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CU20170087A7 - Formas cristalinas de 5-(4-ciclopropil-1 h-imidazol-1-il)-n-(6-(4-isopropil-4h-1 , 2, 4- triazol-3-il)piridin-2-il)-2-fluoro-4-metilbenzamida - Google Patents

Formas cristalinas de 5-(4-ciclopropil-1 h-imidazol-1-il)-n-(6-(4-isopropil-4h-1 , 2, 4- triazol-3-il)piridin-2-il)-2-fluoro-4-metilbenzamida

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Publication number
CU20170087A7
CU20170087A7 CUP2017000087A CU20170087A CU20170087A7 CU 20170087 A7 CU20170087 A7 CU 20170087A7 CU P2017000087 A CUP2017000087 A CU P2017000087A CU 20170087 A CU20170087 A CU 20170087A CU 20170087 A7 CU20170087 A7 CU 20170087A7
Authority
CU
Cuba
Prior art keywords
methylbenzamide
triazol
imidazol
fluoro
ciclopropil
Prior art date
Application number
CUP2017000087A
Other languages
English (en)
Inventor
Mark Andres
Ernest A Carra
Brenda J Burke Chan
Anna Chiu
Olga Viktorovna Lapina
Stephen P Lathrop
Gregory Notte
Valeriya Smolenskaya
Lok Him Yu
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of CU20170087A7 publication Critical patent/CU20170087A7/es

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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
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Abstract

<p>Formas cristalinas de 5-(4-ciclopropil-1 H-imidazol-1-ii)-N-(6-(4-isopropil-4H-1 ,2,4- triazol-3-il)piridin-2-il)-2-fluoro-4-metilbenzamida (Compuesto I) fueron preparadas y caracterizadas en estado sólido:</p> <p>ESPACIO PARA FÓRMULA</p> <p>También se proporcionan procedimientos de fabricación y métodos de utilización de dichas  formas cristalinas, así como de sus sales, co-cristales, hidratos y solvatos, en el tratamiento de enfermedades mediadas por la desregulación de ASK1.</p>
CUP2017000087A 2014-12-23 2015-12-22 Formas cristalinas de 5-(4-ciclopropil-1 h-imidazol-1-il)-n-(6-(4-isopropil-4h-1 , 2, 4- triazol-3-il)piridin-2-il)-2-fluoro-4-metilbenzamida CU20170087A7 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462096406P 2014-12-23 2014-12-23
US201562269066P 2015-12-17 2015-12-17
PCT/US2015/000162 WO2016105453A1 (en) 2014-12-23 2015-12-22 Solid forms of an ask1 inhibitor

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CU20170087A7 true CU20170087A7 (es) 2017-11-07

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US (4) US9643956B2 (es)
EP (2) EP3237402B1 (es)
JP (3) JP2017538774A (es)
KR (1) KR101971387B1 (es)
CN (1) CN107108574A (es)
AU (2) AU2015371629B2 (es)
BR (1) BR102015032466A2 (es)
CA (1) CA2972012C (es)
CL (1) CL2017001617A1 (es)
CO (1) CO2017006099A2 (es)
CR (1) CR20170266A (es)
CU (1) CU20170087A7 (es)
DO (1) DOP2017000145A (es)
EA (1) EA201791066A1 (es)
EC (1) ECSP17038512A (es)
ES (1) ES2955208T3 (es)
GT (1) GT201700136A (es)
IL (1) IL252756A0 (es)
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PE (1) PE20171105A1 (es)
PH (1) PH12017550028A1 (es)
SG (1) SG11201704834UA (es)
SV (1) SV2017005467A (es)
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