DE19926671A1 - Anhydrous composition forming stable, transparent skin-compatible gel for use as cosmetic or dermatological base, containing fatty alcohol or its ester and silicon dioxide - Google Patents

Abstract

An anhydrous composition (I) comprises a hydrophobic phase containing a combination of (a) at least one fatty alcohol and/or fatty alcohol ester and (b) silicon dioxide.

Description

The present invention relates to an anhydrous, transparent gel-like Composition consisting of an oil phase, the oil phase contains at least one fatty alcohol and / or fatty alcohol ester and silicon dioxide.

Gel-like compositions consisting of oils or fatty bodies commonly referred to as oil gels and found particularly in dermatological Area used as a carrier for pharmaceutical or cosmetic active ingredients. For example as a sunscreen.

Oil gels are known from the prior art and consist of an oil body or an oil or fat phase and a viscosity-increasing agent, for example cellulose derivatives, sugar polymers, starch.

However, this type of oil gels have the particular disadvantage that they are in liquid Condition and therefore drip slightly on a surface (e.g. skin) can run quickly and also mostly sticky properties exhibit.

The object of the present invention is therefore in particular for dermatological field usable gel-like composition to provide which have improved properties over the known has gel-like compositions and the disadvantages of the prior art Technology eliminated.

The object was achieved according to the invention by providing an anhydrous, A composition as claimed in claim 1, after which the composition consists of consists of a hydrophobic phase containing a combination of at least a fatty alcohol and / or fatty alcohol ester and silicon dioxide.

Surprisingly, it was found that the use of a combination of at least one fatty alcohol and / or fatty alcohol ester and silicon dioxide in one anhydrous, hydrophobic phase forms a transparent, stable gel which  very excellent properties with regard to skin tolerance, handling, Usability and appearance.

It was found that the composition of the invention improved skin feel, excellent skin care properties and high Skin tolerance unfolds. In addition, the invention is distinguished Composition by a high water resistance. Beyond that too achieves advantageous manageability and multiple usability, for example as a non-dripping or non-flowing pharmaceutical carrier or cosmetic ingredients. The transparency according to the invention achieves Composition also has an advantageous appearance.

In this respect, the composition of the invention can be excellent are used as a carrier material for oil-soluble cosmetic and / or active pharmaceutical ingredients, for example as a carrier material for oil-soluble Sunscreens or wound healing agents common in dermatology.

In the context of the invention, an oil, lipid or Fat phase understood, which is usually in the pharmaceutical and cosmetic Industry for the production of compositions with hydrophobic phases can be used. In particular, this includes plant, animal, mineral, synthetic or semi-synthetic oils which are hydrogenated can, or waxes and mixtures thereof, esters of saturated and / or unsaturated, branched and / or linear alkane carboxylic acids with 6 to 22 Carbon atoms or aromatic carboxylic acids (for example benzoic acid) with saturated and / or unsaturated, branched and / or linear fatty alcohols with 6 to 22 carbon atoms or alcohols with 6 to 26 carbon atoms, Paraffins, lanolin, which can also be hydrogenated or acetylated, silicone oils. Guerbet alcohols based on fatty alcohols with 6 up to 18 carbon atoms, esters of linear and / or branched fatty acids polyhydric alcohols (e.g. propylene glycol) and / or Guerbet alcohols, Triglycerides or liquid mono- / di- / triglyceride mixtures based on fatty acids with 6 to 20 carbon atoms.  

The hydrophobic phase of the composition according to the invention, which Contains fatty alcohol and / or fatty alcohol esters, but also other oil-soluble active ingredients and may contain volatile lower alcohols at room temperature is one Amount between 90.0 and 99.5 wt .-%, with an amount between 93.0 and 97.0% by weight is preferred. The quantities are based on the Overall composition.

However, the hydrophobic phase can also consist solely of fatty alcohols and / or Fatty alcohol esters consist of up to 99.5% by weight of fatty alcohols and / or Fatty alcohol esters.

In this respect, the fatty alcohols and / or fatty alcohol esters can be between 0.1% by weight and 99.5% by weight, based on the total amount of the composition in which hydrophobic phase can be included, a quantity range between 10.0 wt .-% and 99.0% by weight, in particular between 30.0% by weight and 95.0% by weight, are preferred is.

As fatty alcohols, which can be used according to the invention, all come Fatty alcohols with 8 to 22 carbon atoms known to those skilled in the art are suitable for pharmaceutical and / or cosmetic preparations usually used Find.

Typical examples of fatty alcohols which can be used according to the invention are:
Caprylic alcohol, capric alcohol, lauryl alcohol, myristyl alcohol, cetyl alcohol, palmoleyl alcohol, oleyl alcohol, stearyl alcohol, isostearyl alcohol, coconut oil alcohol, cetearyl alcohol, tallow fatty alcohol.

Examples include: Eutanol® G (INCI name: Octyldodecanol), but also additions of solid alcohols such as Lanette® O (INCI Name: Cetearyl Alcohol).

Fatty alcohol esters for the purposes of the present invention include all known Ester oils used in pharmaceutical and / or cosmetic preparations are usually used. These include, for example, methyl myristate, Ethyl myristate, isopropyl myristate, myristyl propionate, ethyl palmitate, methyl palmitate, Isopropyl palmitate, isopropyl stearate, octyl stearate, isopropyl oleate, diisopropyl adipate, 2- Ethylhexylhexanoate, 2-ethylhexyl octanoate, 2-ethylhexyl palmitate, 2-ethylhexyl laurate,  2-hexyldecyl stearate, 2-octyldodecyl palmitate, 2-ethylhexyl-2-ethylhexanoate, Ethyl laurate, hexyl laurate, isohexyl laurate, isodecyl neopentanoate, isobutyl myristate, Butyl myristate, n-decyioleate, n-butyl stearate, isononyl isononanoate, isononyl stearate, Esters of benzoic acid and alcohols with 6 to 26 carbon atoms, esters of Fatty acids with pentaerythrol, mixed esters of glycerin with fatty acids, also Mixtures of these fatty alcohol esters can be used.

Examples of suitable fatty alcohol esters are: Cetiol® 868 (INCI Name: Octyl Stearate), Cetiol® SN (INCI name: Cetearyl Isononanoate), Crodamol® PTIS (INCI name: Pentaerythrityl Tetraisostearate), Finsolv® TN (INCI name: C12-15 alkyl benzoate) or Myritol® 318 (INCI name: Caprylic / Capric Triglyceride), individually or as Mixture.

According to the invention, preference is given to those fatty alcohols and / or fatty alcohol esters those at room temperature, i.e. between 20 ° C and 25 ° C, in the liquid state available. The use according to the invention of such fatty alcohols and / or Fatty alcohol esters not only leave particularly advantageous compositions arise with regard to their consistency, but also has the further advantage that the resulting oil gels can be formed without additional heat can.

The silicon dioxide (SiO ₂ ) or modifications thereof can preferably be contained in an amount of 1.0 to 10.0% by weight, based on the total amount of the composition, in particular in an amount between 3.0 to 7.0% .-%.

Suitable products are preferably those from Aerosil® or CAB-O-SIL® Series, e.g. Aerosil® 130, Aerosil® 200, Aerosil® 255, Aerosil® 300, Aerosil® 380, Aerosil®R 202, Aerosil®US 202, Aerosil®R 812, Aerosil®R 972, Aerosil®R 974, CAB-O-SIL® Fumed Silica, CAB-O-SIL® HS-5, CAB-O-SIL® EH-5, CAB-O-SIL® LM-130, CAB-O-SlL® MS-55 or CAB-O-SIL® M-5.

Surprisingly, it was also found that the invention Composition has a comparatively high sun protection factor (SPF) and in particular provides very good protection against UV-B rays.  

Accordingly, an anhydrous composition according to the Present invention, which is present as a sunscreen. In this case the composition as a further component advantageously at least one Oil-soluble UV filter substance can be added.

All known oil-soluble UVA-, UVB- can be used as oil-soluble UV filter substances. or UVA / UVB filters, individually or in combination with one another, which are usually in known cosmetic and / or dermatological Preparations are included.

The derivatives of dibenzoylmethane are used for UVA filters, for example (e.g. Parsol 1789 from Givaudan / Roure, INCI name: Butyl Methoxydibenzoylmethane) into consideration.

The following compounds can be mentioned as examples of UVB filters: Benzylidene camphor or derivatives thereof, especially methylbenzylidene camphor (for example 3-benzylidene camphor, 3- (4-methylenebenzylidene) dl-camphor), Derivatives and esters of cinnamic acid, especially derivatives and esters of Methoxycinnamic acid (e.g. octyl 4-methoxycinnamate or 4- Isopentyl methoxy cinnamate), derivatives and esters of benzoic acid, especially 4-aminobenzoic acids, polyhydroxybenzoic acids (for example Polyhydroxybenzoic acid methyl ester or polyhydroxybenzoic acid propyl ester), Esters of salicylic acid (e.g. salicylic acid (2-ethylhexyl) ester or Salicylic acid (4-isopropylbenzyl) ester), acrylic acid ester (e.g. octocrylene). Examples include: Neo Heliopan® BB (INCI name: Benzophenone-3), Neo Heliopan® AV (INCI name: Octyl Methoxycinnamate), Neo Heliopan® MBC (INCI name: 4-Methylbenzylidene Camphor), Neo Heliopan® Type 303 (INCI name: Octocrylene).

The oil-soluble UVA, UVB and / or UVB / UVA filters can be used in the composition according to the invention in a total amount between 0.1 to 30.0% by weight, in particular between 0.5 to 20.0% by weight, preferably between 1.0 and 15.0% by weight based on the total amount of the composition his.  

In addition to the silicon dioxide as the UV light absorbing pigment, other UV light absorbing inorganic pigments can also be present in the composition according to the invention. Metal compounds or semimetal compounds which are sparingly soluble or insoluble in water, in ionic as well as non-ionic or in oxidized form, are particularly suitable for this purpose. Examples include titanium oxides (for example TiO ₂ ), zinc oxides (for example ZnO), aluminum oxides (for example Al ₂ O ₃ ), iron oxides (for example Fe ₂ O ₃ ), manganese oxides (for example MnO), or mixtures thereof.

Pigments are also suitable which primarily do not absorb UV light Exercise function, but exert optical effects, for example Mica pigments.

These additional inorganic pigments can be used in the invention Contain composition in a total amount between 0.01 to 5.0 wt .-% his.

The other oil-soluble active ingredients for the composition according to the invention Vitamin A palmitate, tocopherol or Tocopheryl acetate (vitamin E and its derivatives), bisabolol, carrot oil, nut oils, Carotene.

Lower alcohols which are volatile at room temperature come with monohydric alcohols primary, secondary or tertiary aliphatic alcohols with 1 to 4 carbon atoms into consideration, for example ethanol, propanol or isopropanol.

It has been found that adding ethanol is very special can produce advantageous composition according to the present invention, which is characterized by a particularly transparent oil gel. Ethanol is therefore prefers.

The composition according to the invention can advantageously additionally contain at least one synthetic polymer. The synthetic polymers are preferably those from the group of siloxanes and silicones (for example Abil Wax® 9801D, INCI name: Cetyl Dimethicone) or the PVP polymers and Copolymers (for example Antaron® V 216, INCI name: PVP / Hexadecene  Copolymer). However, polymers from the group of the siloxanes and Silicones.

The addition of such polymers can increase the water resistance of the invention Improve composition further, which ultimately also has an advantageous influence on the Stability and the increase in SPF can take.

The synthetic polymers in question can be in a total amount between 1.0 and 35 wt .-%, in particular between 5.0 and 30.0 wt .-%, based on the Total amount of the composition.

Furthermore, it has proven to be advantageous if the invention Composition contains no emulsifier. This ensures that the Composition becomes very skin-friendly, excellent skin care Properties unfolded and conveyed a pleasant feeling.

It is known that emulsifiers trigger allergic reactions and under UV light Cause dermatosis or the unwanted penetration of chemical Can promote substances into the skin.

An emulsifier-free composition is within the scope of the present invention hence a preferred item.

The composition according to the invention has a gel-like structure, so that so that a particularly advantageous handling is achieved. For example prevents bleeding on the skin or dripping during use. Of course, the composition of the invention can all for skin and Hair cosmetics contain customary and known additives, auxiliaries and carriers.

In principle, the person skilled in the art knows which additives, auxiliaries and carriers in the hair and skin cosmetics are used, so that the detailed explanations only have exemplary character and only for further illustration of the are intended to serve the present invention.

For the rest, reference can be made to the present literature, which the describe the general structure of cosmetic compositions, for example SCHRADER, K., basics and formulations of cosmetics, 2.  Edition, 1989, or DOMSCH, A., The cosmetic preparations, publishing house for chemical Industry (H. Ziolkowsky, Ed.), 4th edition, 1992, or LOWE, N.J. & SHAAT, N.A., Suncreens, Development, Evaluation and Regulatory Aspects, Marcel Dekker Inc., 1990.

Only a few may therefore be mentioned as examples of additives, auxiliaries and carriers, wherein this list is not exhaustive: care substances (such as Lanolin derivatives, vitamins or provitamins), anti-fatty substances, preservatives (such as parahydroxybenzoic acid esters), non-aqueous solvents, Antioxidants (such as tocopherols or esters thereof), dyes as well Fragrances or perfumes.

The additives, auxiliaries and carriers can be those known to those skilled in the art usual amounts used and incorporated by methods known per se become.

The following examples are intended to explain the present invention in more detail, the percentages are percentages by weight and refer to the total amount or the total weight of the compositions are based.

The individual substances and raw materials specified in the examples are commercial available. Reference can also be made to known literature, for example to International Cosmetic Ingredient Dictionary and Handbook, Seventh Edition, 1997.  

Examples 1-6

Example 7

Example 8

The finished gel with silica from Example 7 was mixed with 6.0% ethanol, it remained clear and gel-like

Example 9

Example 10

Example 11

Example 12

Example 13

Example 14

Example 15

Example 16

Example 17

Example 18

Claims (12)

1. anhydrous composition consisting of a hydrophobic phase, containing a combination of at least one fatty alcohol and / or Fatty alcohol esters and silicon dioxide. 2. Anhydrous composition according to claim 1, characterized in that the fatty alcohol and / or fatty alcohol ester is liquid at room temperature are. 3. Anhydrous composition according to claims 1 and 2, characterized characterized in that the hydrophobic phase in a total amount between 90.0 and 99.5 wt .-% is present. 4. Anhydrous composition according to claims 1 to 3, characterized characterized in that the silicon oxide in a total amount between 1.0 and 10.0% by weight. 5. Anhydrous composition according to claims 1 to 4, characterized characterized in that they additionally have at least one monovalent primary, secondary or tertiary aliphatic alcohol with 1 to 20 Contains carbon atoms. 6. Anhydrous composition according to claim 5, characterized in that that the alcohol is ethanol. 7. Anhydrous composition according to claims 1 to 6, characterized characterized that it is present as a sunscreen. 8. An anhydrous composition according to claim 7, characterized in that that the hydrophobic phase of the sunscreen additionally at least contains an oil-soluble UV filter substance.   9. Anhydrous composition according to claim 8, characterized in that that the oil-soluble UV filter is a UVA, UVB or a UVA / UVB filter substance or a mixture thereof. 10. Anhydrous composition according to claims 7 to 9, characterized characterized in that they additionally have at least one inorganic, particulate Contains UV filter substance. 11. Anhydrous composition according to claims 1 to 11, characterized characterized that it is emulsifier free. 12. Use of an anhydrous composition according to claims 1 to 11 as a carrier material for cosmetic and / or pharmaceutical active ingredients.