DE19900471A1 - Imidazo[4,5c]-pyridin-4-on-derivate - Google Patents

Imidazo[4,5c]-pyridin-4-on-derivate

Info

Publication number: DE19900471A1
Authority: DE; Germany
Prior art keywords: formula; compounds; group; salts; acid
Prior art date: 1999-01-08
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

DE19900471A

Other languages

German (de)

English (en)

Inventor

Werner Mederski

Horst Juraszyk

Hanns Wurziger

Christos Tsaklakidis

Dieter Dorsch

Sabine Bernotat-Danielowski

Guido Melzer

Soheila Anzali

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Merck Patent GmbH

Original Assignee

Merck Patent GmbH

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-01-08

Filing date

1999-01-08

Publication date

2000-07-13

1999-01-08 Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH

1999-01-08 Priority to DE19900471A priority Critical patent/DE19900471A1/de

1999-12-21 Priority to JP2000592291A priority patent/JP2002534429A/ja

1999-12-21 Priority to KR1020017007074A priority patent/KR20010086085A/ko

1999-12-21 Priority to PL99349341A priority patent/PL349341A1/xx

1999-12-21 Priority to AU30417/00A priority patent/AU3041700A/en

1999-12-21 Priority to SK944-2001A priority patent/SK9442001A3/sk

1999-12-21 Priority to PCT/EP1999/010236 priority patent/WO2000040583A2/de

1999-12-21 Priority to CA002357771A priority patent/CA2357771A1/en

1999-12-21 Priority to EP99964639A priority patent/EP1149099A2/de

1999-12-21 Priority to CN99815465A priority patent/CN1333772A/zh

1999-12-21 Priority to BR9916774-3A priority patent/BR9916774A/pt

1999-12-21 Priority to CZ20012407A priority patent/CZ20012407A3/cs

1999-12-21 Priority to HU0105054A priority patent/HUP0105054A3/hu

2000-01-07 Priority to ARP000100062A priority patent/AR022220A1/es

2000-07-13 Publication of DE19900471A1 publication Critical patent/DE19900471A1/de

2001-07-06 Priority to NO20013384A priority patent/NO20013384D0/no

2001-08-06 Priority to ZA200106454A priority patent/ZA200106454B/en

Status Withdrawn legal-status Critical Current

Links

PPNFWYUJXHAZIN-UHFFFAOYSA-N imidazo[4,5-c]pyridin-4-one Chemical class O=C1N=CC=C2N=CN=C12 PPNFWYUJXHAZIN-UHFFFAOYSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 claims abstract description 64
108010074860 Factor Xa Proteins 0.000 claims abstract description 15
239000003112 inhibitor Substances 0.000 claims abstract 2
ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical compound C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 claims description 26
150000003839 salts Chemical class 0.000 claims description 24
238000000034 method Methods 0.000 claims description 18
125000004432 carbon atom Chemical group C* 0.000 claims description 17
125000006239 protecting group Chemical group 0.000 claims description 16
239000002253 acid Substances 0.000 claims description 15
239000004305 biphenyl Substances 0.000 claims description 13
235000010290 biphenyl Nutrition 0.000 claims description 13
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 13
125000001624 naphthyl group Chemical group 0.000 claims description 12
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 12
125000000217 alkyl group Chemical group 0.000 claims description 10
208000007536 Thrombosis Diseases 0.000 claims description 9
125000003739 carbamimidoyl group Chemical group C(N)(=N)* 0.000 claims description 9
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 9
125000003277 amino group Chemical group 0.000 claims description 8
229910052794 bromium Inorganic materials 0.000 claims description 8
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239000003795 chemical substances by application Substances 0.000 claims description 7
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238000002360 preparation method Methods 0.000 claims description 7
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 6
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125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 4
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125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims description 3
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125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims description 3
238000003797 solvolysis reaction Methods 0.000 claims description 3
IZXIZTKNFFYFOF-UHFFFAOYSA-N 2-Oxazolidone Chemical class O=C1NCCO1 IZXIZTKNFFYFOF-UHFFFAOYSA-N 0.000 claims description 2
NRFUAARNGNIZJI-UHFFFAOYSA-N 3-[[5-(3-carbamimidoylphenyl)-4-oxo-2-propan-2-ylimidazo[4,5-c]pyridin-3-yl]methyl]benzenecarboximidamide Chemical compound O=C1C=2N(CC=3C=C(C=CC=3)C(N)=N)C(C(C)C)=NC=2C=CN1C1=CC=CC(C(N)=N)=C1 NRFUAARNGNIZJI-UHFFFAOYSA-N 0.000 claims description 2
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239000012442 inert solvent Substances 0.000 description 7
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239000003826 tablet Substances 0.000 description 6
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150000002825 nitriles Chemical class 0.000 description 5
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AEOCXXJPGCBFJA-UHFFFAOYSA-N ethionamide Chemical compound CCC1=CC(C(N)=S)=CC=N1 AEOCXXJPGCBFJA-UHFFFAOYSA-N 0.000 description 1
125000003754 ethoxycarbonyl group Chemical group C(=O)(OCC)* 0.000 description 1
238000001704 evaporation Methods 0.000 description 1
230000008020 evaporation Effects 0.000 description 1
230000029142 excretion Effects 0.000 description 1
239000003889 eye drop Substances 0.000 description 1
229940012356 eye drops Drugs 0.000 description 1
229940012952 fibrinogen Drugs 0.000 description 1
239000000796 flavoring agent Substances 0.000 description 1
235000019634 flavors Nutrition 0.000 description 1
239000011737 fluorine Substances 0.000 description 1
235000011389 fruit/vegetable juice Nutrition 0.000 description 1
239000001530 fumaric acid Substances 0.000 description 1
239000008273 gelatin Substances 0.000 description 1
229920000159 gelatin Polymers 0.000 description 1
239000007903 gelatin capsule Substances 0.000 description 1
235000019322 gelatine Nutrition 0.000 description 1
235000011852 gelatine desserts Nutrition 0.000 description 1
239000000174 gluconic acid Substances 0.000 description 1
235000012208 gluconic acid Nutrition 0.000 description 1
235000013773 glyceryl triacetate Nutrition 0.000 description 1
239000008187 granular material Substances 0.000 description 1
150000008282 halocarbons Chemical class 0.000 description 1
230000023597 hemostasis Effects 0.000 description 1
125000000623 heterocyclic group Chemical group 0.000 description 1
125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
150000004677 hydrates Chemical class 0.000 description 1
150000004678 hydrides Chemical class 0.000 description 1
229930195733 hydrocarbon Natural products 0.000 description 1
150000002430 hydrocarbons Chemical class 0.000 description 1
238000005984 hydrogenation reaction Methods 0.000 description 1
WTDHULULXKLSOZ-UHFFFAOYSA-N hydroxylamine hydrochloride Substances Cl.ON WTDHULULXKLSOZ-UHFFFAOYSA-N 0.000 description 1
WCYJQVALWQMJGE-UHFFFAOYSA-M hydroxylammonium chloride Chemical compound [Cl-].O[NH3+] WCYJQVALWQMJGE-UHFFFAOYSA-M 0.000 description 1
239000005457 ice water Substances 0.000 description 1
150000002463 imidates Chemical class 0.000 description 1
JBFYUZGYRGXSFL-UHFFFAOYSA-N imidazolide Chemical compound C1=C[N-]C=N1 JBFYUZGYRGXSFL-UHFFFAOYSA-N 0.000 description 1
239000007943 implant Substances 0.000 description 1
238000011065 in-situ storage Methods 0.000 description 1
239000013067 intermediate product Substances 0.000 description 1
230000000302 ischemic effect Effects 0.000 description 1
125000004491 isohexyl group Chemical group C(CCC(C)C)* 0.000 description 1
238000002955 isolation Methods 0.000 description 1
125000001972 isopentyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 description 1
150000002576 ketones Chemical class 0.000 description 1
TYQCGQRIZGCHNB-JLAZNSOCSA-N l-ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(O)=C(O)C1=O TYQCGQRIZGCHNB-JLAZNSOCSA-N 0.000 description 1
YNESATAKKCNGOF-UHFFFAOYSA-N lithium bis(trimethylsilyl)amide Chemical compound [Li+].C[Si](C)(C)[N-][Si](C)(C)C YNESATAKKCNGOF-UHFFFAOYSA-N 0.000 description 1
238000011068 loading method Methods 0.000 description 1
239000000314 lubricant Substances 0.000 description 1
125000000040 m-tolyl group Chemical group [H]C1=C([H])C(*)=C([H])C(=C1[H])C([H])([H])[H] 0.000 description 1
VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
239000011976 maleic acid Substances 0.000 description 1
229960002510 mandelic acid Drugs 0.000 description 1
238000004949 mass spectrometry Methods 0.000 description 1
229940126601 medicinal product Drugs 0.000 description 1
229910052751 metal Inorganic materials 0.000 description 1
239000002184 metal Substances 0.000 description 1
UKVIEHSSVKSQBA-UHFFFAOYSA-N methane;palladium Chemical compound C.[Pd] UKVIEHSSVKSQBA-UHFFFAOYSA-N 0.000 description 1
229940057952 methanol Drugs 0.000 description 1
UZKWTJUDCOPSNM-UHFFFAOYSA-N methoxybenzene Substances CCCCOC=C UZKWTJUDCOPSNM-UHFFFAOYSA-N 0.000 description 1
125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 description 1
239000000178 monomer Substances 0.000 description 1
239000012452 mother liquor Substances 0.000 description 1
LNOPIUAQISRISI-UHFFFAOYSA-N n'-hydroxy-2-propan-2-ylsulfonylethanimidamide Chemical compound CC(C)S(=O)(=O)CC(N)=NO LNOPIUAQISRISI-UHFFFAOYSA-N 0.000 description 1
HEBZZVNXDAMSFN-UHFFFAOYSA-N n-(4-amino-2-chloropyridin-3-yl)-2-methylpropanamide Chemical compound CC(C)C(=O)NC1=C(N)C=CN=C1Cl HEBZZVNXDAMSFN-UHFFFAOYSA-N 0.000 description 1
125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
229940124305 n-propanol Drugs 0.000 description 1
230000014508 negative regulation of coagulation Effects 0.000 description 1
125000001971 neopentyl group Chemical group [H]C([*])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
239000011664 nicotinic acid Substances 0.000 description 1
229960003512 nicotinic acid Drugs 0.000 description 1
235000001968 nicotinic acid Nutrition 0.000 description 1
229910017604 nitric acid Inorganic materials 0.000 description 1
150000002828 nitro derivatives Chemical class 0.000 description 1
125000004433 nitrogen atom Chemical group N* 0.000 description 1
LYGJENNIWJXYER-UHFFFAOYSA-N nitromethane Chemical compound C[N+]([O-])=O LYGJENNIWJXYER-UHFFFAOYSA-N 0.000 description 1
229910000510 noble metal Inorganic materials 0.000 description 1
125000003261 o-tolyl group Chemical group [H]C1=C([H])C(*)=C(C([H])=C1[H])C([H])([H])[H] 0.000 description 1
150000007530 organic bases Chemical class 0.000 description 1
239000012074 organic phase Substances 0.000 description 1
230000003204 osmotic effect Effects 0.000 description 1
BSCHIACBONPEOB-UHFFFAOYSA-N oxolane;hydrate Chemical compound O.C1CCOC1 BSCHIACBONPEOB-UHFFFAOYSA-N 0.000 description 1
125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 description 1
125000000636 p-nitrophenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)[N+]([O-])=O 0.000 description 1
125000001037 p-tolyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])[H] 0.000 description 1
125000003538 pentan-3-yl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])C([H])([H])[H] 0.000 description 1
125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
239000003208 petroleum Substances 0.000 description 1
230000000144 pharmacologic effect Effects 0.000 description 1
125000003884 phenylalkyl group Chemical group 0.000 description 1
150000003016 phosphoric acids Chemical class 0.000 description 1
OXNIZHLAWKMVMX-UHFFFAOYSA-N picric acid Chemical class OC1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O OXNIZHLAWKMVMX-UHFFFAOYSA-N 0.000 description 1
239000006187 pill Substances 0.000 description 1
IUGYQRQAERSCNH-UHFFFAOYSA-N pivalic acid Chemical compound CC(C)(C)C(O)=O IUGYQRQAERSCNH-UHFFFAOYSA-N 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
229920000642 polymer Polymers 0.000 description 1
229910000027 potassium carbonate Inorganic materials 0.000 description 1
239000002244 precipitate Substances 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 description 1
229940039716 prothrombin Drugs 0.000 description 1
238000000746 purification Methods 0.000 description 1
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
230000035484 reaction time Effects 0.000 description 1
238000010992 reflux Methods 0.000 description 1
230000007017 scission Effects 0.000 description 1
125000003548 sec-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
238000000926 separation method Methods 0.000 description 1
150000003354 serine derivatives Chemical class 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
235000017557 sodium bicarbonate Nutrition 0.000 description 1
229910052938 sodium sulfate Inorganic materials 0.000 description 1
235000011152 sodium sulphate Nutrition 0.000 description 1
239000011877 solvent mixture Substances 0.000 description 1
239000008347 soybean phospholipid Substances 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
125000001424 substituent group Chemical group 0.000 description 1
125000000547 substituted alkyl group Chemical group 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
125000000542 sulfonic acid group Chemical group 0.000 description 1
150000003460 sulfonic acids Chemical class 0.000 description 1
150000003462 sulfoxides Chemical class 0.000 description 1
239000000725 suspension Substances 0.000 description 1
238000003786 synthesis reaction Methods 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 description 1
125000005425 toluyl group Chemical group 0.000 description 1
239000000196 tragacanth Substances 0.000 description 1
235000010487 tragacanth Nutrition 0.000 description 1
229940116362 tragacanth Drugs 0.000 description 1
229960002622 triacetin Drugs 0.000 description 1
YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
235000015112 vegetable and seed oil Nutrition 0.000 description 1
239000008158 vegetable oil Substances 0.000 description 1
229940088594 vitamin Drugs 0.000 description 1
239000011782 vitamin Substances 0.000 description 1
235000013343 vitamin Nutrition 0.000 description 1
229930003231 vitamin Natural products 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1
238000010626 work up procedure Methods 0.000 description 1
239000008096 xylene Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Hematology (AREA)
Diabetes (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

DE19900471A 1999-01-08 1999-01-08 Imidazo[4,5c]-pyridin-4-on-derivate Withdrawn DE19900471A1 (de)

Priority Applications (16)

Application Number	Priority Date	Filing Date	Title
DE19900471A DE19900471A1 (de)	1999-01-08	1999-01-08	Imidazo[4,5c]-pyridin-4-on-derivate
CA002357771A CA2357771A1 (en)	1999-01-08	1999-12-21	Imidazo[4,5-c]-pyridine-4-one derivatives
BR9916774-3A BR9916774A (pt)	1999-01-08	1999-12-21	Derivados de imidazo[4,5-c]piridina-4-ona
PL99349341A PL349341A1 (en)	1999-01-08	1999-12-21	Imidazo[4,5-c]-pyridine-4-on-derivatives
AU30417/00A AU3041700A (en)	1999-01-08	1999-12-21	Imidazo(4,5-c)-pyridine-4-on-derivatives
SK944-2001A SK9442001A3 (en)	1999-01-08	1999-12-21	Imidazo[4,5-c]-pyridine-4-on-derivatives, process for the preparation thereof, use thereof and pharmaceutical composition comprising same
PCT/EP1999/010236 WO2000040583A2 (de)	1999-01-08	1999-12-21	Imidazo[4,5-c]-pyridin-4-on-derivate
JP2000592291A JP2002534429A (ja)	1999-01-08	1999-12-21	イミダゾ［４，５−ｃ］ピリジン−４−オン誘導体
EP99964639A EP1149099A2 (de)	1999-01-08	1999-12-21	Imidazo[4,5-c]-pyridin-4-on-derivate
CN99815465A CN1333772A (zh)	1999-01-08	1999-12-21	咪唑并(4,5－c)吡啶－4－酮衍生物
KR1020017007074A KR20010086085A (ko)	1999-01-08	1999-12-21	이미다조[４,５-ｃ]-피리딘-４-온-유도체
CZ20012407A CZ20012407A3 (cs)	1999-01-08	1999-12-21	Derivát imidazol [4,5-c]pyridin-4-onu, způsob jeho přípravy, jeho pouľití a farmaceutický prostředek, který ho obsahuje
HU0105054A HUP0105054A3 (en)	1999-01-08	1999-12-21	Imidazo[4,5-c]-pyridine-4-on-derivatives, pharmaceutical compositions containing them and process for their preparation
ARP000100062A AR022220A1 (es)	1999-01-08	2000-01-07	Derivados de la imidazo[4,5-c]-piridin-4-ona, un procedimiento para su preparacion, el empleo de los mismos para preparar un medicamento, los medicamentosa base de estos compuestos, las composiciones farmaceuticas que contienen estos compuestos y un procedimiento para preparar estas composiciones fa
NO20013384A NO20013384D0 (no)	1999-01-08	2001-07-06	Imidazo[4,5-c]pyridin-4-on-derivater
ZA200106454A ZA200106454B (en)	1999-01-08	2001-08-06	Imidazo[4,5-c]-pyridine-4-on-derivatives.

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19900471A DE19900471A1 (de)	1999-01-08	1999-01-08	Imidazo[4,5c]-pyridin-4-on-derivate

Publications (1)

Publication Number	Publication Date
DE19900471A1 true DE19900471A1 (de)	2000-07-13

Family

ID=7893790

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE19900471A Withdrawn DE19900471A1 (de)	1999-01-08	1999-01-08	Imidazo[4,5c]-pyridin-4-on-derivate

Country Status (16)

Country	Link
EP (1)	EP1149099A2 (pt)
JP (1)	JP2002534429A (pt)
KR (1)	KR20010086085A (pt)
CN (1)	CN1333772A (pt)
AR (1)	AR022220A1 (pt)
AU (1)	AU3041700A (pt)
BR (1)	BR9916774A (pt)
CA (1)	CA2357771A1 (pt)
CZ (1)	CZ20012407A3 (pt)
DE (1)	DE19900471A1 (pt)
HU (1)	HUP0105054A3 (pt)
NO (1)	NO20013384D0 (pt)
PL (1)	PL349341A1 (pt)
SK (1)	SK9442001A3 (pt)
WO (1)	WO2000040583A2 (pt)
ZA (1)	ZA200106454B (pt)

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Publication number	Priority date	Publication date	Assignee	Title
WO2007009883A1 (en) *	2005-07-15	2007-01-25	F. Hoffmann-La Roche Ag	Novel heteroaryl fused cyclic amines
EP2982668A2 (en)	2002-12-03	2016-02-10	Pharmacyclics LLC	2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine derivatives as factor viia inhibitors for the treatment of thromboembolic disorders

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Publication number	Priority date	Publication date	Assignee	Title
EA004515B1 (ru)	1998-12-23	2004-04-29	Дюпон Фармасьютикалз Компани	АЗОТСОДЕРЖАЩИЕ ГЕТЕРОБИЦИКЛЫ В КАЧЕСТВЕ ИНГИБИТОРОВ ФАКТОРА Xa
US6506771B2 (en)	2000-06-23	2003-01-14	Bristol-Myers Squibb Pharma Company	Heteroaryl-phenyl heterobicyclic factor Xa inhibitors
EP1414449A4 (en)	2001-05-22	2005-04-06	Bristol Myers Squibb Co	FACTOR XA BICYCLIC INHIBITORS
GB0215293D0 (en)	2002-07-03	2002-08-14	Rega Foundation	Viral inhibitors
GB0225399D0 (en) *	2002-10-31	2002-12-11	Merck Sharp & Dohme	Therapeutic agents
KR20050122220A (ko)	2003-03-25	2005-12-28	다케다 샌디에고, 인코포레이티드	디펩티딜 펩티다제 억제제
WO2004103993A1 (en)	2003-05-14	2004-12-02	Syrrx, Inc.	Dipeptidyl peptidase inhibitors
BRPI0413452A (pt)	2003-08-13	2006-10-17	Takeda Pharmaceutical	composto, composição farmacêutica, kit, artigo de fabricação, e, métodos de inibir dpp-iv, terapêutico e de tratar um estado de doença, cáncer, distúrbios autoimunes, uma condição einfecção por hiv
ES2381890T3 (es)	2003-12-22	2012-06-01	K.U.Leuven Research & Development	Compuesto de imidazo[4,5-c]piridina y métodos de tratamiento antiviral
PT1841765E (pt)	2004-12-21	2009-05-14	Gilead Sciences Inc	Anticorpos para mcp-1 humano
GEP20135838B (en)	2005-09-14	2013-06-10	Takeda Pharmaceutical	Dipeptidyl peptidase inhibitors usage at diabetes treatment
CA2622642C (en)	2005-09-16	2013-12-31	Takeda Pharmaceutical Company Limited	Dipeptidyl peptidase inhibitors
WO2007112347A1 (en)	2006-03-28	2007-10-04	Takeda Pharmaceutical Company Limited	Dipeptidyl peptidase inhibitors
CA2656415C (en)	2006-07-07	2012-05-22	Gilead Sciences, Inc.	Novel pyridazine compound and use thereof
TW200838536A (en)	2006-11-29	2008-10-01	Takeda Pharmaceutical	Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor
UA99466C2 (en)	2007-07-06	2012-08-27	Гилиад Сайенсиз, Инк.	Crystalline pyridazine compound
US10005775B2 (en) *	2014-08-12	2018-06-26	Syngenta Participations, Ag	Pesticidally active heterocyclic derivatives with sulphur containing substituents

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TW219935B (pt) *	1991-12-25	1994-02-01	Mitsubishi Chemicals Co Ltd
WO1999027930A1 (en) *	1997-12-01	1999-06-10	Merck & Co., Inc.	Thrombin inhibitors

1999
- 1999-01-08 DE DE19900471A patent/DE19900471A1/de not_active Withdrawn
- 1999-12-21 AU AU30417/00A patent/AU3041700A/en not_active Abandoned
- 1999-12-21 BR BR9916774-3A patent/BR9916774A/pt not_active Application Discontinuation
- 1999-12-21 CZ CZ20012407A patent/CZ20012407A3/cs unknown
- 1999-12-21 CN CN99815465A patent/CN1333772A/zh active Pending
- 1999-12-21 CA CA002357771A patent/CA2357771A1/en not_active Abandoned
- 1999-12-21 WO PCT/EP1999/010236 patent/WO2000040583A2/de not_active Ceased
- 1999-12-21 HU HU0105054A patent/HUP0105054A3/hu unknown
- 1999-12-21 SK SK944-2001A patent/SK9442001A3/sk unknown
- 1999-12-21 KR KR1020017007074A patent/KR20010086085A/ko not_active Withdrawn
- 1999-12-21 EP EP99964639A patent/EP1149099A2/de not_active Withdrawn
- 1999-12-21 JP JP2000592291A patent/JP2002534429A/ja active Pending
- 1999-12-21 PL PL99349341A patent/PL349341A1/xx unknown
2000
- 2000-01-07 AR ARP000100062A patent/AR022220A1/es unknown
2001
- 2001-07-06 NO NO20013384A patent/NO20013384D0/no not_active Application Discontinuation
- 2001-08-06 ZA ZA200106454A patent/ZA200106454B/en unknown

Cited By (3)

* Cited by examiner, † Cited by third party
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EP2982668A2 (en)	2002-12-03	2016-02-10	Pharmacyclics LLC	2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine derivatives as factor viia inhibitors for the treatment of thromboembolic disorders
WO2007009883A1 (en) *	2005-07-15	2007-01-25	F. Hoffmann-La Roche Ag	Novel heteroaryl fused cyclic amines
US7417144B2 (en)	2005-07-15	2008-08-26	Hoffman-La Roche Inc.	Factor Xa inhibitors

Also Published As

Publication number	Publication date
WO2000040583A3 (de)	2000-09-21
EP1149099A2 (de)	2001-10-31
JP2002534429A (ja)	2002-10-15
CZ20012407A3 (cs)	2001-12-12
NO20013384L (no)	2001-07-06
SK9442001A3 (en)	2002-05-09
HUP0105054A2 (hu)	2002-05-29
PL349341A1 (en)	2002-07-15
CN1333772A (zh)	2002-01-30
AU3041700A (en)	2000-07-24
HUP0105054A3 (en)	2002-12-28
ZA200106454B (en)	2002-11-06
NO20013384D0 (no)	2001-07-06
AR022220A1 (es)	2002-09-04
KR20010086085A (ko)	2001-09-07
WO2000040583A2 (de)	2000-07-13
BR9916774A (pt)	2001-10-30
CA2357771A1 (en)	2000-07-13

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EP1480948A1 (de)	2004-12-01	Semicarbazidderivate und ihre verwendung als antithrombotika

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