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DE19681439T1 - Modifizierung von Polypeptidarzneimitteln zur Erhöhung des Elektrotransportflusses - Google Patents

Modifizierung von Polypeptidarzneimitteln zur Erhöhung des Elektrotransportflusses

Info

Publication number
DE19681439T1
DE19681439T1 DE19681439T DE19681439T DE19681439T1 DE 19681439 T1 DE19681439 T1 DE 19681439T1 DE 19681439 T DE19681439 T DE 19681439T DE 19681439 T DE19681439 T DE 19681439T DE 19681439 T1 DE19681439 T1 DE 19681439T1
Authority
DE
Germany
Prior art keywords
electrotransport
modification
increase
flow
polypeptide drugs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19681439T
Other languages
English (en)
Inventor
Leslie A Holladay
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alza Corp
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Publication of DE19681439T1 publication Critical patent/DE19681439T1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1075—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of amino acids or peptide residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Cosmetics (AREA)
  • Electrotherapy Devices (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
DE19681439T 1995-06-06 1996-06-06 Modifizierung von Polypeptidarzneimitteln zur Erhöhung des Elektrotransportflusses Withdrawn DE19681439T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46661095A 1995-06-06 1995-06-06
PCT/US1996/009377 WO1996039422A2 (en) 1995-06-06 1996-06-06 Modification of polypeptide drugs to increase electrotransport flux

Publications (1)

Publication Number Publication Date
DE19681439T1 true DE19681439T1 (de) 1998-07-23

Family

ID=23852435

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19681439T Withdrawn DE19681439T1 (de) 1995-06-06 1996-06-06 Modifizierung von Polypeptidarzneimitteln zur Erhöhung des Elektrotransportflusses

Country Status (12)

Country Link
US (2) US7324846B2 (de)
JP (2) JP4354529B2 (de)
AU (1) AU6590396A (de)
BE (1) BE1009704A3 (de)
BR (1) BR9609149A (de)
CA (1) CA2220146A1 (de)
DE (1) DE19681439T1 (de)
FR (1) FR2735132B1 (de)
GB (1) GB2317179B (de)
IT (1) IT1285405B1 (de)
NL (1) NL1003283C2 (de)
WO (1) WO1996039422A2 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1285405B1 (it) * 1995-06-06 1998-06-03 Alza Corp Modificazione di farmaci polipeptidici per accrescere il flusso per elettrotrasporto.
ATE344055T1 (de) 1999-10-14 2006-11-15 Pola Chem Ind Inc Zusammensetzungen für die elektroporation
US6946548B2 (en) * 2000-09-08 2005-09-20 Massachusetts Institute Of Technology G-CSF analog compositions and methods
WO2004022033A1 (en) * 2002-09-04 2004-03-18 Microchips, Inc. Method and device for the controlled delivery of parathyroid hormone
CN1688696A (zh) * 2002-09-18 2005-10-26 蒙特利尔大学医疗中心 Ghrh类似物
US7488316B2 (en) 2005-01-25 2009-02-10 Microchips, Inc. Control of drug release by transient modification of local microenvironments
MX2012010148A (es) 2010-03-04 2013-01-22 Pfenex Inc Metodo para producir proteinas de interferon recombinantes solubles sin desnaturalizacion.
PL2552949T3 (pl) 2010-04-01 2017-01-31 Pfenex Inc. Sposoby wytwarzania G-CSF w komórce gospodarza Pseudomonas
CA2857502C (en) 2011-11-30 2019-08-13 3M Innovative Properties Company Microneedle device including a peptide therapeutic agent and an amino acid and methods of making and using the same
SI3122426T1 (sl) 2014-03-28 2023-04-28 Duke University Zdravljenje raka dojk z uporabo selektivnih modulatorjev estrogenskih receptorjev
IL255189B2 (en) 2015-04-29 2024-04-01 Radius Pharmaceuticals Inc A combination of rad1901 and a cdk4/6 inhibitor for use in treating cancer
ES2981967T3 (es) 2017-01-05 2024-10-14 Radius Pharmaceuticals Inc Formas polimórficas de RAD1901-2HCl
WO2020010216A1 (en) 2018-07-04 2020-01-09 Radius Pharmaceuticals, Inc. Polymorphic forms of rad 1901-2hcl
PH12021551950A1 (en) 2019-02-12 2022-05-23 Radius Pharmaceuticals Inc Processes and compounds

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4250878A (en) 1978-11-22 1981-02-17 Motion Control, Inc. Non-invasive chemical species delivery apparatus and method
US4431739A (en) 1979-11-05 1984-02-14 Genentech, Inc. Transformant bacterial culture capable of expressing heterologous protein
US4383529A (en) 1980-11-03 1983-05-17 Wescor, Inc. Iontophoretic electrode device, method and gel insert
US4628043A (en) * 1983-04-26 1986-12-09 The Salk Institute For Biological Studies Hypothalamic GRF agonists
US4528190A (en) * 1983-10-25 1985-07-09 The Salk Institute For Biological Studies GRF Analogs IV
US4631211A (en) 1985-03-25 1986-12-23 Scripps Clinic & Research Foundation Means for sequential solid phase organic synthesis and methods using the same
US4722726A (en) 1986-02-12 1988-02-02 Key Pharmaceuticals, Inc. Method and apparatus for iontophoretic drug delivery
US5250022A (en) 1990-09-25 1993-10-05 Rutgers, The State University Of New Jersey Iontotherapeutic devices, reservoir electrode devices therefore, process and unit dose
AU609769B2 (en) 1987-02-10 1991-05-09 Drug Delivery Systems Inc. Electrolytic transdermal delivery of proteins
US5013653A (en) 1987-03-20 1991-05-07 Creative Biomolecules, Inc. Product and process for introduction of a hinge region into a fusion protein to facilitate cleavage
EP0429842B1 (de) 1989-10-27 1996-08-28 Korea Research Institute Of Chemical Technology Vorrichtung zur transdermalen Applikation von Protein- oder Peptid-Medikamenten
GB9107846D0 (en) * 1990-04-30 1991-05-29 Ici Plc Polypeptides
DK10191D0 (da) 1991-01-22 1991-01-22 Novo Nordisk As Hidtil ukendte peptider
CA2087087C (en) 1992-01-22 2000-07-18 Burton H. Sage, Jr. Molecules for iontophoretic delivery
WO1993025197A1 (en) * 1992-06-12 1993-12-23 Affymax Technologies N.V. Compositions and methods for enhanced drug delivery
US5814603A (en) * 1992-06-12 1998-09-29 Affymax Technologies N.V. Compounds with PTH activity
DE69316774T2 (de) * 1992-12-31 1998-09-17 Alza Corp Elektrophorese-system mit biegsamen mitteln
JP2809510B2 (ja) * 1993-06-08 1998-10-08 久光製薬株式会社 イオントフォレーゼ用システム
EP0643981B1 (de) * 1993-09-22 2002-01-09 Hisamitsu Pharmaceutical Co., Inc. Iontophoresematrix
DE4404168A1 (de) * 1994-02-10 1995-08-17 Hoechst Ag Hirudinderivate und Verfahren zu deren Herstellung
IT1285405B1 (it) * 1995-06-06 1998-06-03 Alza Corp Modificazione di farmaci polipeptidici per accrescere il flusso per elettrotrasporto.

Also Published As

Publication number Publication date
BR9609149A (pt) 1999-02-23
JP2009149639A (ja) 2009-07-09
JP4354529B2 (ja) 2009-10-28
AU6590396A (en) 1996-12-24
GB2317179A (en) 1998-03-18
JPH11507341A (ja) 1999-06-29
FR2735132A1 (fr) 1996-12-13
GB9725981D0 (en) 1998-02-04
CA2220146A1 (en) 1996-12-12
US20090275877A1 (en) 2009-11-05
US7324846B2 (en) 2008-01-29
ITTO960496A1 (it) 1997-12-05
FR2735132B1 (fr) 1998-04-24
BE1009704A3 (fr) 1997-07-01
IE960413A1 (en) 1996-12-11
US20020107505A1 (en) 2002-08-08
WO1996039422A3 (en) 1997-03-06
IT1285405B1 (it) 1998-06-03
ITTO960496A0 (it) 1996-06-05
GB2317179B (en) 1999-07-28
WO1996039422A2 (en) 1996-12-12
NL1003283C2 (nl) 1997-05-02
NL1003283A1 (nl) 1996-12-09

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Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
8139 Disposal/non-payment of the annual fee