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DE60002733D1 - Diester prodrugs von decahydroischinoline-3-carbonsäure - Google Patents

Diester prodrugs von decahydroischinoline-3-carbonsäure

Info

Publication number
DE60002733D1
DE60002733D1 DE60002733T DE60002733T DE60002733D1 DE 60002733 D1 DE60002733 D1 DE 60002733D1 DE 60002733 T DE60002733 T DE 60002733T DE 60002733 T DE60002733 T DE 60002733T DE 60002733 D1 DE60002733 D1 DE 60002733D1
Authority
DE
Germany
Prior art keywords
decahydroischinoline
prodrugs
carbonic acid
prodrug forms
decahydroisoquinoline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60002733T
Other languages
English (en)
Other versions
DE60002733T2 (de
Inventor
John Bleisch
Louis Mattiuz
Leslie Ornstein
Eugene Stratford
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of DE60002733D1 publication Critical patent/DE60002733D1/de
Application granted granted Critical
Publication of DE60002733T2 publication Critical patent/DE60002733T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE60002733T 1999-07-06 2000-06-13 Diester prodrugs von decahydroischinoline-3-carbonsäure Expired - Fee Related DE60002733T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14248499P 1999-07-06 1999-07-06
US142484P 1999-07-06
PCT/US2000/015030 WO2001002367A2 (en) 1999-07-06 2000-06-13 Diester prodrugs of a decahydroisoquinoline-3-carboxylic acid

Publications (2)

Publication Number Publication Date
DE60002733D1 true DE60002733D1 (de) 2003-06-18
DE60002733T2 DE60002733T2 (de) 2004-03-18

Family

ID=22500022

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60002733T Expired - Fee Related DE60002733T2 (de) 1999-07-06 2000-06-13 Diester prodrugs von decahydroischinoline-3-carbonsäure

Country Status (7)

Country Link
US (1) US6486175B1 (de)
EP (1) EP1208087B1 (de)
AT (1) ATE240299T1 (de)
AU (1) AU5591900A (de)
DE (1) DE60002733T2 (de)
ES (1) ES2198323T3 (de)
WO (1) WO2001002367A2 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA004290B1 (ru) 1999-07-06 2004-02-26 Эли Лилли Энд Компани СЕЛЕКТИВНЫЕ АНТАГОНИСТЫ РЕЦЕПТОРА iGluR5 ДЛЯ ЛЕЧЕНИЯ МИГРЕНИ
US6579886B2 (en) 1999-12-22 2003-06-17 Eli Lilly And Company Selective iglur5 receptor antagonists
US6855725B2 (en) 2001-01-05 2005-02-15 Eli Lilly And Company Excitatory amino acid receptor antagonists
US7205313B2 (en) 2001-01-05 2007-04-17 Eli Lilly And Company Excitatory amino acid receptor antagonists
US6924294B2 (en) 2001-01-05 2005-08-02 Eli Lilly And Company Excitatory amino acid receptor antagonists
US6953805B2 (en) 2001-01-05 2005-10-11 Eli Lilly And Company Excitatory amino acid receptor antagonists
EP1355640A1 (de) * 2001-01-23 2003-10-29 Neurosearch A/S Verwendung von nicht kompetitiven und selektiven glur5-antagonisten als modulierende verbindungen des glutamatrezeptors
SI1511741T1 (sl) * 2002-04-26 2013-02-28 Eli Lilly And Company Esterski derivativi dekahidroizokinolin-3-karboksilne kisline kot analgetiki
DK2083811T3 (en) 2006-11-22 2017-01-30 Clinical Res Ass Llc PROCEDURES FOR TREATING DOWNS SYNDROME, FRAGILT X SYNDROME AND AUTISM
EP2544688B1 (de) 2010-03-02 2016-09-07 President and Fellows of Harvard College Verfahren und zusammensetzungen zur behandlung des angelman-syndroms
WO2011150380A1 (en) 2010-05-28 2011-12-01 Xenoport, Inc. Methods of treatment of fragile x syndrome, down's syndrome, autism and related disorders
WO2012009646A1 (en) 2010-07-15 2012-01-19 Xenoport, Inc. Methods of treating fragile x syndrome, down's syndrome, autism and related disorders
WO2012054724A1 (en) 2010-10-21 2012-04-26 Massachusetts Institute Of Technology Methods of treating seizure disorders
EP4175635A4 (de) 2020-07-02 2024-06-26 Sea Pharmaceuticals LLC Pharmazeutische zusammensetzungen aus 6-(2-(2h-tetrazol-5-yl)ethyl)-6-fluordecahydroisochinolin-3-carbonsäure und esterderivaten davon

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2252381B (en) 1990-12-14 1995-08-09 Charles Bickford Improved fixing
US5284957A (en) * 1992-09-03 1994-02-08 Eli Lilly And Company Excitatory amino acid receptor antagonists
US5446051A (en) 1994-05-31 1995-08-29 Eli Lilly And Company Aryl-spaced decahydroisoquinoline-3-carboxylic acids as excitatory amino acid receptor antagonists
BR9809071A (pt) 1997-04-07 2000-08-01 Lilly Co Eli Agentes farmacológicos

Also Published As

Publication number Publication date
AU5591900A (en) 2001-01-22
EP1208087A2 (de) 2002-05-29
EP1208087B1 (de) 2003-05-14
US6486175B1 (en) 2002-11-26
WO2001002367A2 (en) 2001-01-11
ES2198323T3 (es) 2004-02-01
WO2001002367A3 (en) 2001-03-08
DE60002733T2 (de) 2004-03-18
ATE240299T1 (de) 2003-05-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee