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DE106004T1 - Verfahren zur bildung einer hydraphilen beschichtung auf einem substrat. - Google Patents

Verfahren zur bildung einer hydraphilen beschichtung auf einem substrat.

Info

Publication number
DE106004T1
DE106004T1 DE198282850200T DE82850200T DE106004T1 DE 106004 T1 DE106004 T1 DE 106004T1 DE 198282850200 T DE198282850200 T DE 198282850200T DE 82850200 T DE82850200 T DE 82850200T DE 106004 T1 DE106004 T1 DE 106004T1
Authority
DE
Germany
Prior art keywords
substrate
copolymer
coating
polyisocyanate
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE198282850200T
Other languages
English (en)
Inventor
R. Alastair Santa Barbara California 93105 Winn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
International Silicone Corp
Original Assignee
International Silicone Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39587954&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE106004(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by International Silicone Corp filed Critical International Silicone Corp
Publication of DE106004T1 publication Critical patent/DE106004T1/de
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/08—Materials for coatings
    • A61L29/085—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0076—Chemical modification of the substrate
    • A61L33/0088—Chemical modification of the substrate by grafting of a monomer onto the substrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/06—Use of macromolecular materials
    • A61L33/064—Use of macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/06—Use of macromolecular materials
    • A61L33/064—Use of macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A61L33/066—Rubbers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05D7/00—Processes, other than flocking, specially adapted for applying liquids or other fluent materials to particular surfaces or for applying particular liquids or other fluent materials
    • B05D7/02—Processes, other than flocking, specially adapted for applying liquids or other fluent materials to particular surfaces or for applying particular liquids or other fluent materials to macromolecular substances, e.g. rubber
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/40—High-molecular-weight compounds
    • C08G18/62—Polymers of compounds having carbon-to-carbon double bonds
    • C08G18/6283—Polymers of nitrogen containing compounds having carbon-to-carbon double bonds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J7/00—Chemical treatment or coating of shaped articles made of macromolecular substances
    • C08J7/04—Coating
    • C08J7/0427—Coating with only one layer of a composition containing a polymer binder
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J7/00—Chemical treatment or coating of shaped articles made of macromolecular substances
    • C08J7/04—Coating
    • C08J7/043—Improving the adhesiveness of the coatings per se, e.g. forming primers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J7/00—Chemical treatment or coating of shaped articles made of macromolecular substances
    • C08J7/04—Coating
    • C08J7/056—Forming hydrophilic coatings
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J7/00—Chemical treatment or coating of shaped articles made of macromolecular substances
    • C08J7/12—Chemical modification
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K3/00—Materials not provided for elsewhere
    • C09K3/18—Materials not provided for elsewhere for application to surfaces to minimize adherence of ice, mist or water thereto; Thawing or antifreeze materials for application to surfaces
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2439/00—Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Derivatives of such polymers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/31504—Composite [nonstructural laminate]
    • Y10T428/31551—Of polyamidoester [polyurethane, polyisocyanate, polycarbamate, etc.]
    • Y10T428/31562—Next to polyamide [nylon, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/31504—Composite [nonstructural laminate]
    • Y10T428/31551—Of polyamidoester [polyurethane, polyisocyanate, polycarbamate, etc.]
    • Y10T428/31573—Next to addition polymer of ethylenically unsaturated monomer
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/31504—Composite [nonstructural laminate]
    • Y10T428/31551—Of polyamidoester [polyurethane, polyisocyanate, polycarbamate, etc.]
    • Y10T428/31573—Next to addition polymer of ethylenically unsaturated monomer
    • Y10T428/31576—Ester monomer type [polyvinylacetate, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/31504—Composite [nonstructural laminate]
    • Y10T428/31551—Of polyamidoester [polyurethane, polyisocyanate, polycarbamate, etc.]
    • Y10T428/31573—Next to addition polymer of ethylenically unsaturated monomer
    • Y10T428/3158—Halide monomer type [polyvinyl chloride, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Immunology (AREA)
  • Surgery (AREA)
  • Materials Engineering (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Wood Science & Technology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Transplantation (AREA)
  • Combustion & Propulsion (AREA)
  • Biotechnology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Materials For Medical Uses (AREA)
  • Application Of Or Painting With Fluid Materials (AREA)
  • Liquid Deposition Of Substances Of Which Semiconductor Devices Are Composed (AREA)

Claims (22)

υ ι υ υ υ υ 82 850 200.5 International Silicone Corporation PATENTANSPRÜCHE
1. Verfahren zur Herstellung eines hydrophilen Überzuges auf einem Substrat, vorzugsweise einem biologisch-medizinischen Substrat, dadurch gekennzeichnet, daß man unumgesetzte Isocyanatgruppen auf der
jr Oberfläche des Substrates bildet und die Oberfläche des Substrates mit einem hydrophilen Copolymer behandelt, das kovalente Bindungen mit dem unumgesetzten Isocyanat bilden kann.
2. Verfahren nach Anspruch 1, dadurch gekennzeichnet, daß man einen Überzug aus einer Lösungsmittellösung eines Polyisocyanates auf der Oberfläche des Substrates unter Bildung eines Kopplungsüberzuges mit unumgesetzten Isocyanaten aufbringt, eine Lösungsmittel-
2g lösung eines hydrophilen Copolymers, das mit Isocyanat unter Bildung einer kovalenten Bindung zwischen diesem Kupplungsüberzug und hydrophilem Copolymer reagiert, aufbringt, das Lösungsmittel verdampft und die Isocyanate umsetzt.
3. Verfahren nach Anspruch 1, dadurch gekennzeichnet, daß man gleichzeitig Lösungsmittellösung, die PoIyisocyanat und hydrophiles Copolymer, welches bei der Umsetzung mit Isocyanaten kovalente Bindungen bildet, aufbringt, das Lösungsmittel eliminiert und das PoIyisocyanat und reaktive Copolymer umsetzt.
4. Verfahren nach Anspruch 3, dadurch gekennzeichnet, daß die Lösungsmittellösung ein reaktives Verdünnungsmittel enthält, das im wesentlichen in situ polymerisiert.
5. Verfahren nach Anspruch 4, dadurch gekennzeichent, daß das Verdünnungsmittel in der Lösung bis zu etwa 100% ausmacht.
6· Verfahren nach Anspruch 4 oder 5, dadurch gekennzeichnet, daß das reaktive Verdünnungsmittel ein UV-gehärtetes vinylhaltiges Monomer, Dimer oder Trimer, vorzugsweise aus der Gruppe Hydroxymethyl-methacrylat, Acrylsäure, Methacrylsäure und Acrylamid, ist.
.
7. Verfahren nach Anspruch 2 oder 3, dadurch gekennzeichnet, daß das Substrat ein Polymersubstrat aus der Gruppe Polyurethanharz, Vinylharz, Polyacrylat, Polycarbonat, Polyester und Kautschuk, wie Latexkautschuk, Polyisopren und Butadien-Styrol-Copolymer ist.
8. Verfahren nach Anspruch 4, dadurch gekennzeichnet, daß ein Lösungsmittel ausgewählt wird, das nicht mit Isocyanaten reagiert.
9. Verfahren nach Anspruch 4 oder 8, dadurch gekennzeichnet, daß das Substrat aus der Gruppe Vinyl- oder Butadien-Styrol-Kautschuk, Polyethylen und PoIypropylen ausgewählt ist.
10. Verfahren nach Anspruch 9, dadurch gekennzeichnet, daß man das Substrat mit chemischen Modifiziermitteln aus der Gruppe der gamma-Aminopropyl-funktionellen Silane und Ozon oder mit einer Plasmaentladung oder mit hoher Strahlungsenergie behandelt.
11. Verfahren nach Anspruch 1, dadurch gekennzeichnet, daß das Polyisocyanat aus der Gruppe Polmethylenpolyphenylisocyanat, 4,4'-Diphenylmethandiisocyanat und Stellungsisomeren hiervon, •2,4-Toluoldiisocyanat und Stellungsisomeren hiervon, 3, 4-Dichlorphenyldiisocyanat und Isoferronisocyanat ausgewählt wird.
12. Verfahren nach Anspruch 1, dadurch gekennzeichnet, daß das Polyisocyanat ein geblocktes Isocyanat, vorzugsweise ein solches aus der Gruppe von phenolgeblocktem Diphenylmethan-4,4'-diisocyanat und ketoximgeblocktem Tetraisocyanat ist.
13. Verfahren nach einem der Ansprüche 2, 11 oder 12,
dadurch gekennzeichnet, daß das Poyisocyanat aus einer Lösungsmittellösung aufgebracht wird, die wenigstens etwa 0,1 Gewichts/Volumenprozent, vorzugsweise etwa 0,3 bis etwa 15 Gewichts/Volumenprozent enthält.
14. Verfahren nach Anspruch 2, dadurch gekennzeichnet, daß die Polyisocyanatlösung mit dem Substrat weniger als etwa 120 Minuten, wie 5 bis 20 Minuten, beispielsweise etwa 10 Minuten, in Berührung gehalten wird.
15. Verfahren nach Anspruch 1, dadurch gekennzeichnet, daß das Copolymer ein mittleres Molekulargewicht von wenigstens 100.000 hat.
16. Verfahren nach Anspruch 1 oder 15, dadurch gekennzeichnet, daß das Copolymer im Mittel wenigstens zwei aktive Wasserstoffatomstellen im Molekül hat.
17. Verfahren nach Anspruch 16, dadurch gekennzeichnet, daß das Copolymer in einem wäßrigen Medium quellbar und vorzugsweise auch in nicht-wäßrigen Lösungsmitteln, die nicht mit Isocyanat reagieren, löslich ist.
01ÜÖUU4
18. Verfahren nach Anspruch 16, dadurch gekennzeichnet, daß das Copolymer hauptsächlich aus sich wiederholenden Einheiten besteht, die keine reaktiven Wasserstoff atome enthalten.
.
19. Verfahren nach Anspruch 16, dadurch gekennzeichnet, daß die monomeren des Copolymers aus der Gruppe -Vinylmethyläther, Vinylpyridin, N-Vinyl-2-pyrrolidon, Acrylamid, Hydroxyethylacrylat, Acrylsäure, Hydroxypropylmethacrylat und Hydroxythylmethacrylat ausgewählt sind.
20. Biologisch-medizinisches Produkt mit einem hydrophilen Überzug, dadurch gekennzeichnet, daß es ein Substrat, einen hydrophilen Copolymerüberzug und einen zurückhaltenden Überzug zur Beibehaltung des hydrophilen Überzuges auf dem Substrat durch eine kovalente Bindung umfaßt, wobei das Copolymer im Mittel wenigstens 2 oder mehr Stellen besitzt, die in der Lage sind, an einen Polyisocyanatkopplungsüberzug kovalent gebunden zu werden.
21. Produkt nach Anspruch 20, dadurch gekennzeichnet, daß das Substrat ein Polymersubstrat aus der Gruppe eines Polyurethanharzes, eines Vinylharzes, eines Polyacrylate, eines Polycabonats, eines Polyesters oder Kautschuks, wie Latexkautschuk, Polyisopren oder Styrol-Butadien, ist.
22. Produkt nach Anspruch 20, dadurch gekennzeichnet, daß das Substrat ein medizinisches Instrument umfaßt, das für den Kontakt mit Blut oder subkutanem Gewebe geeignet ist, wie beispielsweise eine intravenöse Kanüle, eine Wundendrainage oder ein chirurgisches Werkzeug, wie ein chirurgisches rostfreies Stahlwerkzeug.
DE198282850200T 1981-05-18 1982-10-14 Verfahren zur bildung einer hydraphilen beschichtung auf einem substrat. Pending DE106004T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US06/264,957 US4373009A (en) 1981-05-18 1981-05-18 Method of forming a hydrophilic coating on a substrate
FI823505A FI76820C (fi) 1981-05-18 1982-10-14 Foerfarande foer bildande av en hydrofil belaeggning pao ett substrat.
DK455382A DK166156C (da) 1981-05-18 1982-10-14 Fremgangsmaade til dannelse af et hydrofilt overtraek paa en genstand eller et substrat, samt genstand til biomedicinsk anvendelse forsynet med et saadant overtraek
EP19820850200 EP0106004B1 (de) 1981-05-18 1982-10-14 Verfahren zur Bildung einer hydrophilen Beschichtung auf einem Substrat

Publications (1)

Publication Number Publication Date
DE106004T1 true DE106004T1 (de) 1984-10-11

Family

ID=39587954

Family Applications (2)

Application Number Title Priority Date Filing Date
DE198282850200T Pending DE106004T1 (de) 1981-05-18 1982-10-14 Verfahren zur bildung einer hydraphilen beschichtung auf einem substrat.
DE8282850200T Expired DE3277899D1 (en) 1981-05-18 1982-10-14 Method of forming a hydrophilic coating on a substrate

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE8282850200T Expired DE3277899D1 (en) 1981-05-18 1982-10-14 Method of forming a hydrophilic coating on a substrate

Country Status (9)

Country Link
US (1) US4373009A (de)
EP (1) EP0106004B1 (de)
JP (1) JPS5981341A (de)
AT (1) ATE31628T1 (de)
AU (1) AU556584B2 (de)
DE (2) DE106004T1 (de)
DK (1) DK166156C (de)
FI (1) FI76820C (de)
GB (1) GB2128500B (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3444935A1 (de) * 1984-12-08 1986-06-12 Pfrimmer-Viggo GmbH & Co KG, 8520 Erlangen Mandrin zum versteifen von sonden

Families Citing this family (212)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE430695B (sv) * 1982-04-22 1983-12-05 Astra Meditec Ab Forfarande for framstellning av en hydrofil beleggning samt enligt forfarandet framstellda medicinska artiklar
SE8205908D0 (sv) * 1982-10-18 1982-10-18 Pharmacia Diagnostics Ab Sett att bilda polymerskikt
SE8305444L (sv) * 1983-10-04 1985-04-05 Vilhelm Einar Stellan Hjerten Bakterieavvisande ytor
US4687482A (en) * 1984-04-27 1987-08-18 Scripps Clinic And Research Foundation Vascular prosthesis
US4589873A (en) * 1984-05-29 1986-05-20 Becton, Dickinson And Company Method of applying a hydrophilic coating to a polymeric substrate and articles prepared thereby
JPS60259269A (ja) * 1984-06-04 1985-12-21 テルモ株式会社 医療用具およびその製造方法
EP0166998B1 (de) * 1984-06-04 1991-05-08 TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION Medizinisches Werkzeug und Verfahren zur Herstellung
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AU8947382A (en) 1984-05-03
JPH0377819B2 (de) 1991-12-11
FI76820C (fi) 1988-12-12
GB2128500A (en) 1984-05-02
DK166156B (da) 1993-03-15
DE3277899D1 (en) 1988-02-11
EP0106004A1 (de) 1984-04-25
FI823505L (fi) 1984-04-15
US4373009A (en) 1983-02-08
EP0106004B1 (de) 1988-01-07
ATE31628T1 (de) 1988-01-15
DK455382A (da) 1984-04-15
GB2128500B (en) 1986-06-25
FI76820B (fi) 1988-08-31
AU556584B2 (en) 1986-11-13
DK166156C (da) 1993-08-23
JPS5981341A (ja) 1984-05-11

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