DD283932A5 - Verfahren zur herstellung einer pharmazeutischen zusammensetzung zur verhuetung von sexuell uebertragbaren krankheiten - Google Patents
Verfahren zur herstellung einer pharmazeutischen zusammensetzung zur verhuetung von sexuell uebertragbaren krankheiten Download PDFInfo
- Publication number
- DD283932A5 DD283932A5 DD89330678A DD33067889A DD283932A5 DD 283932 A5 DD283932 A5 DD 283932A5 DD 89330678 A DD89330678 A DD 89330678A DD 33067889 A DD33067889 A DD 33067889A DD 283932 A5 DD283932 A5 DD 283932A5
- Authority
- DD
- German Democratic Republic
- Prior art keywords
- tampon
- pharmaceutical composition
- gel
- sexually transmitted
- transmitted diseases
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 28
- 230000002265 prevention Effects 0.000 title claims abstract description 20
- 201000010099 disease Diseases 0.000 title description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title description 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 claims abstract description 37
- 208000019802 Sexually transmitted disease Diseases 0.000 claims abstract description 25
- 210000004400 mucous membrane Anatomy 0.000 claims abstract description 20
- 241000700605 Viruses Species 0.000 claims abstract description 18
- 230000035515 penetration Effects 0.000 claims abstract description 13
- 239000003112 inhibitor Substances 0.000 claims abstract description 12
- 230000008569 process Effects 0.000 claims abstract description 11
- 230000009471 action Effects 0.000 claims abstract description 10
- 239000013543 active substance Substances 0.000 claims abstract description 9
- 238000002360 preparation method Methods 0.000 claims abstract description 8
- 241000894006 Bacteria Species 0.000 claims abstract description 7
- 239000000203 mixture Substances 0.000 claims description 23
- 239000004480 active ingredient Substances 0.000 claims description 15
- NRHMKIHPTBHXPF-TUJRSCDTSA-M sodium cholate Chemical compound [Na+].C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC([O-])=O)C)[C@@]2(C)[C@@H](O)C1 NRHMKIHPTBHXPF-TUJRSCDTSA-M 0.000 claims description 15
- 239000002270 dispersing agent Substances 0.000 claims description 14
- 229960000686 benzalkonium chloride Drugs 0.000 claims description 12
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims description 12
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 12
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims description 12
- 229920004918 nonoxynol-9 Polymers 0.000 claims description 12
- 229940087419 nonoxynol-9 Drugs 0.000 claims description 12
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 12
- FBWNMEQMRUMQSO-UHFFFAOYSA-N tergitol NP-9 Chemical compound CCCCCCCCCC1=CC=C(OCCOCCOCCOCCOCCOCCOCCOCCOCCO)C=C1 FBWNMEQMRUMQSO-UHFFFAOYSA-N 0.000 claims description 12
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 8
- 239000006260 foam Substances 0.000 claims description 8
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 8
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 8
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 8
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 8
- BHQCQFFYRZLCQQ-OELDTZBJSA-N cholic acid Chemical class C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 BHQCQFFYRZLCQQ-OELDTZBJSA-N 0.000 claims description 7
- 150000001875 compounds Chemical class 0.000 claims description 6
- 239000003937 drug carrier Substances 0.000 claims description 5
- 239000002562 thickening agent Substances 0.000 claims description 5
- 238000003780 insertion Methods 0.000 claims description 4
- 230000037431 insertion Effects 0.000 claims description 4
- 229920001296 polysiloxane Polymers 0.000 claims description 4
- 229920002635 polyurethane Polymers 0.000 claims description 4
- 239000004814 polyurethane Substances 0.000 claims description 4
- 239000000934 spermatocidal agent Substances 0.000 claims description 3
- 239000008365 aqueous carrier Substances 0.000 claims description 2
- 229920000847 nonoxynol Polymers 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 abstract description 9
- 210000004877 mucosa Anatomy 0.000 abstract description 8
- 229940079593 drug Drugs 0.000 abstract description 2
- 239000003814 drug Substances 0.000 abstract description 2
- 239000000499 gel Substances 0.000 description 47
- 230000000694 effects Effects 0.000 description 18
- 239000002775 capsule Substances 0.000 description 13
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 11
- 238000005470 impregnation Methods 0.000 description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- 208000015181 infectious disease Diseases 0.000 description 7
- 230000003253 viricidal effect Effects 0.000 description 7
- 208000030507 AIDS Diseases 0.000 description 6
- 230000001568 sexual effect Effects 0.000 description 6
- 238000011200 topical administration Methods 0.000 description 6
- 239000008213 purified water Substances 0.000 description 5
- 241000222122 Candida albicans Species 0.000 description 4
- 241000725303 Human immunodeficiency virus Species 0.000 description 4
- 241000700584 Simplexvirus Species 0.000 description 4
- 230000000844 anti-bacterial effect Effects 0.000 description 4
- 239000003899 bactericide agent Substances 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- 229940095731 candida albicans Drugs 0.000 description 4
- 210000001215 vagina Anatomy 0.000 description 4
- 238000003466 welding Methods 0.000 description 4
- 241000191967 Staphylococcus aureus Species 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- 244000052616 bacterial pathogen Species 0.000 description 3
- 239000002812 cholic acid derivative Substances 0.000 description 3
- 239000003433 contraceptive agent Substances 0.000 description 3
- 230000002254 contraceptive effect Effects 0.000 description 3
- 238000009826 distribution Methods 0.000 description 3
- 230000005764 inhibitory process Effects 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 238000002560 therapeutic procedure Methods 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 2
- 102100034343 Integrase Human genes 0.000 description 2
- 241000588652 Neisseria gonorrhoeae Species 0.000 description 2
- 108010092799 RNA-directed DNA polymerase Proteins 0.000 description 2
- 206010040070 Septic Shock Diseases 0.000 description 2
- 206010044248 Toxic shock syndrome Diseases 0.000 description 2
- 231100000650 Toxic shock syndrome Toxicity 0.000 description 2
- 208000036142 Viral infection Diseases 0.000 description 2
- 230000002141 anti-parasite Effects 0.000 description 2
- 230000002421 anti-septic effect Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000000295 complement effect Effects 0.000 description 2
- 239000000470 constituent Substances 0.000 description 2
- 239000006071 cream Substances 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 230000002779 inactivation Effects 0.000 description 2
- 239000012678 infectious agent Substances 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- 231100000252 nontoxic Toxicity 0.000 description 2
- 230000003000 nontoxic effect Effects 0.000 description 2
- 238000007911 parenteral administration Methods 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 230000002093 peripheral effect Effects 0.000 description 2
- -1 polyoxyethylene Polymers 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- 230000002441 reversible effect Effects 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- 230000001150 spermicidal effect Effects 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 230000000699 topical effect Effects 0.000 description 2
- 230000009385 viral infection Effects 0.000 description 2
- BHQCQFFYRZLCQQ-UHFFFAOYSA-N (3alpha,5alpha,7alpha,12alpha)-3,7,12-trihydroxy-cholan-24-oic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 BHQCQFFYRZLCQQ-UHFFFAOYSA-N 0.000 description 1
- OHXPGWPVLFPUSM-KLRNGDHRSA-N 3,7,12-trioxo-5beta-cholanic acid Chemical compound C1CC(=O)C[C@H]2CC(=O)[C@H]3[C@@H]4CC[C@H]([C@@H](CCC(O)=O)C)[C@@]4(C)C(=O)C[C@@H]3[C@]21C OHXPGWPVLFPUSM-KLRNGDHRSA-N 0.000 description 1
- 235000001674 Agaricus brunnescens Nutrition 0.000 description 1
- 239000004380 Cholic acid Substances 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 102000004163 DNA-directed RNA polymerases Human genes 0.000 description 1
- 108090000626 DNA-directed RNA polymerases Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 206010048461 Genital infection Diseases 0.000 description 1
- 241000700721 Hepatitis B virus Species 0.000 description 1
- 208000001688 Herpes Genitalis Diseases 0.000 description 1
- IGFHQQFPSIBGKE-UHFFFAOYSA-N Nonylphenol Natural products CCCCCCCCCC1=CC=C(O)C=C1 IGFHQQFPSIBGKE-UHFFFAOYSA-N 0.000 description 1
- 241001631646 Papillomaviridae Species 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 208000035415 Reinfection Diseases 0.000 description 1
- 241000191940 Staphylococcus Species 0.000 description 1
- 241000193985 Streptococcus agalactiae Species 0.000 description 1
- 108700033101 Streptococcus agalactiae CIP Proteins 0.000 description 1
- 241000224527 Trichomonas vaginalis Species 0.000 description 1
- 206010046914 Vaginal infection Diseases 0.000 description 1
- 108010003533 Viral Envelope Proteins Proteins 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 210000003484 anatomy Anatomy 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- JBIROUFYLSSYDX-UHFFFAOYSA-M benzododecinium chloride Chemical compound [Cl-].CCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 JBIROUFYLSSYDX-UHFFFAOYSA-M 0.000 description 1
- 210000000941 bile Anatomy 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000013043 chemical agent Substances 0.000 description 1
- 239000000731 choleretic agent Substances 0.000 description 1
- 235000019416 cholic acid Nutrition 0.000 description 1
- 229960002471 cholic acid Drugs 0.000 description 1
- 230000001427 coherent effect Effects 0.000 description 1
- 229940124558 contraceptive agent Drugs 0.000 description 1
- 239000012050 conventional carrier Substances 0.000 description 1
- 230000002498 deadly effect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 229960002997 dehydrocholic acid Drugs 0.000 description 1
- KXGVEGMKQFWNSR-LLQZFEROSA-N deoxycholic acid Chemical compound C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 KXGVEGMKQFWNSR-LLQZFEROSA-N 0.000 description 1
- 229960003964 deoxycholic acid Drugs 0.000 description 1
- KXGVEGMKQFWNSR-UHFFFAOYSA-N deoxycholic acid Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 KXGVEGMKQFWNSR-UHFFFAOYSA-N 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 230000003628 erosive effect Effects 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 239000004088 foaming agent Substances 0.000 description 1
- 108010025899 gelatin film Proteins 0.000 description 1
- 201000004946 genital herpes Diseases 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 210000004379 membrane Anatomy 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 231100000404 nontoxic agent Toxicity 0.000 description 1
- SNQQPOLDUKLAAF-UHFFFAOYSA-N nonylphenol Chemical compound CCCCCCCCCC1=CC=CC=C1O SNQQPOLDUKLAAF-UHFFFAOYSA-N 0.000 description 1
- 150000007523 nucleic acids Chemical group 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
- A61K9/0036—Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Reproductive Health (AREA)
- Virology (AREA)
- Inorganic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gynecology & Obstetrics (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Absorbent Articles And Supports Therefor (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8809418 | 1988-07-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DD283932A5 true DD283932A5 (de) | 1990-10-31 |
Family
ID=9368330
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DD89330678A DD283932A5 (de) | 1988-07-11 | 1989-07-11 | Verfahren zur herstellung einer pharmazeutischen zusammensetzung zur verhuetung von sexuell uebertragbaren krankheiten |
Country Status (38)
| Country | Link |
|---|---|
| US (1) | US5439685A (ro) |
| EP (1) | EP0351301B1 (ro) |
| JP (1) | JPH0774164B2 (ro) |
| KR (1) | KR0143231B1 (ro) |
| CN (1) | CN1035038C (ro) |
| AP (1) | AP108A (ro) |
| AR (1) | AR243381A1 (ro) |
| AT (1) | ATE97570T1 (ro) |
| BR (1) | BR8903523A (ro) |
| CA (1) | CA1341304C (ro) |
| CZ (1) | CZ280722B6 (ro) |
| DD (1) | DD283932A5 (ro) |
| DE (1) | DE68910892T2 (ro) |
| DK (1) | DK173527B1 (ro) |
| ES (1) | ES2062065T3 (ro) |
| FI (1) | FI101595B (ro) |
| HK (1) | HK131095A (ro) |
| HU (1) | HU206634B (ro) |
| IE (1) | IE63115B1 (ro) |
| IL (1) | IL90910A (ro) |
| LT (1) | LT3754B (ro) |
| LV (1) | LV10573B (ro) |
| MA (1) | MA22036A1 (ro) |
| MD (1) | MD406C2 (ro) |
| MX (1) | MX170801B (ro) |
| MY (1) | MY106242A (ro) |
| NO (1) | NO178843C (ro) |
| NZ (1) | NZ229891A (ro) |
| OA (1) | OA09123A (ro) |
| PL (1) | PL161848B1 (ro) |
| PT (1) | PT91108B (ro) |
| RU (1) | RU2065742C1 (ro) |
| SK (1) | SK278614B6 (ro) |
| TN (1) | TNSN89074A1 (ro) |
| TR (1) | TR28353A (ro) |
| UA (1) | UA26124A (ro) |
| YU (1) | YU47899B (ro) |
| ZA (1) | ZA895263B (ro) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH02258718A (ja) * | 1989-03-31 | 1990-10-19 | Nippon Kayaku Co Ltd | ペースト状基剤及び製剤 |
| US5693769A (en) * | 1991-12-13 | 1997-12-02 | Transcell Technologies, Inc. | Glycosylated steroid derivatives for transport across biological membranes and process for making and using same |
| US5795870A (en) * | 1991-12-13 | 1998-08-18 | Trustees Of Princeton University | Compositions and methods for cell transformation |
| IT1255450B (it) * | 1992-06-30 | 1995-10-31 | Montefarmaco Spa | Uso di acidi biliari come agenti antivirali |
| WO1995003056A1 (en) * | 1993-07-19 | 1995-02-02 | Tokyo Tanabe Company Limited | Hepatitis c virus proliferation inhibitor |
| DE4341139C1 (de) * | 1993-12-02 | 1995-04-13 | Upmeyer Hans Juergen | Dimeticon zur Behandlung von Aphthen |
| US5667492A (en) * | 1994-10-07 | 1997-09-16 | Columbia Laboratories, Inc. | Use and composition of an anti-sexually transmitted diseases formulation |
| FR2728464B1 (fr) * | 1994-12-22 | 1997-04-30 | Innothera Lab Sa | Forme galenique unitaire, son procede d'obtention et ses utilisations |
| US5700679A (en) * | 1996-06-07 | 1997-12-23 | Novavax, Inc. | Lipid vesicles having a bilayer containing a surfactant with anti-viral and spermicidal activity |
| AU4214497A (en) * | 1996-09-12 | 1998-04-02 | Simon Everard Barton | Composition comprising an antiviral or antibacterial agent for preventing transmission of diseases |
| US6287286B1 (en) * | 1998-08-25 | 2001-09-11 | Kimberly-Clark Worldwide, Inc. | Absorbent article having a reduced viability of candida albicans |
| US6211243B1 (en) | 1999-09-22 | 2001-04-03 | B. Ron Johnson | Methods for treating cold sores with anti-infective compositions |
| US8173709B2 (en) * | 1999-09-22 | 2012-05-08 | Quadex Pharmaceuticals, Llc | Anti-infective methods for treating pathogen-induced disordered tissues |
| US6759434B2 (en) | 1999-09-22 | 2004-07-06 | B. Ron Johnson | Anti-infective compositions, methods and systems for treating disordered tissue |
| US20050232868A1 (en) * | 1999-10-19 | 2005-10-20 | The Procter & Gamble Company | Methods of entrapping, inactivating, and removing viral infections by the administration of respiratory tract compositions |
| FR2803208A1 (fr) * | 1999-12-29 | 2001-07-06 | Jean Bastien Pasquini | Tampon periodique antiseptique et son procede de preparation |
| WO2001066084A2 (en) * | 2000-03-07 | 2001-09-13 | Rush-Presbyterian-St. Luke's Medical Center | Compositions and methods for trapping and inactivating pathogenic microbes and spermatozoa |
| GB2412121B (en) * | 2001-04-11 | 2006-01-11 | Playtex Products Inc | Tampon with malodour counteractant |
| US8093446B2 (en) * | 2001-04-11 | 2012-01-10 | Playtex Products, Inc. | Fibrous absorbent articles having malodor counteractant |
| GB2415626B (en) * | 2001-04-11 | 2006-03-08 | Playtex Products Inc | Use of a catamenial tampon which comprises a cationic surfactant for the treatment of vaginal malodor |
| SE0102152L (sv) * | 2001-06-18 | 2002-12-19 | Sca Hygiene Prod Ab | Ny produkt |
| EP1506781B1 (de) * | 2003-11-03 | 2005-02-23 | Peter-Hansen Volkmann | Vaginalpflegezusammensetzung |
| KR101413361B1 (ko) * | 2005-08-29 | 2014-06-27 | 셉시큐어,엘.엘.씨. | 그람-양성 박테리아에 의해 유발되는 질병의 치료 또는예방 방법 |
| DE102006020644A1 (de) * | 2006-04-28 | 2007-10-31 | Bayer Innovation Gmbh | Antiseptikahaltige Silikonelastomere |
| US8409557B2 (en) | 2006-09-28 | 2013-04-02 | Clji Ip Company, Llc | Topical formulations for the prevention of sexually transmitted disease and methods of producing the same |
| US8062631B2 (en) | 2006-09-28 | 2011-11-22 | Clji I.P. Company, Llc | Topical formulations for the prevention of sexually transmitted disease and methods of producing the same |
| AU2012203566B1 (en) * | 2008-03-27 | 2013-09-12 | Clji I.P. Company, Llc | Topical formulations for the prevention of sexually transmitted disease and methods of producing the same |
| KR101130754B1 (ko) | 2010-06-25 | 2012-03-28 | 제일약품주식회사 | 난용성 트리사이클릭 유도체 화합물의 용해도가 향상된 약학적 조성물 |
| CA2817713C (en) | 2010-11-12 | 2018-12-04 | The University Of Utah Research Foundation | Intravaginal devices for controlled delivery of lubricants |
| US10426761B2 (en) | 2011-04-19 | 2019-10-01 | Arms Pharmaceutical, Llc | Method for treatment of disease caused or aggravated by microorganisms or relieving symptoms thereof |
| EP2699246B1 (en) | 2011-04-19 | 2023-06-14 | Arms Pharmaceutical LLC. | Method of inhibiting harmful microorganisms and barrier-forming composition therefor |
| CA2781379C (en) | 2012-03-26 | 2013-09-03 | Clji Ip Company, Llc | Topical formulations for the prevention of sexually transmitted disease and methods of producing the same |
| US9463180B2 (en) | 2013-03-14 | 2016-10-11 | Quadex Pharmaceuticals, Llc | Treatment of molluscum contagiosum |
| US9125911B2 (en) | 2013-03-14 | 2015-09-08 | Quadex Pharmaceuticals, Llc | Combined systemic and topical treatment of disordered tissues |
| US9549930B2 (en) | 2013-03-14 | 2017-01-24 | Quadex Pharmaceuticals, Llc | Combined systemic and topical treatment of disordered and/or prodromal stage tissue |
| DE102020131233A1 (de) * | 2020-11-25 | 2022-05-25 | Netzsch Trockenmahltechnik Gmbh | Verfahren zur herstellung eines homogenisierten gemischs aus kohlenstoff, schwefel und ptfe |
| KR102399883B1 (ko) * | 2021-02-09 | 2022-05-20 | 재단법인대구경북과학기술원 | 압출용 복합고분자 펠릿 및 이의 제조방법 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1161484A (en) * | 1965-08-20 | 1969-08-13 | Mediline Ag | Toilet Preparation |
| SE353658B (ro) * | 1967-06-13 | 1973-02-12 | Dow Corning | |
| US3710795A (en) * | 1970-09-29 | 1973-01-16 | Alza Corp | Drug-delivery device with stretched, rate-controlling membrane |
| US3770648A (en) * | 1971-07-12 | 1973-11-06 | Bristol Myers Co | Anhydrous aerosol foam |
| BE791632A (fr) * | 1971-11-20 | 1973-05-21 | Schering Ag | Supports a base de caoutchouc siliconique pour agents medicamenteux |
| US4393871A (en) * | 1977-06-27 | 1983-07-19 | Vli Corporation | Vaginal device |
| US4228797A (en) * | 1978-09-25 | 1980-10-21 | Dickey Richard P | Intravaginal contraception method |
| ZA827582B (en) * | 1981-11-06 | 1983-08-31 | Ansell Inc | Spermicidal condom |
| AU9131982A (en) * | 1981-12-07 | 1983-06-16 | Syntex (U.S.A.) Inc. | Contraceptive device releasing 1-substituted imadazoles |
| DE3204124A1 (de) * | 1982-02-06 | 1983-08-18 | Bayer Ag, 5090 Leverkusen | Antimykotische tampons mit hoher wirkstoff-freisetzung |
| AU2272883A (en) * | 1982-12-22 | 1984-06-28 | Herpes Pharmaceutical Inc. | Pharmaceutical compositions of steriods for treatment of herpes simplex infections |
| DE3346641A1 (de) * | 1983-12-23 | 1985-07-04 | Dynamit Nobel Ag, 5210 Troisdorf | Silanmodifizierte estergemische |
| GB8402748D0 (en) * | 1984-02-02 | 1984-03-07 | Dunlop Ltd | Intravaginal device |
| NL8600929A (nl) * | 1986-04-11 | 1987-11-02 | Fundatech Sa | Werkwijze voor het vervaardigen van een gemedicateerd wegwerp-pessarium en gemedicateerd wegwerp-pessarium. |
| IT1213323B (it) * | 1986-08-07 | 1989-12-20 | Crinos Industria Farmaco | Composizione per uso locale ad atti vita' spermicida virulicida ,disinfettante e/o battericida |
| US4952411A (en) * | 1987-02-25 | 1990-08-28 | Trustees Of Columbia University In The City Of New York | Method of inhibiting the transmission of AIDS virus |
| GB8706313D0 (en) * | 1987-03-17 | 1987-04-23 | Health Lab Service Board | Treatment & prevention of viral infections |
| FR2614525B1 (fr) * | 1987-04-29 | 1995-11-10 | Jacques Augros | Tampon en eponge elastique, notamment tampon vaginal |
| US4922928A (en) * | 1988-08-17 | 1990-05-08 | Michael Burnhill | Vaginal device |
-
1989
- 1989-07-07 NO NO892826A patent/NO178843C/no unknown
- 1989-07-10 AR AR89314348A patent/AR243381A1/es active
- 1989-07-10 IL IL9091089A patent/IL90910A/en not_active IP Right Cessation
- 1989-07-10 PT PT91108A patent/PT91108B/pt not_active IP Right Cessation
- 1989-07-10 EP EP89401979A patent/EP0351301B1/fr not_active Expired - Lifetime
- 1989-07-10 DK DK198903402A patent/DK173527B1/da not_active IP Right Cessation
- 1989-07-10 ES ES89401979T patent/ES2062065T3/es not_active Expired - Lifetime
- 1989-07-10 UA UA4614544A patent/UA26124A/uk unknown
- 1989-07-10 CA CA000605271A patent/CA1341304C/fr not_active Expired - Fee Related
- 1989-07-10 HU HU893459A patent/HU206634B/hu not_active IP Right Cessation
- 1989-07-10 YU YU135789A patent/YU47899B/sh unknown
- 1989-07-10 MY MYPI89000940A patent/MY106242A/en unknown
- 1989-07-10 MA MA21844A patent/MA22036A1/fr unknown
- 1989-07-10 TN TNTNSN89074A patent/TNSN89074A1/fr unknown
- 1989-07-10 RU SU4614544/14A patent/RU2065742C1/ru not_active IP Right Cessation
- 1989-07-10 DE DE89401979T patent/DE68910892T2/de not_active Expired - Fee Related
- 1989-07-10 IE IE221889A patent/IE63115B1/en not_active IP Right Cessation
- 1989-07-10 FI FI893340A patent/FI101595B/fi not_active IP Right Cessation
- 1989-07-10 MX MX016734A patent/MX170801B/es unknown
- 1989-07-10 AT AT89401979T patent/ATE97570T1/de not_active IP Right Cessation
- 1989-07-11 SK SK4238-89A patent/SK278614B6/sk unknown
- 1989-07-11 PL PL89280531A patent/PL161848B1/pl unknown
- 1989-07-11 KR KR1019890009850A patent/KR0143231B1/ko not_active Expired - Lifetime
- 1989-07-11 CZ CS894238A patent/CZ280722B6/cs not_active IP Right Cessation
- 1989-07-11 OA OA59610A patent/OA09123A/xx unknown
- 1989-07-11 CN CN89104829A patent/CN1035038C/zh not_active Expired - Lifetime
- 1989-07-11 JP JP1177278A patent/JPH0774164B2/ja not_active Expired - Fee Related
- 1989-07-11 NZ NZ229891A patent/NZ229891A/xx unknown
- 1989-07-11 DD DD89330678A patent/DD283932A5/de not_active IP Right Cessation
- 1989-07-11 TR TR00603/89A patent/TR28353A/xx unknown
- 1989-07-11 BR BR898903523A patent/BR8903523A/pt not_active IP Right Cessation
- 1989-07-11 AP APAP/P/1989/000133A patent/AP108A/en active
- 1989-07-11 ZA ZA895263A patent/ZA895263B/xx unknown
-
1992
- 1992-12-22 US US07/995,522 patent/US5439685A/en not_active Expired - Lifetime
-
1993
- 1993-02-25 LV LVP-93-140A patent/LV10573B/en unknown
- 1993-12-22 LT LTIP1660A patent/LT3754B/lt not_active IP Right Cessation
-
1994
- 1994-12-30 MD MD95-0089A patent/MD406C2/ro unknown
-
1995
- 1995-08-17 HK HK131095A patent/HK131095A/xx not_active IP Right Cessation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE68910892T2 (de) | Arzneimittel zur Verhütung von sexuell übertragbaren Krankheiten. | |
| DE69533724T2 (de) | Zusammensetzung zum inaktivieren von reizstoffen in flüssigkeiten | |
| DE69837348T2 (de) | Verfahren zur inaktivierung von bakterien mit einbegriff von bakteriensporen | |
| DE60105283T2 (de) | Zusammensetzungen die molekulares iod enthalten | |
| DE69130871T2 (de) | Verfahren zur inaktivierung von spermien | |
| DE2611725A1 (de) | Zinksulfadiazin und dieses enthaltende dermatotherapeutische mittel zur behandlung von verbrennungen | |
| DE3529397A1 (de) | Fungizide zusammensetzung mit verlaengerter wirkungsdauer | |
| DE69921119T2 (de) | Verwendung von mikrobiziden und spermiziden zusammensetzungen zur inaktivierung von nichtumhüllten viren | |
| DE69825128T2 (de) | Verwendung von azithromycin zur topischen behandlung von augeninfektionen | |
| DE60027209T2 (de) | Behandlung von Knochengewebserkrankungen | |
| WO1988007364A1 (fr) | Onguent medicinal, son procede de production, formes d'application utilisant cet onguent et sa production | |
| DE69532809T2 (de) | Pharmazeutische präparate, insbesondere ovula, die viele verschiedene aktive bestandteile enthalten | |
| DE69024047T2 (de) | Nimbaumöl enthaltende Zusammensetzung zur Fertilitätskontrolle und zur Schwangerschaftsverhütung. | |
| DD279408A5 (de) | Verfahren zur herstellung einer substanz oder zusammenstetzung, die mindestens ein einzelliges lebewesen hemmt oder zerstoert | |
| DE3710216A1 (de) | Verwendung von dihydroergotamin und seinen salzen zur lokalen behandlung trophischer stoerungen | |
| DE69221454T2 (de) | Systemisch gegen Ektoparasiten anwendbare Juvenilhormone | |
| DE2201357A1 (de) | Osmotische Wirkstoffabgabevorrichtung | |
| EP1196159B1 (de) | Verwendung von tosylchloramid(en) zur behandlung von erkrankungen der haut, der schleimhaut, von organen und geweben | |
| JP2559735B2 (ja) | 抗ー微生物組成物 | |
| DE68915154T2 (de) | Anwendung von gegen retroviren aktiven wirkstoffen und so erhaltene produkte. | |
| EP0403575B1 (de) | Acyl-carnitin zur behandlung und zur verhütung von virusinfektionen | |
| DE1669869A1 (de) | Sanitaeres prophylaktisches Mittel | |
| US4147785A (en) | Method for the treatment of onchocerciasis | |
| HRP921074A2 (en) | A process for the production of a preparation for preventing sexual deseases from spreading | |
| DE2844814A1 (de) | Zinkchelate bildende fungizide zusammensetzung |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ENJ | Ceased due to non-payment of renewal fee |