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TR200200494T2 - Yağlı asit sintazı inhibitörleri. - Google Patents

Yağlı asit sintazı inhibitörleri.

Info

Publication number
TR200200494T2
TR200200494T2 TR2002/00494T TR200200494T TR200200494T2 TR 200200494 T2 TR200200494 T2 TR 200200494T2 TR 2002/00494 T TR2002/00494 T TR 2002/00494T TR 200200494 T TR200200494 T TR 200200494T TR 200200494 T2 TR200200494 T2 TR 200200494T2
Authority
TR
Turkey
Prior art keywords
fatty acid
acid synthase
synthase inhibitors
inhibitors
compounds
Prior art date
Application number
TR2002/00494T
Other languages
English (en)
Inventor
Jack Leber D.
Li Mei
Weinstock Joseph
Gaitanopoulos Dimitri
Original Assignee
Smithkline Beecham Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corporation filed Critical Smithkline Beecham Corporation
Publication of TR200200494T2 publication Critical patent/TR200200494T2/tr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Bu bulus, bilesimlerin yagli asit sintazi FabH'nin inhibitiörleri olarak kullanilmasiyla ilgilidir.
TR2002/00494T 1999-08-23 2000-08-23 Yağlı asit sintazı inhibitörleri. TR200200494T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US15027799P 1999-08-23 1999-08-23

Publications (1)

Publication Number Publication Date
TR200200494T2 true TR200200494T2 (tr) 2003-02-21

Family

ID=22533810

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2002/00494T TR200200494T2 (tr) 1999-08-23 2000-08-23 Yağlı asit sintazı inhibitörleri.

Country Status (20)

Country Link
US (1) US6559179B1 (tr)
EP (1) EP1206465A4 (tr)
JP (1) JP2003507469A (tr)
KR (1) KR20020033767A (tr)
CN (1) CN1370158A (tr)
AR (1) AR029001A1 (tr)
AU (1) AU6935900A (tr)
BR (1) BR0013515A (tr)
CA (1) CA2384197A1 (tr)
CZ (1) CZ2002638A3 (tr)
HK (1) HK1047927A1 (tr)
HU (1) HUP0202457A3 (tr)
IL (1) IL148324A0 (tr)
MX (1) MXPA02001821A (tr)
NO (1) NO20020609L (tr)
NZ (1) NZ517322A (tr)
PL (1) PL364920A1 (tr)
TR (1) TR200200494T2 (tr)
WO (1) WO2001014364A1 (tr)
ZA (1) ZA200201426B (tr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101117328B (zh) * 2006-08-01 2012-11-07 中国人民解放军军事医学科学院毒物药物研究所 脂肪酸合成酶抑制剂及其用于治疗细菌感染的用途
CN101190904A (zh) * 2006-11-23 2008-06-04 中国人民解放军军事医学科学院毒物药物研究所 脂肪酸合成酶抑制剂及其制药用途
CN101450912B (zh) * 2007-11-24 2012-05-30 山东轩竹医药科技有限公司 四氢化萘取代的苯甲酸衍生物
CN101450911B (zh) * 2007-11-30 2012-02-29 山东轩竹医药科技有限公司 被金刚烷取代的苯甲酸衍生物
CA2798330A1 (en) 2010-05-05 2011-11-10 Infinity Pharmaceuticals, Inc. Tetrazolones as inhibitors of fatty acid synthase
WO2011140296A1 (en) 2010-05-05 2011-11-10 Infinity Pharmaceuticals Triazoles as inhibitors of fatty acid synthase
CN102675211A (zh) * 2011-03-17 2012-09-19 南京大学 塞克硝唑肉桂酸酯衍生物的合成及其在抗菌药物方面的应用
MX364895B (es) 2013-03-13 2019-05-10 Forma Therapeutics Inc Nuevos compuestos y composiciones para la inhibicion de fasn.
US10966981B2 (en) 2016-04-21 2021-04-06 Duke University Fatty acid synthase inhibitors
TWI767148B (zh) 2018-10-10 2022-06-11 美商弗瑪治療公司 抑制脂肪酸合成酶(fasn)
WO2020092395A1 (en) 2018-10-29 2020-05-07 Forma Therapeutics, Inc. SOLID FORMS OF (4-(2-FLUORO-4-(1-METHYL-1 H-BENZO[d]IMIDAZOL-5-YL)BENZOYL) PIPERAZIN-1-YL)(1-HYDROXYCYCLOPROPYL)METHANONE

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2676052B1 (fr) * 1991-05-02 1994-04-29 Cird Galderma Nouveaux composes polycycliques aromatiques et leur utilisation en medecine humaine ou veterinaire et en cosmetique.
US5369127A (en) * 1993-04-21 1994-11-29 Allergan, Inc. 1,3-benzodioxole and 1,2-dialkoxybenzene derivatives as ocular hypotensive agents

Also Published As

Publication number Publication date
HK1047927A1 (zh) 2003-03-14
BR0013515A (pt) 2002-05-07
EP1206465A4 (en) 2003-01-02
CA2384197A1 (en) 2001-03-01
AR029001A1 (es) 2003-06-04
PL364920A1 (en) 2004-12-27
US6559179B1 (en) 2003-05-06
ZA200201426B (en) 2003-11-26
WO2001014364A1 (en) 2001-03-01
NZ517322A (en) 2003-11-28
KR20020033767A (ko) 2002-05-07
IL148324A0 (en) 2002-09-12
CN1370158A (zh) 2002-09-18
MXPA02001821A (es) 2002-08-06
AU6935900A (en) 2001-03-19
CZ2002638A3 (cs) 2002-05-15
JP2003507469A (ja) 2003-02-25
EP1206465A1 (en) 2002-05-22
NO20020609D0 (no) 2002-02-07
NO20020609L (no) 2002-02-07
HUP0202457A2 (en) 2002-10-28
HUP0202457A3 (en) 2003-03-28

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