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DE60030554D1 - Verwendungen von et743 zur behandlung von krebs - Google Patents

Verwendungen von et743 zur behandlung von krebs

Info

Publication number
DE60030554D1
DE60030554D1 DE60030554T DE60030554T DE60030554D1 DE 60030554 D1 DE60030554 D1 DE 60030554D1 DE 60030554 T DE60030554 T DE 60030554T DE 60030554 T DE60030554 T DE 60030554T DE 60030554 D1 DE60030554 D1 DE 60030554D1
Authority
DE
Germany
Prior art keywords
cancer
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60030554T
Other languages
English (en)
Other versions
DE60030554T2 (de
DE60030554T8 (de
Inventor
Angela Bowman
Esteban Cvitkovic
George Daniel Demetri
Cecilia Guzman
Jose Jimeno
Lazaro Luis Lopez
Jean Louis Misset
C Twelves
Hoff Daniel D Von
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmamar SA
Original Assignee
Pharmamar SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9911183.3A external-priority patent/GB9911183D0/en
Priority claimed from GBGB9911346.6A external-priority patent/GB9911346D0/en
Priority claimed from GBGB9918534.0A external-priority patent/GB9918534D0/en
Priority claimed from GBGB9927005.0A external-priority patent/GB9927005D0/en
Priority claimed from GBGB9927106.6A external-priority patent/GB9927106D0/en
Priority claimed from GB0007637A external-priority patent/GB0007637D0/en
Application filed by Pharmamar SA filed Critical Pharmamar SA
Publication of DE60030554D1 publication Critical patent/DE60030554D1/de
Publication of DE60030554T2 publication Critical patent/DE60030554T2/de
Application granted granted Critical
Publication of DE60030554T8 publication Critical patent/DE60030554T8/de
Active legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4995—Pyrazines or piperazines forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE60030554T 1999-05-13 2000-05-15 Verwendungen von et743 zur behandlung von krebs Active DE60030554T8 (de)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
GBGB9911183.3A GB9911183D0 (en) 1999-05-13 1999-05-13 Treatment of cancers
GB9911183 1999-05-13
GB9911346 1999-05-14
GBGB9911346.6A GB9911346D0 (en) 1999-05-14 1999-05-14 Treatment of cancers
GB9918534 1999-08-05
GBGB9918534.0A GB9918534D0 (en) 1999-08-05 1999-08-05 Treatment of cancers
GB9927005 1999-11-15
GBGB9927005.0A GB9927005D0 (en) 1999-11-15 1999-11-15 Treatment of cancers
GBGB9927106.6A GB9927106D0 (en) 1999-11-16 1999-11-16 Cancer treatment
GB9927106 1999-11-16
GB0007637 2000-03-29
GB0007637A GB0007637D0 (en) 2000-03-29 2000-03-29 Antitumour compound
PCT/GB2000/001857 WO2000069441A1 (en) 1999-05-13 2000-05-15 Compositions and uses of et743 for treating cancer

Publications (3)

Publication Number Publication Date
DE60030554D1 true DE60030554D1 (de) 2006-10-19
DE60030554T2 DE60030554T2 (de) 2007-09-13
DE60030554T8 DE60030554T8 (de) 2008-01-10

Family

ID=27546594

Family Applications (4)

Application Number Title Priority Date Filing Date
DE122008000013C Pending DE122008000013I1 (de) 1999-05-13 2000-05-15 Verwendung von et743 in kombinationstherapie mit dexamethason zur behandlung von krebs
DE60045720T Expired - Lifetime DE60045720D1 (de) 1999-05-13 2000-05-15 Behandlung von Krebs beim Menschen mit ET743
DE60036826T Expired - Lifetime DE60036826T2 (de) 1999-05-13 2000-05-15 Verwendung von et743 in kombinationstherapie mit dexamethason zur behandlung von krebs
DE60030554T Active DE60030554T8 (de) 1999-05-13 2000-05-15 Verwendungen von et743 zur behandlung von krebs

Family Applications Before (3)

Application Number Title Priority Date Filing Date
DE122008000013C Pending DE122008000013I1 (de) 1999-05-13 2000-05-15 Verwendung von et743 in kombinationstherapie mit dexamethason zur behandlung von krebs
DE60045720T Expired - Lifetime DE60045720D1 (de) 1999-05-13 2000-05-15 Behandlung von Krebs beim Menschen mit ET743
DE60036826T Expired - Lifetime DE60036826T2 (de) 1999-05-13 2000-05-15 Verwendung von et743 in kombinationstherapie mit dexamethason zur behandlung von krebs

Country Status (32)

Country Link
US (1) US8119638B2 (de)
EP (3) EP1176964B8 (de)
JP (2) JP2002544231A (de)
KR (1) KR20020019914A (de)
CN (2) CN1360503A (de)
AR (1) AR028476A1 (de)
AT (3) ATE375795T1 (de)
AU (2) AU777417B2 (de)
BG (1) BG65680B1 (de)
BR (1) BR0010531A (de)
CA (1) CA2373794C (de)
CY (4) CY1105818T1 (de)
CZ (1) CZ301482B6 (de)
DE (4) DE122008000013I1 (de)
DK (3) DK1716853T3 (de)
ES (2) ES2272279T3 (de)
FR (1) FR08C0013I2 (de)
HU (2) HU229866B1 (de)
IL (2) IL146434A0 (de)
LU (1) LU91418I2 (de)
MX (1) MXPA01011562A (de)
MY (1) MY164077A (de)
NL (1) NL300337I2 (de)
NO (2) NO324564B1 (de)
NZ (1) NZ515423A (de)
PL (1) PL198185B1 (de)
PT (3) PT1702618E (de)
SI (3) SI1716853T1 (de)
SK (1) SK287580B6 (de)
TR (1) TR200103819T2 (de)
UA (1) UA74782C2 (de)
WO (1) WO2000069441A1 (de)

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MY164077A (en) 1999-05-13 2017-11-30 Pharma Mar Sa Compositions and uses of et743 for treating cancer
MXPA02011319A (es) 2000-05-15 2003-06-06 Pharma Mar Sa Analogos antitumorales de ecteinascidina 743.
JP4391083B2 (ja) * 2000-11-06 2009-12-24 ファルマ・マール・ソシエダード・アノニマ 効果的な抗腫瘍治療
GB0117402D0 (en) * 2001-07-17 2001-09-05 Pharma Mar Sa New antitumoral derivatives of et-743
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GB0202544D0 (en) 2002-02-04 2002-03-20 Pharma Mar Sa The synthesis of naturally occuring ecteinascidins and related compounds
GB0312407D0 (en) * 2003-05-29 2003-07-02 Pharma Mar Sau Treatment
GB0324201D0 (en) * 2003-10-15 2003-11-19 Pharma Mar Sau Improved antitumoral combinations
DK1689404T3 (da) * 2003-11-13 2009-01-26 Pharma Mar Sau Kombination af et-743 med 5-fluoracil-prodrugs til behandling af cancer
GB0326486D0 (en) * 2003-11-14 2003-12-17 Pharma Mar Sau Combination treatment
CA2545054A1 (en) * 2003-11-14 2005-06-02 Pharma Mar, S.A. Combination therapy comprising the use of et-743 and paclitaxel for treating cancer
AU2005261860A1 (en) * 2004-07-09 2006-01-19 Pharma Mar, S.A. Use of ecteinascidin in the treatment of cancer in patients with low level of BRCA1
ATE430586T1 (de) * 2004-10-26 2009-05-15 Pharma Mar Sa Pegyliertes liposomales doxorubicin in kombination mit ecteinescidin 743
KR101188691B1 (ko) 2004-10-29 2012-10-09 파르마 마르 에스.에이. 엑티나시딘 및 디사카라이드를 포함하는 제제
GB0522082D0 (en) * 2005-10-31 2005-12-07 Pharma Mar Sa Formulations
CA2652035A1 (en) * 2006-05-12 2007-11-22 Pharma Mar, S.A. Anticancer treatments
US20100267732A1 (en) * 2007-10-19 2010-10-21 Pharma Mar, S.A. Prognostic Molecular Markers for ET-743 Treatment
KR20180103965A (ko) * 2016-02-04 2018-09-19 지앙수 헨그루이 메디슨 컴퍼니 리미티드 위장관 외용을 위한 트라벡테딘-함유 주사가능한 약학적 조성물 및 그의 제조 방법
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام
WO2020239478A1 (en) 2019-05-28 2020-12-03 Pharma Mar, S.A. Trabectedin for treating sarcomas based on genomic markers
CN112574234B (zh) * 2019-09-27 2022-05-24 江苏恒瑞医药股份有限公司 一种海鞘素衍生物的制备方法
ES2981253T3 (es) 2020-04-15 2024-10-08 Ever Valinject Gmbh Composición que comprende trabectedina y un aminoácido
EP3960177A1 (de) * 2020-08-26 2022-03-02 Anturec Pharmaceuticals GmbH Zusammensetzung mit ttf-ngr zur verwendung in der behandlung von weichgewebesarkom
US12303506B2 (en) 2022-01-20 2025-05-20 Extrovis Ag Trabectedin composition

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GB0312407D0 (en) 2003-05-29 2003-07-02 Pharma Mar Sau Treatment
GB0324201D0 (en) 2003-10-15 2003-11-19 Pharma Mar Sau Improved antitumoral combinations
DK1689404T3 (da) 2003-11-13 2009-01-26 Pharma Mar Sau Kombination af et-743 med 5-fluoracil-prodrugs til behandling af cancer
CA2545054A1 (en) 2003-11-14 2005-06-02 Pharma Mar, S.A. Combination therapy comprising the use of et-743 and paclitaxel for treating cancer
GB0326486D0 (en) 2003-11-14 2003-12-17 Pharma Mar Sau Combination treatment
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ATE430586T1 (de) 2004-10-26 2009-05-15 Pharma Mar Sa Pegyliertes liposomales doxorubicin in kombination mit ecteinescidin 743
KR101188691B1 (ko) 2004-10-29 2012-10-09 파르마 마르 에스.에이. 엑티나시딘 및 디사카라이드를 포함하는 제제
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CA2652035A1 (en) 2006-05-12 2007-11-22 Pharma Mar, S.A. Anticancer treatments

Also Published As

Publication number Publication date
BG65680B1 (bg) 2009-06-30
IL146434A (en) 2008-03-20
KR20020019914A (ko) 2002-03-13
NO324564B1 (no) 2007-11-19
ATE500830T1 (de) 2011-03-15
IL146434A0 (en) 2002-07-25
DK1176964T3 (da) 2007-01-15
CY1107143T1 (el) 2010-07-28
AU2005200180B9 (en) 2008-05-29
DE60030554T2 (de) 2007-09-13
DE60036826D1 (de) 2007-11-29
SK16442001A3 (sk) 2002-03-05
UA74782C2 (uk) 2006-02-15
NO2008005I2 (de) 2010-09-27
CY1112753T1 (el) 2016-02-10
HUP0201187A2 (en) 2002-09-28
FR08C0013I1 (de) 2008-05-30
PT1702618E (pt) 2008-01-11
ES2294756T3 (es) 2008-04-01
AR028476A1 (es) 2003-05-14
AU777417B2 (en) 2004-10-14
CZ20014081A3 (cs) 2002-11-13
ATE338552T1 (de) 2006-09-15
TR200103819T2 (tr) 2002-04-22
SI1176964T1 (sl) 2007-02-28
WO2000069441A1 (en) 2000-11-23
DE60045720D1 (de) 2011-04-21
PL198185B1 (pl) 2008-06-30
NL300337I1 (nl) 2008-05-01
EP1702618A2 (de) 2006-09-20
SI1702618T1 (sl) 2008-02-29
CY2008007I1 (el) 2009-11-04
SK287580B6 (sk) 2011-03-04
EP1716853A2 (de) 2006-11-02
BR0010531A (pt) 2002-06-04
LU91418I2 (fr) 2008-05-13
NO2008005I1 (no) 2008-06-09
EP1716853B9 (de) 2011-09-28
CZ301482B6 (cs) 2010-03-17
SI1716853T1 (sl) 2011-10-28
FR08C0013I2 (fr) 2009-10-30
CY1105818T1 (el) 2011-02-02
EP1716853B1 (de) 2011-03-09
AU2005200180A1 (en) 2005-02-10
NL300337I2 (nl) 2008-09-01
HUS1500001I1 (hu) 2016-08-29
US8119638B2 (en) 2012-02-21
HUP0201187A3 (en) 2002-11-28
ES2272279T3 (es) 2007-05-01
EP1702618B1 (de) 2007-10-17
BG106171A (en) 2002-06-28
CA2373794A1 (en) 2000-11-23
MXPA01011562A (es) 2002-07-30
PT1176964E (pt) 2007-01-31
DE122008000013I1 (de) 2008-08-07
JP2002544231A (ja) 2002-12-24
DE60036826T2 (de) 2008-08-28
AU2005200180B2 (en) 2007-12-13
US20070275942A1 (en) 2007-11-29
PL352931A1 (en) 2003-09-22
LU91418I9 (de) 2019-01-02
DK1716853T3 (da) 2011-06-27
CY2008007I2 (el) 2009-11-04
DE60030554T8 (de) 2008-01-10
NZ515423A (en) 2004-04-30
PT1716853E (pt) 2011-05-12
EP1176964B8 (de) 2007-10-10
ATE375795T1 (de) 2007-11-15
CN1679631A (zh) 2005-10-12
JP5777562B2 (ja) 2015-09-09
HU229866B1 (en) 2014-10-28
CN100477993C (zh) 2009-04-15
DK1702618T3 (da) 2008-02-25
MY164077A (en) 2017-11-30
EP1716853A3 (de) 2006-11-15
AU4597500A (en) 2000-12-05
EP1176964B1 (de) 2006-09-06
CN1360503A (zh) 2002-07-24
NO20015516D0 (no) 2001-11-12
CA2373794C (en) 2005-10-11
EP1702618A3 (de) 2006-12-27
NO20015516L (no) 2002-01-11
JP2012149095A (ja) 2012-08-09
EP1176964A1 (de) 2002-02-06

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8381 Inventor (new situation)

Inventor name: BOWMAN, ANGELA, EDINBURGH EH4 2XU, GB

Inventor name: CVITKOVIC, ESTEBAN, F-94278 LE KREMLIN-BICETRE, FR

Inventor name: DEMETRI, GEORGE DANIEL, BOSTON, MA 02115, US

Inventor name: GUZMAN, CECILIA, TRES CANTOS, E-28760 MADRID, ES

Inventor name: JIMENO, JOSE, TRES CANTOS, E-28760 MADRID, ES

Inventor name: LOPEZ LAZARO, LUIS, TRES CANTOS, E-28760 MADRI, ES

Inventor name: MISSET, JEAN LOUIS, F-94804 VILLEJUIF CEDEX, FR

Inventor name: TWELVES, C., BEARSDEN, GLASGOW G61 1BD, GB

Inventor name: VON HOFF, DANIEL D., TUSCON, A Z 85724-5024, US

8364 No opposition during term of opposition
8381 Inventor (new situation)

Inventor name: CVITKOVIC, ESTEBAN, F-94278 LE KREMLIN-BICETRE, FR

Inventor name: DEMETRI, GEORGE DANIEL, BOSTON, MA 02115, US

Inventor name: GUZMAN, CECILIA, TRES CANTOS, E-28760 MADRID, ES

Inventor name: JIMENO, JOSE, TRES CANTOS, E-28760 MADRID, ES

Inventor name: LOPEZ LAZARO, LUIS, TRES CANTOS, E-28760 MADRI, ES

Inventor name: MISSET, JEAN LOUIS, F-94804 VILLEJUIF CEDEX, FR

Inventor name: TWELVES, C., BEARSDEN, GLASGOW G61 1BD, GB

Inventor name: VON HOFF, DANIEL D., TUSCON, A Z 85724-5024, US