DE60032600D1 - Spermin:peptidhaltige tenside - Google Patents
Spermin:peptidhaltige tensideInfo
- Publication number
- DE60032600D1 DE60032600D1 DE60032600T DE60032600T DE60032600D1 DE 60032600 D1 DE60032600 D1 DE 60032600D1 DE 60032600 T DE60032600 T DE 60032600T DE 60032600 T DE60032600 T DE 60032600T DE 60032600 D1 DE60032600 D1 DE 60032600D1
- Authority
- DE
- Germany
- Prior art keywords
- container
- peptide containing
- peptide
- spermine
- tenside
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
- PFNFFQXMRSDOHW-UHFFFAOYSA-N spermine Chemical compound NCCCNCCCCNCCCN PFNFFQXMRSDOHW-UHFFFAOYSA-N 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 3
- 229940063675 spermine Drugs 0.000 abstract 2
- 239000004094 surface-active agent Substances 0.000 abstract 2
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C211/09—Diamines
- C07C211/11—Diaminopropanes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
- C07C233/35—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/36—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- C07C237/10—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
- C07K5/06069—Ser-amino acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Physics & Mathematics (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Plant Pathology (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
- Medicinal Preparation (AREA)
- Indole Compounds (AREA)
- Detergent Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9914045 | 1999-06-16 | ||
| GBGB9914045.1A GB9914045D0 (en) | 1999-06-16 | 1999-06-16 | Novel compounds |
| PCT/GB2000/002364 WO2000077032A2 (en) | 1999-06-16 | 2000-06-16 | Spermine:peptide-based surfactant compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60032600D1 true DE60032600D1 (de) | 2007-02-08 |
| DE60032600T2 DE60032600T2 (de) | 2007-05-03 |
Family
ID=10855486
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60032600T Expired - Lifetime DE60032600T2 (de) | 1999-06-16 | 2000-06-16 | Spermin:peptidhaltige tenside |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US6835712B1 (de) |
| EP (1) | EP1187806B1 (de) |
| JP (1) | JP4759193B2 (de) |
| AT (1) | ATE349419T1 (de) |
| AU (1) | AU5690400A (de) |
| DE (1) | DE60032600T2 (de) |
| ES (1) | ES2278618T3 (de) |
| GB (1) | GB9914045D0 (de) |
| WO (1) | WO2000077032A2 (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9914045D0 (en) * | 1999-06-16 | 1999-08-18 | Smithkline Beecham Plc | Novel compounds |
| WO2003082809A1 (en) * | 2002-03-27 | 2003-10-09 | Glaxo Group Limited | Diaminoacid-aminoacid-polyamine based gemini surfactant compounds |
| GB0425555D0 (en) * | 2004-11-19 | 2004-12-22 | Glaxo Group Ltd | Novel compounds |
| GB0425556D0 (en) * | 2004-11-19 | 2004-12-22 | Glaxo Group Ltd | Novel compounds |
| GB0502482D0 (en) * | 2005-02-07 | 2005-03-16 | Glaxo Group Ltd | Novel compounds |
| GB0512751D0 (en) * | 2005-06-22 | 2005-07-27 | Glaxo Group Ltd | New adjuvant |
| CN105030654A (zh) * | 2006-10-03 | 2015-11-11 | 阿尔尼拉姆医药品有限公司 | 含脂质的制品 |
| EP1935434A1 (de) * | 2006-12-19 | 2008-06-25 | Novosom AG | Konstruktion und Verwendung von transfektionsverstärkenden Elementen |
| JPWO2008105441A1 (ja) * | 2007-02-27 | 2010-06-03 | 味の素株式会社 | リン吸収抑制活性を有するポリアミノ酸化合物及びリン吸収抑制剤 |
| CN102941160A (zh) * | 2012-12-13 | 2013-02-27 | 贵州大学 | 一种硅酸盐矿物浮选捕收剂 |
| KR20220039719A (ko) | 2019-07-03 | 2022-03-29 | 팩터 바이오사이언스 인크. | 양이온성 지질 및 이의 용도 |
| US10501404B1 (en) | 2019-07-30 | 2019-12-10 | Factor Bioscience Inc. | Cationic lipids and transfection methods |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6117542A (ja) * | 1984-07-03 | 1986-01-25 | Takeda Chem Ind Ltd | スペルミン誘導体 |
| US5837533A (en) * | 1994-09-28 | 1998-11-17 | American Home Products Corporation | Complexes comprising a nucleic acid bound to a cationic polyamine having an endosome disruption agent |
| US5767099A (en) * | 1994-12-09 | 1998-06-16 | Genzyme Corporation | Cationic amphiphiles containing amino acid or dervatized amino acid groups for intracellular delivery of therapeutic molecules |
| US6051429A (en) * | 1995-06-07 | 2000-04-18 | Life Technologies, Inc. | Peptide-enhanced cationic lipid transfections |
| AU707947B2 (en) * | 1995-07-21 | 1999-07-22 | Promega Biosciences, Inc. | Novel amide-based cationic lipids |
| US5744335A (en) | 1995-09-19 | 1998-04-28 | Mirus Corporation | Process of transfecting a cell with a polynucleotide mixed with an amphipathic compound and a DNA-binding protein |
| FR2741066B1 (fr) | 1995-11-14 | 1997-12-12 | Rhone Poulenc Rorer Sa | Nouveaux agents de transfection et leurs applications pharmaceutiques |
| GB9726073D0 (en) | 1997-12-09 | 1998-02-04 | Smithkline Beecham Plc | Novel compounds |
| NZ512244A (en) * | 1998-11-12 | 2003-12-19 | Invitrogen Corp | Polycationic transfection reagents for introducing anions into a cell |
| GB9914045D0 (en) * | 1999-06-16 | 1999-08-18 | Smithkline Beecham Plc | Novel compounds |
-
1999
- 1999-06-16 GB GBGB9914045.1A patent/GB9914045D0/en not_active Ceased
-
2000
- 2000-06-16 DE DE60032600T patent/DE60032600T2/de not_active Expired - Lifetime
- 2000-06-16 AU AU56904/00A patent/AU5690400A/en not_active Abandoned
- 2000-06-16 AT AT00942194T patent/ATE349419T1/de not_active IP Right Cessation
- 2000-06-16 ES ES00942194T patent/ES2278618T3/es not_active Expired - Lifetime
- 2000-06-16 JP JP2001503889A patent/JP4759193B2/ja not_active Expired - Fee Related
- 2000-06-16 US US10/018,547 patent/US6835712B1/en not_active Expired - Lifetime
- 2000-06-16 WO PCT/GB2000/002364 patent/WO2000077032A2/en not_active Ceased
- 2000-06-16 EP EP00942194A patent/EP1187806B1/de not_active Expired - Lifetime
-
2004
- 2004-11-17 US US10/990,819 patent/US20050089493A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000077032A2 (en) | 2000-12-21 |
| JP4759193B2 (ja) | 2011-08-31 |
| JP2003504311A (ja) | 2003-02-04 |
| ES2278618T3 (es) | 2007-08-16 |
| US6835712B1 (en) | 2004-12-28 |
| EP1187806A2 (de) | 2002-03-20 |
| ATE349419T1 (de) | 2007-01-15 |
| GB9914045D0 (en) | 1999-08-18 |
| WO2000077032A3 (en) | 2001-05-31 |
| EP1187806B1 (de) | 2006-12-27 |
| DE60032600T2 (de) | 2007-05-03 |
| US20050089493A1 (en) | 2005-04-28 |
| AU5690400A (en) | 2001-01-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8327 | Change in the person/name/address of the patent owner |
Owner name: SMITHKLINE BEECHAM P.L.C., BRENTFORD, MIDDLESE, GB |
|
| 8364 | No opposition during term of opposition |