DD146458A5 - Verfahren zur herstellung von 2-chlorsulfinylazetidin-4-onen - Google Patents

Verfahren zur herstellung von 2-chlorsulfinylazetidin-4-onen Download PDF

Info

Publication number: DD146458A5
Authority: DD; German Democratic Republic
Prior art keywords: group; formula; methyl; nitrobenzyl; crosslinked
Prior art date: 1978-11-13

Application number

DD79216206A

Other languages

German (de)

English (en)

Inventor

Ta-Sen Chou

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-11-13

Filing date

1979-10-12

Publication date

1981-02-11

1979-10-12 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1981-02-11 Publication of DD146458A5 publication Critical patent/DD146458A5/de

Links

238000000034 method Methods 0.000 title claims abstract description 108
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238000002360 preparation method Methods 0.000 title claims abstract description 22
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150000001875 compounds Chemical class 0.000 claims abstract description 50
229920000642 polymer Polymers 0.000 claims abstract description 44
MYRTYDVEIRVNKP-UHFFFAOYSA-N 1,2-Divinylbenzene Chemical compound C=CC1=CC=CC=C1C=C MYRTYDVEIRVNKP-UHFFFAOYSA-N 0.000 claims abstract description 22
239000003960 organic solvent Substances 0.000 claims abstract description 16
KDXFMMHNGFNJFA-UHFFFAOYSA-N 4-oxoazetidine-2-sulfinyl chloride Chemical compound ClS(=O)C1CC(=O)N1 KDXFMMHNGFNJFA-UHFFFAOYSA-N 0.000 claims abstract description 15
229920002717 polyvinylpyridine Polymers 0.000 claims abstract description 15
239000007858 starting material Substances 0.000 claims abstract description 15
YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims description 87
229910052757 nitrogen Inorganic materials 0.000 claims description 40
238000006243 chemical reaction Methods 0.000 claims description 26
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238000004132 cross linking Methods 0.000 claims description 25
UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims description 24
239000003795 chemical substances by application Substances 0.000 claims description 21
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 21
WDRFYIPWHMGQPN-UHFFFAOYSA-N 2-chloroisoindole-1,3-dione Chemical compound C1=CC=C2C(=O)N(Cl)C(=O)C2=C1 WDRFYIPWHMGQPN-UHFFFAOYSA-N 0.000 claims description 17
230000002140 halogenating effect Effects 0.000 claims description 16
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FCZNNHHXCFARDY-WQRUCBPWSA-N (2s,5r,6r)-3,3-dimethyl-4,7-dioxo-6-[(2-phenylacetyl)amino]-4$l^{4}-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid Chemical compound N([C@H]1[C@@H]2N(C1=O)[C@H](C(S2=O)(C)C)C(O)=O)C(=O)CC1=CC=CC=C1 FCZNNHHXCFARDY-WQRUCBPWSA-N 0.000 claims description 12
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125000003277 amino group Chemical group 0.000 claims description 4
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TXUICONDJPYNPY-UHFFFAOYSA-N (1,10,13-trimethyl-3-oxo-4,5,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl) heptanoate Chemical compound C1CC2CC(=O)C=C(C)C2(C)C2C1C1CCC(OC(=O)CCCCCC)C1(C)CC2 TXUICONDJPYNPY-UHFFFAOYSA-N 0.000 description 13
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DHHIKEVWSRQXQP-UHFFFAOYSA-N n-chloro-4-methylbenzamide Chemical compound CC1=CC=C(C(=O)NCl)C=C1 DHHIKEVWSRQXQP-UHFFFAOYSA-N 0.000 description 1
DTMXHYUPALBXFG-UHFFFAOYSA-N n-chloro-n,4-dimethylbenzenesulfonamide Chemical compound CN(Cl)S(=O)(=O)C1=CC=C(C)C=C1 DTMXHYUPALBXFG-UHFFFAOYSA-N 0.000 description 1
KZOXUQBSBWDWQQ-UHFFFAOYSA-N n-chloro-n-(4-methylphenyl)propane-2-sulfonamide Chemical compound CC(C)S(=O)(=O)N(Cl)C1=CC=C(C)C=C1 KZOXUQBSBWDWQQ-UHFFFAOYSA-N 0.000 description 1
NJTUFLWJRSZJPA-UHFFFAOYSA-N n-chloro-n-(4-nitrophenyl)cyclohexanesulfonamide Chemical compound C1=CC([N+](=O)[O-])=CC=C1N(Cl)S(=O)(=O)C1CCCCC1 NJTUFLWJRSZJPA-UHFFFAOYSA-N 0.000 description 1
PMXQDTBJZLOVSV-UHFFFAOYSA-N n-chloro-n-cyclohexylacetamide Chemical compound CC(=O)N(Cl)C1CCCCC1 PMXQDTBJZLOVSV-UHFFFAOYSA-N 0.000 description 1
RWVOAAWFMJRINI-UHFFFAOYSA-N n-chloro-n-cyclohexylbenzenesulfonamide Chemical compound C=1C=CC=CC=1S(=O)(=O)N(Cl)C1CCCCC1 RWVOAAWFMJRINI-UHFFFAOYSA-N 0.000 description 1
YTYAPSXIGOPIOH-UHFFFAOYSA-N n-chloro-n-cyclohexylcyclohexanesulfonamide Chemical compound C1CCCCC1S(=O)(=O)N(Cl)C1CCCCC1 YTYAPSXIGOPIOH-UHFFFAOYSA-N 0.000 description 1
YEXVRBUZIOSARW-UHFFFAOYSA-N n-chloro-n-cyclohexylethanesulfonamide Chemical compound CCS(=O)(=O)N(Cl)C1CCCCC1 YEXVRBUZIOSARW-UHFFFAOYSA-N 0.000 description 1
FGJCTKGHKMARPX-UHFFFAOYSA-N n-chloro-n-ethyl-3-nitrobenzenesulfonamide Chemical compound CCN(Cl)S(=O)(=O)C1=CC=CC([N+]([O-])=O)=C1 FGJCTKGHKMARPX-UHFFFAOYSA-N 0.000 description 1
XPTJWKPOBFHDHX-UHFFFAOYSA-N n-chloro-n-ethylbenzamide Chemical compound CCN(Cl)C(=O)C1=CC=CC=C1 XPTJWKPOBFHDHX-UHFFFAOYSA-N 0.000 description 1
DQJKBIDVOSQVEV-UHFFFAOYSA-N n-chloro-n-methylacetamide Chemical compound CN(Cl)C(C)=O DQJKBIDVOSQVEV-UHFFFAOYSA-N 0.000 description 1
WQJHFILPJKSLJW-UHFFFAOYSA-N n-chloro-n-phenylbenzenesulfonamide Chemical compound C=1C=CC=CC=1S(=O)(=O)N(Cl)C1=CC=CC=C1 WQJHFILPJKSLJW-UHFFFAOYSA-N 0.000 description 1
RKLUHJIBJTXOQU-UHFFFAOYSA-N n-chloro-n-phenylpropanamide Chemical compound CCC(=O)N(Cl)C1=CC=CC=C1 RKLUHJIBJTXOQU-UHFFFAOYSA-N 0.000 description 1
UFICRBPXWFJZFC-UHFFFAOYSA-N n-chloro-n-propylbenzenesulfonamide Chemical compound CCCN(Cl)S(=O)(=O)C1=CC=CC=C1 UFICRBPXWFJZFC-UHFFFAOYSA-N 0.000 description 1
HSPSCWZIJWKZKD-UHFFFAOYSA-N n-chloroacetamide Chemical compound CC(=O)NCl HSPSCWZIJWKZKD-UHFFFAOYSA-N 0.000 description 1
CHVZPRDGLWBEMJ-UHFFFAOYSA-N n-chlorobenzenesulfonamide Chemical compound ClNS(=O)(=O)C1=CC=CC=C1 CHVZPRDGLWBEMJ-UHFFFAOYSA-N 0.000 description 1
KFKMOYYBYVVHQQ-UHFFFAOYSA-N n-chloromethanesulfonamide Chemical compound CS(=O)(=O)NCl KFKMOYYBYVVHQQ-UHFFFAOYSA-N 0.000 description 1
UPSNOKIUEULXHF-UHFFFAOYSA-N n-chloropropanamide Chemical compound CCC(=O)NCl UPSNOKIUEULXHF-UHFFFAOYSA-N 0.000 description 1
125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
230000006855 networking Effects 0.000 description 1
230000007935 neutral effect Effects 0.000 description 1
150000004967 organic peroxy acids Chemical class 0.000 description 1
239000012074 organic phase Substances 0.000 description 1
239000007800 oxidant agent Substances 0.000 description 1
125000004430 oxygen atom Chemical group O* 0.000 description 1
238000005949 ozonolysis reaction Methods 0.000 description 1
125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 description 1
125000000636 p-nitrophenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)[N+]([O-])=O 0.000 description 1
125000001037 p-tolyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])[H] 0.000 description 1
150000002960 penicillins Chemical class 0.000 description 1
WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical compound OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 description 1
DLRJIFUOBPOJNS-UHFFFAOYSA-N phenetole Chemical compound CCOC1=CC=CC=C1 DLRJIFUOBPOJNS-UHFFFAOYSA-N 0.000 description 1
QRUSAMIBASLVND-UHFFFAOYSA-N phenyl n,n-dichlorocarbamate Chemical compound ClN(Cl)C(=O)OC1=CC=CC=C1 QRUSAMIBASLVND-UHFFFAOYSA-N 0.000 description 1
WXVSGQIVJIHVKH-UHFFFAOYSA-N phenyl n-chloro-n-phenylcarbamate Chemical compound C=1C=CC=CC=1N(Cl)C(=O)OC1=CC=CC=C1 WXVSGQIVJIHVKH-UHFFFAOYSA-N 0.000 description 1
LAIWRIKKCCMYIX-UHFFFAOYSA-N phenyl n-chloro-n-propylcarbamate Chemical compound CCCN(Cl)C(=O)OC1=CC=CC=C1 LAIWRIKKCCMYIX-UHFFFAOYSA-N 0.000 description 1
FJVNNOMOBHNDRT-UHFFFAOYSA-N phenyl n-chlorocarbamate Chemical compound ClNC(=O)OC1=CC=CC=C1 FJVNNOMOBHNDRT-UHFFFAOYSA-N 0.000 description 1
230000000379 polymerizing effect Effects 0.000 description 1
238000001556 precipitation Methods 0.000 description 1
CYAFWKWGHFXITJ-UHFFFAOYSA-N propan-2-yl n-chloro-n-(4-methylphenyl)carbamate Chemical compound CC(C)OC(=O)N(Cl)C1=CC=C(C)C=C1 CYAFWKWGHFXITJ-UHFFFAOYSA-N 0.000 description 1
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
230000035484 reaction time Effects 0.000 description 1
238000001953 recrystallisation Methods 0.000 description 1
230000007017 scission Effects 0.000 description 1
238000000926 separation method Methods 0.000 description 1
238000007086 side reaction Methods 0.000 description 1
238000007873 sieving Methods 0.000 description 1
URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 1
235000017557 sodium bicarbonate Nutrition 0.000 description 1
229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
229910052938 sodium sulfate Inorganic materials 0.000 description 1
235000011152 sodium sulphate Nutrition 0.000 description 1
229910052717 sulfur Inorganic materials 0.000 description 1
YBBRCQOCSYXUOC-UHFFFAOYSA-N sulfuryl dichloride Chemical class ClS(Cl)(=O)=O YBBRCQOCSYXUOC-UHFFFAOYSA-N 0.000 description 1
239000004094 surface-active agent Substances 0.000 description 1
230000002522 swelling effect Effects 0.000 description 1
GCHUGYWXPVALSI-UHFFFAOYSA-N tert-butyl 2-(3-benzamido-2-chlorosulfinyl-4-oxoazetidin-1-yl)-3-methylbut-3-enoate Chemical compound O=C1N(C(C(=C)C)C(=O)OC(C)(C)C)C(S(Cl)=O)C1NC(=O)C1=CC=CC=C1 GCHUGYWXPVALSI-UHFFFAOYSA-N 0.000 description 1
YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
CXWXQJXEFPUFDZ-UHFFFAOYSA-N tetralin Chemical compound C1=CC=C2CCCCC2=C1 CXWXQJXEFPUFDZ-UHFFFAOYSA-N 0.000 description 1
LERKSQCWFABOTJ-UHFFFAOYSA-N thionyl dichloride;2,2,2-trichloroethyl 2-[2-chlorosulfinyl-4-oxo-3-[(2-phenoxyacetyl)amino]azetidin-1-yl]-3-methylbut-3-enoate Chemical compound ClS(Cl)=O.O=C1N(C(C(=C)C)C(=O)OCC(Cl)(Cl)Cl)C(S(Cl)=O)C1NC(=O)COC1=CC=CC=C1 LERKSQCWFABOTJ-UHFFFAOYSA-N 0.000 description 1
229910052718 tin Inorganic materials 0.000 description 1
125000006000 trichloroethyl group Chemical group 0.000 description 1
125000004385 trihaloalkyl group Chemical group 0.000 description 1
150000003672 ureas Chemical class 0.000 description 1
KAKZBPTYRLMSJV-UHFFFAOYSA-N vinyl-ethylene Natural products C=CC=C KAKZBPTYRLMSJV-UHFFFAOYSA-N 0.000 description 1
238000010792 warming Methods 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
- C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
- C07D205/095—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4 and with a nitrogen atom directly attached in position 3
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Cephalosporin Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)

DD79216206A 1978-11-13 1979-10-12 Verfahren zur herstellung von 2-chlorsulfinylazetidin-4-onen DD146458A5 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US96034778A	1978-11-13	1978-11-13
US06/049,266 US4289695A (en)	1978-11-13	1979-06-18	Process for preparing 2-chlorosulfinylazetidinones

Publications (1)

Publication Number	Publication Date
DD146458A5 true DD146458A5 (de)	1981-02-11

Family

ID=26727009

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DD79216206A DD146458A5 (de)	1978-11-13	1979-10-12	Verfahren zur herstellung von 2-chlorsulfinylazetidin-4-onen

Country Status (22)

Country	Link
US (1)	US4289695A (es)
EP (1)	EP0011370B1 (es)
AU (1)	AU5147679A (es)
CA (1)	CA1131646A (es)
CH (1)	CH642624A5 (es)
DD (1)	DD146458A5 (es)
DE (1)	DE2962639D1 (es)
DK (1)	DK165687C (es)
ES (1)	ES8205198A1 (es)
FI (1)	FI793095A7 (es)
FR (1)	FR2440945A1 (es)
GB (1)	GB2034701B (es)
GR (1)	GR73093B (es)
HU (1)	HU180232B (es)
IE (1)	IE48963B1 (es)
IL (1)	IL58405A (es)
LU (1)	LU81768A1 (es)
NO (1)	NO793272L (es)
OA (1)	OA06356A (es)
PL (1)	PL218929A1 (es)
PT (1)	PT70264A (es)
YU (1)	YU241279A (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4937330A (en) *	1985-08-12	1990-06-26	The Upjohn Company	Conversion of cephalosporin hydrohalide salt to alkali metal salt
FI103048B (fi) *	1989-03-22	1999-04-15	Dsm Nv	Menetelmä 3-eksometyleenikefaamisulfoksidijohdannaisten valmistamiseks i
US4950753A (en) *	1989-05-17	1990-08-21	Eli Lilly And Company	Process for 3-exomethylenecepham sulfoxide esters
IN173329B (es) *	1989-11-06	1994-04-02	Ranbaxy Lab Ltd
US5126446A (en) *	1991-01-04	1992-06-30	Eli Lilly And Company	Process for 3-exomethylenecepham sulfoxide esters
US5350845A (en) *	1992-04-08	1994-09-27	Eli Lilly And Company	Process for preparing 7-substituted-amino-3-hydroxy-3-cephem-4-protected carboxy-sulfoxide esters
US5347000A (en) *	1992-11-05	1994-09-13	Ranbaxy Laboratories Ltd.	Process for the preparation of 2-chlorosulfinylazetidinone
US5604222A (en) *	1993-12-27	1997-02-18	Lupin Laboratories, Ltd.	Method for the preparation of 2-chloro sulfinyl azetidinones
US5578721A (en) *	1994-07-11	1996-11-26	Lupin Laboratories Limited	Process for preparation of 3-exomethylene cepham sulfoxide esters
AUPP939299A0 (en) *	1999-03-23	1999-04-15	University Of Melbourne, The	Polymer gels and methods for their preparation
CN1281711C (zh) *	2002-04-16	2006-10-25	Sasol技术股份有限公司	采用烃合成催化剂和酸性催化剂的烃合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1069126A (en) *	1974-12-24	1980-01-01	Eli Lilly And Company	Sulfinyl halides and their preparation from penicillin sulfoxides
CA1056372A (en) *	1974-12-24	1979-06-12	Eli Lilly And Company	Method of preparation of 3-methylenecephams
US4075203A (en) *	1976-06-16	1978-02-21	Eli Lilly And Company	Process for preparing a 3-exomethylenecepham sulfoxide from penicillin sulfoxides
US4159272A (en) *	1977-09-01	1979-06-26	Eli Lilly And Company	Process for 2-chlorosulfinylazetidin-4-ones

1979
- 1979-06-18 US US06/049,266 patent/US4289695A/en not_active Expired - Lifetime
- 1979-10-02 PT PT70264A patent/PT70264A/pt unknown
- 1979-10-03 YU YU02412/79A patent/YU241279A/xx unknown
- 1979-10-04 FR FR7924713A patent/FR2440945A1/fr active Granted
- 1979-10-04 AU AU51476/79A patent/AU5147679A/en not_active Abandoned
- 1979-10-05 IL IL58405A patent/IL58405A/xx unknown
- 1979-10-05 FI FI793095A patent/FI793095A7/fi not_active Application Discontinuation
- 1979-10-08 GR GR60216A patent/GR73093B/el unknown
- 1979-10-09 GB GB7935054A patent/GB2034701B/en not_active Expired
- 1979-10-09 DE DE7979302153T patent/DE2962639D1/de not_active Expired
- 1979-10-09 EP EP79302153A patent/EP0011370B1/en not_active Expired
- 1979-10-10 CA CA337,272A patent/CA1131646A/en not_active Expired
- 1979-10-10 ES ES484918A patent/ES8205198A1/es not_active Expired
- 1979-10-10 LU LU81768A patent/LU81768A1/fr unknown
- 1979-10-11 NO NO793272A patent/NO793272L/no unknown
- 1979-10-12 PL PL21892979A patent/PL218929A1/xx unknown
- 1979-10-12 CH CH923879A patent/CH642624A5/fr not_active IP Right Cessation
- 1979-10-12 HU HU79EI882A patent/HU180232B/hu unknown
- 1979-10-12 DD DD79216206A patent/DD146458A5/de unknown
- 1979-10-12 DK DK431379A patent/DK165687C/da active
- 1979-10-12 IE IE1940/79A patent/IE48963B1/en not_active IP Right Cessation
- 1979-10-13 OA OA56916A patent/OA06356A/xx unknown

Also Published As

Publication number	Publication date
EP0011370B1 (en)	1982-04-28
IE791940L (en)	1980-05-13
FR2440945B1 (es)	1982-12-31
EP0011370A1 (en)	1980-05-28
PT70264A (en)	1979-11-01
DK165687C (da)	1993-06-07
ES484918A0 (es)	1981-11-01
GB2034701B (en)	1983-06-15
HU180232B (en)	1983-02-28
FR2440945A1 (fr)	1980-06-06
DK165687B (da)	1993-01-04
IL58405A0 (en)	1980-01-31
AU5147679A (en)	1980-05-22
DK431379A (da)	1980-05-14
OA06356A (fr)	1981-06-30
CA1131646A (en)	1982-09-14
YU241279A (en)	1983-10-31
FI793095A7 (fi)	1981-01-01
GB2034701A (en)	1980-06-11
CH642624A5 (fr)	1984-04-30
IL58405A (en)	1982-08-31
US4289695A (en)	1981-09-15
LU81768A1 (fr)	1980-01-24
NO793272L (no)	1980-05-14
GR73093B (es)	1984-02-01
ES8205198A1 (es)	1981-11-01
PL218929A1 (es)	1980-06-16
DE2962639D1 (en)	1982-06-09
IE48963B1 (en)	1985-06-26

Publication	Publication Date	Title
DD146458A5 (de)	1981-02-11	Verfahren zur herstellung von 2-chlorsulfinylazetidin-4-onen
DE60225486T2 (de)	2009-04-02	Verfahren zur herstellung von 4'-brommethyl-2-cyanobiphenyl
DE60000226T3 (de)	2012-02-16	Verfahren zur Herstellung von 5-Carboxyphthalid
DE2221361A1 (de)	1972-11-30	Verbindungen der Cephalosporinklasse und Verfahren zu deren Herstellung
DE2726394C2 (es)	1990-03-15
DE2047846C3 (de)	1978-03-02	4-Piperidonenoläther, Verfahren zu deren Herstellung und deren Verwendung zum Stabilisieren von synthetischen Polymeren
DE3035259C2 (de)	1986-03-13	Cephalosporinverbindungen, Verfahren zu deren Herstellung und Arzneimittel, welche diese enthalten
DE2627223C2 (es)	1990-05-03
DE1237553B (de)	1967-03-30	Verfahren zur Herstellung eines alpha-Chlor-acetessigsaeureamids
EP0043573B1 (de)	1983-08-31	Verfahren zur Herstellung von 2,6-Dichlorbenzoxazol bzw. 2,6-Dichlorbenzthiazol
DE1693164A1 (de)	1971-03-04	Verfahren zur Herstellung von Azo-di-isobuttersaeureamidin
DE1670939A1 (de)	1971-02-25	Verfahren zur Herstellung von 2-Isothiuroniummethyl-3-carbon-saeureamido-chinoxalin-di-N-oxid-(1,4)-halogeniden
DD249909A5 (de)	1987-09-23	Verfahren zur herstellung von carbocyclischen acetidin-3-saeuren und deren salzen
DE2721738C2 (de)	1985-07-11	Verfahren zur Herstellung von N-Chlorphthalimid
DE2838073A1 (de)	1979-03-15	Verfahren zur herstellung von substituierten 3-methyl-2-azetidinyl-3- butensaeureestern
DE1570195A1 (de)	1970-02-12	Verfahren zur Herstellung von Polyamiden durch Polymerisation von Lactamen
DE19744362A1 (de)	1998-04-23	Verfahren zur Herstellung von 4,6-Diaminoresorcinen
AT273959B (de)	1969-09-10	Verfahren zur Herstellung von Benzimidazolderivaten
DE19826669B4 (de)	2007-02-15	Verfahren zur Herstellung von Pyrazolen
DE3411196A1 (de)	1985-10-10	Verfahren zur herstellung von 4-halogennaphthalsaeureanhydriden
DE1155245B (de)	1963-10-03	Verfahren zur Herstellung von Isopropenylpyridinpolymeren
DE1800328C (de)	1972-11-02	Verfahren zur Herstellung von 3,5-Dihydroxy-1,2-dioxolanen
AT239440B (de)	1965-04-12	Verfahren zur Herstellung von neuen Derivaten der 6-Amino-Penicillansäure
DE1468618C (de)	1971-04-15	Verfahren zur Herstellung von TeIo mensationsprodukten
JPS641469B2 (es)	1989-01-11