AR054033A1 - Derivados de triazinas su preparacion y su aplicacion en terapeutica - Google Patents
Derivados de triazinas su preparacion y su aplicacion en terapeuticaInfo
- Publication number
- AR054033A1 AR054033A1 ARP060101561A ARP060101561A AR054033A1 AR 054033 A1 AR054033 A1 AR 054033A1 AR P060101561 A ARP060101561 A AR P060101561A AR P060101561 A ARP060101561 A AR P060101561A AR 054033 A1 AR054033 A1 AR 054033A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- atom
- alkyl
- therapeutics
- heterocycloalkyl
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 2
- 150000003918 triazines Chemical class 0.000 title abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 4
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 4
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- JYEUMXHLPRZUAT-UHFFFAOYSA-N 1,2,3-triazine Chemical group C1=CN=NN=C1 JYEUMXHLPRZUAT-UHFFFAOYSA-N 0.000 abstract 1
- -1 C1- alkoxy groups 4 Chemical group 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D253/075—Two hetero atoms, in positions 3 and 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Derivados de triazinas de formula general (1) en la que R1 representa un grupo heteroarilo o arilo, estando dichos grupos heteroarilo o arilo opcionalmente sustituidos por uno o varios grupos seleccionados entre los átomos de halogeno y los grupos alquilo C1-4, alcoxi C1-4, cicloalquilo C3-7, arilo, hidroxi, cano, -NH2, -NO2; R2 representa un átomo de H o un grupo alquilo C1-4; R3 representa un grupo -(CH2)n-NR4R5 en el que n es igual a 2, 3 o 4 y R4 y R5 representan, independientemente uno del otro, un grupo alquilo C1-4, o cicloalquilo C3-7, o bien R4 y R5 forman junto con e átomo de N que les transporta un grupo heterocicloalquilo C3-9; o R3 representa un grupo -(CH2)mR6 en el que m es igual a 0, 1, 2, 3 o 4 y R6 representa un grupo heterocicloalquilo C3-9 que comporta al menos un átomo de N y unido al nucleo de triazina por n átomo de C, estando el grupo heterocicloalquilo C3-9 opcionalmente sustituido por uno o varios grupos alquilo C1-4; o bien R2 y R3 forman conjuntamente, con e átomo de N que les transporta, un heterocicloalquilo C5-9 que comprende 2 átomos de N; en el estado de base o de sal de adicion a un ácido, así como en el estado de hidrato o de solvato. Procedimiento de preparacion y aplicacion en terapéutica.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0504042A FR2884822B1 (fr) | 2005-04-22 | 2005-04-22 | Derives de triazines, leur preparation et leur application en therapeutique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR054033A1 true AR054033A1 (es) | 2007-05-30 |
Family
ID=35219499
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060101561A AR054033A1 (es) | 2005-04-22 | 2006-04-20 | Derivados de triazinas su preparacion y su aplicacion en terapeutica |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US7517881B2 (es) |
| EP (1) | EP1874761B1 (es) |
| JP (1) | JP4966295B2 (es) |
| AR (1) | AR054033A1 (es) |
| AT (1) | ATE478068T1 (es) |
| CY (1) | CY1111288T1 (es) |
| DE (1) | DE602006016258D1 (es) |
| DK (1) | DK1874761T3 (es) |
| ES (1) | ES2350950T3 (es) |
| FR (1) | FR2884822B1 (es) |
| HR (1) | HRP20100604T1 (es) |
| PL (1) | PL1874761T3 (es) |
| PT (1) | PT1874761E (es) |
| RS (1) | RS51557B (es) |
| SI (1) | SI1874761T1 (es) |
| TW (1) | TW200708506A (es) |
| WO (1) | WO2006111662A2 (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0220581D0 (en) | 2002-09-04 | 2002-10-09 | Novartis Ag | Organic Compound |
| PE20060437A1 (es) | 2004-06-18 | 2006-06-08 | Novartis Ag | COMPUESTOS AZA-BICICLONONANOS COMO LIGANDOS COLINERGICOS DE nAChR |
| GB0415746D0 (en) | 2004-07-14 | 2004-08-18 | Novartis Ag | Organic compounds |
| GB0521508D0 (en) | 2005-10-21 | 2005-11-30 | Novartis Ag | Organic compounds |
| GB0525672D0 (en) | 2005-12-16 | 2006-01-25 | Novartis Ag | Organic compounds |
| GB0525673D0 (en) | 2005-12-16 | 2006-01-25 | Novartis Ag | Organic compounds |
| TWI558398B (zh) | 2009-09-22 | 2016-11-21 | 諾華公司 | 菸鹼乙醯膽鹼受體α７活化劑之用途 |
| KR102472011B1 (ko) * | 2016-05-12 | 2022-11-28 | 버크 인스티튜트 포 리서치 온 에이징 | App 의 정상 가공을 촉진하는 화합물 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4774604B2 (ja) * | 2000-02-14 | 2011-09-14 | 和光純薬工業株式会社 | 第４級アンモニウム塩の製造方法 |
| JP4616971B2 (ja) * | 2000-07-18 | 2011-01-19 | 田辺三菱製薬株式会社 | １−アザビシクロアルカン化合物およびその医薬用途 |
| WO2003029252A1 (en) * | 2001-10-02 | 2003-04-10 | Pharmacia & Upjohn Company | Azabicyclic-substituted fused-heteroaryl compounds for the treatment of disease |
| SE0301320D0 (sv) * | 2003-05-06 | 2003-05-06 | Astrazeneca Ab | Positive modulators of nicotinic acetylcholine receptors |
-
2005
- 2005-04-22 FR FR0504042A patent/FR2884822B1/fr not_active Expired - Fee Related
-
2006
- 2006-04-20 AR ARP060101561A patent/AR054033A1/es unknown
- 2006-04-21 EP EP06755440A patent/EP1874761B1/fr active Active
- 2006-04-21 DK DK06755440.2T patent/DK1874761T3/da active
- 2006-04-21 PL PL06755440T patent/PL1874761T3/pl unknown
- 2006-04-21 RS RSP-2010/0487A patent/RS51557B/sr unknown
- 2006-04-21 JP JP2008507128A patent/JP4966295B2/ja not_active Expired - Fee Related
- 2006-04-21 TW TW095114225A patent/TW200708506A/zh unknown
- 2006-04-21 ES ES06755440T patent/ES2350950T3/es active Active
- 2006-04-21 DE DE602006016258T patent/DE602006016258D1/de active Active
- 2006-04-21 SI SI200630825T patent/SI1874761T1/sl unknown
- 2006-04-21 WO PCT/FR2006/000887 patent/WO2006111662A2/fr not_active Ceased
- 2006-04-21 HR HR20100604T patent/HRP20100604T1/hr unknown
- 2006-04-21 AT AT06755440T patent/ATE478068T1/de active
- 2006-04-21 PT PT06755440T patent/PT1874761E/pt unknown
-
2007
- 2007-10-09 US US11/869,260 patent/US7517881B2/en not_active Expired - Fee Related
-
2010
- 2010-11-12 CY CY20101101023T patent/CY1111288T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HRP20100604T1 (hr) | 2010-12-31 |
| DK1874761T3 (da) | 2010-12-13 |
| WO2006111662A3 (fr) | 2006-11-30 |
| EP1874761B1 (fr) | 2010-08-18 |
| JP4966295B2 (ja) | 2012-07-04 |
| EP1874761A2 (fr) | 2008-01-09 |
| PL1874761T3 (pl) | 2011-02-28 |
| WO2006111662A2 (fr) | 2006-10-26 |
| TW200708506A (en) | 2007-03-01 |
| SI1874761T1 (sl) | 2010-12-31 |
| DE602006016258D1 (de) | 2010-09-30 |
| US7517881B2 (en) | 2009-04-14 |
| FR2884822B1 (fr) | 2007-06-29 |
| JP2008536902A (ja) | 2008-09-11 |
| ES2350950T3 (es) | 2011-01-28 |
| RS51557B (sr) | 2011-06-30 |
| CY1111288T1 (el) | 2015-08-05 |
| US20080096891A1 (en) | 2008-04-24 |
| FR2884822A1 (fr) | 2006-10-27 |
| ATE478068T1 (de) | 2010-09-15 |
| PT1874761E (pt) | 2010-11-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |