CY1111288T1 - Παραγωγα των 4η-1,2,4-τριαζιν-5-ονων, η παρασκευη τους και η χρηση τους ως υποδοχεις ακετυλοχωλινης του νικοτινικου τυπου αλφα7 - Google Patents
Παραγωγα των 4η-1,2,4-τριαζιν-5-ονων, η παρασκευη τους και η χρηση τους ως υποδοχεις ακετυλοχωλινης του νικοτινικου τυπου αλφα7Info
- Publication number
- CY1111288T1 CY1111288T1 CY20101101023T CY101101023T CY1111288T1 CY 1111288 T1 CY1111288 T1 CY 1111288T1 CY 20101101023 T CY20101101023 T CY 20101101023T CY 101101023 T CY101101023 T CY 101101023T CY 1111288 T1 CY1111288 T1 CY 1111288T1
- Authority
- CY
- Cyprus
- Prior art keywords
- group
- denotes
- nicotinic
- preparation
- types7
- Prior art date
Links
- BFNNILAMSKQDRN-UHFFFAOYSA-N 2h-1,2,4-triazin-5-one Chemical compound O=C1C=NNC=N1 BFNNILAMSKQDRN-UHFFFAOYSA-N 0.000 title 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 4
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 3
- 229910052757 nitrogen Inorganic materials 0.000 abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 1
- JYEUMXHLPRZUAT-UHFFFAOYSA-N 1,2,3-triazine Chemical group C1=CN=NN=C1 JYEUMXHLPRZUAT-UHFFFAOYSA-N 0.000 abstract 1
- 108010009685 Cholinergic Receptors Proteins 0.000 abstract 1
- 102000034337 acetylcholine receptors Human genes 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 150000003918 triazines Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D253/075—Two hetero atoms, in positions 3 and 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Η εφεύρεση αφορά τα παράγωγα τριαζίνων του γενικού τύπου (I) όπου το R1 δηλώνει μια ομάδα ετεροαρυλίου ή αρυλίου, το R2 δηλώνει ένα άτομο υδρογόνου ή μια ομάδα (C1-C4)αλκυλίου, το R3 δηλώνει μια ομάδα -(CH2)n-NR4R5 όπου το n είναι ίσο με 2, 3 ή 4 και το R4 και το R5 δηλώνουν, ανεξάρτητα το ένα από το άλλο, μια ομάδα (C1-C4)αλκυλίου, ή (C3-C7) κυκλοαλκυλίου, ή ακόμα το R4 και το R5 σχηματίζουν από κοινού, μαζί με το άτομο αζώτου που τα φέρει, μια ομάδα (C3-C9)ετεροκυκλοαλκυλίου, ή το R3 δηλώνει μια ομάδα -(CH2)mR6 όπου το m είναι ίσο με 0, 1 , 2, 3 ή 4 και το R6 δηλώνει μια ομάδα (C3-C9)ετεροκυκλοαλκυλίου που φέρει τουλάχιστον ένα άτομο αζώτου και το οποίο συνδέεται με τον πυρήνα τριαζίνης με ένα άτομο άνθρακα, ή ακόμα το R2 και το R3 σχηματίζουν από κοινού, μαζί με το άτομο αζώτου που τα φέρει, ένα (C5-C9)ετεροκυκλοαλκύλιο, που φέρει 2 άτομα αζώτου, στην κατάσταση βάσης ή άλατος προσθήκης σε ένα οξύ, καθώς και στην κατάσταση ένυδρου άλατος ή διαλύτη. Διαδικασία παρασκευής και χρήση ως δεσμοί των υποδοχέων ακετυλοχολίνης του νικοτινικού τύπου α7.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0504042A FR2884822B1 (fr) | 2005-04-22 | 2005-04-22 | Derives de triazines, leur preparation et leur application en therapeutique |
| EP06755440A EP1874761B1 (fr) | 2005-04-22 | 2006-04-21 | Derives de 4h-1,2,4-triazin-5-0nes, leur preparation et leur utilisation comme des recepteurs a l'acetylcholine de type nicotiniques alpha7 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1111288T1 true CY1111288T1 (el) | 2015-08-05 |
Family
ID=35219499
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20101101023T CY1111288T1 (el) | 2005-04-22 | 2010-11-12 | Παραγωγα των 4η-1,2,4-τριαζιν-5-ονων, η παρασκευη τους και η χρηση τους ως υποδοχεις ακετυλοχωλινης του νικοτινικου τυπου αλφα7 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US7517881B2 (el) |
| EP (1) | EP1874761B1 (el) |
| JP (1) | JP4966295B2 (el) |
| AR (1) | AR054033A1 (el) |
| AT (1) | ATE478068T1 (el) |
| CY (1) | CY1111288T1 (el) |
| DE (1) | DE602006016258D1 (el) |
| DK (1) | DK1874761T3 (el) |
| ES (1) | ES2350950T3 (el) |
| FR (1) | FR2884822B1 (el) |
| HR (1) | HRP20100604T1 (el) |
| PL (1) | PL1874761T3 (el) |
| PT (1) | PT1874761E (el) |
| RS (1) | RS51557B (el) |
| SI (1) | SI1874761T1 (el) |
| TW (1) | TW200708506A (el) |
| WO (1) | WO2006111662A2 (el) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0220581D0 (en) | 2002-09-04 | 2002-10-09 | Novartis Ag | Organic Compound |
| PE20060437A1 (es) | 2004-06-18 | 2006-06-08 | Novartis Ag | COMPUESTOS AZA-BICICLONONANOS COMO LIGANDOS COLINERGICOS DE nAChR |
| GB0415746D0 (en) | 2004-07-14 | 2004-08-18 | Novartis Ag | Organic compounds |
| GB0521508D0 (en) | 2005-10-21 | 2005-11-30 | Novartis Ag | Organic compounds |
| GB0525673D0 (en) | 2005-12-16 | 2006-01-25 | Novartis Ag | Organic compounds |
| GB0525672D0 (en) | 2005-12-16 | 2006-01-25 | Novartis Ag | Organic compounds |
| TWI558398B (zh) | 2009-09-22 | 2016-11-21 | 諾華公司 | 菸鹼乙醯膽鹼受體α７活化劑之用途 |
| JP7027341B2 (ja) * | 2016-05-12 | 2022-03-01 | バック・インスティテュート・フォー・リサーチ・オン・エイジング | Ａｐｐの正常なプロセシングを促進する化合物 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4774604B2 (ja) * | 2000-02-14 | 2011-09-14 | 和光純薬工業株式会社 | 第４級アンモニウム塩の製造方法 |
| JP4616971B2 (ja) * | 2000-07-18 | 2011-01-19 | 田辺三菱製薬株式会社 | １−アザビシクロアルカン化合物およびその医薬用途 |
| PL369895A1 (en) * | 2001-10-02 | 2005-05-02 | Pharmacia & Upjohn Company | Azabicyclic-substituted fused-heteroaryl compounds for the treatment of disease |
| SE0301320D0 (sv) * | 2003-05-06 | 2003-05-06 | Astrazeneca Ab | Positive modulators of nicotinic acetylcholine receptors |
-
2005
- 2005-04-22 FR FR0504042A patent/FR2884822B1/fr not_active Expired - Fee Related
-
2006
- 2006-04-20 AR ARP060101561A patent/AR054033A1/es unknown
- 2006-04-21 TW TW095114225A patent/TW200708506A/zh unknown
- 2006-04-21 EP EP06755440A patent/EP1874761B1/fr active Active
- 2006-04-21 SI SI200630825T patent/SI1874761T1/sl unknown
- 2006-04-21 JP JP2008507128A patent/JP4966295B2/ja not_active Expired - Fee Related
- 2006-04-21 HR HR20100604T patent/HRP20100604T1/hr unknown
- 2006-04-21 DK DK06755440.2T patent/DK1874761T3/da active
- 2006-04-21 DE DE602006016258T patent/DE602006016258D1/de active Active
- 2006-04-21 ES ES06755440T patent/ES2350950T3/es active Active
- 2006-04-21 RS RSP-2010/0487A patent/RS51557B/sr unknown
- 2006-04-21 PL PL06755440T patent/PL1874761T3/pl unknown
- 2006-04-21 AT AT06755440T patent/ATE478068T1/de active
- 2006-04-21 WO PCT/FR2006/000887 patent/WO2006111662A2/fr not_active Ceased
- 2006-04-21 PT PT06755440T patent/PT1874761E/pt unknown
-
2007
- 2007-10-09 US US11/869,260 patent/US7517881B2/en not_active Expired - Fee Related
-
2010
- 2010-11-12 CY CY20101101023T patent/CY1111288T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FR2884822B1 (fr) | 2007-06-29 |
| WO2006111662A2 (fr) | 2006-10-26 |
| EP1874761B1 (fr) | 2010-08-18 |
| TW200708506A (en) | 2007-03-01 |
| DE602006016258D1 (de) | 2010-09-30 |
| PT1874761E (pt) | 2010-11-18 |
| RS51557B (sr) | 2011-06-30 |
| SI1874761T1 (sl) | 2010-12-31 |
| ATE478068T1 (de) | 2010-09-15 |
| ES2350950T3 (es) | 2011-01-28 |
| DK1874761T3 (da) | 2010-12-13 |
| AR054033A1 (es) | 2007-05-30 |
| US20080096891A1 (en) | 2008-04-24 |
| FR2884822A1 (fr) | 2006-10-27 |
| EP1874761A2 (fr) | 2008-01-09 |
| WO2006111662A3 (fr) | 2006-11-30 |
| JP4966295B2 (ja) | 2012-07-04 |
| HRP20100604T1 (hr) | 2010-12-31 |
| JP2008536902A (ja) | 2008-09-11 |
| US7517881B2 (en) | 2009-04-14 |
| PL1874761T3 (pl) | 2011-02-28 |
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