재	유전자 조환에 의한 사람 인슐린 전구체의 제조 및 이를 이용한 인슐린의 제조방법

2000
- 2000-12-04 RU RU2002120512/13A patent/RU2283846C2/ru not_active IP Right Cessation
- 2000-12-04 CN CNB008179603A patent/CN100432104C/zh not_active Expired - Lifetime
- 2000-12-04 HU HU0203475A patent/HUP0203475A3/hu unknown
- 2000-12-04 KR KR1020027008588A patent/KR20030004317A/ko not_active Withdrawn
- 2000-12-04 CA CA2392840A patent/CA2392840C/en not_active Expired - Fee Related
- 2000-12-04 WO PCT/DK2000/000665 patent/WO2001049742A1/en not_active Ceased
- 2000-12-04 AU AU18506/01A patent/AU1850601A/en not_active Abandoned
- 2000-12-04 DE DE60039074T patent/DE60039074D1/de not_active Expired - Lifetime
- 2000-12-04 JP JP2001550282A patent/JP4773023B2/ja not_active Expired - Fee Related
- 2000-12-04 AT AT00981169T patent/ATE397017T1/de not_active IP Right Cessation
- 2000-12-04 EP EP00981169A patent/EP1246845B1/de not_active Expired - Lifetime
- 2000-12-04 ES ES00981169T patent/ES2307544T3/es not_active Expired - Lifetime
- 2000-12-04 BR BR0016867-0A patent/BR0016867A/pt not_active Application Discontinuation

Also Published As

Publication number	Publication date
BR0016867A (pt)	2002-10-08
KR20030004317A (ko)	2003-01-14
EP1246845B1 (de)	2008-05-28
ES2307544T3 (es)	2008-12-01
CN100432104C (zh)	2008-11-12
EP1246845A1 (de)	2002-10-09
PL355871A1 (en)	2004-05-31
AU1850601A (en)	2001-07-16
CA2392840A1 (en)	2001-07-12
RU2002120512A (ru)	2004-01-27
JP2003518945A (ja)	2003-06-17
HUP0203475A3 (en)	2005-11-28
WO2001049742A1 (en)	2001-07-12
JP4773023B2 (ja)	2011-09-14
HUP0203475A2 (hu)	2003-02-28
CA2392840C (en)	2012-07-17
RU2283846C2 (ru)	2006-09-20
CN1414974A (zh)	2003-04-30
ATE397017T1 (de)	2008-06-15

Publication	Publication Date	Title
DE60039074D1 (de)	2008-07-10	Verfahren zur herstellung von insulinvorläufern und von analogen von insulinvorläufern
DE69104280D1 (de)	1994-11-03	Verfahren zur Herstellung von hochreiner Isophthalsäure.
AU2003264419A1 (en)	2004-04-30	Kdr peptides and vaccines containing the same
ATE316100T1 (de)	2006-02-15	Exendin-analoga, verfahren zu deren herstellung und diese enthaltende arzneimittel
DE3583824D1 (de)	1991-09-26	Vorlaeufer des insulins, verfahren zu seiner herstellung und verfahren zur herstellung von humaninsulin aus solchen vorlaeufern des insulins.
ATE443082T1 (de)	2009-10-15	Insulinvorstufen und verfahren zu deren herstellung
DE3774197D1 (de)	1991-12-05	Verfahren zur herstellung von rindlaktoferrin in hoher reinheit.
DE59304248D1 (de)	1996-11-28	Mehrstufenprozess zur Herstellung von thermoplastisch verarbeitbaren Polyurethan-Elastomeren
DE69902139D1 (de)	2002-08-22	Verfahren zur Herstellung von Salpetersäure
DE69206542D1 (de)	1996-01-18	Verfahren zur Herstellung von Ethylenoxyd.
FI934812A0 (fi)	1993-10-29	Stabiliserade entzymer
DE69005154D1 (de)	1994-01-27	Verfahren zur Herstellung von nichtwässrigen Elektrolyten.
WO2001085781A3 (en)	2002-03-28	Repair of nerve damage
DE69110590D1 (de)	1995-07-27	Verfahren zur Herstellung von Anilin von hoher Reinheit.
DE69101337D1 (de)	1994-04-14	Verfahren zur Herstellung von Anilin hoher Reinheit.
AU2099301A (en)	2001-07-09	Method for obtaining proteins having improved functional characteristics
ATE474930T1 (de)	2010-08-15	Verfahren zur herstellung von insulinvorläufern und analogen von insulinvorläufern mit verbesserter fermentationsausbeute in hefe
ATE60042T1 (de)	1991-02-15	Verfahren zur herstellung von 1-chlor-1,1difluor\|than.
DE69413946D1 (de)	1998-11-19	Verfahren zur Herstellung von hochreiner 2,6-Naphthalindicarbonsäure
DE3887197D1 (de)	1994-03-03	Verfahren zur Herstellung von Glucosedehydrogenase aus Bacillus megaterium.
DE59308152D1 (de)	1998-03-26	Mehrstufenprozess zur Herstellung von thermoplastisch verarbeitbaren Polyurethan-Elastomeren
DE59404911D1 (de)	1998-02-12	Verfahren zur Herstellung von Stiften, insbes. von Kosmetikstiften
DE69105615D1 (de)	1995-01-19	Verfahren zur Herstellung von hochreiner Isophthalsäure.
DE69328043D1 (de)	2000-04-13	Verbessertes Verfahren zur Herstellung von 1,3-Butylenglykol
DE68910087D1 (de)	1993-11-25	Verfahren zur Herstellung von harten, ein Enzym enthaltenden Kandis.

Legal Events

Date	Code	Title	Description
2009-06-18	8364	No opposition during term of opposition