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CR20120347A - Agentes inductores de apoptosis para el tratamiento de cáncer y enfermedades inmunes y autoinmunes - Google Patents

Agentes inductores de apoptosis para el tratamiento de cáncer y enfermedades inmunes y autoinmunes

Info

Publication number
CR20120347A
CR20120347A CR20120347A CR20120347A CR20120347A CR 20120347 A CR20120347 A CR 20120347A CR 20120347 A CR20120347 A CR 20120347A CR 20120347 A CR20120347 A CR 20120347A CR 20120347 A CR20120347 A CR 20120347A
Authority
CR
Costa Rica
Prior art keywords
immune
cancer
treatment
autoimmune diseases
inductive agents
Prior art date
Application number
CR20120347A
Other languages
English (en)
Inventor
Milan Bruncko
Yujia Dai
Hong Ding
George A Doherty
Steven W Elmore
Lisa Hasvold
Laura Hexamer
Aaron Kunzer
Robert A Mantei
William J Mcclellan
Chang H Park
Cheol-Min Park
Andrew M Petros
Xiaohng Song
Andrew J Souers
Gerard Sullivan
Zhi-Gu Tao
Gary T Wang
Le Wang
Xilu Wang
Michael D Wendt
Todd M Hansen
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42463423&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CR20120347(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of CR20120347A publication Critical patent/CR20120347A/es

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
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Abstract

Compuestos que inhiben la actividad de proteínas anti-apoptóticas Bcl-2, composiciones que contienen a dichos compuestos y métodos de tratamiento de enfermedades durante cuyo transcurso hay expresión de la proteína anti-apoptótica Bcl-2.
CR20120347A 2009-12-04 2012-06-25 Agentes inductores de apoptosis para el tratamiento de cáncer y enfermedades inmunes y autoinmunes CR20120347A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12/631,367 US20100160322A1 (en) 2008-12-04 2009-12-04 Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases

Publications (1)

Publication Number Publication Date
CR20120347A true CR20120347A (es) 2012-08-14

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CR20120347A CR20120347A (es) 2009-12-04 2012-06-25 Agentes inductores de apoptosis para el tratamiento de cáncer y enfermedades inmunes y autoinmunes

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US (5) US20100160322A1 (es)
EP (1) EP2507211B1 (es)
JP (1) JP5589090B2 (es)
CN (2) CN103097352A (es)
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CL (1) CL2012001421A1 (es)
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