CU23895B1 - Anticuerpos recombinantes contra el factor de crecimiento del endotelio vascular (vegf) obtenidos mediante mutagénesis de regiones variables - Google Patents

Anticuerpos recombinantes contra el factor de crecimiento del endotelio vascular (vegf) obtenidos mediante mutagénesis de regiones variables

Info

Publication number: CU23895B1
Authority: CU; Cuba
Prior art keywords: vegf; mutagenesis; growth factor; antibodies against; variable regions
Prior art date: 2010-12-28

Application number

CU20100264A

Other languages

English (en)

Other versions

CU20100264A7 (es

Inventor

Sanchez Lincidio Perez

Merino Amaury Pupo

Pozo Yasmiana Munoz

Ordas Humberto Lamdan

Avila Marta Ayala

Dorantes Gertrudis Rojas

Cowley Jorge Victor Gavilondo

Original Assignee

Biorec Sa

Ct Ingenieria Genetica Biotech

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2010-12-28

Filing date

2010-12-28

Publication date

2013-05-31

2010-12-28 Application filed by Biorec Sa, Ct Ingenieria Genetica Biotech filed Critical Biorec Sa

2010-12-28 Priority to CU20100264A priority Critical patent/CU23895B1/es

2011-12-26 Priority to KR1020137019847A priority patent/KR101896108B1/ko

2011-12-26 Priority to AU2011352474A priority patent/AU2011352474B2/en

2011-12-26 Priority to MYPI2013701133A priority patent/MY166550A/en

2011-12-26 Priority to JP2013546584A priority patent/JP6082698B2/ja

2011-12-26 Priority to RU2013134983/10A priority patent/RU2557309C2/ru

2011-12-26 Priority to EP11820879.2A priority patent/EP2662388B1/en

2011-12-26 Priority to CN201180066879.4A priority patent/CN103370336B/zh

2011-12-26 Priority to US13/976,060 priority patent/US9505830B2/en

2011-12-26 Priority to BR112013016684A priority patent/BR112013016684A2/pt

2011-12-26 Priority to MX2013007645A priority patent/MX344915B/es

2011-12-26 Priority to ES11820879.2T priority patent/ES2687183T3/es

2011-12-26 Priority to CA2823233A priority patent/CA2823233C/en

2011-12-26 Priority to PCT/CU2011/000009 priority patent/WO2012089176A1/es

2011-12-27 Priority to ARP110104967A priority patent/AR084618A1/es

2011-12-27 Priority to TW100148878A priority patent/TWI555757B/zh

2011-12-28 Priority to UY0001033844A priority patent/UY33844A/es

2012-07-31 Publication of CU20100264A7 publication Critical patent/CU20100264A7/es

2013-05-31 Publication of CU23895B1 publication Critical patent/CU23895B1/es

2013-07-04 Priority to ZA2013/05031A priority patent/ZA201305031B/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1021—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against cytokines, e.g. growth factors, VEGF, TNF, lymphokines or interferons
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Immunology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Epidemiology (AREA)
Physics & Mathematics (AREA)
Optics & Photonics (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Vascular Medicine (AREA)
Ophthalmology & Optometry (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Urology & Nephrology (AREA)
Oncology (AREA)
Microbiology (AREA)
Mycology (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

CU20100264A 2010-12-28 2010-12-28 Anticuerpos recombinantes contra el factor de crecimiento del endotelio vascular (vegf) obtenidos mediante mutagénesis de regiones variables CU23895B1 (es)

Priority Applications (18)

Application Number	Priority Date	Filing Date	Title
CU20100264A CU23895B1 (es)	2010-12-28	2010-12-28	Anticuerpos recombinantes contra el factor de crecimiento del endotelio vascular (vegf) obtenidos mediante mutagénesis de regiones variables
BR112013016684A BR112013016684A2 (pt)	2010-12-28	2011-12-26	anticorpos recombinantes, vetores que codificam para os anticorpos recombinantes, composições farmacêuticas e uso dos anticorpos recombinantes
MX2013007645A MX344915B (es)	2010-12-28	2011-12-26	Anticuerpos recombinantes contra el factor de crecimiento del endotelio vascular (vegf) obtenidos mediante mutagenesis de regiones variables.
MYPI2013701133A MY166550A (en)	2010-12-28	2011-12-26	Recombinant antibodies against the vascular endothelium growth factor (vegf) obtained by variable region mutagenesis
JP2013546584A JP6082698B2 (ja)	2010-12-28	2011-12-26	可変領域の突然変異誘発によって得られる血管内皮増殖因子（ｖｅｇｆ）に対する組換え抗体
RU2013134983/10A RU2557309C2 (ru)	2010-12-28	2011-12-26	Рекомбинантные антитела против фактора роста эндотелия сосудов (vegf), полученные посредством мутагенеза вариабельной области
EP11820879.2A EP2662388B1 (en)	2010-12-28	2011-12-26	Recombinant antibodies to the vascular endothelial growth factor (vegf) which are obtained by means of mutagenesis of variable regions
CN201180066879.4A CN103370336B (zh)	2010-12-28	2011-12-26	通过可变区诱变获得的抗血管内皮生长因子(vegf)重组抗体
US13/976,060 US9505830B2 (en)	2010-12-28	2011-12-26	Recombinant antibodies to the vascular endothelial growth factor (VEGF) which are obtained by means of mutagenesis of variable regions
KR1020137019847A KR101896108B1 (ko)	2010-12-28	2011-12-26	가변부의 돌연변이에 의하여 제조한 맥관 내피 성장 인자(vegf)에 대한 재조합 항체
AU2011352474A AU2011352474B2 (en)	2010-12-28	2011-12-26	Recombinant antibodies to the vascular endothelial growth factor (VEGF-A) which are obtained by means of mutagenesis of variable regions
ES11820879.2T ES2687183T3 (es)	2010-12-28	2011-12-26	Anticuerpos recombinantes contra el factor de crecimiento endotelial vascular (VEGF) que se obtienen mediante mutagénesis de regiones variables
CA2823233A CA2823233C (en)	2010-12-28	2011-12-26	Recombinant antibodies against the vascular endothelium growth factor (vegf) obtained by variable region mutagenesis
PCT/CU2011/000009 WO2012089176A1 (es)	2010-12-28	2011-12-26	Anticuerpos recombinantes contra el factor de crecimiento del endotelio vascular (vegf) obtenidos mediante mutagenesis de regiones variables
ARP110104967A AR084618A1 (es)	2010-12-28	2011-12-27	Anticuerpos recombinantes contra el factor de crecimiento del endotelio vascular (vegf) obtenidos mediante mutagenesis de regiones variables
TW100148878A TWI555757B (zh)	2010-12-28	2011-12-27	藉變異區突變獲得的抗血管內皮生長因子（ｖｅｇｆ）之重組抗體
UY0001033844A UY33844A (es)	2010-12-28	2011-12-28	Anticuerpos recombinantes contra el factor de crecimiento del endotelio vascular (vegf)obtenidos mediante mutagenesis de regiones variables
ZA2013/05031A ZA201305031B (en)	2010-12-28	2013-07-04	Recombinant antibodies to the vascular endothelial growth factor (vegf) which are obtained by means of matagenesis of variable regions

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CU20100264A CU23895B1 (es)	2010-12-28	2010-12-28	Anticuerpos recombinantes contra el factor de crecimiento del endotelio vascular (vegf) obtenidos mediante mutagénesis de regiones variables

Publications (2)

Publication Number	Publication Date
CU20100264A7 CU20100264A7 (es)	2012-07-31
CU23895B1 true CU23895B1 (es)	2013-05-31

Family

ID=45768110

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CU20100264A CU23895B1 (es)	2010-12-28	2010-12-28	Anticuerpos recombinantes contra el factor de crecimiento del endotelio vascular (vegf) obtenidos mediante mutagénesis de regiones variables

Country Status (18)

Country	Link
US (1)	US9505830B2 (es)
EP (1)	EP2662388B1 (es)
JP (1)	JP6082698B2 (es)
KR (1)	KR101896108B1 (es)
CN (1)	CN103370336B (es)
AR (1)	AR084618A1 (es)
AU (1)	AU2011352474B2 (es)
BR (1)	BR112013016684A2 (es)
CA (1)	CA2823233C (es)
CU (1)	CU23895B1 (es)
ES (1)	ES2687183T3 (es)
MX (1)	MX344915B (es)
MY (1)	MY166550A (es)
RU (1)	RU2557309C2 (es)
TW (1)	TWI555757B (es)
UY (1)	UY33844A (es)
WO (1)	WO2012089176A1 (es)
ZA (1)	ZA201305031B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US9840553B2 (en)	2014-06-28	2017-12-12	Kodiak Sciences Inc.	Dual PDGF/VEGF antagonists
CL2014002941A1 (es) *	2014-10-30	2015-04-06	Univ Concepcion	Moléculas polipeptídicas contra el factor de crecimiento del endotelio vascular (vegf)
CN108712911A (zh)	2015-12-30	2018-10-26	科达制药股份有限公司	抗体及其缀合物
EP3731864A1 (en) *	2017-12-29	2020-11-04	F. Hoffmann-La Roche SA	Anti-vegf antibodies and methods of use
WO2019169341A1 (en)	2018-03-02	2019-09-06	Kodiak Sciences Inc.	Il-6 antibodies and fusion constructs and conjugates thereof
WO2020127864A1 (en) *	2018-12-21	2020-06-25	F. Hoffmann-La Roche Ag	Method for improving inhibition of vegf-binding to vegf-r1 of an anti-vegf antibody
US11912784B2 (en)	2019-10-10	2024-02-27	Kodiak Sciences Inc.	Methods of treating an eye disorder
CU24770B1 (es)	2021-12-15	2025-09-01	Ct Ingenieria Genetica Biotecnologia	Polipéptidos que se unen al factor de crecimiento del endotelio vascular y al factor básico de crecimiento de fibroblastos

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU690528B2 (en)	1992-12-04	1998-04-30	Medical Research Council	Multivalent and multispecific binding proteins, their manufacture and use
US5730977A (en)	1995-08-21	1998-03-24	Mitsui Toatsu Chemicals, Inc.	Anti-VEGF human monoclonal antibody
US20050106667A1 (en)	2003-08-01	2005-05-19	Genentech, Inc	Binding polypeptides with restricted diversity sequences
CU23636A1 (es) *	2006-11-01	2011-03-21	Ct Ingenieria Genetica Biotech	Anticuerpos recombinantes contra el factor de crecimiento del endotelio vascular (vegf)
US8040615B2 (en)	2007-02-27	2011-10-18	Nikon Corporation	Zoom lens and optical apparatus equipped therewith
US9209965B2 (en)	2014-01-14	2015-12-08	Microsemi Semiconductor Ulc	Network interface with clock recovery module on line card

2010
- 2010-12-28 CU CU20100264A patent/CU23895B1/es active IP Right Grant
2011
- 2011-12-26 ES ES11820879.2T patent/ES2687183T3/es active Active
- 2011-12-26 WO PCT/CU2011/000009 patent/WO2012089176A1/es not_active Ceased
- 2011-12-26 MX MX2013007645A patent/MX344915B/es active IP Right Grant
- 2011-12-26 JP JP2013546584A patent/JP6082698B2/ja not_active Expired - Fee Related
- 2011-12-26 CA CA2823233A patent/CA2823233C/en not_active Expired - Fee Related
- 2011-12-26 CN CN201180066879.4A patent/CN103370336B/zh not_active Expired - Fee Related
- 2011-12-26 US US13/976,060 patent/US9505830B2/en active Active
- 2011-12-26 EP EP11820879.2A patent/EP2662388B1/en active Active
- 2011-12-26 MY MYPI2013701133A patent/MY166550A/en unknown
- 2011-12-26 KR KR1020137019847A patent/KR101896108B1/ko not_active Expired - Fee Related
- 2011-12-26 RU RU2013134983/10A patent/RU2557309C2/ru active
- 2011-12-26 BR BR112013016684A patent/BR112013016684A2/pt not_active Application Discontinuation
- 2011-12-26 AU AU2011352474A patent/AU2011352474B2/en not_active Ceased
- 2011-12-27 TW TW100148878A patent/TWI555757B/zh not_active IP Right Cessation
- 2011-12-27 AR ARP110104967A patent/AR084618A1/es unknown
- 2011-12-28 UY UY0001033844A patent/UY33844A/es not_active Application Discontinuation
2013
- 2013-07-04 ZA ZA2013/05031A patent/ZA201305031B/en unknown

Also Published As

Publication number	Publication date
JP6082698B2 (ja)	2017-02-15
AR084618A1 (es)	2013-05-29
TWI555757B (zh)	2016-11-01
ZA201305031B (en)	2014-03-26
CN103370336B (zh)	2015-11-25
MY166550A (en)	2018-07-16
TW201305203A (zh)	2013-02-01
CA2823233C (en)	2020-06-09
KR101896108B1 (ko)	2018-09-10
AU2011352474B2 (en)	2017-02-16
US9505830B2 (en)	2016-11-29
CU20100264A7 (es)	2012-07-31
BR112013016684A2 (pt)	2017-06-06
KR20140019316A (ko)	2014-02-14
EP2662388B1 (en)	2018-08-22
WO2012089176A1 (es)	2012-07-05
CN103370336A (zh)	2013-10-23
ES2687183T3 (es)	2018-10-24
MX2013007645A (es)	2013-12-02
MX344915B (es)	2017-01-10
UY33844A (es)	2012-07-31
JP2014504498A (ja)	2014-02-24
RU2557309C2 (ru)	2015-07-20
CA2823233A1 (en)	2012-07-05
RU2013134983A (ru)	2015-02-10
US20140086829A1 (en)	2014-03-27
EP2662388A1 (en)	2013-11-13
AU2011352474A1 (en)	2013-08-15

Publication	Publication Date	Title
LTC2785706I2 (lt)	2023-07-10	Pakeistieji 4-fenil-piridinai, skirti su nk-receptoriumi susijusių ligų gydymui
CU23895B1 (es)	2013-05-31	Anticuerpos recombinantes contra el factor de crecimiento del endotelio vascular (vegf) obtenidos mediante mutagénesis de regiones variables
EP2830533A4 (en)	2015-12-30	BIOKOMPATIBLE NETWORK IMPLANT
LT2916860T (lt)	2020-07-10	Diabeto gydymui skirta kompozicija, apimanti oksintomodulino analogą
EP2880863A4 (en)	2016-04-27	CONTEXT-CONTROLLED ADJUSTMENT OF CAMERA PARAMETERS
BR112013019558A2 (pt)	2018-07-10	válvula cardíaca protética.
PL3287142T3 (pl)	2021-12-27	Sposoby leczenia chorób związanych z aktywacją dopełniacza zależną od masp-2
EP2779855A4 (en)	2015-12-16	AUTOMATED MANUFACTURE OF SHOES
BR112013019556A2 (pt)	2018-07-10	válvula cardíaca protética
HUE071324T2 (hu)	2025-08-28	Szívbillentyû protézis
DK3646824T3 (da)	2021-05-25	Kateterbaseret hjerteklapprotese
CO6910165A2 (es)	2014-03-31	Variantes del factor 21 del crecimiento de fibroblastos
PL2861629T3 (pl)	2016-12-30	NDBR o wysokich wartościach Mooneya ze skokiem Mooneya
EP2706957A4 (en)	2015-03-25	PROCEDURE FOR NETWORK SKIN PROTESTS
UA110813C2 (uk)	2016-02-25	Лікування ліподистрофії
FR2994831B1 (fr)	2015-08-21	Prothese de main.
EP2661243A4 (en)	2016-01-20	FABRICED CONSTRUCTS
HRP20180962T1 (hr)	2018-10-19	Liječenje bolesti zgrušavanja primjenom rekombinantnog vwf
BR112014029176A2 (pt)	2017-06-27	formulações injetáveis de aprepitante
ZA201402570B (en)	2015-03-25	Method for controlling the planting of olive trees for the continuous mechanical harvesting of the olives
BR112017021043A2 (pt)	2018-07-24	“previsão de produção de safra nacional durante o período de crescimento”
EP2844692A4 (en)	2016-03-09	OXYGEN ABSORBING COMPOSITIONS
EP2780012A4 (en)	2015-07-29	Methods of treatment with deferiprone
EP2777314A4 (en)	2015-04-22	Feedback messaging
IL227998B (en)	2018-12-31	Pest control

Legal Events

Date	Code	Title	Description
2013-04-08	FG	Grant of patent