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CR8288A - 6-[ (sustituido) fenil] triazolopirimidinas como agentes anticancer - Google Patents

6-[ (sustituido) fenil] triazolopirimidinas como agentes anticancer

Info

Publication number
CR8288A
CR8288A CR8288A CR8288A CR8288A CR 8288 A CR8288 A CR 8288A CR 8288 A CR8288 A CR 8288A CR 8288 A CR8288 A CR 8288A CR 8288 A CR8288 A CR 8288A
Authority
CR
Costa Rica
Prior art keywords
phenyl
replaced
triazolopirimidinas
anticancer agents
compounds
Prior art date
Application number
CR8288A
Other languages
English (en)
Inventor
Zhang Nan
Kaloustian Semiramis
Hiep Nguyen Thai
Tong Wei
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of CR8288A publication Critical patent/CR8288A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Esta invencion se relaciona con algunos compuestos de 6-[ (SUSTITUIDO) FENIL] TRIAZOLOPIRIMIDINAS o de sales farmaceuticamente aceptables de los mismos y con composiciones que coentienen estos compuestos o las sales farmaceuticamente aceptables de los mismos, en donde estos compuestos son agentes anti-cancer utiles para el tratamiento de cancer en mamiferos.
CR8288A 2003-09-24 2006-03-14 6-[ (sustituido) fenil] triazolopirimidinas como agentes anticancer CR8288A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US50554403P 2003-09-24 2003-09-24

Publications (1)

Publication Number Publication Date
CR8288A true CR8288A (es) 2006-10-04

Family

ID=34393032

Family Applications (1)

Application Number Title Priority Date Filing Date
CR8288A CR8288A (es) 2003-09-24 2006-03-14 6-[ (sustituido) fenil] triazolopirimidinas como agentes anticancer

Country Status (30)

Country Link
US (1) US7507739B2 (es)
EP (1) EP1680425B1 (es)
JP (1) JP2007506744A (es)
KR (1) KR20060098368A (es)
CN (1) CN100519559C (es)
AR (1) AR045810A1 (es)
AU (1) AU2004276240A1 (es)
BR (1) BRPI0414700A (es)
CA (1) CA2539252A1 (es)
CO (1) CO5690598A2 (es)
CR (1) CR8288A (es)
CY (1) CY1106392T1 (es)
DE (1) DE602004004295T8 (es)
DK (1) DK1680425T3 (es)
EC (1) ECSP066458A (es)
ES (1) ES2279452T3 (es)
GT (1) GT200400190A (es)
IL (1) IL174281A0 (es)
MX (1) MXPA06003206A (es)
NO (1) NO20061318L (es)
PA (1) PA8613301A1 (es)
PE (1) PE20050433A1 (es)
PL (1) PL1680425T3 (es)
PT (1) PT1680425E (es)
RU (1) RU2006107579A (es)
SA (1) SA04250302A (es)
SI (1) SI1680425T1 (es)
TW (1) TW200512211A (es)
WO (1) WO2005030775A1 (es)
ZA (1) ZA200602387B (es)

Families Citing this family (15)

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US6255309B1 (en) * 1999-03-19 2001-07-03 American Cyanomid Co. Fungicidal trifluoromethylalkylamino-triazolopyrimidines
BR0112038A (pt) * 2000-06-30 2003-04-01 Wyeth Corp Triazolopirimidinas substituìdas como agentes anticâncer
DK1680425T3 (da) 2003-09-24 2007-03-19 Wyeth Corp 6-[(substitueret)phenyl]triazolopyrimidiner som anticancermidler
US7419982B2 (en) * 2003-09-24 2008-09-02 Wyeth Holdings Corporation Crystalline forms of 5-chloro-6-{2,6-difluoro-4-[3-(methylamino)propoxy]phenyl}-N-[(1S)-2,2,2-trifluoro-1-methylethyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine salts
MY179926A (en) * 2003-12-08 2020-11-19 Wyeth Corp Process for the preparation of tubulin inhibitors
CN101193884A (zh) 2005-06-13 2008-06-04 惠氏公司 微管蛋白抑制剂和其制备方法
MX2007015718A (es) * 2005-06-13 2008-02-21 Wyeth Corp Inhibidor de tubulina y proceso para su preparacion.
BRPI0612676A2 (pt) * 2005-06-27 2016-11-29 Basf Ag processo para preparar compostos, compostos, e, uso de compostos
TW200730530A (en) * 2005-12-16 2007-08-16 Wyeth Corp Lyophilized compositions of a triazolopyrimidine compound
CA2633962A1 (en) * 2005-12-16 2007-07-05 Wyeth Dimers and adducts of 6-[(substituted) phenyl] triazolopyrimidines useful as anticancer agents
WO2008084027A1 (de) * 2007-01-08 2008-07-17 Basf Se Verwendung von azolopyrimidinen zur bekämpfung von pflanzenpathogenen schadpilzen
EP2903436B1 (en) * 2012-09-19 2019-07-17 The Trustees Of The University Of Pennsylvania Heterocyclic compounds and their use for the treatment of neurodegenerative tauopathies
EP3758696A4 (en) * 2018-03-02 2021-12-08 The Trustees of the University of Pennsylvania [1,2,4] TRIAZOLO [1,5-A] PYRIMIDINE COMPOUNDS AND USE THEREOF TO STABILIZE MICROTUBULES
JP7646140B2 (ja) * 2020-04-14 2025-03-17 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア 置換された｛１，２，４，｝トリアゾロ｛１，５－ａ｝ピリミジン化合物および微小管の安定化におけるその使用
CN114369098B (zh) * 2022-01-06 2023-03-10 苏州大学 一种三唑并嘧啶醇类化合物及其制备方法和应用

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TW224044B (es) 1991-12-30 1994-05-21 Shell Internat Res Schappej B V
JP2794510B2 (ja) 1992-03-27 1998-09-10 富士写真フイルム株式会社 ハロゲン化銀写真感光材料
IL108747A (en) 1993-03-04 1999-03-12 Shell Int Research Mushroom-killing preparations containing a history of 6 metamorphoses of 5 - 7 Dihalo - 1, 2 - 4 Triazlo [A-1,5] Pyrimidine Certain such new compounds and their preparation
TW258648B (es) 1993-03-04 1995-10-01 Shell Internat Res Schappej Bv
RU2147584C1 (ru) 1995-10-27 2000-04-20 Американ Цианамид Компани Способ получения дигалоидазолопиримидинов и способ получения дигидроксиазолопиримидинов
US5817663A (en) 1996-10-07 1998-10-06 American Cyanamid Company Pentafluorophenylazolopyrimidines
EP0984919B1 (en) 1997-03-18 2003-01-22 Basf Aktiengesellschaft Process for the preparation of arylmalonates
US5750766A (en) 1997-03-18 1998-05-12 American Cyanamid Company Process for the preparation of arylmalonates
US6117876A (en) 1997-04-14 2000-09-12 American Cyanamid Company Fungicidal trifluorophenyl-triazolopyrimidines
US6255309B1 (en) 1999-03-19 2001-07-03 American Cyanomid Co. Fungicidal trifluoromethylalkylamino-triazolopyrimidines
TW460476B (en) 1997-04-14 2001-10-21 American Cyanamid Co Fungicidal trifluoromethylalkylamino-triazolopyrimidines
US5948783A (en) 1997-04-14 1999-09-07 American Cyanamid Company Fungicidal trifluoromethylalkylamino-triazolopyrimidines
TWI252231B (en) 1997-04-14 2006-04-01 American Cyanamid Co Fungicidal trifluorophenyl-triazolopyrimidines
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WO1999041255A1 (en) 1998-02-11 1999-08-19 American Cyanamid Company Fungicidal 7-alkyl-triazolopyrimidines
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US5981534A (en) 1998-09-25 1999-11-09 American Cyanamid Company Fungicidal 6-(2,6-difluoro-4-alkoxyphenyl)-triazolopyrimidines
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US6521628B1 (en) 1999-01-29 2003-02-18 Basf Aktiengesellschaft Fungicidal mixtures
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US6559151B2 (en) 2000-05-08 2003-05-06 Basf Aktiengesellschaft 6-(2-trifluoromethyl-phenyl)-triazolopyrimidines
BR0112038A (pt) * 2000-06-30 2003-04-01 Wyeth Corp Triazolopirimidinas substituìdas como agentes anticâncer
UA74007C2 (en) 2000-08-25 2005-10-17 Basf Ag Fungicidal mixture
US6459602B1 (en) * 2000-10-26 2002-10-01 O2 Micro International Limited DC-to-DC converter with improved transient response
US6855718B2 (en) 2000-11-13 2005-02-15 Basf Aktiengesellschaft 7-(r)-aminotriazolopyrimidines, the production thereof and use of the same for combatting phytopathogenic fungi
JP2004515502A (ja) 2000-12-06 2004-05-27 ビーエーエスエフ アクチェンゲゼルシャフト 殺真菌性を有する６−（トリフルオロメチル−フェニル）−トリアゾロピリミジン類
DE10063115A1 (de) 2000-12-18 2002-06-27 Bayer Ag Triazolopyrimidine
WO2002067679A1 (en) 2001-02-19 2002-09-06 Basf Aktiengesellschaft Fungicidal mixtures
EP1381609B1 (en) 2001-04-11 2005-01-19 Basf Aktiengesellschaft 5-halogen-6-phenyl-7-fluoroalkylamino-triazolopyrimidines as fungicides
DE10124208A1 (de) 2001-05-18 2002-11-21 Bayer Ag Verwendung von Triazolopyrimidin-Derivaten als Mikrobizide
EP1412356A1 (en) 2001-07-18 2004-04-28 Basf Aktiengesellschaft Substituted 6-(2-methoxyphenyl)triazolopyrimidines as fungicides
DK1680425T3 (da) 2003-09-24 2007-03-19 Wyeth Corp 6-[(substitueret)phenyl]triazolopyrimidiner som anticancermidler

Also Published As

Publication number Publication date
PT1680425E (pt) 2007-02-28
CA2539252A1 (en) 2005-04-07
EP1680425A1 (en) 2006-07-19
ES2279452T3 (es) 2007-08-16
CY1106392T1 (el) 2011-10-12
DE602004004295T8 (de) 2007-09-20
SI1680425T1 (sl) 2007-04-30
AU2004276240A1 (en) 2005-04-07
EP1680425B1 (en) 2007-01-10
ZA200602387B (en) 2008-11-26
MXPA06003206A (es) 2006-06-23
TW200512211A (en) 2005-04-01
BRPI0414700A (pt) 2006-11-14
PL1680425T3 (pl) 2007-05-31
SA04250302A (ar) 2005-12-03
PE20050433A1 (es) 2005-07-21
PA8613301A1 (es) 2005-11-25
CN1867569A (zh) 2006-11-22
GT200400190A (es) 2005-05-02
WO2005030775A1 (en) 2005-04-07
HK1090374A1 (en) 2006-12-22
RU2006107579A (ru) 2007-10-27
DE602004004295D1 (de) 2007-02-22
ECSP066458A (es) 2006-09-18
IL174281A0 (en) 2006-08-01
DK1680425T3 (da) 2007-03-19
US20050090508A1 (en) 2005-04-28
DE602004004295T2 (de) 2007-06-06
KR20060098368A (ko) 2006-09-18
NO20061318L (no) 2006-04-21
CO5690598A2 (es) 2006-10-31
CN100519559C (zh) 2009-07-29
AR045810A1 (es) 2005-11-16
US7507739B2 (en) 2009-03-24
JP2007506744A (ja) 2007-03-22

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal (granting procedure)