DE1940223A1 - Oral care products - Google Patents

Description

Colgafce-Palmolive -'Company '.-' (U ₀ S ₀ - 751 35ä = prio. August 9, 1968 Haw York. SMT. 10022 / ÜSA 6440)

Hamburg, August 5th, 1969

Oral care products

The present "invention relates to oral hygiene products _B that separate 8.1 oh iiiöhfc, usui for hygiene in the or-slbereioh"

Es v; ui * de festgeat; alli; _A the ßextranaee 'for example thru the? ; Salmstaiiibildusig or VsphisMlerang of deposits in people and mammals is extremely advantageous "'Dextranase is, however, with certain' so far available benign binders or" ösliermlbtelsi not ^ e ^ fci'glitfhf eo that, for example, dextranase - like dextranase in - each örrnigöi? 2'alinpasta · -zusass ^ iöss riilfe Cü daipivafcsn very saefeall einöF SnueiLmsig. deit "consistency is wpri'en /, where" sioli üiy iilüsaigsn constituents "/ on solid

The object of the invention is; sa _p - diesö ilaoUteils 211 baseifelgen a better MusepjTIegeniitfeel containing DsKtrasiase

To solve this task, an oral care solution is required to be provided for _p wölehes daduifüh keiiSiiseiuhnot. lst _a that es and ale BiMewifctel is Irish. odsr Öimn contains tragacanth

Baa erfindusigftgeosiisss PrSpamt may in particular -as öre'mefUrmige Or gelarfelge Sahnpssta or used as Musadspülmittöl ^ In äligeifteisieri the erfindurtgisgeiiillsseii FrSparate eathalten koör Polierrmittel but Diö at MundspÜliaitteln nioht required uli> d "

Dextranase let; a K & izym "which prevents baldness and which can be produced in a nutrient medium containing Oex.tr m according to β" British Dental Journal "* M ₅ 12 *", pages 3 * 7 to 3 ^ 9 (ϊ9δ8) nioht-kariogeriafi Streptooooo ^ nefcäiMnenp as AFOC IÖ *> 58 _s 90 ^ * 1600 IIAi ^ 3 or · yon LeuQüfiüBfcOö ineseayfeerioldes manufactured and - cleaned ₉ as ee in "Arohlyea of Oral Biology ⁴ * ,, Vol ₀ H ₉ page 1039 ( 1966 ') ff _{? #} Where, however, ^ -''''■' _{/ t} Lo mesenteflöldee at 25 ⁰ C gezüohfcet wlrd _o M. ^

Dextranase can be divided from dextran by vaccinating voo Penlui 11 ium funlcuioBuia lii containers which contain 250 ml of a medium which contains 0.5% yeast extract in dextran. The KolbC-si are kept at 30 ° for 4 days ■, armohlAeüend wJlr * i the culture aentrifuglert 20 minutes 3oOOO g and filtered Anschliaöerid '/ ilini in a Dialyeesohlauch against distilled Waseer dialyöLör and around the SOtmahan value duroh dialysis against Polyäthylengiyool old molecular weight yo £ i SO ₀ OOO kosizonkrlertV the thus prepared dextranase has a molecular weight of about 200,000 ='m 275o000 ₀ OegebensnfJllö can be dextranase iiotsh further purified by sulfate Prakklonie ^ s with Ammoniu,

The in erfifidungsgeaKsRein Präparatess Dextranaseaienge iiSngt on the activity of dextranase and deiBZtifolge from the Pricing & i eiiungsverfahre from, 'Be le pi ei "as has a DextrafiaBeiinziimpräpapat eiae AktivUät of 800 units per mg, one unit is the BnzymmeHge 1 mg equivalent IeoBjaltoseroonohydrat in 1 hour at 40 ⁰ C and a "pH-value of 5.1 at 2.5 tigernDextran generated (" Journal of Bacteriology ", Vol ₃ 64, page 513) 0

8ADORiQiNAL

Although lesser amounts of dextranea can be used, will dee above arwMhnta Dsxtranaseeiisya in amounts vos about From 100 to 50% of the mouthperture tea, but preferably in amounts of 0.01 bla 2 and in particular in amounts of £ 0.01 used ', These amounts refer to the Dextranase in product «being dextranase in general • the raw · preparation is available.

The binding agent used according to the invention is Iriach Moos and / or Oun Tragacanth, although Irish moss is preferred willo

The synthetic binders used up to now, such as cellulose derivatives, for example Mstrliunoarboxynethyl «cellulose, NitrlusKiarboxyaethyihdroxylthylthylceilulose and Mettay! Cellulose are also mixed, because they let the preparation become permanent and promote a separation into liquid and solid oils _P as in Qua Karaya,

The binding agent is generally used in amounts of about 10%, but preferably in amounts of up to 5 and in particular in amounts of 0.2 to 1.5 %, based on the total amount.

To produce suitable oral care products according to the invention, among other things, are suitable and non-toxic aqueous solutions Liquid components with the relevant solid components, such as binders and, for example, in the case of toothbrushes, Bollard means, veroiiecht. The liquid parts in the Tested beef common water, glycerin, anhydrous

0 0 9 8 12/1808

Soreltoll solutions, propylene glycol, PolyHfchylorsgljrcol 40Q and the general result will be a Kiaeixung Water and a peuah holder such as glycerin or Sorbitol, precautionary, with animal-greased liquid content he generally lies at 20 rock 75 qewji of the preparation.

Ereme-like or gel-like masses are preferred Bit of the best sona existence established, eo dafl aie can be easily squeezed out of suitable tubes or containers.

In the case of the invented teeth, it becomes common a water-insulative! polishing agent »such as Dicaleitisipli & late »TridalisluBpkospnat« unluslioliea

Magnesium carbonates

Caleiuao carbonate, calcium prophosphate, calcined Altuan lumo silitsat, caloius sulfate, bentonite »Polyethylaethaerjrlat The water phosphates and in particular the Kafcrluiaraeta are preferred. Ufiä / öder a Caloiuaphoephat «like Dioaloiun-

In general, the poiier means lie

al * Batiptaiiteil ^ the solid constituents iror, being quantities up to 75 @ «wjS, for example SO to 75 öewji * on dan gesseten gaimorecie, are suitable.

Erfloduagsgenlüisen Mittel! iahen 1 * general one pB «W« rt swise ^ n% and 9 and inabeaondere in a bar rm. H big 6g mteel suitable® buffer yateoe was used, then k £ kt £ nm _s piled over into a staring area & u

lniltea · '■: - ^:. ■;' ■ "; ■. /

surfactants or surfactants that the Increase the phjrlactic effect at the same time

0098 12/1808 BADOFtIGtNAL

Complete dispersion of the green and sweet preparations in the oral cavity and, in addition to the better distribution, cause an improvement in quality from a cosmetic point of view how the Natrlurcsalz of monosulfatlertem Monoglycerld hydrogenated coconut oil fatty acids, higher alkyl sulfates such as Natrlumlaury sulfate!, alkyl aryl sulfonates such as sodium »dodeoylbenzolsulforsat, higher Alkylsulfoaoe did _e higher fatty acid ester of I _t 2 ° dihydroxy propane sulfonates, and the substantially saturated higher aliphatic acyl amides of lower aliphatlsoher Aoiinocarbonsäureverbindungens for example, The fatty acid contains 12 to 16 carbon atoms, alkyl or aoyl radicals. Examples of the amides mentioned last are N ° lsuroylsarcosines and sodium, potassium and Xth anolaminsalze of N-lauroyl = _s N 't4tyristoyl ° or & ° Palmltoylsiaruosinate ₀ which should be as söifenf rei or Himliohs higher fatty acid supplements do not contain Solian, reduce the effect of these compounds, "The use of Sarcoslnaten in toothpastes according to the invention 1st particularly advantageous since These compounds cause a longer and clearer prevention of acid formation in the mouth and cavity through carbohydrates and also reduce the solubility of the 2ahns @ hm @ lzes in acidic solutions.

Other non-ionic surfactants are, for example, condensate « cation products of sorbltammonostearate with about 60 moles Ethylene oxide, condensation products of ethylene oxide with Propylene oxide condensation preparations of propylene glycol, furthermore cationic surfactants with germicidal effect and furthermore

■ h ^ immQm 0 0981.2 / 180 8 _; ■ '-'.

bactericidal compounds »like

Chloride, tertiary :: Ληΐιΐϋ "it is a fatty alkylate with, for example, XS to 18 carbon atoms and stalk polyoxyethy lernest s, which are gsbussden on the nitrogen atom, where a total of S to 5 ° ^ thanoxyr-eel;" are present per molecule as well as their salsa with eiräspi 'Aching acids and compounds of the following general I? ormsl

_y H

in which R is a fatty alkyl radical with 12 to 18 Xolilenatoff atoms and x, y and Rd ?, a total of 5 or »lehi? aim! as well as salts of these compounds with mineral acids.

Preferably, 0.05 to 5% of the total amount of surface-active substances are used in the anti-fusing preparations

Furthermore, the arfißdungsgemässen * Präparatö yet Zus & tx @ g as belspielsitrelae dyes or 'On remedies, protective substances "silicones ^ Chlorophyllvsrblnüungsn UTTD Anür _k onii containing Visrbinduüge ?!" may as Hannetof £% Diaairaoniumphos phat included.

Other bactericidal substances include the the following connections are used:

00981.2 / 180

J = f lÄüxryldi H; Gt; hylaiW! OnJ.u {n} * - 8 = (!! «chl-orubtrni ^ icli.aiif thyl

■ iJ "Amino"! # 5

cowiG the eiifciipr ^ cSvcficiüii aeuren AcSditioriaeatÄe “-. These Whose in quantities of 0,, Ol to 5 ur4 previous week yob 0.05

Furthermore, suitable Aroraai toffe or Stiätmifctet added Wenien, such as ilpearäinzUle Pfefferinisis, WlnteFgrün, SessefreB ,. Clove oil, Eiücalyptus, marjoram, lemon or orange _c £ ioitBi further süwie Hßtriununetlx3rlsfillö; / lat _o Ais sweeteners may Suörose LakUose _f * i "ktlfeoße sorbitol _f ^ NßtriuaoyolaESSt wnd yenicndet Saceharin; werdeüe DieseJ flavor "and SUSuiigeraittiGl can iit amounts of Ö _'9 to 5 0l ^ or more eingeeetsfc

The inventive Itond care products strengthen the Kimd hygiene and reduce in particular deposits, urge the solubility of the tooth enamel ssurüok imd prevent a tooth decayc This will in particular: then ersieitj, if the successfully completed preparations are blurred and DextreniftBe contain, AIe Fiuoi ^ erbindungen siftd uriter other Katriuoifluorid, Siim = S ^ fiuoi * Id, Ka-üumflüorid and the double rice Snl'goKF and KatriyahexaTluorostannat « Tin = H = chlorofluoride, NatriuiRfiuoi * © EirkotiBt "and NatriuraüKino =

I 2/1

fluorophosphate suitable ₀ These compounds dissociate or give off fluorine-containing zones In aqueous solution in non-toxic amounts, usually in a range from 0.1 % to 1% and preferably about 0.1% based on the preparation. Tin H-fluoride and Matriuirnnonöfluorophoaphnt are particularly preferred tin H-fluoride is generally in amounts of 0.04 to 4.1 Ji, in particular in amounts of 0% and MatrliuiDonof luorophosphat in amounts of about. 076 to 7 »6 Oew £ and preferably used in Hesse by 0.76 % .

Oral care products containing fluoride with a content of dextranase are usually called HundspUlalttel or as Toothpaste used The mouthwashes contain the stock » parts in water or as an aqueous solution with a suitable alcohol, Hie ethyl alcohol, the ito general is used in amounts of 5 to 20 ounces.

The dentifrice can also be used as tooth powder or toothpaste or dishwashing detergent, as tooth remnants or as oils, an aqueous solution generally containing glycerine, aqueous solutions of sorbitol, propylene glycol, polyethylene glycol and the like in amounts of 20 to 75 # are available on the total weight.

The fluorine-containing dentifrices can also contain a binding agent, with Irisoh moss or gum tragacanth usually used as binding agent in amounts of 0.2 to 10 and preferably in amounts of 0.2 to 1.5 % to maintain the consistency and to prevent separation will.

0 098 12/1808

In the case of tooth powder, toothpaste or “1” mouth rinsing agent, a contractual diering agent is used, which preferably contains a major part of insoluble sodium metaphoephate. Thus, for example, dloaluminophosphate and larger quantities of undesirable nematophosphate are mixed. Preferably, the CalolUm- or dicalcium phosphate forms the major component of the polishing agent * "daa old Hatriummonofluorphosphat let vertrlglloh, the polishing agent is Xm generally used in amounts from 20 to 99 OEW £ of Zahnpflegealttela and inebeeondere in amounts of 20 bia 75% besogen the Zahnpaata or the mouthwash and in quantities of 75 to 99 % for tooth powder

An additional advantage of the invention Is it that the preparations containing Zlnn-2S compounds? a good aeaohtnaok and pliysikaiieohe Besohaffenhslt in Dextranase and Irieoh moss or Qum tragacanth contained Preparations show, although one was previously the analyst, dad such tin-II compounds, trie Zirm-I ^ fluoride, Kftllum-Zinn-ttriuüi * id and 2inn "S" ehlorf; li> orld an aohleohten Oeruoh «peculiar and la connection with binders a very real one Show surface texture.

In the following, the invention will be described in more detail by means of examples are explained «whereby all quantities are referenced to the Oewiohfc relate.

009812/1808

BaiSDl »! 1

became «in Zahnoraae also following«! Components manufactured*

Components Oewioht parts aiyoerin 19,950 Tetranatriuapgrropbosphate 0.250 Katrluesaecharin 0.200 Hatriuette sauce 0.500 Irish moss 0.850 distilled water 19.977 Caloium carbonate 5,000 Dihydrate phosphate dihydrate «, 750 Natriuro-N-lauroylearooainate (59Ji) 5.714 Aroma substances 0.800

Dextranase (activity 800 units / «g) 0.009o

This mixture kept its consistency and left sioh without difficulty from an ordinary Aluainiujit Even after long periods of storage, squeeze out the toothpaste tube in the tube.

Corresponding tooth areas were produced · where instead of by Irish Hoos Now Oum Tragacanth was used

At VerglelohsvereUohen was by Ersats von Ir ie oh Moos by sodium oarboxymethyloellulose and sodium oarboxy = methylhydroxyäthyloelluloae found that the preparations very much lost their original consistency and very much became liquid, because sioh the solids from the liquid Separate components

00 98 12/1808 BADORlQiNAL

_:: 19Λ0

Il "» ■

Example 2

Be one of the following dog grooming products Components manufactured and packed in tubes *

Components Parts by weight Glycerin 10,000 aorbltol Irish moss 2,000 Sodium bencoat 0.500 Hatriwssaooharln 0.200 Natrluoilauryleuifet 1,500 Ethanol 10,000 Flavorings lOOO Dextranase . -. (Activity 800 units / mg) 0.009

This composition retains its consistency and flows easily squeeze out of the tube even after long periods of storage.

Example 3

The following composition was tintered in a pressurized can Packaged nitrogen:

Components parts by weight Glycerin 27,550 Irish moss 0.600 Hatrluabenoat 0.500 Katrlusaaooharin ' 0.200 water 13,827 Caloiuao carbonate 5,000 Dloaloltinphoepiiat 46 ..QOO ' ! Utriuji-il-lÄuroylearcoainat (? 53 O 5,714 Aroma substances 0.800

Dejctranase (activity 800 units /

mg) 0.009.

0 0 98 1 2/180 8

This dental care kit retained its consistency and read out the pressurized can without difficulty near longer »express camps»

Example 4 Maintaining the consistency of mixtures which Dextranase and the mistake? contain binders,

is by Vlskeeit & tibieseuiigen at 20 ⁰ C ait a

Braokfield tfiskosiaeter, model LVT and a spindle Hr ₀

at JO Hndrebuisgen per minute duroh the following measurements bestMUgtg

Ingredients Viscosity in centi ßoise

0-2elt 1 day § Tej ^ e

irish moss I30Q I500

1% Irish moss and

£ 0.01 dextranase 1300

q ^ yl cellulose 4 * 0 1700

cellulose and 0 * 01 $

Dextranase 420

1180 ISi

Dextranase 680 0

1080 98O

Kathjloelluleee and

0.01 :% dextranase 1160 240

Gum Karaya 1480 I300 Dextranase (§20 920 S ■% du «Tragaoanth 3480 3460 Oük Tragaeanth and

0.01 Ü ^ extraiMse 35 * 0 3480

0098 1 27 1808

; ^ v _r vr

In all cases a dextranase was found with activity of 800 units per mg used

From the above values, wlmS clearly shows which preparations Irish moss or gum tragacanth and dextranase contain » soap the desired consistency while using preparations synthetic cellulose derivatives other than binders or other Oumblndemltteln, such as Qua Karaya »respectively together with dextranase, an undesirable one very quickly Assume viscosity and become fluid.

Example 5 The following two toothpastes were made and

in aluminum tube! * s

Components Qewichtsteile Qewlohtatelle Glycerin 27.100 ii.lÖÖ Irish moss 1,400 1,100 Chain liquid benzo & t 0.150 O.50O Sodium saooharine 0.200 O ₀ 200

Sorbitol ~ 20,000

Water 22,041 U

- 5 * 714

Natrlum «lauryleulf & t 1,500 *>

insoluble matriuiaaäsfca-

phosphate 4O _P 6OO 41,350

hydratized aluminium dioxide I όΟΟΟ

Dioaloiumphoephat 5 ^ 000 5,000 Titanium oxide _e 4O0 0.400 Sodium monofluorophosphate "Ö" 760 Tin ° II ° fluoride 0 ₀ 400 => Flavorings 1,200 O.900 Dextranase (activity

800 units per mg) 0 «009 0

981271808

I & eae KUehungen «own a recorded effect on the ventMricung of the Hysienewiriomgen in the Miadnunle and keep theirs even after long storage Ronsistentis at

BeUpiej. 6th

Sa was a Munlapuliimittel from the following components

manufactured

QeKlohtateile 8J.759

Q.030

Ethanol I4o782

O.ai8 dea sorbitan "

Bonolaurats

O »O76

Dyes 0 * 320 DesEtranase (activity 800 units / oig) 0.100

QO 9β12 / 1808

~ W BAD ORlßlisiAi

Claims (1)

I. MuJtägefltgeait $ el _$ dadursh gtkannseiehnefc ,, das es Dextroses « und! Risen Hoc» »ui ^ l / odei ¹ Oun Trsgft @ & nth ale Blndeam«! »Nthtlt. 2 · fSundpfl «g« ilttel n & ah As ^ prueh I ₉ d * S BM O ₉ OOi to S Gew £ D ^ cts * an «se and 0« S bia IO Irlfiob Moos tmä / oäer ®uh ^ ragaoamth HuQdpfl «gefld.ttel, nash Asispruohi usul 2 _f dsäurch recognized« «Sol et nooh a polishing agent, especially in phosphate« eeüLr Musäpflegeaifefe «! According to itoeprueis i "thus kensmeiohnet" d & S · β Oestrasiasci "preventive white in amounts of O ₉ OOl to 5 J6 ussS a FJUsor ranMl © Terbißduiig" preventively 0.01 to I Qm ^ WliSQV Iteferaäe _{ode ode ode s} in particular tin "XI Contains Hetriuia ^ nofiuorpisospliAt and 0 to IO GeWfI ₀ voraugsweiee Q _$ 2 to 10 Qetfj $ Zrisoh Mdos or Qua Trageosmth as binders. ueesohc 009812/180