[go: up one dir, main page]

CU24352B1 - DERIVADOS DE ISOINDOLINA O ISOQUINOLINA ÚTILES COMO INHIBIDORES ANTIAPOPTÓTICOS DE Bcl-2 EN EL TRATAMIENTO DE CÁNCERES Y ENFERMEDADES AUTOINMUNES Y DEL SISTEMA INMUNITARIO, Y COMPOSICIONES FARMACÉUTICAS QUE LOS CONTIENEN - Google Patents

DERIVADOS DE ISOINDOLINA O ISOQUINOLINA ÚTILES COMO INHIBIDORES ANTIAPOPTÓTICOS DE Bcl-2 EN EL TRATAMIENTO DE CÁNCERES Y ENFERMEDADES AUTOINMUNES Y DEL SISTEMA INMUNITARIO, Y COMPOSICIONES FARMACÉUTICAS QUE LOS CONTIENEN

Info

Publication number
CU24352B1
CU24352B1 CUP2016000010A CU20160010A CU24352B1 CU 24352 B1 CU24352 B1 CU 24352B1 CU P2016000010 A CUP2016000010 A CU P2016000010A CU 20160010 A CU20160010 A CU 20160010A CU 24352 B1 CU24352 B1 CU 24352B1
Authority
CU
Cuba
Prior art keywords
antiapoptotic
bcl
inhibitors
useful
pharmaceutical compositions
Prior art date
Application number
CUP2016000010A
Other languages
English (en)
Spanish (es)
Other versions
CU20160010A7 (es
Inventor
Paul Brough
I-Jen Chen
James Edward Paul Davidson
Nanteuil Guillaume De
Mark Dodsworth
Imre Fejes
Olivier Geneste
Anne-Françoise Guillouzic
Jean-Michel Henlin
András Kotschy
Diguarher Thierry Le
Tiran Arnaud Le
Johannes W G Meissner
James Brooke Murray
Miklós Nyerges
Jérôme-Benoît Starck
Zoltán Szlávik
János Tatai
Claire Walmsley
Original Assignee
Servier Lab
Vernalis R&D Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab, Vernalis R&D Ltd filed Critical Servier Lab
Publication of CU20160010A7 publication Critical patent/CU20160010A7/es
Publication of CU24352B1 publication Critical patent/CU24352B1/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/472Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965Non-condensed pyrazines
    • A61K31/497Non-condensed pyrazines containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • A61K31/675Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/10X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
CUP2016000010A 2013-07-23 2014-07-22 DERIVADOS DE ISOINDOLINA O ISOQUINOLINA ÚTILES COMO INHIBIDORES ANTIAPOPTÓTICOS DE Bcl-2 EN EL TRATAMIENTO DE CÁNCERES Y ENFERMEDADES AUTOINMUNES Y DEL SISTEMA INMUNITARIO, Y COMPOSICIONES FARMACÉUTICAS QUE LOS CONTIENEN CU24352B1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR1357276A FR3008977A1 (fr) 2013-07-23 2013-07-23 Nouveaux derives d'isoindoline ou d'isoquinoline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
PCT/EP2014/065764 WO2015011164A1 (en) 2013-07-23 2014-07-22 New isoindoline or isoquinoline compounds, a process for their preparation and pharmaceutical compositions containing them

Publications (2)

Publication Number Publication Date
CU20160010A7 CU20160010A7 (es) 2016-06-29
CU24352B1 true CU24352B1 (es) 2018-07-05

Family

ID=49911606

Family Applications (1)

Application Number Title Priority Date Filing Date
CUP2016000010A CU24352B1 (es) 2013-07-23 2014-07-22 DERIVADOS DE ISOINDOLINA O ISOQUINOLINA ÚTILES COMO INHIBIDORES ANTIAPOPTÓTICOS DE Bcl-2 EN EL TRATAMIENTO DE CÁNCERES Y ENFERMEDADES AUTOINMUNES Y DEL SISTEMA INMUNITARIO, Y COMPOSICIONES FARMACÉUTICAS QUE LOS CONTIENEN

Country Status (49)

Country Link
US (3) US9809574B2 (xx)
EP (1) EP3024826B1 (xx)
JP (1) JP6395829B2 (xx)
KR (1) KR102008431B1 (xx)
CN (2) CN109456324B (xx)
AP (1) AP2016008989A0 (xx)
AR (1) AR097009A1 (xx)
AU (1) AU2014295101B2 (xx)
BR (1) BR112016001080B1 (xx)
CA (1) CA2919572C (xx)
CL (1) CL2016000148A1 (xx)
CR (1) CR20160030A (xx)
CU (1) CU24352B1 (xx)
CY (1) CY1121247T1 (xx)
DK (1) DK3024826T3 (xx)
DO (1) DOP2016000009A (xx)
EA (1) EA032301B1 (xx)
ES (1) ES2711371T3 (xx)
FR (1) FR3008977A1 (xx)
GE (2) GEP20207070B (xx)
HK (1) HK1218754A1 (xx)
HR (1) HRP20190277T1 (xx)
HU (1) HUE041443T2 (xx)
IL (1) IL243449A0 (xx)
JO (1) JO3457B1 (xx)
LT (1) LT3024826T (xx)
MA (1) MA38801B1 (xx)
MD (1) MD4793C1 (xx)
ME (1) ME03346B (xx)
MX (1) MX365373B (xx)
MY (1) MY193619A (xx)
NI (1) NI201600016A (xx)
NZ (1) NZ716155A (xx)
PE (1) PE20160241A1 (xx)
PH (1) PH12016500034A1 (xx)
PL (1) PL3024826T3 (xx)
PT (1) PT3024826T (xx)
RS (1) RS58344B1 (xx)
RU (1) RU2689305C2 (xx)
SA (1) SA516370439B1 (xx)
SG (1) SG11201600205XA (xx)
SI (1) SI3024826T1 (xx)
TN (1) TN2016000003A1 (xx)
TR (1) TR201819155T4 (xx)
TW (1) TWI560184B (xx)
UA (1) UA117490C2 (xx)
UY (1) UY35664A (xx)
WO (1) WO2015011164A1 (xx)
ZA (1) ZA201600198B (xx)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3008977A1 (fr) * 2013-07-23 2015-01-30 Servier Lab Nouveaux derives d'isoindoline ou d'isoquinoline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
SG11201809173TA (en) 2016-04-20 2018-11-29 Bristol Myers Squibb Co Substituted bicyclic heterocyclic compounds
AU2019295765B2 (en) 2018-06-27 2024-08-29 Yumanity, Inc. Proteasome activity enhancing compounds
PH12022551189A1 (en) * 2019-11-15 2023-10-09 Wuhan Ll Science & Technology Development Co Ltd Rock inhibitor, preparation method therefor and use thereof
CN112010796B (zh) * 2020-09-17 2022-04-22 浙江大学 光学活性3-(1,1-二氟-2-氧-2-芳基乙基)异吲哚啉-1-酮衍生物制备方法
TWI843989B (zh) 2021-02-19 2024-06-01 美商美威高能離子醫療系統公司 用於粒子治療系統之支架
US20240208926A1 (en) * 2021-03-24 2024-06-27 Les Laboratoires Servier New process for the synthesis of 5-{5-chloro-2-[(3s)-3-[(morpholin-4-yl)methyl]-3,4-dihydroisoquinoline-2(1h)- carbonyl]phenyl}-1,2-dimethyl-1h-pyrrole-3-carboxylic acid derivatives and its application for the production of pharmaceutical compounds
KR20240152365A (ko) 2022-02-24 2024-10-21 르 라보레또레 쎄르비에르 5-[7-(3,4-디히드로-1h-이소퀴놀린-2-카르보닐)-1,2,3,4-테트라히드로이소퀴놀린-6-일]-1h-피롤-3-카르복스아미드유도체, 그를 함유하는 제약 조성물 및 아폽토시스촉진제로서의 그의 용도
IL317101A (en) 2022-05-20 2025-01-01 Novartis Ag Antibody-drug conjugates of anticancer compounds and methods of using them
KR20250149173A (ko) * 2023-03-31 2025-10-15 미쓰이 가가쿠 가부시키가이샤 카바메이트 화합물
WO2025111450A1 (en) 2023-11-22 2025-05-30 Les Laboratoires Servier Anti-cd74 antibody-drug conjugates and methods of use thereof
WO2025111431A1 (en) 2023-11-22 2025-05-30 Les Laboratoires Servier Anti-cd7 antibody-drug conjugates and methods of use thereof

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003234464B2 (en) 2002-05-03 2009-06-04 Exelixis, Inc. Protein kinase modulators and methods of use
WO2004096774A1 (en) * 2003-05-01 2004-11-11 Glaxo Group Limited Acyl isoindoline derivatives and acyl isoquinoline derivatives as anti-viral agents
US20050070570A1 (en) 2003-06-18 2005-03-31 4Sc Ag Novel potassium channels modulators
EP1778206A4 (en) * 2004-08-20 2009-08-05 Univ Michigan SMALL MOLECULE INHIBITORS FROM MEMBERS OF THE ANTIOPTOTIC BCL-2 FAMILY AND USES THEREOF
BRPI0514504A (pt) * 2004-08-20 2008-06-10 Univ Michigan pequenas moléculas inibidoras de membros da famìlia bcl-2 anti-apoptóticos e os usos das mesmas
KR20070107000A (ko) * 2005-02-15 2007-11-06 노보 노르디스크 에이/에스 3,4-디히드로-1h-이소퀴놀린-2-카르복실산5-아미노피리딘-2-일 에스테르
EP3243814B1 (en) 2007-04-16 2018-10-17 AbbVie Inc. 7-substituted indole as mcl-1 inhibitors
WO2009073545A2 (en) 2007-11-30 2009-06-11 Maxthera, Inc. Tetrahydro-isoquinoline ppat inhibitors as antibacterial agents
WO2009102468A1 (en) 2008-02-13 2009-08-20 Cgi Pharmaceuticals, Inc. 6-aryl-imidaz0[l, 2-a] pyrazine derivatives, method of making, and method of use thereof
WO2009102463A2 (en) 2008-02-14 2009-08-20 Connor Reynolds Pet waste vacuum system and apparatus, disposable liners therefor, and a method of collecting pet waste using same
EP2714681B1 (en) * 2011-05-25 2015-06-24 Bristol-Myers Squibb Company Substituted sulfonamides useful as antiapoptotic bcl inhibitors
KR20140104047A (ko) * 2011-12-23 2014-08-27 노파르티스 아게 Bcl2와 결합 파트너의 상호작용을 억제하기 위한 화합물
KR101682779B1 (ko) 2011-12-27 2016-12-05 인텔 코포레이션 게이팅된 도메인의 부하 조건들에 기초하여 게이팅된 도메인의 활성 상태 동안 전력 게이트들을 제어하기 위한 방법들 및 시스템들
FR2986002B1 (fr) * 2012-01-24 2014-02-21 Servier Lab Nouveaux derives d'indolizine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR3008977A1 (fr) * 2013-07-23 2015-01-30 Servier Lab Nouveaux derives d'isoindoline ou d'isoquinoline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR3008979B1 (fr) * 2013-07-23 2015-07-24 Servier Lab Nouveaux derives phosphates, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
CR20160030A (es) 2016-03-09
PH12016500034B1 (en) 2016-03-28
CY1121247T1 (el) 2020-05-29
HK1222856A1 (en) 2017-07-14
TW201504228A (zh) 2015-02-01
CA2919572A1 (en) 2015-01-29
EA201600122A1 (ru) 2016-07-29
US20160194304A1 (en) 2016-07-07
MA38801A1 (fr) 2018-05-31
DK3024826T3 (en) 2019-03-04
CN109456324B (zh) 2022-04-22
CA2919572C (en) 2017-06-20
JP6395829B2 (ja) 2018-09-26
RU2016106003A (ru) 2017-08-28
US11028070B2 (en) 2021-06-08
GEAP201914063A (en) 2019-10-25
JO3457B1 (ar) 2020-07-05
PL3024826T3 (pl) 2019-05-31
EP3024826B1 (en) 2018-11-14
ME03346B (me) 2019-10-20
SA516370439B1 (ar) 2019-06-27
NZ716155A (en) 2019-05-31
PE20160241A1 (es) 2016-04-30
TR201819155T4 (tr) 2019-01-21
SI3024826T1 (sl) 2019-03-29
CN105431422B (zh) 2019-08-30
LT3024826T (lt) 2019-02-25
HUE041443T2 (hu) 2019-05-28
TWI560184B (en) 2016-12-01
AU2014295101B2 (en) 2018-05-31
HRP20190277T1 (hr) 2019-04-05
ES2711371T3 (es) 2019-05-03
MD4793C1 (ro) 2022-09-30
US20180002313A1 (en) 2018-01-04
UY35664A (es) 2015-01-30
WO2015011164A1 (en) 2015-01-29
UA117490C2 (uk) 2018-08-10
CN105431422A (zh) 2016-03-23
NI201600016A (es) 2016-02-11
AP2016008989A0 (en) 2016-01-31
DOP2016000009A (es) 2016-03-15
MA38801B1 (fr) 2019-03-29
CN109456324A (zh) 2019-03-12
KR20160033224A (ko) 2016-03-25
RS58344B1 (sr) 2019-03-29
US10689364B2 (en) 2020-06-23
MX365373B (es) 2019-05-31
MD20160018A2 (ro) 2016-07-31
CL2016000148A1 (es) 2016-08-12
US9809574B2 (en) 2017-11-07
PT3024826T (pt) 2019-01-28
EA032301B1 (ru) 2019-05-31
FR3008977A1 (fr) 2015-01-30
AU2014295101A1 (en) 2016-02-04
EP3024826A1 (en) 2016-06-01
HK1218754A1 (zh) 2017-03-10
CU20160010A7 (es) 2016-06-29
IL243449A0 (en) 2016-02-29
JP2016525529A (ja) 2016-08-25
AR097009A1 (es) 2016-02-10
MX2016000904A (es) 2016-04-25
KR102008431B1 (ko) 2019-08-07
RU2689305C2 (ru) 2019-05-27
SG11201600205XA (en) 2016-02-26
BR112016001080B1 (pt) 2022-04-05
MY193619A (en) 2022-10-20
TN2016000003A1 (en) 2017-07-05
ZA201600198B (en) 2019-07-31
PH12016500034A1 (en) 2016-03-28
GEP20207070B (en) 2020-02-25
MD4793B1 (ro) 2022-02-28
BR112016001080A2 (xx) 2017-07-25
US20200262816A1 (en) 2020-08-20

Similar Documents

Publication Publication Date Title
CU24352B1 (es) DERIVADOS DE ISOINDOLINA O ISOQUINOLINA ÚTILES COMO INHIBIDORES ANTIAPOPTÓTICOS DE Bcl-2 EN EL TRATAMIENTO DE CÁNCERES Y ENFERMEDADES AUTOINMUNES Y DEL SISTEMA INMUNITARIO, Y COMPOSICIONES FARMACÉUTICAS QUE LOS CONTIENEN
MX2017004541A (es) Derivados espirodiamina como inhibidores de la aldosterona sintasa.
CU20160011A7 (es) Derivados de tetrahidroisoquinolina útiles como inhibidores bcl-2 antiapoptóticos y composiciones farmacéuticas que los contienen
CL2017002452A1 (es) Nuevos compuestos bicíclicos
CU20160162A7 (es) Derivados de pirrolidina-2,5-diona,para usar como inhibidores ido1 y composiciones farmacéuticas que los contienen
MX2016012103A (es) Agonistas del receptor muscarinico.
NI201400079A (es) Nuevos derivados de pirrol, su procedimiento de preparación y las composiciones farmacéuticas que los contienen
ECSP14008606A (es) Nuevos derivados de indolizina, su procedimiento de preparación y las composiciones farmacéuticas que los contienen
NI201400080A (es) Nuevos derivados fosfatos, su procedimiento de preparación y las composiciones farmacéuticas que los contienen
UY35898A (es) ?compuestos inhibidores de syk y composiciones que los comprenden?.
CR20140106A (es) Compuestos y composiciones como inhibidores de la quinasa c-kit
MX378155B (es) Derivados de 9h-pirrolo-dipiridina.
CL2016000150A1 (es) Compuestos y composiciones como inhibidores de la mek
UY35653A (es) Nuevos derivados de indol y de pirrol, su procedimiento de preparación y las composiciones farmacéuticas que los contienen
TR201908265T4 (tr) Isı şok transkripsiyon faktörü 1 in inhibitörleri olarak kaynaşık 1,4-dihidrodioksin türevleri.
CL2016001937A1 (es) Compuestos de benzopirano funcionalizados y uso de los mismos
CY1120602T1 (el) [1,2,4]τριαζολο[4,3-β]πυριδαζινες για χρηση στη θεραπευτικη αντιμετωπιση πολλαπλασιαστικων ασθενειων
PE20150674A1 (es) Azaheterociclos como inhibidores de bir2 y/o bir3
BR112015029216A2 (pt) tratamento de vasculopatia coroidal polipoidal
UY35600A (es) "composiciones farmacéuticas que comprenden compuestos derivados de triazolopiridina y métodos para prepararlas"
UY34459A (es) Compuestos para tratamiento y prevención de adherencias, composiciones farmacéuticas relacionadas c on los compuestos y métodos para la prevención y tratamiento de adherencias
EA202091923A1 (ru) Замещенные трициклические соединения как ингибиторы fgfr