CZ55697A3 - Surface-active preparations - Google Patents

Abstract

The invention relates to surface-active soap formulations, comprising: (a) 0.01 to 5 % by weight of a microbicidal active substance selected from the group consisting of (a1) phenol derivatives (a2) diphenyl compounds (a3) benzyl alcohols (a4) chlorohexidine (a5) C12-C14alkylbetaines and C8-C18fatty acid amidoalkylbetaines (a6) amphoteric surfactants and (a7) trihalocarbanilides; (b) 0.1 to 25 % by weight of one or more than one hydrotropic agent; (c) 0 to 10 % by weight of one or more than one synthetic surface-active substance or of a soap or of combinations of the cited substances; (d) 0 to 8 % by weight of a salt of a saturated and/or unsaturated C8-C22fatty acid; (e) 0 to 50 % by weight of a dihydric alcohol; (f) 0 to 70 % by weight of a monohydric alcohol or of a mixture of several monohydric alcohols; and (g) mains water or deionised water to make up 100 %, with the proviso that the formulations contain at least one of components (c) and (d). The formulations are used for the disinfection and cleansing of the human skin and hands and of hard objects.

Description

and durable items.

BACKGROUND OF THE INVENTION

It is generally known that the antimicrobial / microbicidal properties of the active ingredients in aqueous soap solutions or active ingredients are strongly influenced by non-cellular so that they can be almost completely blocked.

Surface area systems and

SUMMARY OF THE INVENTION Surprisingly, it has been found that certain hydrctropic microbicidal inhibitory potency of these active ions

It has now been with agents to suppress the effectiveness of various active ingredients in soaps and surfactant surfactant system surfactant systems

The invention is based on a novel feature which comprises systems (the so-called deblock). The prott can be significantly increased in many antimicrobial / microbicidal antimicrobials.

surfactant composition (a) 0.01 to 5% by weight of a microbicidal active substance selected from the group consisting wbrané _(t) phenol derivatives _(A;) diphenyl compounds, (A) benzyl alcohol "/ (aj chlorhexidine,

- (C 12 -C 14 alkyl betaines and C 8 -C 18 amido alkyl betaines) (and amphoteric surfactants, (and _T ) trihalogen carbanilides, and (and _d) quaternary ammonium salts, (b) 0.1 to 25% by weight of one or more than one hydroprocessing agent, (o) 0 to 10% by weight of one or more than one synthetic surfactant or soap or combination thereof, (d) 0 to 3% by weight salts of saturated and / or unsaturated fatty acids with 8 to 22 carbon atoms, (e10 to 50% by weight of a dihydric alcohol, (t) C to 70% by weight of a monohydric alcohol or a mixture of several monohydric alcohols, and (g) or deionized water to 100%, the composition comprising at least one of components (c) and (d).

Soap preparations are understood to be aqueous soap solutions which can be obtained as soaps or as so-called syndet solutions (synthetic detergents).

The antimicrobial effect of deblocked surface active systems is achieved in gram-positive and gram-negative bacteria as well as in yeast, dermatophytes and the like.

Compounds of component _(a;) preferably correspond to formula I

OH

where (I)

R _{@ 1} is hydrogen, hydroxy, alkyl, carbon, chlorine, nitro, phenyl: benzyl,

R 1 is a hydrogen atom, a hydroxy group, an alkyl group having carbon atoms or a halogen atom,

R 1 is a hydrogen atom, an alkyl group having 1 to ζ atoms. hydroxy, chloro, nitro or Lu; its alkali metal salts or ammonium salts: P _M is a hydrogen atom or a meth group.

_R is hydrogen or nitro.

The halogen atom is a bromine atom or preferably a Cr atom. These compounds are, for example, chlorophenols (o-, chlorophenols), 2,4-dichlorophenol, p-nitrophenol, p-xylenol acid, p-chloro-m-xylenol, cresol. , m ·, the prodrug of 1, p-chloro-m-cresol, pyrocatechin, resorcinol resorption, pyrogaiol, fluoroglucin, p-chlorothymol, o-phenylphenoid, o-benzylpheno1, p-culorophenol and 4-phenol sulfonic acid.

The compounds of the component (preferably also correspond to both formulas II to 4) or 1 to 6 µl of ethanol.

m-, quartz, sclv), hexylhymol, enzyme

R, (II where

X is a sulfur atom or a methylene group, a hydrogen atom or a halogen atom.

R ₁ and R 1 are hydroxy, and

R ' ₂ , R ₃ , R' j, R ₄ , R '', R ₄ and R 'are independently of the soc atom

Typical examples of compounds are chloroten, from acoro Loro phen, d. Dichlorodiphenyl sulfide, 2,2'-d phenylsultide, 2,2'-dihydroxy sulfide, and 3,3'-dibromo-5, 5'-d. 1 '

Compounds of components' and j of formula III

(II) are hexachlorophene, 2,3,3-dihydroxy-5,5'hydroxy-2,3 ', 5,5'-tetrachloride. 1,5 ', 5', 6 ', 6'-hexachlorodiphenyl-2,2'-dihydroxy-diphenylamine.

; ·; preferably correspond to the general formula wherein R 6, chlorine atom,

(III),

R 1 and R 3 are independently hydrogen or

Examples of benzyl alcohol, 2,4-, compounds of formula III include 3,5- or 2,6-dichlorobenzyl alcohol and trichiorbenzylaicchol.

Component (a.h is chlorhexidine and its salts with organic and inorganic acids, this type of compound can be preferably incorporated in the dc syndet system.

Component (? ₅ ;? 13 carbon atoms).

For example, cocoamido-propyl betaine with 8 to 8 carbon atoms

Suitably, the amphoteric surfactants corresponding to component (a _s ) are C12 alkyl alkylaminocarboxylic acids and C 1 -C 3 alkanecarboxylic acids such as alkyl aminoacetates or alkylaminopropionates.

The compounds of component (a) ₇ preferably correspond to the general formula IV. C

Hal, IV

Hal

where

K and m are chlorine or bromine, n and m are 1 or 2, and n + m is 3.

The quaternary ammonium salts of the component (preferably also correspond to the general formula V)

R _o I _RN + _n _and ir ₇ (V) where

R _3, R and R _{7z R}} are independently alkyl radicals having 1 to 13 carbon atoms, alkoxy having 1 to 13 carbon atoms or cenyl-lower alkyl group, and

Sludge is a chlorine or bromine atom.

Of these salts, the compound of formula VI is particularly preferred

CH ₃ b (C (C 1 H) - - CH ₂ ^{n 1} )

CHo cr (VI) wherein n is an integer from 7 to 17.

The following compounds are suitable for use as component (b):

(bj: sulphonates, preferably sol; terperolds or aromatic compounds with one or two nuclei, for example sulphonates of camphor, toluene, xylene, cumene or naphthene, (b ₂ ):

acids acid saturated or unsaturated with 3 to 12 carbon atoms, succinic acid, lime gl pimelic acid, sub * sebacic acid, uric acid dodecanecarboxylic acid, tartaric acid and malic acid and aconic acid, di- or polycarboxylic acids such as malonic acid, aric acid, adipic acid, thi, azelaic acid, and ricarboxylic acid, and truvic acid, maleic acid, and citric acid (bj): aliphatic saturated or unsaturated monocarboxylic acids having 1 to 11 atoms carbon such as acetic acid, propionic acid, hexane acid; tartaric acid or undecylenic acid,

- saturated or unsaturated di- or polycarboxylic acids having 3 to 12 carbon atoms, for example malonic acid, succinic acid, glutaric acid, adipic acid, pimelic acid, suberic acid, azeic acid and sebacic acid, undecanecarboxylic acid and dodecanedicarboxylic acid, fumaric acid, maleic acid, tartaric acid and malic acid, as well as citric acid and aconitic acid,

-aminocarboxylic acids such as ethylenediaminetetraacetic acid, hydroxyethylenediaminetetraacetic acid and nitrilotriacetic acid,

-cycloaliphatic carboxylic acids, such as camphoric acid,

-aromatic carboxylic acids, for example benzoic acid, phenylacetic acid, phenoxyacetic acid and cinnamic acid, 2-, 3- and 4-hydroxybenzoic acid, anilic acid as well as o-, m- and p-chloro-acetic acid and o-, ma- p-chlorophenoxyacetic acid,

-Ί-salts of inorganic acids with alkali metals and amines, such as sodium or potassium salts and ammonium (NRtRjRj) salts of hydrochloric, sulfuric, phosphoric, alkylphosphoric, where the alkyl group has 1 to 10 carbon atoms, and boric, where the ammonium and , are as defined above,

- 2-hydroxyethanesulfonic acid,

- tannic acid,

- acid amides of general formula VEE

R _R CO-N (VII)

Ri where

R is hydrogen or C 1 -C 12 alkyl, and P; and P 1 are independently hydrogen, C 1 -C 12 alkyl, C 2 -C 12 alkenyl, C 1 -C 12 hydroxyalkyl, C 2 -C 12 hydroxyalkenyl or C 1 -C 12 polyglycol ether chain up to 30 -CK ₂ -CH ₂ -O- groups or -CKY _; -O- groups where one of Y or Y ₂ is hydrogen and the other is methyl, for example N-methylacetamide, -urea derivatives of the formula VE E1

Ri

N-CO-N

Z r ₂

Ri (VIII)

where

R., _R2, R; and R ₄ are independently hydrogen, C 1 -C 8 alkyl, C 2 -C 8 alkenyl, C 1 -C 8 hydroxyalkyl, or C 2 -C 8 hydroxyalkenyl,

3-monohydric aliphatic alcohol having 4 to 13 carbon atoms and monocyclic alcohols, for example alkanols having 2 to 13 carbon atoms, alkenols having 2 to 18 carbon atoms and terpenic alcohols, for example ethanol, propanol, isopropanol, nicanol, cis 3-hexen-1-ol, trans-2-hexen-1-ol, L-hex-3-ol, heptanol, octanol, trans-2-cis-6-nonadien-1-ol, decanol , linaloi, gera.niol, dihydroterpineol, myrcenol, nopol and terpir.eol,

- aromatic alcohols of the general formula

where

X is - (CH 2) -, -CH = CH-CH 2 - or -O- (CH 3) a

R 1, R 2 and R 3 are independently hydrogen, hydroxy, halogen or alkoxy of up to 6 carbon atoms, for example benzyl alcohol, 2,4-dichlorobenzyl alcohol, phenoxyethanol, 1-phenoxy-2-propanol (phenoxyisocropanoi) and cinnamyl alcohol; polyhydric alcohols and polyhydric and alkoxylated, in particular ethoxylated and / or propoxylated alcohols, and their ethers and esters of the general formula X

R.-O-X-O-R; (XI 'where

R 1 and R 3 are independently hydrogen, C 1 -C 12 alkyl, C 2 -C 12 alkenyl, C 1 -C 3 alkanoyl, C 3 -C 18 alkenoyl, and formula (I)

R ₃ - (OCH-CH ₂ -) no where

-9 R 1 is hydrogen, C 1 -C 12 alkyl or C 2 -C 12 alkenyl, and P. is hydrogen or -CH _{) (} and

X is alkyl. C 2 -C 10 or C 2 -C 10 alkenylene, - (Cbb CH ₂ O 3 ..., -, CH ₂ -Ar 1 -, - or

- (CH ₂ -CH-O> 5Q-CU ₂ -CHCH ₃ Cl ₃₎

All organic acids mentioned under ^a b) can also be obtained in the form of their water-soluble salts, such as alkali metal salts, preferably sodium or potassium salts, or ammonium salts (NR ^ R), wherein

R, _R and _R; independently of one another are hydrogen, alkyl of 1 to 3 carbon atoms, alkenyl of 2 to 5 carbon atoms, hydroxyalkyl of 1 to 3 carbon atoms, cycloalkyl of 1 to 3 carbon atoms or polyalkenyleneoxyalkyl of 1 to 13 atoms atoms in the alkyl moiety, or R ,, R and _R together with the nitrogen atom to which they are attached form unsubstituted or C 1 -C 4 alkyl-substituted morfeiinoskupinu.

Component (b, ') may consist of only one subclass compound (b.J) or also mixtures of one or more than one subclass compound (b.J), also together with components of other subclasses.

Special antimicrobial efficacy is achieved by combining one or more than one subclass compound (bj and one or more than one subclass compound (bj). A combination of cumene sulfenate and citric acid monohydrate is particularly preferred.

Suitable components (c) are anionic, nonionic or zwitterionic and amphoteric synthetic surfactants.

Suitable anionic surfactants are: -sulfates, e.g.

- L0 to 18 carbon atoms in the alkyl chain of lauryl alcohol,

fatty alcohol ether sulfates, for example acid esters or sol; ethylene oxide per mole of alkali metal fatty alcohol, C8-C20 ammonium fatty acids as soaps, for example alkyl amide fatty acid sulfates,

-alkylamide ether sulfates,

-alkylaryl polyether sulfates, -monoglyceride sulfates, -8 to 20-chain alkane sulfonates, for example doaecylsulfonate, -alkylamide sulfonates,

-alkylarylsulfonates,

- α-olefin sulfonates,

-sulfosuccinic acid derivatives, sulfosuccinates, aikylethersui fosuk; cinamidú,

-N- [alkylamidoalkyll amino acids ob of: 1, for example sulfated with 8 to 22 carbon atoms, polyaducts 2 to 30 mol, 1; having 8 to 22 carbon atoms, a salt or a salt with an amino amine, which are designated. Γ. 2 <S. <3 33 V-ΞSC carbon atoms in alkyl, for example, alkyl ester derivatives or alkylsulphosucculant XI

Y / (XI)

CH ₃ (CH ₂ ) _n -CO-N 2 CH-Z-COOM "where

X is hydrogen, alkyl of 1 to 4 carbon atoms or COO'M ‘, γ is hydrogen or alkyl of 1 to 4 carbon atoms,

Z is - (CH 2) _ffl . , _t -,

-L1 (Π; is 1 to 5, n is an integer between 6 and 18, and ~

M is an alkali metal ion or an α-in ion,

-alkylene carboxylates and alkylaryl etherbosylates of the general formula (XII)

-ÍCH

2/579

N where

X is the remainder of the formulas

^-

?. is hydrogen or alkyl of 1 to 4 carbon atoms,

Y is - (CHCXO),

A is - (CH 2; m _; - CO 2) or U / °

-P \ ^x OM * m, is 1 to 6, and

M is an alkali metal or amine cation.

Further, anionic surfactants include fatty acid methyltaurides, alkyl isothionates, fatty acid and polypeptide condensates, and phosphoric acid esters of fatty alcohols. The alkyl radicals in these compounds preferably contain 3 to 24 carbon atoms.

Fatty alcohols which may be present in the above-mentioned surfactants include alcohols having 8 to 22 carbon atoms, preferably 8 to 18 carbon atoms, for example octyl alcohol, decyl alcohol, lauryl alcohol, tridecyl alcohol, myristyl alcohol, cetyl alcohol, stearyl alcohol, oleyl alcohol , arachidyl alcohol or behenylalcohol.

The anionic surfactants are usually obtained in the form of their water-soluble salts, such as alkali metal salts, ammonium salts and amine salts. Typical examples of such salts are lithium, sodium, potassium, ammonium

-12 salts and salts with triethylamine, ethanolamine, diethanolamine or triethanolamine. Preference is given to the use of sodium or potassium salts or of the ammonium (NP..P > R) salts, wherein R ₁ , R ₂ and R ₃ are each independently hydrogen, C 1 -C 4 alkyl or C 1 -C 4 hydroxyalkyl. 4 carbon atoms.

The anionic surfactants used in the preparation according to the invention are alcohol ethers of fatty acids having 8 to 22 carbon atoms, in particular alkali metal salts of lauryl ether sulphate.

Particularly preferred anionic surfactants in the novel formulation are moncethanolamine lauryl sulfate or alkali metal fatty alcohol sulfate salts, preferably sodium lauryl sulfate and the reaction product of 2 to 4 moles of ethylene oxide and sodium lauryl ether sulfate.

Suitable zwitterionic and amphoteric surfactants are C 8 -C 18 betaines, C 8 -C 18 sulphetaines, C 3 -C 24 alkylamidoalkylenefacetines and C 1 -C 4 alkylene moieties, imidazinecarboxylates, alkylamphocarboxylic acids, alkylamphocarbocarboxylates acids (e.g., lauroamphoglycinate) and N-alkyl-β-aminoprocicates or H-alkyl-βiminodipropionates. It is preferred to use C 10 -C 20 alkylamidoalkylenefetaines and C 1 -C 4 alkylene moieties, and in particular cocoamidopropyl betaine.

Nonionic surfactants are propylene oxide / ethylene oxide adduct derivatives having a molecular weight of 1000 to 15000, fatty alcohol ethoxylates (1 to 50 EO), alkylphenol polyglycol ethers (1 to 50 EO), ethoxylated carbohydrates, fatty acid partial esters of glycol ammonium, for example diethylene glycol monostearate fatty acids and fatty acid dialkanolamides, ethoxylated fatty acid alkanolamides and fatty acid amine oxides. Particular mention should be made of fatty acid alkanolamides and fatty acid dialkanolamides, preferably cocodiethanolamide.

Suitable components (d; are salts of saturated or unsaturated C12-C22 fatty acids, for example lauric acid, myristic acid, palmitic acid, stearic acid, arachidic acid, behenic acid, dodecenoic acid, tetradecenic acid , octadecenic acid, oleic acid, eicosanoic acid and erucic acid, as well as technical mixtures of these acids, for example, preferably a coconut fatty acid is used in the novel formulation, these acids being obtainable in the form of salts, suitable cations being alkali metal cations, such as sodium and potassium cations, metal atoms such as zinc and aluminum atoms, or nitrogen-containing organic compounds of sufficient basicity, such as amines or ethoxylated amines, may also be prepared in situ using a mixture of said salts.

Suitable components (e) are preferably those containing from 2 to 6 carbon atoms in the alkylene chain, for example ethylene glycol, 1,2- or 1,3-propanediol, 1,3-, 1,4- or 2,3-butanediol; , 5-pentariol and 1,6-hexanediol.

Preferred is 1,2-propanediol (propylene glycol;

Component (z) is preferably ethanol, n-propanol and isopropanol or a mixture of these alcohols.

Preferred novel formulations comprise (a) a compound of formula (I)

As a component. (d) dibasic alcohols, p

R.

R.

(I) where

R ₁ is hydrogen, hydroxy, C 1 -C 4 alkyl, chloro, nitro, phenyl or benzyl,

R _; is hydrogen, hydroxy, (C1-C6) -alkyl or chlorine,

R 1 is hydrogen, C 1 -C 6 alkyl, hydroxy, chloro, nitro or ir; a 1f group in the form of its alkali metal or ammonium salts thereof is a hydrogen atom or a methyl group, and R 1 is a hydrogen atom or a nitro group, (b) 0.1 to 25% by weight of a mixture of sodium 1-phonate and acid monohydrate (c) 1 to 10% by weight of a C8-C22 fatty alcohol ether, (e) 0 to 50% by weight of a dihydric alcohol, (E) 0 to 70% by weight of a monohydric alcohol or a mixture of several monohydric alcohols, and (g) ) as main constituent water or deionized water up to 100%. The pK of the novel formulation is 3 to 10, preferably 4.5 to 10

The novel preparations obtained as soaps or as so-called syndet solutions may further contain conventional additives such as masking agents, colorants, perfumed oils, thickeners or reinforcing agents (consistency regulators), emollients, UV absorbers, skin protection agents, antioxidants, additives which improve mechanical properties such as dicarboxylic acids and / or salts of fatty acids having 14 to 22 carbon atoms with aluminum, zinc, calcium or magnesium, and optionally stabilizers.

The new soap bars can be prepared in a known manner, for example by mixing the new components (a) and (b) and optionally (c), (d), (e) and (f), as well as any ingredients in the mixer at up to 25 ° C. Thereafter, the resulting mixture is extruded at a temperature of 40 to 60 ° C, preferably at 45 to 50 ° C, and then cut and pressed in molds.

The soap compositions of the invention may be prepared by mixing components (a) and (b) and optionally (c), (d), (e) and (f) in water and in any order with the necessary amount until homogeneous. The mixture is replenished

For disinfection and counting; Lucky item can be new soap ρ or undiluted form, suitable

mixing the mixture ’% with additional water, ip. Hence, an intermediate reaction. For example, in a dilute 2 ml dilution, for r 4 in water and water.

disinfection of the hands preferably in the controller

The present invention will give them closer; oo; and that in the following examples. Parts and percentages are parts and percentages by weight.

DETAILED DESCRIPTION OF THE INVENTION

Example 1

1, o part o-phenylpheno lu, 4.0 part laurylether -2-sodium sulphate, 8.0 part powdered kumer.su 1 for. sodium 8.0 part monohydrate citric acid,

10.0 parts of propylene glycol, and water to 130 parts are mixed to homogeneity and then about 30% of the necessary water is added. The pH is adjusted to 5.5 with monoethanolamine. Deionized water was then added to the solution to make a total of 100 parts. The pH is checked again and, if necessary, adjusted to pH 5.5 with monoethanolamine.

Example 2

1.0 part o-phenylphenol,

4.0 parts of sodium lauryl ether 4-sulphate,

8.0 parts of sodium cumene sulphate powder, 8.0 parts of citric acid monohydrate, 10.0 parts of propylene glycol, and

- ίο -

water dc LOO díl mixes to homogeneity and then 3 .; ex <: will give about 90% necessary water. Value The pH is adjusted to 5.5 mono ethanolarnine. Then se k this solution ionized water, which is adjusted to

ce of LOO parts. Again 7.2./.,11.^ 5. ij ^'I / A and if necessary adjusted to ρ monoethanolam flax. ^; ί

1.0 parts of p-chloro-m-xylene,

4.0 parts of sodium lauryl ether-2-sulphate,

3.0 parts of sodium cumensulphonate powder, 3.0 parts of citric acid monohydrate, 10.0 parts of propylene glycol, and

water to LOO parts <6 (Π IS L to of homogeneity and then at gives about 90 p necessary water. Value pH is adjusted to 5.5 mono- .-t hano lam i ne m. Then take k this roz! flow added deionized water, thereby is adjusted to

total 100 parts. The pH is checked again and, if necessary, adjusted to pH 3.3 with monoethanolamine.

Example 4

1.0 parts of p-chloro-o-benzylphenol,

4.0 parts of sodium lauryl ether-2-sulphate,

3.0 parts of sodium cumene sulphonate powder,

3.0 parts citric acid monohydrate,

10.0 parts of propylene glycol, and water to the LOO part were mixed to homogeneity and then about 90% of the necessary water was added. The cH value is adjusted to 5.5 with monoethanolamine. Deionized water was then added to the solution to make a total of 100 parts. The pH is checked again and, if necessary, adjusted to pH 5.5 with monoethanolamine.

-17 Example 5

2.0 parts of benzyl alcohol,

4.0 parts of sodium lauryl sulphate,

5.0 parts of powdered sodium cumensulphonate,

8.0 parts citric acid monohydrate,

10.0 parts of propylene glycol, and water to 100 parts are mixed in homogeneity and then about 90% of the necessary water is added. The pH is adjusted to 5.5 with monoethanolamine. Deionized water was then added to the solution to make a total of 100 parts. The pH is checked again and, if necessary, adjusted to pH 5.5 with monoethanolamine.

Example 6

4.0 parts of cocoamidopropyl betaine,

5.0 parts sodium cumene sulphonate,

10.0 parts propylene glycol,

8.0 parts of citric acid monohydrate and water to the ICO parts are mixed to homogeneity and then about 90 to the necessary water is added. The pH is adjusted to 5.5 with monoethanolamine. Deionized water is then added to this solution to make it 100 total. The pK is checked again and, if necessary, adjusted to pH 4.0 with monoethanolamine.

Example 7

4.0 parts of cocoamidopropyl betaine,

12.0 parts of ethanol,

8.0 parts of citric acid monohydrate and water up to 100 parts are mixed to homogeneity and then about 90% of the necessary water is added.

The pK value is adjusted to 5.5 with monoethanolamine. Deionized water, total LOG parts are then added to this solution. The pH is again checked and the monoethane is adjusted to pH 4.0.

adjusting to and if necessary

Example 3

4.0 parts of lauramine crude oil ionate,

5.0 parts of sodium cumensuifonate,

10.0 parts propylene glycol,

8.0 parts of Ltronic acid monohydrate and water to 100 parts are mixed to homogeneity and then about 90% of the necessary water is added. The pH was adjusted to pH 5.5 with monoethanolamine. Deionized water was then added to the solution to make a total of 100 parts. The pH is checked again and, if necessary, adjusted to pH 4.0 with monoethanolamine.

Example

4.0 parts of sodium lauraminopropionate,

12.0 parts of ethanol,

8.0 parts of citric acid monohydrate, and water to 100 parts are mixed to homogeneity and then about 90% of the necessary water is added. The pH is adjusted to 5.5. monoethanolamine. Deionized water was then added to the solution to make a total of 100 parts. The pH is checked again and, if necessary, adjusted to pH 4.0 with monoethanolamine.

EXAMPLE 10

L is a compound of formula

-19CH ₃ ch ₃

H ₃ C- (CH ₂ ) - |

Cl · where n is an integer from 7 to 17,

4.0 parts of cocoamidopropyl betaine,

12.0 parts of ethanol,

8.0 parts of citric acid monohydrate, and water to 100 parts are mixed to homogeneity and then about 90% of the necessary water is added. The pH is adjusted to 5.5 with monoethanolamine. Deionized water was then added to the solution to make a total of 100 parts. The pH is checked again and, if necessary, adjusted to ρΗ 5,5 with monoethanolamine.

Example II

1,0 parts 2,4-dichlorobenzyl alcohol,

4.0 parts of sodium lauryl sulphate,

5.0 parts sodium cumene sulphonate,

1.0 parts propylene glycol,

8.0 parts of citric acid monohydrate, and water to 100 parts are mixed to homogeneity and then about 90% of the necessary water is added. The pH is adjusted to 5.5 with monoethanolamine. Deionized water was then added to the solution to make a total of 100 parts. The pH is checked again and, if necessary, adjusted to pH 5.5 with monoethanolamine.

Example 12

Microbicidal activity test of new formulations

'Microbe Lei. days of efficacy (in decimal logarithm; the novel formulations of Examples L-11 are determined by a suspension test. This test is used to evaluate the bactericidal activity of water-soluble antiseptic agents, disinfectants and liquid soaps. After a period of contact, the aitquot amount is collected and the number of surviving bacilli is determined. The concentration is 90 seconds.

ρ Contact time is 30

The following bacLL · / were used:

ex.  Staph. aureus ; ATCC 9144 j Shards, j faecalis ATCC 10541 ; £ .What L i ATCC 10536 P.aerug i nosa CIP A-22 Serratia marcescens ATCC 13380 and í ¹ 4, b i> 5.1 ! -5.3 > 5, 3 > 5,4 ! ² i> 5.5 •> 5.2 \> 5, L > 5,3 > 5,5 3 ¹ > 5.5 > 5,2 > 5, 1 > 5,3 > 5,5 4 > 5,5 > 5,2 > 5.1 > 5,3 > 5,5 I-- 1 ⁵ > 3 > 6 > 6 > 6 > 6 ! -ί— 2 0.2 1.4 > 6 2.7 7 0 0.5 2, 6 > 6 1.3 3 0.1 0, 3 0.7 > 6 2.5 9 ; 3.5 > 6 > 6 > 6 4.2 10 ! 1 1.7 > 6 > 6 4.7 11 3.4 > 6 > 6 > 6 > 6

y. i -

Claims (12)

P A T Ε N T O 7 í-? \ J 1. A surfactant composition. in that it contains 0.01 to 5% by weight of k. substance selected from the group consisting of _(t) phenol derivatives, (a.) diphenyl merged LNY (A) benzyl 1 alcohols (A ") chlorhexidine (and ₅₎ betaines having 12 to 14 carbon atoms and amidoalkyl betaines fatty acids 8-18 carbon atoms, · (even amphoteric surfactants (and ₇₎ trihalogenkarbanilidy, and (although a quaternary ammonium salt (b) 0.1 to 25% by weight of one or more than one hydrotropic agent, (c) 0 to 10% by weight of one or more than one synthetic surfactant or soap or combination thereof, (d) 0 to 8% by weight of a saturated and / or unsaturated fatty acid having 8 to 22 carbon atoms, (e) 0 to 50% by weight (f) 0 to 70% by weight of a monohydric alcohol or a mixture of several monohydric alcohols; and (g) as a main constituent water or deionized water up to 100%, the composition comprising at least one of components (c) and ( d). A composition according to claim 1, characterized in that it comprises as component (a) a compound of the formula I wherein R. is hydrogen, hydroxy, (C 1 -C 4) alkyl, chloro, nitro, phenyl or benzyl, R _; is hydrogen, hydroxy, (C 1 -C 6) alkyl or halogen; R 1 is hydrogen, C 1 -C 6 alkyl, hydroxy, chlorine, nitro or sulfo in the form of its alkali metal or ammonium salts, R ₄ is a hydrogen atom or a methyl group, R ₅ is hydrogen or nitro. 3. A composition according to claim 1, characterized in that it comprises as a component of formula II i, characterized by (a.) A compound of the general formula wherein X is a sulfur atom or a methylene group, R 1 and R 2 are hydroxy, and R, R _', R, R' i, R _4, R \ _R; and R ' _s are independently hydrogen or halogen. « -2 3 · 4. The composition of claim 1 including considerable uj d c d in that as component ^of a.) The compound of the formula III Cu ₂ -OH her, (III) n. Where R ₁ , R ₂ , R 3, P 3, and R 3 are independently hydrogen or chlorine. Composition according to claim 1, characterized in that it comprises as component (a) chlorhexidine or a salt thereof with an organic or inorganic acid. 6. The composition of claim 1, wherein said betaine. according to claim 1, characterized in that it contains cocoamidopropyl as component (a,) Composition according to claim 1, characterized in that it comprises as component (aj) a C 12 alkylaminocarboxylic acid or a C 1 -C 3 alkanecarboxylic acid. Composition according to claim 1, characterized in that it comprises as component (a) a compound of the formula IV Hal Hal, NH-CO-NH- (IV) wherein Hal is chlorine or bromine, n and m are 1 or 2, and n + m is 3. The formula cc ^r on rox is characterized by the fact that as component of z, it contains the formula VI CH-j H ₃ C- (CH ₂ ) —f i ⁺ —CH-, ⁿ I ch ₃ // cr (VI) wherein n is an integer from 7 to 17. Composition according to any one of claims 1 to 9, characterized in that it comprises, as component (b _x ), a sulphonate, preferably a salt of a terpenoid or a aromatic compound with one or two nuclei. Composition according to claim 10, characterized in that it contains camphor, toluene, xylene, cumene or naphthene sulphonate as the one or two-core aromatic compound. * Composition according to any one of claims 1 to 11, characterized in that the component (b) consists of only one subclass compound (bL) or also a mixture of one or more than one subclass compound (b1) and also a mixture with components of other subclasses. Composition according to any one of claims 1 to 11, characterized in that it comprises as component (b) a combination of one or more than one compound of subclass (b) and one or more than one compound of subclass (b ₂ ). 14. A formulation according to claim 13 comprising a combination of kurnensulphonate and citric acid monohydrate. Composition according to any one of claims 1 to 14, characterized in that it comprises as component (c) an anionic surfactant in the form of its water-soluble salt. Composition according to claim 15, characterized in that it comprises as component (c) a fatty alcohol ether sulfate of 8 to 22 carbon atoms. Composition according to claim 16, characterized in that it comprises, as component (c), an alkali metal salt of lauryl ether sulfate. Composition according to any one of claims 1 to 17, characterized in that it comprises, as component (e), a substance selected from the group consisting of lauric acid, myristic acid, palmitic acid, stearic acid, arachidic acid, behenic acid, dodecenoic acid, acid tetradecenic acid, octadecenic acid, oleic acid, eicosenoic acid and erucic acid. Composition according to any one of claims 1 to 18, characterized in that it comprises propylene glycol as component (e). A composition according to any one of claims 1 to 19, characterized in that it comprises, as component (f), a substance selected from the group. _; including ethanol, propanol, isopropanol and mixtures of these alcohols. 21. A surfactant comprising (a) a compound of formula (I) R, R, (I) R, R < where R1 is hydrogen, hydrogen, C1-C4alkyl, chlorine, nitro, phenyl or benzyl, R 1 is a hydrogen atom, a hydroxy group, an alkyl group having 1 to 6 carbon atoms or a halogen atom, R 1 is hydrogen, C 1 -C 6 alkyl, hydroxy, chlorine, nitro or sulfo in the form of its alkali metal or ammonium salts, or methyl, or nitro, (b) 0.1 to 25 % by weight of a mixture of sodium cumene sulphonate and citric acid monohydrate, (c) 0 to 10% by weight of a C8-C22 fatty alcohol ether ester, (e) 0 to 50% of a dibasic alcohol, a mixture of several monohydric alcohols, and (g) as the main constituent water or deionized water up to 100 is a voaix atom is a hydrogen atom * 5. ~ '/, Ί Use of an antimicrobial antifungal composition according to any one of claims 1 to 21 for the day of infection and cleansing of human skin and hands and resistant articles.