ATE464390T1 - Verfahren zur herstellung von insulinverbindungen - Google Patents

Verfahren zur herstellung von insulinverbindungen

Info

Publication number: ATE464390T1
Authority: AT; Austria
Prior art keywords: insulin compounds; producing insulin; compounds; insulin; ester
Prior art date: 2001-11-19

Application number

AT02779247T

Other languages

English (en)

Inventor

Are Bogsnes

Ingun Christiansen

Per Balschmidt

Original Assignee

Novo Nordisk As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-11-19

Filing date

2002-11-15

Publication date

2010-04-15

2002-11-15 Application filed by Novo Nordisk As filed Critical Novo Nordisk As

2010-04-15 Application granted granted Critical

2010-04-15 Publication of ATE464390T1 publication Critical patent/ATE464390T1/de

Links

NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical class N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 4
238000004519 manufacturing process Methods 0.000 title 1
102000004877 Insulin Human genes 0.000 abstract 1
108090001061 Insulin Proteins 0.000 abstract 1
-1 amino acid ester Chemical class 0.000 abstract 1
239000012736 aqueous medium Substances 0.000 abstract 1
230000008878 coupling Effects 0.000 abstract 1
238000010168 coupling process Methods 0.000 abstract 1
238000005859 coupling reaction Methods 0.000 abstract 1
230000002255 enzymatic effect Effects 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
229940125396 insulin Drugs 0.000 abstract 1
239000013067 intermediate product Substances 0.000 abstract 1
239000003960 organic solvent Substances 0.000 abstract 1
230000007030 peptide scission Effects 0.000 abstract 1
239000002243 precursor Substances 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Diabetes (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Zoology (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Endocrinology (AREA)
Wood Science & Technology (AREA)
Animal Behavior & Ethology (AREA)
Hematology (AREA)
Veterinary Medicine (AREA)
Toxicology (AREA)
Pharmacology & Pharmacy (AREA)
Gastroenterology & Hepatology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biophysics (AREA)
Obesity (AREA)
Public Health (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Emergency Medicine (AREA)
General Engineering & Computer Science (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

AT02779247T 2001-11-19 2002-11-15 Verfahren zur herstellung von insulinverbindungen ATE464390T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DKPA200101716		2001-11-19
PCT/DK2002/000765 WO2003044210A2 (en)	2001-11-19	2002-11-15	Process for preparing insulin compounds

Publications (1)

Publication Number	Publication Date
ATE464390T1 true ATE464390T1 (de)	2010-04-15

Family

ID=8160841

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02779247T ATE464390T1 (de)	2001-11-19	2002-11-15	Verfahren zur herstellung von insulinverbindungen

Country Status (15)

Country	Link
EP (1)	EP1448786B1 (de)
JP (1)	JP4404631B2 (de)
KR (1)	KR100925381B1 (de)
CN (1)	CN100424179C (de)
AT (1)	ATE464390T1 (de)
AU (1)	AU2002342597A1 (de)
BR (1)	BR0213583A (de)
CA (1)	CA2464616C (de)
DE (1)	DE60236014D1 (de)
ES (1)	ES2344448T3 (de)
HU (1)	HU228934B1 (de)
IL (2)	IL161358A0 (de)
PL (1)	PL210437B1 (de)
RU (1)	RU2376379C2 (de)
WO (1)	WO2003044210A2 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE102006031955A1 (de) *	2006-07-11	2008-01-17	Sanofi-Aventis Deutschland Gmbh	Verfahren zur Herstellung von Insulinanaloga mit dibasischem B-Kettenende
DE102006031962A1 (de)	2006-07-11	2008-01-17	Sanofi-Aventis Deutschland Gmbh	Amidiertes Insulin Glargin
TW200902708A (en) *	2007-04-23	2009-01-16	Wyeth Corp	Methods of protein production using anti-senescence compounds
LT3228320T (lt)	2008-10-17	2020-03-10	Sanofi-Aventis Deutschland Gmbh	Insulino ir glp-1 agonisto derinys
SG178306A1 (en) *	2009-08-11	2012-03-29	Biocon Ltd	Chromatographic processes and purified compounds thereof
KR101772372B1 (ko)	2009-11-13	2017-08-29	사노피-아벤티스 도이칠란트 게엠베하	Ｇｌｐ-1 효능제 및 메티오닌을 포함하는 약제학적 조성물
PE20121362A1 (es)	2009-11-13	2012-10-17	Sanofi Aventis Deutschland	Composicion farmaceutica que comprende despro36exendina-4(1-39)-lys6-nh2, insulina gly(a21)-arg(b31)-arg(b32) y metionina
EP2611458B1 (de)	2010-08-30	2016-09-21	Sanofi-Aventis Deutschland GmbH	Verwendung von ave0010 für die herstellung eines medikaments zur behandlung von diabetes mellitus typ 2
US9821032B2 (en)	2011-05-13	2017-11-21	Sanofi-Aventis Deutschland Gmbh	Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
AU2012300978B2 (en)	2011-08-29	2017-04-27	Sanofi-Aventis Deutschland Gmbh	Pharmaceutical combination for use in glycemic control in diabetes type 2 patients
TWI559929B (en)	2011-09-01	2016-12-01	Sanofi Aventis Deutschland	Pharmaceutical composition for use in the treatment of a neurodegenerative disease
CN102703552B (zh) *	2012-05-15	2014-10-29	山东阿华生物药业有限公司	重组人胰岛素的制备方法及其产品
CN102816819B (zh) *	2012-08-13	2014-10-29	山东阿华生物药业有限公司	提高人胰岛素前体融合蛋白酶切转换成b30缺苏氨酸人胰岛素产率的方法
CN103305581B (zh) *	2013-07-04	2015-05-27	珠海联邦制药股份有限公司	一种重组人胰岛素的制备方法
EP3087192B1 (de) *	2013-12-23	2020-08-12	Biocon Biologics India Limited	Verfahren zur herstellung von humaninsulinmethylester
HRP20230470T1 (hr)	2014-12-12	2023-07-21	Sanofi-Aventis Deutschland Gmbh	Formulacija fiksnog omjera inzulin glargin/liksisenatid
TWI748945B (zh)	2015-03-13	2021-12-11	德商賽諾菲阿凡提斯德意志有限公司	第２型糖尿病病患治療
TW201705975A (zh)	2015-03-18	2017-02-16	賽諾菲阿凡提斯德意志有限公司	第２型糖尿病病患之治療
JP2018531007A (ja) *	2015-09-24	2018-10-25	ハンミファーマシューティカルカンパニーリミテッド	インスリンの製造方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4343898A (en)	1980-02-11	1982-08-10	Novo Industri A/S	Process for preparing esters of human insulin
DE3262052D1 (en)	1981-08-10	1985-03-07	Nordisk Insulinlab	Process for the enzymatic preparation of human insulin
US4601979A (en)	1981-09-15	1986-07-22	Nordisk Insulinlaboratorium	Process for preparing human insulin or B-30 esters thereof
DK149824C (da)	1982-01-22	1987-03-16	Carlsberg Biotechnology Ltd	Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyrer i insuliner
EP0087238A1 (de)	1982-02-08	1983-08-31	Biogen N.V.	Methode zur Herstellung von menschlichem Insulin aus nichtmenschlichem Insulin-
DK347086D0 (da)	1986-07-21	1986-07-21	Novo Industri As	Novel peptides
PH25772A (en)	1985-08-30	1991-10-18	Novo Industri As	Insulin analogues, process for their preparation
CA1339955C (en) *	1986-10-14	1998-07-14	Richard Eugene Heiney	Process for transforming a human insulin precursor to human insulin
ES2053723T3 (es)	1987-02-25	1994-08-01	Novo Nordisk As	Nuevos derivados de insulina.
HU217684B (hu)	1993-09-17	2000-03-28	Novo Nordisk A/S	Acilezett inzulinszármazékok és azokat tartalmazó gyógyszerkészítmények és előállításuk
US6011007A (en)	1993-09-17	2000-01-04	Novo Nordisk A/S	Acylated insulin
RU2141531C1 (ru) *	1999-05-26	1999-11-20	Российское акционерное общество открытого типа "Биопрепарат"	Способ получения рекомбинантного инсулина человека
RU2283846C2 (ru)	1999-12-29	2006-09-20	Ново Нордиск А/С	Предшественник инсулина, способ его получения и применение
KR20030004315A (ko)	1999-12-29	2003-01-14	노보 노르디스크 에이/에스	효모에서 개선된 발효 수율을 갖는 인슐린 선구물질 및인슐린 선구물질 유사체의 제조 방법
WO2001079250A1 (en)	2000-04-14	2001-10-25	University Of Maryland Biotechnology Institute	Enhanced protein thermostability and temperature resistance
WO2002079254A1 (en)	2001-03-29	2002-10-10	Janoff Edward N	Human monoclonal antibodies against capsular polysaccharides of streptococcus pneumoniae

2002
- 2002-11-15 AT AT02779247T patent/ATE464390T1/de not_active IP Right Cessation
- 2002-11-15 RU RU2004118503/13A patent/RU2376379C2/ru not_active IP Right Cessation
- 2002-11-15 ES ES02779247T patent/ES2344448T3/es not_active Expired - Lifetime
- 2002-11-15 WO PCT/DK2002/000765 patent/WO2003044210A2/en not_active Ceased
- 2002-11-15 KR KR1020047007129A patent/KR100925381B1/ko not_active Expired - Fee Related
- 2002-11-15 HU HU0500037A patent/HU228934B1/hu not_active IP Right Cessation
- 2002-11-15 IL IL16135802A patent/IL161358A0/xx unknown
- 2002-11-15 DE DE60236014T patent/DE60236014D1/de not_active Expired - Lifetime
- 2002-11-15 EP EP02779247A patent/EP1448786B1/de not_active Expired - Lifetime
- 2002-11-15 CA CA2464616A patent/CA2464616C/en not_active Expired - Fee Related
- 2002-11-15 JP JP2003545831A patent/JP4404631B2/ja not_active Expired - Lifetime
- 2002-11-15 CN CNB028229622A patent/CN100424179C/zh not_active Expired - Lifetime
- 2002-11-15 AU AU2002342597A patent/AU2002342597A1/en not_active Abandoned
- 2002-11-15 BR BR0213583-3A patent/BR0213583A/pt not_active Application Discontinuation
- 2002-11-15 PL PL369447A patent/PL210437B1/pl unknown
2004
- 2004-04-14 IL IL161358A patent/IL161358A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
AU2002342597A8 (en)	2003-06-10
WO2003044210A3 (en)	2004-03-25
WO2003044210A2 (en)	2003-05-30
CN100424179C (zh)	2008-10-08
KR100925381B1 (ko)	2009-11-09
PL210437B1 (pl)	2012-01-31
RU2376379C2 (ru)	2009-12-20
ES2344448T3 (es)	2010-08-27
HUP0500037A3 (en)	2010-01-28
PL369447A1 (en)	2005-04-18
CA2464616C (en)	2012-07-24
CA2464616A1 (en)	2003-05-30
AU2002342597A1 (en)	2003-06-10
KR20050044855A (ko)	2005-05-13
EP1448786A2 (de)	2004-08-25
JP2005509687A (ja)	2005-04-14
JP4404631B2 (ja)	2010-01-27
RU2004118503A (ru)	2005-06-10
BR0213583A (pt)	2004-08-24
CN1589328A (zh)	2005-03-02
HUP0500037A2 (hu)	2005-03-29
EP1448786B1 (de)	2010-04-14
HU228934B1 (hu)	2013-06-28
IL161358A (en)	2011-05-31
DE60236014D1 (de)	2010-05-27
IL161358A0 (en)	2004-09-27

Publication	Publication Date	Title
ATE464390T1 (de)	2010-04-15	Verfahren zur herstellung von insulinverbindungen
ATE461270T1 (de)	2010-04-15	Verfahren zur herstellung von l-aminosäuren
DE60238745D1 (de)	2011-02-10	Glucosamin und verfahren zur herstellung von glucosamin aus mikrobieller biomasse
DE60028777D1 (de)	2006-07-27	Verfahren zur herstellung von 1,3-propanediol durch einen rekombinanten micro-organismus in abwesenheit von coenzym b12
ATE367450T1 (de)	2007-08-15	Verfahren zur herstellung sequenzspezifischer proteasen durch gezielte evolution
ATE458066T1 (de)	2010-03-15	Verfahren zur herstellung von substituierten carbonsäureestern mittels enzymatischer hydrolyse
DE50311645D1 (de)	2009-08-13	Verfahren zur enzymatischen Herstellung enantiomerenangereicherter Beta-Aminosäuren
ATE332391T1 (de)	2006-07-15	Verfahren zur enzymatischen herstellung enantiomerenangereicherter beta-aminosäuren
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DE60015931D1 (de)	2004-12-23	Verfahren zur herstellung eines chiralen-beta-aminosäureesters
ATE301637T1 (de)	2005-08-15	Verfahren zur herstellung von n-geschützten azetidin-2-carbonsäuren
ATA2852003A (de)	2004-02-15	Verfahren zur herstellung chiraler alpha-hydroxycarbonsäuren durch enzymatische hydrolyse von chiralen cyanhydrinen
DE69528160D1 (de)	2002-10-17	Verfahren zur herstellung von 5,7 dichlor-4-hydroxychinolin
WO2004081220A3 (en)	2005-01-27	A process for enzymatically resolving an enantiomeric mixture of alpha-hydroxy acids
ATE430735T1 (de)	2009-05-15	Verfahren zur herstellung von 10,11-dihydro-10- hydroxy-5-h-dibenzäb,füazepin-5-carbonsäureamid
ATE423215T1 (de)	2009-03-15	Verfahren zur herstellung von lysosphingolipiden
DE60034699D1 (de)	2007-06-14	Verfahren zur herstellung von fumagillin
ATE296895T1 (de)	2005-06-15	Verfahren zur herstellung von c4-c12-fettsäuren
ATE321030T1 (de)	2006-04-15	Verfahren zur herstellung von phenylen-bis- benzimidazol-tetrasulfonsäure-dinatriumsalz
DE69900850D1 (de)	2002-03-14	Verfahren zur herstellung von aspartyl-cyclohexylalaninamid

Legal Events

Date	Code	Title	Description
2010-10-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties