[go: up one dir, main page]

DE122004000043I1 - Carbostryril-Derivate. - Google Patents

Carbostryril-Derivate.

Info

Publication number
DE122004000043I1
DE122004000043I1 DE200412000043 DE122004000043C DE122004000043I1 DE 122004000043 I1 DE122004000043 I1 DE 122004000043I1 DE 200412000043 DE200412000043 DE 200412000043 DE 122004000043 C DE122004000043 C DE 122004000043C DE 122004000043 I1 DE122004000043 I1 DE 122004000043I1
Authority
DE
Germany
Prior art keywords
carbostryril
derivatives
carbostryril derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE200412000043
Other languages
English (en)
Other versions
DE122004000043I2 (de
Inventor
Yasuo Oshiro
Seiji Sato
Nobuyuki Kurahashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=17576714&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE122004000043(I1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Publication of DE122004000043I1 publication Critical patent/DE122004000043I1/de
Publication of DE122004000043I2 publication Critical patent/DE122004000043I2/de
Active legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20Oxygen atoms
    • C07D215/22Oxygen atoms attached in position 2 or 4
    • C07D215/227Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE200412000043 1988-10-31 1989-10-27 Carbostyril-Derivate. Active DE122004000043I2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP27695388 1988-10-31

Publications (2)

Publication Number Publication Date
DE122004000043I1 true DE122004000043I1 (de) 2005-02-03
DE122004000043I2 DE122004000043I2 (de) 2005-06-16

Family

ID=17576714

Family Applications (2)

Application Number Title Priority Date Filing Date
DE68925405T Expired - Lifetime DE68925405T2 (de) 1988-10-31 1989-10-27 Carbostyril-Derivate
DE200412000043 Active DE122004000043I2 (de) 1988-10-31 1989-10-27 Carbostyril-Derivate.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE68925405T Expired - Lifetime DE68925405T2 (de) 1988-10-31 1989-10-27 Carbostyril-Derivate

Country Status (10)

Country Link
US (1) US5006528A (de)
EP (1) EP0367141B1 (de)
KR (1) KR0138529B1 (de)
CN (1) CN1028104C (de)
DE (2) DE68925405T2 (de)
DK (1) DK168485B1 (de)
ES (1) ES2084594T3 (de)
HK (1) HK1002706A1 (de)
MX (1) MX9202934A (de)
NL (1) NL300161I2 (de)

Families Citing this family (171)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2311734C (en) * 2000-04-12 2011-03-08 Bristol-Myers Squibb Company Flash-melt oral dosage formulation
US7053092B2 (en) * 2001-01-29 2006-05-30 Otsuka Pharmaceutical Co., Ltd. 5-HT1a receptor subtype agonist
AR032641A1 (es) * 2001-01-29 2003-11-19 Otsuka Pharma Co Ltd Agonista de subtipo de receptor 5-ht 1a.
MY129350A (en) 2001-04-25 2007-03-30 Bristol Myers Squibb Co Aripiprazole oral solution
RU2259366C2 (ru) * 2001-09-25 2005-08-27 Оцука Фармасьютикал Ко., Лтд. Арипипразоловое лекарственное средство с низкой гигроскопичностью и способы его получения
AR033485A1 (es) 2001-09-25 2003-12-26 Otsuka Pharma Co Ltd Sustancia medicinal de aripiprazol de baja higroscopicidad y proceso para la preparacion de la misma
US8703772B2 (en) 2001-09-25 2014-04-22 Otsuka Pharmaceutical Co., Ltd. Low hygroscopic aripiprazole drug substance and processes for the preparation thereof
MY138669A (en) * 2001-09-25 2009-07-31 Otsuka Pharma Co Ltd Low hygroscopic aripiprazole drug substance and processes for the preparation thereof
TWI324074B (en) * 2001-10-09 2010-05-01 Bristol Myers Squibb Co Flashmelt oral dosage formulation
SE0200301D0 (sv) * 2002-02-01 2002-02-01 Axon Biochemicals Bv Thio-carbostyril derivative
HRP20050149B1 (hr) * 2002-08-20 2014-09-12 Otsuka Pharmaceutical Co., Ltd. Formulacija aripiprazol kompleksa i postupak
GB0220581D0 (en) 2002-09-04 2002-10-09 Novartis Ag Organic Compound
AU2003291757A1 (en) * 2002-11-08 2004-06-03 Bristol-Myers Squibb Company Formulations of low solubility bioactive agents and processes for making the same
AR042806A1 (es) * 2002-12-27 2005-07-06 Otsuka Pharma Co Ltd Combinacion de derivados de carboestirilo e inhibidores de la reabsorcion de serotonina para el tratamiento de trastornos del animo
EP1723957A3 (de) 2002-12-27 2013-01-23 Otsuka Pharmaceutical Co., Ltd. Carbostyril-Derivate mit selektiven Serotonin-Aufnahme Inhibitoren, zur Behandlung von Gemütskrankheiten
DE60302139T3 (de) 2003-01-09 2011-02-24 Otsuka Pharmaceutical Co., Ltd. Verfahren zur herstellung von aripiprazole
WO2004064752A2 (en) * 2003-01-22 2004-08-05 Alkermes Controlled Therapeutics, Inc. Method of preparing sustained release microparticles
US7491726B2 (en) * 2003-03-21 2009-02-17 Hetero Drugs Limited Crystalline forms of aripiprazole
WO2004106322A2 (en) * 2003-04-25 2004-12-09 Cadila Healthcare Limited Polymorphs of aripiprazole
CA2428237C (en) * 2003-05-08 2010-07-20 Delmar Chemicals Inc. Process for the preparation of carbostyril derivatives
WO2004100992A2 (en) * 2003-05-16 2004-11-25 Pfizer Products Inc. Therapeutic combinations of atypical antipsychotics with gaba modulators, anticonvulsants or benzodiazapines
UA92453C2 (ru) 2003-05-23 2010-11-10 Оцука Фармасьютикел Ко., Лтд. Производные карбостирила и стабилизаторы настроения для лечения расстройств настроения
US7456181B2 (en) * 2003-07-25 2008-11-25 Hetero Drugs Limited Aripiprazole crystalline forms
US20050032781A1 (en) * 2003-08-06 2005-02-10 Elliot Ehrich Methods for administering active agents to CYP 2D6 sensitive patients
US6987111B2 (en) 2003-08-06 2006-01-17 Alkermes Controlled Therapeutics, Ii Aripiprazole, olanzapine and haloperidol pamoate salts
US20050031713A1 (en) * 2003-08-06 2005-02-10 Elliot Ehrich Methods for administering active agents to CYP3A4 sensitive patients
US20050032811A1 (en) * 2003-08-06 2005-02-10 Josiah Brown Methods for administering aripiprazole
US7160888B2 (en) * 2003-08-22 2007-01-09 Warner Lambert Company Llc [1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia
ES2803516T3 (es) * 2003-10-16 2021-01-27 Symed Labs Ltd Una forma cristalina de linezolid
TWI371274B (en) 2003-10-23 2012-09-01 Bristol Myers Squibb Co Process for making sterile aripiprazole of desired mean particle size
PT1675573E (pt) * 2003-10-23 2008-12-30 Otsuka Pharma Co Ltd Formulação de iripiprazole injectável estéril de libertação controlada e um processo para a sua preparação
GB0326148D0 (en) 2003-11-10 2003-12-17 Lilly Co Eli Morpholine derivatives
TW200529850A (en) * 2003-12-16 2005-09-16 Teva Pharma Methods of preparing aripiprazole crystalline forms
US7714129B2 (en) * 2003-12-16 2010-05-11 Teva Pharmaceutical Industries Ltd. Methods of preparing anhydrous aripiprazole form II
CN1304373C (zh) * 2003-12-25 2007-03-14 成都康弘科技实业(集团)有限公司 阿立哌唑的制备方法和中间体
WO2006001846A1 (en) * 2004-02-05 2006-01-05 Teva Pharmaceutical Industries Ltd. Method of making 7-(4-bromobutoxy)-3,4-dihydrocarbostyril
JP2007517916A (ja) * 2004-02-05 2007-07-05 テバ ファーマシューティカル インダストリーズ リミティド アリピプラゾールを調製するための方法
CN100497325C (zh) * 2004-04-21 2009-06-10 齐鲁制药有限公司 哌嗪衍生物及其在制备喹啉酮衍生物中的用途
US7507823B2 (en) * 2004-05-06 2009-03-24 Bristol-Myers Squibb Company Process of making aripiprazole particles
CA2565996A1 (en) * 2004-05-11 2005-11-17 Pfizer Products Inc. Combination of atypical antipsychotics and 5-ht1b receptor antagonists
AR049401A1 (es) * 2004-06-18 2006-07-26 Novartis Ag Aza-biciclononanos
WO2006012237A2 (en) * 2004-06-25 2006-02-02 Shanghai Institute Of Pharmaceutical Industry Aripiprazole crystaline forms and associated methods
TW200616608A (en) * 2004-07-09 2006-06-01 Forest Laboratories Memantine as adjunctive treatment to atypical antipsychotics in schizophrenia patients
GB0415746D0 (en) 2004-07-14 2004-08-18 Novartis Ag Organic compounds
US20060024362A1 (en) 2004-07-29 2006-02-02 Pawan Seth Composition comprising a benzimidazole and process for its manufacture
EP1797039A1 (de) * 2004-09-13 2007-06-20 Matrix Laboratories Ltd Verfahren zur herstellung von polymorphen, solvaten von aripiprazol unter verwendung von aripiprazolsäuresalzen
NZ554731A (en) * 2004-10-08 2009-12-24 Suven Life Sciences Ltd Novel Intermediates Useful For The Preparation Of Aripiprazole And Methods For The Preparation Of The Novel Intermediates And Aripiprazole
US20060079690A1 (en) * 2004-10-12 2006-04-13 Vladimir Naddaka Processes for preparing 7-hydroxy-3,4-dihydro-2(1H)-quinolinone and the use in aripiprazole preparation thereof
DE102005048695A1 (de) * 2004-10-12 2006-05-18 Chemagis Ltd. Verfahren zur Herstellung und Reinigung von Carbostyrilverbindungen wie beispielsweise Aripiprazol und 7-(4-Halobutoxy)-3,4-dihydro-2(1H)-quinolinonen
GB0424564D0 (en) 2004-11-05 2004-12-08 Novartis Ag Organic compounds
CN101111481A (zh) * 2004-11-18 2008-01-23 斯索恩有限公司 制备结晶阿立哌唑的方法
CN101087760B (zh) * 2004-11-18 2011-09-28 斯索恩有限公司 结晶的阿立哌唑溶剂化物
CN1303068C (zh) * 2005-01-11 2007-03-07 中国人民解放军第二军医大学 一种阿立哌唑的制备方法
EP1686117A1 (de) * 2005-01-27 2006-08-02 Sandoz AG Polymorph und Solvate von Aripiprazol
EP2093217B1 (de) * 2005-01-27 2014-03-12 Sandoz AG Verfahren zur Herstellung von Form X von Aripiprazol
EP1686126A1 (de) * 2005-01-27 2006-08-02 Sandoz AG Aripiprazol-Salze
CZ300352B6 (cs) * 2005-02-15 2009-04-29 Zentiva, A. S. Zpusob prípravy fosforecnanu aripiprazolu
CZ300456B6 (cs) * 2005-02-15 2009-05-27 Zentiva, A. S. Zpusob prípravy vinanu aripiprazolu v krystalické forme
WO2006090272A1 (en) * 2005-02-22 2006-08-31 Warner-Lambert Company Llc Isoquinoline [1,8]naphthyridin-2-ones and related compounds for treatment of schizophrenia
CA2600542A1 (en) * 2005-03-17 2006-09-21 Synthon B.V. Pharmaceutical tablets of crystalline type ii aripiprazole
WO2006097343A1 (en) 2005-03-17 2006-09-21 Synthon B.V. Process of making crystalline type ii aripiprazole
CA2603049A1 (en) * 2005-04-01 2006-10-05 Warner-Lambert Company Llc Tetrahydro-pyridoazepin-8-ones and related compounds for the treatment of schizophrenia
GB0507298D0 (en) 2005-04-11 2005-05-18 Novartis Ag Organic compounds
TWI320783B (en) 2005-04-14 2010-02-21 Otsuka Pharma Co Ltd Heterocyclic compound
CZ300351B6 (cs) * 2005-05-26 2009-04-29 Zentiva, A. S. Zpusob prípravy 7-hydroxy-3,4-dihydrokarbostyrilu
CN100432053C (zh) * 2005-06-07 2008-11-12 上海医药工业研究院 阿立哌唑晶型及其制备方法
HUP0500683A3 (en) * 2005-07-14 2009-03-30 Egis Gyogyszergyar Nyilvanosan New arylpiprazole salts for producing pharmaceutical composition
AR055203A1 (es) 2005-08-31 2007-08-08 Otsuka Pharma Co Ltd Derivados de benzotiofeno con propiedades antipsicoticas
EP1933814A2 (de) 2005-09-15 2008-06-25 Elan Pharma International Limited Nanoteilchenförmige aripiprazol-formulierungen
JP2008521835A (ja) 2005-09-29 2008-06-26 テバ ファーマシューティカル インダストリーズ リミティド 無水アリピプラゾールフォームiiの調製方法
CZ299485B6 (cs) * 2005-10-11 2008-08-13 Zentiva, A. S. Zpusob výroby aripiprazolu
GB0525672D0 (en) 2005-12-16 2006-01-25 Novartis Ag Organic compounds
GB0525673D0 (en) 2005-12-16 2006-01-25 Novartis Ag Organic compounds
WO2007075871A2 (en) * 2005-12-22 2007-07-05 Teva Pharmaceutical Industries Ltd. Processes for reducing particle size of aripiprazole
US20070149782A1 (en) * 2005-12-23 2007-06-28 Michael Brand Methods of preparing a crystalline form of 7-(4-chlorobutoxy)-3,4-dihydro-2(1h)-quinolinone and the use thereof in the synthesis of Aripiprazole
EP1988899A4 (de) * 2006-02-03 2009-12-30 Reddys Lab Ltd Dr Aripiprazol-co-kristalle
EP1988077A4 (de) 2006-02-23 2009-09-02 Shionogi & Co Nitrogene heterocyclische derivate, die mit cyclischen gruppen substituiert sind
US20070213535A1 (en) * 2006-03-07 2007-09-13 Chemagis Ltd. Process for the manufacture of aripiprazole by using purified carbostyril compounds such as 7-(4-halobutoxy)-3,4-dihydro-2(1H)-quinolinones
US20060223820A1 (en) * 2006-03-21 2006-10-05 Chemagis Ltd. Crystalline aripiprazole salts and processes for preparation and purification thereof
WO2007113846A1 (en) * 2006-04-03 2007-10-11 Alembic Limited A process for the preparation of aripiprazole
DE602007001620D1 (de) * 2006-04-10 2009-09-03 Ranbaxy Lab Ltd Verbesserter Herstellungsprozess für Aripipirazol
WO2007144874A1 (en) 2006-06-12 2007-12-21 Hadasit Medical Research Services And Development Ltd. Rgs2 genotypes associated with extrapyramidal symptoms induced by antipsychotic medication
WO2007148191A2 (en) * 2006-06-20 2007-12-27 Orchid Chemicals & Pharmaceuticals Limited An improved process for the preparation of aripiprazole
WO2008001188A2 (en) * 2006-06-29 2008-01-03 Cadila Pharmaceuticals Limited An improved process for the preparation of substantially pure aripiprazole
US7799790B2 (en) * 2006-07-20 2010-09-21 Helm Ag Amorphous aripiprazole and process for the preparation thereof
EP1880714A1 (de) * 2006-07-20 2008-01-23 Helm AG Amorphes Aripiprazol und Verfahren zu dessen Herstellung
TR200604349A2 (tr) 2006-08-15 2008-03-21 NOBEL İLAÇ SANAYii VE TiCARET A.Ş. Aripiprazol içeren farmasötik bileşimler
US20080103154A1 (en) * 2006-08-24 2008-05-01 Concert Pharmaceuticals Inc. 3, 4-dihydro-2(IH)-quinolinone and 2(1H)-quinolinone derivatives
UA94624C2 (uk) * 2006-09-22 2011-05-25 Крка, Товарна Здравіл, Д.Д., Ново Мєсто Арипіпразолу геміфумарат і спосіб його одержання
EP2084133A2 (de) * 2006-09-28 2009-08-05 Cadila Healthcare Limited Verfahren zur herstellung von kristallinem aripiprazol
EP2079723B1 (de) * 2006-10-24 2012-12-19 Cambrex Charles City, Inc. Verfahren zur herstellung von wasserfreiem aripiprazol vom typ i
WO2008090632A1 (en) * 2007-01-26 2008-07-31 Otsuka Pharmaceutical Co., Ltd. Marker for detecting the proposed efficacy of treatment
EP1972628A1 (de) * 2007-03-21 2008-09-24 Schwarz Pharma Ag Indolizine und aza-analoge Derivate davon als CNS-aktive Verbindungen
TW200848041A (en) 2007-03-30 2008-12-16 Otsuka Pharma Co Ltd A medicament for treating schizophrenia comprising cilostazol
WO2008144764A1 (en) 2007-05-21 2008-11-27 Reviva Pharmaceuticals, Inc. Compositions, synthesis, and methods of using quinolinone based atypical antipsychotic agents
US20080299216A1 (en) * 2007-06-01 2008-12-04 Protia, Llc Deuterium-enriched aripiprazole
WO2008146156A2 (en) * 2007-06-01 2008-12-04 Aurobindo Pharma Limited An improved process for the preparation of aripiprazole
JP4879349B2 (ja) * 2007-07-31 2012-02-22 大塚製薬株式会社 アリピプラゾール懸濁液及び凍結乾燥製剤の製造方法
GB2456183A (en) * 2008-01-04 2009-07-08 Gw Pharma Ltd Anti-psychotic composition comprising cannabinoids and anti-psychotic medicament
ATE482691T1 (de) 2008-01-23 2010-10-15 Helm Ag Amorphes aripiprazol und verfahren zu seiner herstellung
CN101538252B (zh) * 2008-03-20 2011-04-20 成都康弘药业集团股份有限公司 阿立哌唑的制备方法及其中间体
US7964605B2 (en) * 2008-05-29 2011-06-21 Sk Holdings Co., Ltd. Phenyl piperazine compounds, pharmaceutical composition comprising the same, and use thereof
US7985752B2 (en) * 2008-05-29 2011-07-26 Sk Holdings Co., Ltd. Phenyl piperazine compounds, pharmaceutical composition including the same and use thereof
WO2010079506A2 (en) 2008-06-23 2010-07-15 Torrent Pharmaceuticals Ltd. Pharmaceutical composition of aripiprazole
CA2727573A1 (en) * 2008-06-25 2009-12-30 Pfizer Inc. Diaryl compounds and uses thereof
EP2233471A1 (de) 2009-02-06 2010-09-29 Adamed Sp. z o.o. Salz aus 7-{4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butoxy}-3,4.dihydro-2(1h)-chinolinon mit 5-sulfosalizyklischer säure und herstellungsverfahren
WO2010106551A2 (en) * 2009-03-09 2010-09-23 Neuland Laboratories Ltd. A process for the manufacture of pure anhydrous aripiprazole form b
EP2238976B1 (de) 2009-04-03 2012-06-27 Hexal AG Oraler Film mit 7-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy]-3,4-dihydro-1H-chinolin-2-on-Base oder Salze oder Hydrate davon
US8815261B2 (en) 2009-06-19 2014-08-26 Medrx Co., Ltd. Composition for external application comprising aripiprazole and organic acid as active ingredients
PT2445502T (pt) * 2009-06-25 2017-09-22 Alkermes Pharma Ireland Ltd Compostos heterocíclicos para o tratamento de distúrbios neurológicos e psicológicos
WO2010151711A1 (en) 2009-06-25 2010-12-29 Alkermes, Inc. Prodrugs of nh-acidic compounds
WO2011023796A1 (en) 2009-08-31 2011-03-03 Abbott Healthcare Products B.V. Bifeprunox for treating addiction
AU2010293647B2 (en) 2009-09-11 2015-06-25 Otsuka Pharmaceutical Co., Ltd. Therapeutic agent for chronic pain
WO2011030213A1 (en) 2009-09-14 2011-03-17 Jubilant Organosys Limited Improved process for the preparation of 7.(4-bromobutoxy) 3,4-dihydrocarbostyril, a precursor of aripiprazole
EP2477609A1 (de) 2009-09-15 2012-07-25 Ratiopharm GmbH Im mund zerfallende pharmazeutische darreichungsform mit aripiprazol
TR201000948A1 (tr) 2010-02-09 2011-08-22 Sanovel İlaç San.Ve Ti̇c.A.Ş. Aripiprazol formülasyonları.
CA2802957A1 (en) 2010-06-16 2011-12-22 Embera Neurotherapeutics, Inc Compositions and methods for the treatment of addiction, psychiatric disorders, and neurodegenerative disease
US8592427B2 (en) 2010-06-24 2013-11-26 Alkermes Pharma Ireland Limited Prodrugs of NH-acidic compounds: ester, carbonate, carbamate and phosphonate derivatives
US9156822B2 (en) 2010-07-02 2015-10-13 The University Of North Carolina At Chapel Hill Functionally selective ligands of dopamine D2 receptors
HRP20190169T1 (hr) 2010-08-23 2019-03-22 Alkermes Pharma Ireland Limited Postupci liječenja povećanja tjelesne težine inducirane antipsihoticima
WO2012026562A1 (en) 2010-08-24 2012-03-01 Otsuka Pharmaceutical Co., Ltd. Suspension and cake composition containing carbostyryl derivative and silicone oil and/or silicone oil derivative
NO3034079T3 (de) 2010-11-15 2018-06-09
AR083884A1 (es) 2010-11-16 2013-03-27 Otsuka Pharma Co Ltd Jeringa prellenable de doble camara y relleno de aripiprazol en la jeringa
LT2667856T (lt) 2011-01-24 2021-11-25 Otsuka Pharmaceutical Co., Ltd. Medicininė priemonė, kurioje yra sausos masės kompozicija, apimanti aripiprazolą kaip veikliąją sudedamąją dalį, ir sausos masės kompozicija, apimanti aripiprazolą kaip veikliąją sudedamąją dalį
HRP20240285T1 (hr) 2011-03-18 2024-05-24 Alkermes Pharma Ireland Limited Farmaceutski pripravci koji sadrže sorbitan estere
WO2012131451A1 (en) 2011-03-30 2012-10-04 Jubilant Life Sciences Limited Process for producing aripiprazole in anhydrous type i crystals
KR101340214B1 (ko) 2011-03-31 2013-12-10 주식회사 대웅제약 무수 아리피프라졸 ⅱ형 결정의 제조방법
JO3410B1 (ar) 2011-06-07 2019-10-20 Otsuka Pharma Co Ltd تركيبة أريبيبرازول مجفف بالتبريد
TW201309651A (zh) 2011-06-29 2013-03-01 Otsuka Pharma Co Ltd 阿立哌唑(aripiprazole)無水物B形結晶微粒子之製造方法
GR1007722B (el) 2011-08-05 2012-10-18 Φαρματεν Αβεε, Μεθοδος για την παρασκευη της αριπιπραζολης
WO2013088255A1 (en) 2011-12-15 2013-06-20 Alkermes Pharma Ireland Limited Prodrugs of secondary amine compounds
CN103172563B (zh) * 2011-12-26 2015-03-25 北京京卫燕康药物研究所有限公司 小粒径的晶型i阿立哌唑的工业化制备
WO2013100878A1 (en) 2011-12-27 2013-07-04 Mahmut Bilgic Pharmaceutical formulations comprising aripiprazole
WO2014104989A1 (en) 2011-12-27 2014-07-03 Mahmut Bilgic Pharmaceutical compositions comprising aripiprazole
TW201343201A (zh) 2012-03-06 2013-11-01 Otsuka Pharma Co Ltd 持續釋放型口服固體製劑
EP2827866B1 (de) 2012-03-19 2023-05-03 Alkermes Pharma Ireland Limited Pharmazeutische zusammensetzungen mit benzylalkohol
ES2764383T3 (es) 2012-03-19 2020-06-03 Alkermes Pharma Ireland Ltd Composiciones farmacéuticas que comprenden ésteres de glicerol
AU2013235519C1 (en) 2012-03-19 2018-04-26 Alkermes Pharma Ireland Limited Pharmaaceutical compositions comprising fatty acid esters
JOP20200109A1 (ar) 2012-04-23 2017-06-16 Otsuka Pharma Co Ltd مستحضر قابل للحقن
KR101571670B1 (ko) 2012-08-08 2015-11-25 주식회사 씨엠지제약 아리피프라졸을 포함하는 경구용 속용 필름 제제
ES2792149T3 (es) 2012-09-19 2020-11-10 Alkermes Pharma Ireland Ltd Composiciones farmacéuticas que tienen estabilidad de almacenamiento mejorada
WO2014059363A1 (en) * 2012-10-11 2014-04-17 Antrim Pharmaceuticals Llc Oral solution formulations of aripiprazole
PL2908859T3 (pl) 2012-10-16 2017-10-31 Arven Ilac Sanayi Ve Ticaret As Formulacje arypiprazolu
US20140206667A1 (en) 2012-11-14 2014-07-24 Michela Gallagher Methods and compositions for treating schizophrenia
AR096131A1 (es) 2013-04-30 2015-12-09 Otsuka Pharma Co Ltd Preparado oral sólido que comprende aripiprazol y un método para producir un preparado oral sólido que comprende aripiprazol
US10525057B2 (en) 2013-09-24 2020-01-07 Otsuka Pharmaceutical Co., Ltd. Method of providing aripiprazole to patients having impaired CYP2D6 or CYP3A4 enzyme function
WO2015067313A1 (en) 2013-11-07 2015-05-14 Synthon B.V. Orodispersible pharmaceutical compositions comprising aripiprazole
NZ722077A (en) 2013-12-20 2021-12-24 Agenebio Inc Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
MX376057B (es) 2014-03-20 2025-03-07 Alkermes Pharma Ireland Ltd Formulaciones de aripiprazol que tienen mayores velocidades de inyeccion.
KR20160139704A (ko) 2015-05-28 2016-12-07 주식회사 씨엠지제약 아리피프라졸을 포함하는 경구용 속용 필름 제제, 및 이의 제조방법
EP3302422A1 (de) 2015-06-08 2018-04-11 Corium International, Inc. Formulierungen zur transdermalen freisetzung von aripiprazol
CN113264939A (zh) 2015-06-19 2021-08-17 艾吉因生物股份有限公司 用于治疗认知损害的苯并二氮杂环庚三烯衍生物、组合物和方法
RU2018101864A (ru) * 2015-06-22 2019-07-22 Эмбера Ньюротерапьютикс, Инк. Композиции и способы для лечения нарушений, связанных с употреблением веществ, зависимости и психических расстройств
CN106608875A (zh) 2015-10-26 2017-05-03 江苏恩华药业股份有限公司 一种稠和杂环类衍生物合成及其应用
US20190160002A1 (en) 2016-07-28 2019-05-30 Mylan Laboratories Limited Process for preparing sterile aripiprazole formulation
CN108069900B (zh) * 2016-11-08 2022-09-23 齐鲁制药有限公司 阿立哌唑盐酸盐的制备方法和用途
TR201617675A2 (tr) 2016-12-02 2018-06-21 Arven Ilac Sanayi Ve Ticaret Anonim Sirketi Ari̇pi̇prazole monohi̇drat formülasyonlarinin ağizda dağilan tablet formu
US11505555B2 (en) 2016-12-19 2022-11-22 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
US20180170941A1 (en) 2016-12-19 2018-06-21 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
WO2018165649A1 (en) 2017-03-10 2018-09-13 Embera Neurotherapeutics, Inc. Pharmaceutical compositions and uses thereof
ES2903278T3 (es) 2017-07-28 2022-03-31 Interquim Sa Procedimiento para la preparación de aripiprazol lauroxil
CN109498556A (zh) * 2017-09-15 2019-03-22 万特制药(海南)有限公司 阿立哌唑口服溶液及其制备方法
AU2019230014B2 (en) 2018-03-05 2024-11-28 Alkermes Pharma Ireland Limited Aripiprazole dosing strategy
US11414425B2 (en) 2018-06-19 2022-08-16 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
CN109180577B (zh) * 2018-10-15 2021-11-16 迪嘉药业集团有限公司 一种阿立哌唑的制备方法
KR102128883B1 (ko) 2019-10-02 2020-07-01 (주)삼화바이오팜 고순도 아리피프라졸의 신규 결정형 및 이의 제조방법
US20240217977A1 (en) * 2021-03-31 2024-07-04 Blueprint Medicines Corporation Diazepanone-fused pyrimidine compounds, compositions and medicinal applications thereof
CN115611828A (zh) * 2021-07-15 2023-01-17 北京万全德众医药生物技术有限公司 一种阿立哌唑关键中间体ii的制备方法
US20240368115A1 (en) * 2021-08-05 2024-11-07 Shujing Biopharma Co., Ltd Regulator containing tricyclic derivative, preparation method therefor and application thereof
CN114751873B (zh) * 2022-04-25 2025-02-18 扬州市普林斯医药科技有限公司 一种1-(2,3-二氯苯基)哌嗪的制备方法
US20240132513A1 (en) 2022-08-19 2024-04-25 Agenebio, Inc. Benzazepine derivatives, compositions, and methods for treating cognitive impairment

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3994900A (en) * 1976-01-23 1976-11-30 E. R. Squibb & Sons, Inc. 6-(Or 8)-[[(substituted amino)alkyl]oxy(or thio)]-3,4-dihydro-4-phenyl-2(1H)-quinolinones
JPS54130587A (en) * 1978-03-30 1979-10-09 Otsuka Pharmaceut Co Ltd Carbostyryl derivative
DE2960178D1 (en) * 1978-06-06 1981-04-09 Hoechst Ag New substituted phenylpiperazine derivatives, pharmaceutical compositions containing them and process for their preparation
DE2827566A1 (de) * 1978-06-23 1980-01-10 Boehringer Mannheim Gmbh 1,2-dihydro-chinolin-2-on-derivate und verfahren zu ihrer herstellung
PH17194A (en) * 1980-03-06 1984-06-19 Otsuka Pharma Co Ltd Novel carbostyril derivatives,and pharmaceutical composition containing the same
JPS58203968A (ja) * 1982-05-21 1983-11-28 Otsuka Pharmaceut Co Ltd イソカルボスチリル誘導体
CN85108214A (zh) * 1984-11-22 1986-08-20 赫彻斯特股份公司 新的取代的苯基哌嗪衍生物及其药物的制造方法
DK588486A (da) * 1985-12-09 1987-06-10 Otsuka Pharma Co Ltd Anvendelse af en forbindelse til behandling af hypoxi

Also Published As

Publication number Publication date
US5006528A (en) 1991-04-09
CN1042537A (zh) 1990-05-30
DK539789D0 (da) 1989-10-30
DE68925405D1 (de) 1996-02-22
EP0367141A3 (de) 1991-06-12
NL300161I2 (nl) 2005-02-01
EP0367141A2 (de) 1990-05-09
EP0367141B1 (de) 1996-01-10
KR0138529B1 (ko) 1998-05-15
CN1028104C (zh) 1995-04-05
DK168485B1 (da) 1994-04-05
HK1002706A1 (en) 1998-09-11
DK539789A (da) 1990-05-01
NL300161I1 (nl) 2004-12-01
KR900006320A (ko) 1990-05-07
ES2084594T3 (es) 1996-05-16
DE122004000043I2 (de) 2005-06-16
DE68925405T2 (de) 1996-06-27
MX9202934A (es) 1992-06-30

Similar Documents

Publication Publication Date Title
DE122004000043I1 (de) Carbostryril-Derivate.
ATE74125T1 (de) Didehydro-vitamin d3-derivate.
DE69008682D1 (de) Guanidinobenzolderivate.
DE58904437D1 (de) Rakelfarbwerk.
DE58904326D1 (de) Rakelfarbwerk.
ATE74350T1 (de) Dehydrocholecalciferolderivate.
DE58902774D1 (de) Pflanztafel.
ATE124407T1 (de) Chromanderivate.
ATE126800T1 (de) Neplanocinderivate.
FI893278A7 (fi) N-fenylpyrazol-4-yleterderivat.
ATE116985T1 (de) Chromanderivate.
DE58902346D1 (de) Traenkeventil.
DE68911192D1 (de) Phosphonoalkylpurin-Derivate.
DE69017657D1 (de) Pyridinderivate.
FI891156A0 (fi) Foerpackningsfoerfarande och -komposition.
DE58903265D1 (de) Fluorcyclopropyl-derivate.
DE58903112D1 (de) Kannenstock.
FI893567L (fi) Foerfarande foer framstaellning av glykosfingolipidderivat.
DE59000510D1 (de) N-phenyltetrahydroindazolderivate.
DE69005904D1 (de) Phenylpyrimidonderivate.
FI904891L (fi) Fenylsulfonderivat.
DE58902190D1 (de) Schaelmaschine.
DE68913856D1 (de) Cycloalkylthiazol-Derivate.
DE59003499D1 (de) 3-Cyano-4-phenyl-pyrrol-Derivate.
FI893144A7 (fi) Substituerade azacyklohexylderivat.