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CY1119862T1 - Ενωσεις χρησιμες στη συνθεση των ενωσεων βενζαμιδιου - Google Patents

Ενωσεις χρησιμες στη συνθεση των ενωσεων βενζαμιδιου

Info

Publication number
CY1119862T1
CY1119862T1 CY20181100109T CY181100109T CY1119862T1 CY 1119862 T1 CY1119862 T1 CY 1119862T1 CY 20181100109 T CY20181100109 T CY 20181100109T CY 181100109 T CY181100109 T CY 181100109T CY 1119862 T1 CY1119862 T1 CY 1119862T1
Authority
CY
Cyprus
Prior art keywords
compounds
benzamidium
composition
compositions useful
useful
Prior art date
Application number
CY20181100109T
Other languages
English (en)
Inventor
Mario Emilov LOZANOV
Anthony Frank SKUFCA
Andrew George ZEILER
Original Assignee
Resverlogix Corp.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Resverlogix Corp. filed Critical Resverlogix Corp.
Publication of CY1119862T1 publication Critical patent/CY1119862T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
    • C07C255/59—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/25—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/38—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
    • C07C255/60—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton at least one of the singly-bound nitrogen atoms being acylated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Οι ενώσεις του Τύπου (I), όπου το R1 επιλέγεται από Br και CN, το R2 επιλέγεται από Η και Br, το R3 είναι Η ή - (C=X)R, το R επιλέγεται από Η, CH3, CF3, CF2H, CFH2, CCl3, CCI2H, CCIH2, CBr3, CBr2H και CBrH2, το Χ είναι Ο ή S. Οι ενώσεις είναι χρήσιμες για τη σύνθεση των παραγώγων του 2-αμινο-4,6-διμεθοξυβενζαμιδίου.
CY20181100109T 2012-10-15 2018-01-30 Ενωσεις χρησιμες στη συνθεση των ενωσεων βενζαμιδιου CY1119862T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261713711P 2012-10-15 2012-10-15
PCT/IB2013/003031 WO2014060852A2 (en) 2012-10-15 2013-10-09 Compounds useful in the synthesis of benzamide compounds

Publications (1)

Publication Number Publication Date
CY1119862T1 true CY1119862T1 (el) 2018-06-27

Family

ID=50475926

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20181100109T CY1119862T1 (el) 2012-10-15 2018-01-30 Ενωσεις χρησιμες στη συνθεση των ενωσεων βενζαμιδιου

Country Status (25)

Country Link
US (1) US8884046B2 (el)
EP (1) EP2906531B1 (el)
JP (2) JP6307087B2 (el)
KR (1) KR101532570B1 (el)
CN (1) CN104884427B (el)
AU (1) AU2013333575B2 (el)
BR (1) BR112015008389B1 (el)
CA (1) CA2888378C (el)
CY (1) CY1119862T1 (el)
DK (1) DK2906531T3 (el)
ES (1) ES2658221T3 (el)
HR (1) HRP20180176T1 (el)
HU (1) HUE036421T2 (el)
IL (2) IL238186A (el)
LT (1) LT2906531T (el)
MX (1) MX338885B (el)
NO (1) NO2992016T3 (el)
NZ (1) NZ707276A (el)
PL (1) PL2906531T3 (el)
PT (1) PT2906531T (el)
RS (1) RS56846B1 (el)
RU (1) RU2593752C1 (el)
SA (1) SA515360284B1 (el)
SI (1) SI2906531T1 (el)
WO (1) WO2014060852A2 (el)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101444489B1 (ko) 2007-02-01 2014-09-24 리스버로직스 코퍼레이션 심혈관 질환을 예방 및 치료하기 위한 화합물
ES2542835T3 (es) 2009-01-08 2015-08-12 Resverlogix Corporation Compuestos para la prevención y el tratamiento de enfermedades cardiovasculares
KR101841003B1 (ko) 2009-03-18 2018-03-22 리스버로직스 코퍼레이션 신규한 소염제
US9757368B2 (en) 2009-04-22 2017-09-12 Resverlogix Corp. Anti-inflammatory agents
US9610251B2 (en) 2011-11-01 2017-04-04 Resverlogix Corp. Pharmaceutical compositions for substituted quinazolinones
WO2014080290A2 (en) 2012-11-21 2014-05-30 Rvx Therapeutics Inc. Cyclic amines as bromodomain inhibitors
US9765039B2 (en) 2012-11-21 2017-09-19 Zenith Epigenetics Ltd. Biaryl derivatives as bromodomain inhibitors
WO2014096965A2 (en) 2012-12-21 2014-06-26 Rvx Therapeutics Inc. Novel heterocyclic compounds as bromodomain inhibitors
CN107530356A (zh) 2015-03-13 2018-01-02 雷斯韦洛吉克斯公司 用于治疗补体相关疾病之组合物及治疗方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0118752D0 (en) * 2001-08-01 2001-09-26 Pfizer Ltd Process for the production of quinazolines
GB0206033D0 (en) * 2002-03-14 2002-04-24 Pfizer Ltd Compounds useful in therapy
US20050080021A1 (en) 2002-08-15 2005-04-14 Joseph Tucker Nitric oxide donating derivatives of stilbenes, polyphenols and flavonoids for the treatment of cardiovascular disorders
US20040033480A1 (en) 2002-08-15 2004-02-19 Wong Norman C.W. Use of resveratrol to regulate expression of apolipoprotein A1
US20050080024A1 (en) 2002-08-15 2005-04-14 Joseph Tucker Nitric oxide donating derivatives for the treatment of cardiovascular disorders
CA2541590A1 (en) 2003-10-10 2005-04-21 Resverlogix Corp. Treatment of diseases associated with the egr-1 enhancer element
GB0512324D0 (en) * 2005-06-16 2005-07-27 Novartis Ag Organic compounds
EP2332527A3 (en) 2004-10-20 2011-11-16 Resverlogix Corp. Flavanoids and Isoflavanoids for the prevention and treatment of cardiovascular diseases
AU2006275514B2 (en) 2005-07-29 2012-04-05 Resverlogix Corp. Pharmaceutical compositions for the prevention and treatment of complex diseases and their delivery by insertable medical devices
KR101444489B1 (ko) 2007-02-01 2014-09-24 리스버로직스 코퍼레이션 심혈관 질환을 예방 및 치료하기 위한 화합물
CA2691100A1 (en) * 2007-06-21 2008-12-24 Irm Llc Protein kinase inhibitors and methods for using thereof
US8114995B2 (en) 2008-06-26 2012-02-14 Resverlogix Corp. Methods of preparing quinazolinone derivatives
ES2542835T3 (es) 2009-01-08 2015-08-12 Resverlogix Corporation Compuestos para la prevención y el tratamiento de enfermedades cardiovasculares
KR101841003B1 (ko) 2009-03-18 2018-03-22 리스버로직스 코퍼레이션 신규한 소염제
US9757368B2 (en) 2009-04-22 2017-09-12 Resverlogix Corp. Anti-inflammatory agents
GB201007286D0 (en) * 2010-04-30 2010-06-16 Astex Therapeutics Ltd New compounds
DE102010048800A1 (de) * 2010-10-20 2012-05-10 Merck Patent Gmbh Chinoxalinderivate
US9610251B2 (en) 2011-11-01 2017-04-04 Resverlogix Corp. Pharmaceutical compositions for substituted quinazolinones
EP2906530B1 (en) * 2012-10-15 2018-01-03 Albemarle Corporation Processes for the synthesis of 2-amino-4,6-dimethoxybenzamide and other benzamide compounds
TWI641936B (zh) * 2012-11-13 2018-11-21 美商慧盛材料美國責任有限公司 漿料供應及／或化學品摻合物供應設備、方法、使用方法及製造方法

Also Published As

Publication number Publication date
US8884046B2 (en) 2014-11-11
CA2888378C (en) 2015-09-22
MX2015004764A (es) 2015-08-14
IL244099A0 (en) 2016-04-21
EP2906531B1 (en) 2018-01-17
KR20150061661A (ko) 2015-06-04
KR101532570B1 (ko) 2015-06-30
SA515360284B1 (ar) 2016-04-19
NZ707276A (en) 2016-02-26
JP6307087B2 (ja) 2018-04-04
RS56846B1 (sr) 2018-04-30
LT2906531T (lt) 2018-02-26
PT2906531T (pt) 2018-02-06
PL2906531T3 (pl) 2018-04-30
HUE036421T2 (hu) 2018-07-30
EP2906531A4 (en) 2016-06-01
IL238186A (en) 2016-03-31
JP2015531403A (ja) 2015-11-02
AU2013333575A1 (en) 2015-05-28
BR112015008389A2 (pt) 2017-07-04
SI2906531T1 (en) 2018-03-30
CA2888378A1 (en) 2014-04-24
NO2992016T3 (el) 2018-03-17
JP2017088632A (ja) 2017-05-25
WO2014060852A3 (en) 2014-07-24
MX338885B (es) 2016-05-04
BR112015008389B1 (pt) 2020-12-15
HK1207623A1 (en) 2016-02-05
US20140107369A1 (en) 2014-04-17
RU2593752C1 (ru) 2016-08-10
HRP20180176T1 (hr) 2018-03-09
ES2658221T3 (es) 2018-03-08
EP2906531A2 (en) 2015-08-19
AU2013333575B2 (en) 2015-07-16
WO2014060852A2 (en) 2014-04-24
CN104884427A (zh) 2015-09-02
CN104884427B (zh) 2016-09-07
DK2906531T3 (en) 2018-02-05

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