CU20180065A7 - Composiciones y métodos para disminuir la expresión de tau - Google Patents
Composiciones y métodos para disminuir la expresión de tauInfo
- Publication number
- CU20180065A7 CU20180065A7 CU2018000065A CU20180065A CU20180065A7 CU 20180065 A7 CU20180065 A7 CU 20180065A7 CU 2018000065 A CU2018000065 A CU 2018000065A CU 20180065 A CU20180065 A CU 20180065A CU 20180065 A7 CU20180065 A7 CU 20180065A7
- Authority
- CU
- Cuba
- Prior art keywords
- compositions
- methods
- tau expression
- decrease tau
- decrease
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/322—2'-R Modification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
- C12N2310/334—Modified C
- C12N2310/3341—5-Methylcytosine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/341—Gapmers, i.e. of the type ===---===
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Psychology (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
<p>Se proporcionan en esta solicitud composiciones y métodos para disminuir Ia expresión de proteína y ARNm tau. Estas composiciones y métodos son útiles en el tratamiento de enfermedades y trastornos relacionados con tau.</p>
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562270165P | 2015-12-21 | 2015-12-21 | |
| PCT/IB2016/057794 WO2017109679A1 (en) | 2015-12-21 | 2016-12-19 | Compositions and methods for decreasing tau expression |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CU20180065A7 true CU20180065A7 (es) | 2018-11-06 |
| CU24574B1 CU24574B1 (es) | 2022-01-13 |
Family
ID=57758674
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CU2018000065A CU24574B1 (es) | 2015-12-21 | 2016-12-19 | Oligonucleótido que contiene una secuencia nucleobase para disminuir la expresión de tau |
Country Status (40)
| Country | Link |
|---|---|
| US (2) | US11473083B2 (es) |
| EP (3) | EP4678748A2 (es) |
| JP (4) | JP7027328B2 (es) |
| KR (2) | KR20250112919A (es) |
| CN (2) | CN109072237B (es) |
| AR (1) | AR107579A1 (es) |
| AU (2) | AU2016376034B2 (es) |
| CA (1) | CA3008094A1 (es) |
| CL (3) | CL2018001652A1 (es) |
| CO (1) | CO2018006297A2 (es) |
| CR (1) | CR20200609A (es) |
| CU (1) | CU24574B1 (es) |
| DK (1) | DK3394259T3 (es) |
| DO (1) | DOP2018000151A (es) |
| EA (2) | EA036417B1 (es) |
| EC (1) | ECSP18050575A (es) |
| ES (1) | ES2984631T3 (es) |
| FI (1) | FI3394259T3 (es) |
| HR (1) | HRP20240672T1 (es) |
| HU (1) | HUE066548T2 (es) |
| IL (3) | IL296844B2 (es) |
| JO (2) | JOP20200228A1 (es) |
| LT (1) | LT3394259T (es) |
| MA (2) | MA71468A (es) |
| MX (2) | MX2018007726A (es) |
| MY (1) | MY191737A (es) |
| PE (2) | PE20241069A1 (es) |
| PH (1) | PH12018501207B1 (es) |
| PL (1) | PL3394259T3 (es) |
| PT (1) | PT3394259T (es) |
| RS (1) | RS65535B1 (es) |
| RU (1) | RU2747734C2 (es) |
| SA (1) | SA518391831B1 (es) |
| SG (2) | SG10201913434PA (es) |
| SI (1) | SI3394259T1 (es) |
| SV (1) | SV2018005714A (es) |
| TW (2) | TWI834177B (es) |
| UY (1) | UY37038A (es) |
| WO (1) | WO2017109679A1 (es) |
| ZA (1) | ZA201803661B (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2831232A4 (en) | 2012-03-30 | 2015-11-04 | Univ Washington | METHOD FOR MODULATING TAU EXPRESSION TO REDUCE PROBLEMS AND MODIFY A NEURODEGENERATIVE SYNDROME |
| TW202246503A (zh) | 2013-07-19 | 2022-12-01 | 美商百健Ma公司 | 用於調節τ蛋白表現之組合物 |
| JOP20190065A1 (ar) | 2016-09-29 | 2019-03-28 | Ionis Pharmaceuticals Inc | مركبات وطرق لتقليل التعبير عن tau |
| MA52149A (fr) * | 2018-03-13 | 2021-01-20 | Janssen Pharmaceutica Nv | Oligonucléotides modifiés et méthodes d'utilisation dans les tauopathies |
| CN112567033A (zh) | 2018-07-03 | 2021-03-26 | 豪夫迈·罗氏有限公司 | 用于调节Tau表达之寡核苷酸 |
| US20230203486A1 (en) * | 2020-03-30 | 2023-06-29 | Alnylam Pharmaceuticals, Inc. | MICROTUBULE ASSOCIATED PROTEIN TAU (MAPT) iRNA AGENT COMPOSITIONS AND METHODS OF USE THEREOF |
| CN113817728A (zh) * | 2020-06-19 | 2021-12-21 | 四川大学华西医院 | 一种有效干扰Tau蛋白表达的重组慢病毒及其应用 |
| EP4355878A4 (en) * | 2021-06-16 | 2025-04-09 | Empirico Inc. | TREATMENT OF MTRES1-RELATED DISEASES AND DISORDERS |
| JP2024525866A (ja) * | 2021-07-16 | 2024-07-12 | アプター バイオ,インク. | 遺伝子発現を調節するためのポリヌクレオチド組成物および方法 |
| MX2024003519A (es) | 2021-09-24 | 2024-04-01 | Alnylam Pharmaceuticals Inc | Composiciones de agentes de acido ribonucleico de interferencia (arni) de proteina tau asociada a microtubulos (mapt) y sus metodos de uso. |
| EP4608981A1 (en) * | 2022-10-25 | 2025-09-03 | Empirico Inc. | Gene therapy treatment of mtres1 related diseases and disorders |
| CN120958129A (zh) * | 2023-01-18 | 2025-11-14 | 阿普塔生物公司 | 用于治疗癌症的多核苷酸组合物和方法 |
| CN121127586A (zh) * | 2023-01-18 | 2025-12-12 | 阿普塔生物公司 | 用于治疗神经退行性疾病的多核苷酸组合物和方法 |
| AU2024258561A1 (en) * | 2023-04-20 | 2025-10-30 | Adarx Pharmaceuticals, Inc. | Mapt-modulating compositions and methods of use thereof |
| WO2025188990A1 (en) * | 2024-03-08 | 2025-09-12 | Eli Lilly And Company | Mapt antisense oligonucleotide |
| US20250302980A1 (en) * | 2024-03-31 | 2025-10-02 | Arrowhead Pharmaceuticals, Inc. | RNAi Agents for Inhibiting Expression of Microtubule Associated Protein Tau (MAPT), Compositions Thereof, and Methods of Use |
Family Cites Families (106)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL154598B (nl) | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
| US3817837A (en) | 1971-05-14 | 1974-06-18 | Syva Corp | Enzyme amplification assay |
| US3939350A (en) | 1974-04-29 | 1976-02-17 | Board Of Trustees Of The Leland Stanford Junior University | Fluorescent immunoassay employing total reflection for activation |
| US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
| US4277437A (en) | 1978-04-05 | 1981-07-07 | Syva Company | Kit for carrying out chemically induced fluorescence immunoassay |
| US4275149A (en) | 1978-11-24 | 1981-06-23 | Syva Company | Macromolecular environment control in specific receptor assays |
| US4366241A (en) | 1980-08-07 | 1982-12-28 | Syva Company | Concentrating zone method in heterogeneous immunoassays |
| WO1991010671A1 (en) | 1990-01-11 | 1991-07-25 | Isis Pharmaceuticals, Inc. | Compositions and methods for detecting and modulating rna activity and gene expression |
| US5149797A (en) | 1990-02-15 | 1992-09-22 | The Worcester Foundation For Experimental Biology | Method of site-specific alteration of rna and production of encoded polypeptides |
| US5789573A (en) | 1990-08-14 | 1998-08-04 | Isis Pharmaceuticals, Inc. | Antisense inhibition of ICAM-1, E-selectin, and CMV IE1/IE2 |
| US20020052331A1 (en) | 1990-08-14 | 2002-05-02 | Brenda Baker | Compositions and methods for antisense inhibition of protein translation |
| US7408027B1 (en) | 1991-12-06 | 2008-08-05 | Max-Planck-Gesellschaft Zur Forderung Der Wissenchaften | Tools for the diagnosis and treatment of Alzheimer's disease |
| EP0618968B1 (en) | 1991-12-06 | 1999-10-13 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Tools for the diagnosis and treatment of alzheimer's disease |
| US5858784A (en) | 1991-12-17 | 1999-01-12 | The Regents Of The University Of California | Expression of cloned genes in the lung by aerosol- and liposome-based delivery |
| HUT73335A (en) * | 1992-10-05 | 1996-07-29 | Isis Pharmaceuticals Inc | Antisense oligonucleotides and methods for inhibition of the human ras genes, methods for inhibition of tumour-cells proliferation and methods for detection of activated ras-genes |
| CA2116460A1 (en) | 1993-03-02 | 1994-09-03 | Mitsubishi Chemical Corporation | Preventive or therapeutic agents for alzheimer's disease, a screening method of alzheimer's disease and tau-protein kinase i originated from human being |
| KR940021073A (ko) | 1993-03-02 | 1994-10-17 | 미야베 요시가즈 | 알쯔하이머병의 예방 또는 치료제, 그 스크리닝 방법 및 인간 유래의 타우 단백질 키나아제 i |
| CN1123038A (zh) | 1993-05-11 | 1996-05-22 | 北卡罗来纳大学查珀尔希尔分校 | 阻止异常剪接的反义寡核苷酸及其使用方法 |
| CZ243498A3 (cs) | 1996-02-14 | 1999-09-15 | Isis Pharmaceuticals, Inc. | Oligonukleotidy s mezerou a modifikovaným cukrem |
| US6770748B2 (en) | 1997-03-07 | 2004-08-03 | Takeshi Imanishi | Bicyclonucleoside and oligonucleotide analogue |
| JP3756313B2 (ja) | 1997-03-07 | 2006-03-15 | 武 今西 | 新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体 |
| AU9063398A (en) | 1997-09-12 | 1999-04-05 | Exiqon A/S | Oligonucleotide analogues |
| US6794499B2 (en) | 1997-09-12 | 2004-09-21 | Exiqon A/S | Oligonucleotide analogues |
| US20040186071A1 (en) | 1998-04-13 | 2004-09-23 | Bennett C. Frank | Antisense modulation of CD40 expression |
| WO1999057129A1 (en) | 1998-05-01 | 1999-11-11 | Mayo Foundation For Medical Education And Research | Pathogeniv tau mutations |
| US6664443B1 (en) | 1998-05-01 | 2003-12-16 | Mayo Foundation For Medical Education And Research | Pathogenic Tau mutations in transgenic mice |
| JP2002520054A (ja) * | 1998-07-14 | 2002-07-09 | コリクサ コーポレイション | 前立腺癌の治療及び診断のための組成物及び方法 |
| DK1152009T4 (en) | 1999-02-12 | 2017-12-11 | Daiichi Sankyo Co Ltd | HIS UNKNOWN NUCLEOSIDES AND OLIGONUCLEOTIDE ANALOGS |
| US7084125B2 (en) | 1999-03-18 | 2006-08-01 | Exiqon A/S | Xylo-LNA analogues |
| US7098192B2 (en) * | 1999-04-08 | 2006-08-29 | Isis Pharmaceuticals, Inc. | Antisense oligonucleotide modulation of STAT3 expression |
| WO2000064262A1 (en) | 1999-04-26 | 2000-11-02 | The University Of North Carolina At Chapel Hill | Antisense human fucosyltransferase sequences and methods of use thereof |
| DK1178999T3 (da) | 1999-05-04 | 2007-08-06 | Santaris Pharma As | L-RIBO-LNA-analoger |
| US6525191B1 (en) | 1999-05-11 | 2003-02-25 | Kanda S. Ramasamy | Conformationally constrained L-nucleosides |
| CN101284873A (zh) * | 1999-06-30 | 2008-10-15 | 科里克萨有限公司 | 用于肺癌治疗和诊断的组合物和方法 |
| JP4151751B2 (ja) | 1999-07-22 | 2008-09-17 | 第一三共株式会社 | 新規ビシクロヌクレオシド類縁体 |
| WO2001053340A2 (en) | 2000-01-21 | 2001-07-26 | Pharmacia & Upjohn Company | Transgenic mouse model of human neurodegenerative disease |
| CN1423696A (zh) * | 2000-02-28 | 2003-06-11 | 解码遗传Ehf公司 | 人类精神分裂症基因 |
| AU2002231741A1 (en) | 2001-01-11 | 2002-07-24 | Bayer Aktiengesellschaft | Regulation of human tau-tubulin kinase |
| US7569575B2 (en) | 2002-05-08 | 2009-08-04 | Santaris Pharma A/S | Synthesis of locked nucleic acid derivatives |
| US20050130924A1 (en) | 2002-06-26 | 2005-06-16 | Monia Brett P. | Antisense inhibition via RNAse H-independent reduction in mRNA |
| WO2004003134A2 (en) | 2002-06-26 | 2004-01-08 | Isis Pharmaceuticals, Inc. | Antisense inhibition via rnase h-independent reduction in mrna |
| US20050106731A1 (en) | 2002-08-05 | 2005-05-19 | Davidson Beverly L. | siRNA-mediated gene silencing with viral vectors |
| US20080176812A1 (en) | 2002-08-05 | 2008-07-24 | Davidson Beverly L | Allele-specific silencing of disease genes |
| US20040241854A1 (en) | 2002-08-05 | 2004-12-02 | Davidson Beverly L. | siRNA-mediated gene silencing |
| DE60334460D1 (de) | 2002-08-14 | 2010-11-18 | Mitsubishi Chem Medience Corp | Antikörper spezifisch für das tau-protein des zentralen nervensystems |
| WO2004041889A2 (en) | 2002-11-05 | 2004-05-21 | Isis Pharmaceuticals, Inc. | Polycyclic sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation |
| US8163896B1 (en) | 2002-11-14 | 2012-04-24 | Rosetta Genomics Ltd. | Bioinformatically detectable group of novel regulatory genes and uses thereof |
| US7250496B2 (en) * | 2002-11-14 | 2007-07-31 | Rosetta Genomics Ltd. | Bioinformatically detectable group of novel regulatory genes and uses thereof |
| US7906326B2 (en) | 2003-05-07 | 2011-03-15 | Rosetta Genomics Ltd. | Bioinformatically detectable group of novel regulatory oligonucleotides associated with alzheimer's disease and uses thereof |
| US7790867B2 (en) | 2002-12-05 | 2010-09-07 | Rosetta Genomics Inc. | Vaccinia virus-related nucleic acids and microRNA |
| US20130130231A1 (en) | 2002-11-26 | 2013-05-23 | Isaac Bentwich | Bioinformatically detectable group of novel viral regulatory genes and uses thereof |
| US20060257851A1 (en) | 2002-11-26 | 2006-11-16 | Itzhak Bentwich | Bioinformatically detectable group of novel viral regulatory genes and uses thereof |
| US7696334B1 (en) | 2002-12-05 | 2010-04-13 | Rosetta Genomics, Ltd. | Bioinformatically detectable human herpesvirus 5 regulatory gene |
| US20070077553A1 (en) | 2003-10-30 | 2007-04-05 | Rosetta Genomics | Bioinformatically detectable group of novel vaccinia regulatory genes and uses thereof |
| AU2003904328A0 (en) | 2003-08-13 | 2003-08-28 | Garvan Institute Of Medical Research | Diagnosis and treatment of neurodegenerative disorders |
| US7888497B2 (en) | 2003-08-13 | 2011-02-15 | Rosetta Genomics Ltd. | Bioinformatically detectable group of novel regulatory oligonucleotides and uses thereof |
| CA2536333C (en) | 2003-08-28 | 2013-01-08 | Jan Weiler | Interfering rna duplex having blunt-ends and 3'-modifications |
| CN1856573A (zh) * | 2003-09-25 | 2006-11-01 | 千叶县政府 | 用于神经母细胞瘤预后诊断的微阵列和神经母细胞瘤预后诊断方法 |
| US20070106066A1 (en) | 2003-10-28 | 2007-05-10 | Alexander Cherkasky | Cherkasky fusion proteins containing antibody-, antigen- and microtubule-binding regions and immune response-triggering regions |
| US20050244851A1 (en) | 2004-01-13 | 2005-11-03 | Affymetrix, Inc. | Methods of analysis of alternative splicing in human |
| WO2005111211A2 (en) * | 2004-05-14 | 2005-11-24 | Rosetta Genomics Ltd. | Micronas and uses thereof |
| US7687616B1 (en) | 2004-05-14 | 2010-03-30 | Rosetta Genomics Ltd | Small molecules modulating activity of micro RNA oligonucleotides and micro RNA targets and uses thereof |
| EP3808845A1 (en) | 2004-06-28 | 2021-04-21 | The University Of Western Australia | Antisense oligonucleotides for inducing exon skipping and methods of use thereof |
| US7312035B2 (en) | 2004-09-03 | 2007-12-25 | Affymetrix, Inc. | Methods of genetic analysis of yeast |
| US7838657B2 (en) | 2004-12-03 | 2010-11-23 | University Of Massachusetts | Spinal muscular atrophy (SMA) treatment via targeting of SMN2 splice site inhibitory sequences |
| CN101102789B (zh) | 2004-12-03 | 2012-05-30 | 罗得岛医院 | 阿尔茨海默病的诊断和治疗 |
| US7833513B2 (en) | 2004-12-03 | 2010-11-16 | Rhode Island Hospital | Treatment of Alzheimer's Disease |
| US20070048756A1 (en) | 2005-04-18 | 2007-03-01 | Affymetrix, Inc. | Methods for whole genome association studies |
| WO2007028065A2 (en) | 2005-08-30 | 2007-03-08 | Isis Pharmaceuticals, Inc. | Chimeric oligomeric compounds for modulation of splicing |
| WO2007047913A2 (en) | 2005-10-20 | 2007-04-26 | Isis Pharmaceuticals, Inc | Compositions and methods for modulation of lmna expression |
| GB0605337D0 (en) * | 2006-03-17 | 2006-04-26 | Genomica Sau | Treatment of CNS conditions |
| US7901882B2 (en) | 2006-03-31 | 2011-03-08 | Affymetrix, Inc. | Analysis of methylation using nucleic acid arrays |
| CA3042781C (en) | 2006-04-03 | 2021-10-19 | Roche Innovation Center Copenhagen A/S | Pharmaceutical composition comprising anti-mirna antisense oligonucleotides |
| WO2008002620A2 (en) | 2006-06-27 | 2008-01-03 | University Of Virginia Patent Foundation | Cell model for alzheimer's disease pathology |
| JP2010509923A (ja) | 2006-11-23 | 2010-04-02 | ミルクス セラピューティクス アンパーツゼルスカブ | 標的rnaの活性を変化させるためのオリゴヌクレオチド |
| JP5721426B2 (ja) | 2007-04-05 | 2015-05-20 | ザ ジェイ.ディヴィッド グラッドストン インスティテューツ | 神経の過度な興奮を緩和する薬剤を識別する方法 |
| JP2008307007A (ja) | 2007-06-15 | 2008-12-25 | Bayer Schering Pharma Ag | 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞 |
| US8404659B2 (en) | 2008-03-07 | 2013-03-26 | Santaris Pharma A/S | Pharmaceutical compositions for treatment of MicroRNA related diseases |
| WO2010122538A1 (en) | 2009-04-24 | 2010-10-28 | Santaris Pharma A/S | Pharmaceutical compositions for treatment of hcv patients that are non-responders to interferon |
| DK2499249T3 (en) | 2009-11-12 | 2018-12-03 | Univ Western Australia | ANTISENCE MOLECULES AND PROCEDURES FOR TREATING PATHOLOGIES |
| US20150018223A1 (en) | 2010-01-28 | 2015-01-15 | University Of Massachusetts Lowell | Methods of diagnosing tau-associated neurodegenerative diseases |
| WO2011117353A1 (en) | 2010-03-24 | 2011-09-29 | Mirrx Therapeutics A/S | Bivalent antisense oligonucleotides |
| ES2633565T3 (es) | 2010-11-12 | 2017-09-22 | The General Hospital Corporation | ARN no codificantes asociados a polycomb |
| WO2012069059A1 (en) | 2010-11-23 | 2012-05-31 | Mirrx Therapeutics A/S | Oligonucleotides for modulation of target rna activity |
| EP2655621B1 (en) | 2010-12-20 | 2018-05-23 | The General Hospital Corporation | Polycomb-associated non-coding rnas |
| EP3072977B1 (en) * | 2011-04-28 | 2018-09-19 | Life Technologies Corporation | Methods and compositions for multiplex pcr |
| WO2013013165A2 (en) | 2011-07-21 | 2013-01-24 | The Trustees Of The University Of Pennsylvania | Use of lna compounds for therapeutic inhibition of mir-21 in systemic lupus erythematosus |
| EP2831232A4 (en) * | 2012-03-30 | 2015-11-04 | Univ Washington | METHOD FOR MODULATING TAU EXPRESSION TO REDUCE PROBLEMS AND MODIFY A NEURODEGENERATIVE SYNDROME |
| JP2015513912A (ja) | 2012-04-02 | 2015-05-18 | モデルナ セラピューティクス インコーポレイテッドModerna Therapeutics,Inc. | タンパク質の産生のための修飾ポリヌクレオチド |
| BR112014030098A2 (pt) | 2012-06-04 | 2017-07-25 | Irm Llc | métodos de rotulagem específica de sítio e moléculas produzidas pelos mesmos |
| JP6243919B2 (ja) | 2012-10-24 | 2017-12-06 | フラウンホーファ−ゲゼルシャフト ツァー フォルデルング デア アンゲバンデン フォルシュンク エー. ファオ.Fraunhofer−Gesellschaft Zur Forderung Der Angewandten Forschung E. V. | 微小管修飾化合物 |
| US9200068B2 (en) | 2012-12-18 | 2015-12-01 | Regents Of The University Of Minnesota | Compositions and methods related to tauopathy |
| EP3885439A1 (en) | 2012-12-20 | 2021-09-29 | Sarepta Therapeutics, Inc. | Improved exon skipping compositions for treating muscular dystrophy |
| KR20150130430A (ko) | 2013-03-14 | 2015-11-23 | 아이시스 파마수티컬즈 인코포레이티드 | 타우 발현을 조절하는 조성물 및 방법 |
| AU2014236140B2 (en) | 2013-03-14 | 2019-10-03 | Sarepta Therapeutics, Inc. | Exon skipping compositions for treating muscular dystrophy |
| ES2714290T3 (es) | 2013-03-14 | 2019-05-28 | Sarepta Therapeutics Inc | Composiciones de salto de exón para el tratamiento de la distrofia muscular |
| WO2014201306A1 (en) | 2013-06-12 | 2014-12-18 | Oncoimmunin, Inc. | Systemic in vivo delivery of oligonucleotides |
| TW202246503A (zh) * | 2013-07-19 | 2022-12-01 | 美商百健Ma公司 | 用於調節τ蛋白表現之組合物 |
| WO2015068075A2 (en) | 2013-10-24 | 2015-05-14 | Institut National De La Sante Et De La Recherche Medicale | Detection of tau |
| CN104711324A (zh) * | 2013-12-11 | 2015-06-17 | 芮屈生物技术(上海)有限公司 | 老年性痴呆病变前期TAU基因的mRNA水平原位杂交筛查试剂盒 |
| EP3736334A1 (en) * | 2014-07-16 | 2020-11-11 | Arrowhead Pharmaceuticals, Inc. | Rnai compositions to treat apoc3-related diseases |
| WO2016019063A1 (en) | 2014-07-29 | 2016-02-04 | Isis Pharmaceuticals, Inc. | Compositions and methods for modulating tau expression |
| SG11201706293XA (en) | 2015-02-04 | 2017-09-28 | Hoffmann La Roche | Tau antisense oligomers and uses thereof |
| US20180023081A1 (en) | 2015-02-04 | 2018-01-25 | Bristol-Myers Squibb Company | Lna oligonucleotides with alternating flanks |
| CN115181778A (zh) | 2015-02-04 | 2022-10-14 | 百时美施贵宝公司 | 选择治疗性分子的方法 |
| US20170035860A1 (en) * | 2015-04-02 | 2017-02-09 | Alexander C. Flynn | Compositions and methods for treatment of neurogenerative diseases |
-
2015
- 2015-12-21 JO JOP/2020/0228A patent/JOP20200228A1/ar unknown
-
2016
- 2016-12-19 SI SI201631822T patent/SI3394259T1/sl unknown
- 2016-12-19 TW TW111120037A patent/TWI834177B/zh active
- 2016-12-19 EP EP25191996.5A patent/EP4678748A2/en active Pending
- 2016-12-19 CA CA3008094A patent/CA3008094A1/en active Pending
- 2016-12-19 HR HRP20240672TT patent/HRP20240672T1/hr unknown
- 2016-12-19 KR KR1020257023205A patent/KR20250112919A/ko active Pending
- 2016-12-19 EA EA201891468A patent/EA036417B1/ru not_active IP Right Cessation
- 2016-12-19 CU CU2018000065A patent/CU24574B1/es unknown
- 2016-12-19 PL PL16823350.0T patent/PL3394259T3/pl unknown
- 2016-12-19 PE PE2023001204A patent/PE20241069A1/es unknown
- 2016-12-19 CN CN201680082326.0A patent/CN109072237B/zh active Active
- 2016-12-19 SG SG10201913434PA patent/SG10201913434PA/en unknown
- 2016-12-19 LT LTEPPCT/IB2016/057794T patent/LT3394259T/lt unknown
- 2016-12-19 UY UY0001037038A patent/UY37038A/es active IP Right Grant
- 2016-12-19 AR ARP160103917A patent/AR107579A1/es unknown
- 2016-12-19 PT PT168233500T patent/PT3394259T/pt unknown
- 2016-12-19 TW TW105142107A patent/TWI787163B/zh active
- 2016-12-19 FI FIEP16823350.0T patent/FI3394259T3/fi active
- 2016-12-19 ES ES16823350T patent/ES2984631T3/es active Active
- 2016-12-19 AU AU2016376034A patent/AU2016376034B2/en active Active
- 2016-12-19 US US15/383,452 patent/US11473083B2/en active Active
- 2016-12-19 RU RU2018126545A patent/RU2747734C2/ru active
- 2016-12-19 CR CR20200609A patent/CR20200609A/es unknown
- 2016-12-19 PE PE2018001176A patent/PE20181448A1/es unknown
- 2016-12-19 KR KR1020187020632A patent/KR102834468B1/ko active Active
- 2016-12-19 EA EA202091865A patent/EA202091865A1/ru unknown
- 2016-12-19 MX MX2018007726A patent/MX2018007726A/es unknown
- 2016-12-19 IL IL296844A patent/IL296844B2/en unknown
- 2016-12-19 IL IL305866A patent/IL305866B2/en unknown
- 2016-12-19 MA MA71468A patent/MA71468A/fr unknown
- 2016-12-19 MY MYPI2018702190A patent/MY191737A/en unknown
- 2016-12-19 PH PH1/2018/501207A patent/PH12018501207B1/en unknown
- 2016-12-19 EP EP16823350.0A patent/EP3394259B1/en active Active
- 2016-12-19 EP EP24154346.1A patent/EP4406541A3/en not_active Withdrawn
- 2016-12-19 HU HUE16823350A patent/HUE066548T2/hu unknown
- 2016-12-19 WO PCT/IB2016/057794 patent/WO2017109679A1/en not_active Ceased
- 2016-12-19 RS RS20240565A patent/RS65535B1/sr unknown
- 2016-12-19 MA MA44426A patent/MA44426B1/fr unknown
- 2016-12-19 JO JOP/2016/0266A patent/JO3790B1/ar active
- 2016-12-19 CN CN202211714988.9A patent/CN116218848A/zh active Pending
- 2016-12-19 DK DK16823350.0T patent/DK3394259T3/da active
- 2016-12-19 SG SG11201804704PA patent/SG11201804704PA/en unknown
- 2016-12-19 JP JP2018550880A patent/JP7027328B2/ja active Active
-
2018
- 2018-06-01 ZA ZA2018/03661A patent/ZA201803661B/en unknown
- 2018-06-18 IL IL260124A patent/IL260124A/en unknown
- 2018-06-18 CL CL2018001652A patent/CL2018001652A1/es unknown
- 2018-06-18 CO CONC2018/0006297A patent/CO2018006297A2/es unknown
- 2018-06-18 SV SV2018005714A patent/SV2018005714A/es unknown
- 2018-06-19 SA SA518391831A patent/SA518391831B1/ar unknown
- 2018-06-20 DO DO2018000151A patent/DOP2018000151A/es unknown
- 2018-06-21 MX MX2023008211A patent/MX2023008211A/es unknown
- 2018-07-05 EC ECSENADI201850575A patent/ECSP18050575A/es unknown
-
2019
- 2019-01-18 CL CL2019000149A patent/CL2019000149A1/es unknown
- 2019-11-25 CL CL2019003420A patent/CL2019003420A1/es unknown
-
2020
- 2020-11-13 AU AU2020267282A patent/AU2020267282B2/en active Active
-
2021
- 2021-04-28 JP JP2021076622A patent/JP2021118732A/ja active Pending
-
2022
- 2022-02-15 JP JP2022021494A patent/JP7594557B2/ja active Active
- 2022-07-20 US US17/813,843 patent/US20220411796A1/en active Pending
-
2024
- 2024-11-21 JP JP2024203529A patent/JP2025026976A/ja active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CU20180065A7 (es) | Composiciones y métodos para disminuir la expresión de tau | |
| PH12019502724A1 (en) | Compositions for modulating c9orf72 expression | |
| MX2016014140A (es) | Composiciones y metodos para modular la expresion de pkk. | |
| CL2017001459A1 (es) | Biarilo compuestos útiles para el tratamiento de enfermedades humanas en oncología, neurología e inmunología | |
| CO2017005784A2 (es) | Compuestos bicíclicos fusionados para el tratamiento de enfermedades | |
| SI3240554T1 (sl) | Blautia stercosis in wexlerae za uporabo v zdravljenju vnetnih in avtoimunskih bolezni | |
| CO2017007121A2 (es) | Compuestos bicíclicos fusionados para el tratamiento de enfermedades | |
| PL3277270T3 (pl) | Kompozycje i sposoby leczenia niedokrwistości | |
| PL3389636T3 (pl) | Kompozycje i metody wytwarzania mikrocząstek białkowych | |
| EP3373962A4 (en) | COMPOSITIONS AND METHODS FOR TREATING AUTOIMMUNE DISEASES AND CANCER DISEASES | |
| MX395231B (es) | Compuestos eficaces en el tratamiento de la hepatotoxicidad y enfermedades de hígado graso, y uso de los mismos. | |
| SI3573620T1 (sl) | Sestavki za zdravljenje hipertenzije | |
| EA201791937A1 (ru) | Противовоспалительные полипептиды | |
| MX2018005987A (es) | Compuestos heterociclicos para el tratamiento de enfermedades. | |
| EP3362085A4 (en) | COMPOSITIONS AND METHOD FOR THE TREATMENT OF DISEASES WITH MUCIN | |
| BR112015019792A2 (pt) | composição para tratamento de hemorróidas e método de preparação | |
| MX380683B (es) | Lisobactina para su uso en el tratamiento de la mastitis bovina. | |
| MX2018002710A (es) | Metodo para el tratamiento de la disfuncion de monocitos y enfermedades microvasculares y macrovasculares inflamatorias crónicas. | |
| CL2018000336A1 (es) | Composición para el tratamiento de la mucosidad en las branquias de los peces | |
| UA99785U (uk) | Застосування субстанції наночастинок срібла як протимікробного засобу при лікуванні гнійно-запальних захворювань щелепно-лицевої ділянки | |
| AR096976A1 (es) | Composiciones para modular la expresión de tau |