CO5611178A2 - Aparato y proceso para preparar particulas cristalinas - Google Patents
Aparato y proceso para preparar particulas cristalinasInfo
- Publication number
- CO5611178A2 CO5611178A2 CO04068635A CO04068635A CO5611178A2 CO 5611178 A2 CO5611178 A2 CO 5611178A2 CO 04068635 A CO04068635 A CO 04068635A CO 04068635 A CO04068635 A CO 04068635A CO 5611178 A2 CO5611178 A2 CO 5611178A2
- Authority
- CO
- Colombia
- Prior art keywords
- substance
- mixing chamber
- liquid
- solvent
- inlet holes
- Prior art date
Links
- 239000002245 particle Substances 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 2
- 239000013078 crystal Substances 0.000 title 1
- 239000000126 substance Substances 0.000 abstract 6
- 239000007788 liquid Substances 0.000 abstract 5
- 239000012296 anti-solvent Substances 0.000 abstract 3
- 230000005855 radiation Effects 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
- B01F31/80—Mixing by means of high-frequency vibrations above one kHz, e.g. ultrasonic vibrations
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
- B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/005—Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/005—Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
- B01D9/0054—Use of anti-solvent
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/0059—General arrangements of crystallisation plant, e.g. flow sheets
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/0081—Use of vibrations, e.g. ultrasound
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/20—Jet mixers, i.e. mixers using high-speed fluid streams
- B01F25/25—Mixing by jets impinging against collision plates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
- B01F31/80—Mixing by means of high-frequency vibrations above one kHz, e.g. ultrasonic vibrations
- B01F31/85—Mixing by means of high-frequency vibrations above one kHz, e.g. ultrasonic vibrations with a vibrating element inside the receptacle
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/71—Feed mechanisms
- B01F35/712—Feed mechanisms for feeding fluids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/71—Feed mechanisms
- B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
- B01F35/7174—Feed mechanisms characterised by the means for feeding the components to the mixer using pistons, plungers or syringes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/71—Feed mechanisms
- B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
- B01F35/7176—Feed mechanisms characterised by the means for feeding the components to the mixer using pumps
- B01F35/717611—Peristaltic pumps
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/71—Feed mechanisms
- B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
- B01F35/71805—Feed mechanisms characterised by the means for feeding the components to the mixer using valves, gates, orifices or openings
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/75—Discharge mechanisms
- B01F35/754—Discharge mechanisms characterised by the means for discharging the components from the mixer
- B01F35/7547—Discharge mechanisms characterised by the means for discharging the components from the mixer using valves, gates, orifices or openings
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
- B01J2/18—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic using a vibrating apparatus
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Crystallography & Structural Chemistry (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Mixers With Rotating Receptacles And Mixers With Vibration Mechanisms (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Steroid Compounds (AREA)
Abstract
1.- Un procedimiento para preparar partículas cristalinas de una sustancia que comprende mezclar, en una célula de flujo continuo en presencia de radiación ultrasónica, una disolución fluyente de una sustancia en un disolvente líquido con un antidisolvente líquido fluyente para dicha sustancia, y recoger las partículas cristalinas resultantes generadas, caracterizado porque la disolución y el antidisolvente se suministran a la célula de flujo continuo en corrientes paralelas en contacto.Un aparato para preparar partículas cristalinas de una sustancia que comprende:(i). un primer depósito de dicha sustancia disuelta en un disolvente líquido;(ii). un segundo depósito de antidisolvente líquido para dicha sustancia;(iii). una cámara de mezcla que tiene un primer y un segundo orificios de entrada y un orificio de salida;(iv). medios para distribuir los contenidos del pri¡ner y segundo depósitos a la cámara de mezcla a través del primer y segundo orificios de entrada respectivamente a un caudal controlado independiente; dichos primer y segundo orificios de entrada están orientados de manera que los contenidos del primer y segundo depósitos se administran a la cámara de mezcla en corrientes paralelas en contacto;(v). una fuente de radiación ultrasónica localizada en la cercanía de la primera entrada;y (vi). medios para recoger las partículas suspendidas en el líquido descargado de la cámara de mezcla en el orificio de salida.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0201400.9A GB0201400D0 (en) | 2002-01-22 | 2002-01-22 | Novel apparatus and process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5611178A2 true CO5611178A2 (es) | 2006-02-28 |
Family
ID=9929515
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO04068635A CO5611178A2 (es) | 2002-01-22 | 2004-07-19 | Aparato y proceso para preparar particulas cristalinas |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US7384478B2 (es) |
| EP (1) | EP1469938B1 (es) |
| JP (1) | JP4408700B2 (es) |
| KR (1) | KR20040082395A (es) |
| CN (1) | CN1620333A (es) |
| AR (1) | AR038200A1 (es) |
| AT (1) | ATE312661T1 (es) |
| BR (1) | BR0306738A (es) |
| CA (1) | CA2473059A1 (es) |
| CO (1) | CO5611178A2 (es) |
| DE (1) | DE60302765T2 (es) |
| ES (1) | ES2253656T3 (es) |
| GB (1) | GB0201400D0 (es) |
| IL (1) | IL162751A0 (es) |
| IS (1) | IS7335A (es) |
| MX (1) | MXPA04007073A (es) |
| NO (1) | NO20043444L (es) |
| PL (1) | PL372897A1 (es) |
| RU (1) | RU2004120549A (es) |
| TW (1) | TW200302129A (es) |
| WO (1) | WO2003061816A1 (es) |
| ZA (1) | ZA200405143B (es) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1688169A4 (en) * | 2003-11-28 | 2008-10-01 | Mitsubishi Chem Corp | PROCESS FOR PRODUCING FINE PARTICLES OF AN ORGANIC COMPOUND |
| JP2005177746A (ja) * | 2003-11-28 | 2005-07-07 | Mitsubishi Chemicals Corp | 有機化合物微粒子の製造方法 |
| GB0406069D0 (en) * | 2004-03-17 | 2004-04-21 | Thompson James | Process |
| GB0507165D0 (en) * | 2005-04-08 | 2005-05-18 | Glaxo Group Ltd | Novel crystalline pharmaceutical product |
| DE102005053862A1 (de) | 2005-11-04 | 2007-05-10 | Pharmasol Gmbh | Verfahren und Vorrichtung zur Herstellung hochfeiner Partikel sowie zur Beschichtung solcher Partikel |
| JP4597107B2 (ja) * | 2006-03-02 | 2010-12-15 | 三井金属鉱業株式会社 | 砒素含有体からの砒素除去方法及び砒素除去装置 |
| TW200817047A (en) * | 2006-04-03 | 2008-04-16 | Teva Pharma | Drug microparticles |
| GB0705159D0 (en) | 2007-03-19 | 2007-04-25 | Prosonix Ltd | Process for making crystals |
| GB0711680D0 (en) * | 2007-06-18 | 2007-07-25 | Prosonix Ltd | Process |
| GB0900080D0 (en) | 2009-01-06 | 2009-02-11 | Prosonix Ltd | An apparatus and process for producing crystals |
| GB0918149D0 (en) | 2009-10-16 | 2009-12-02 | Jagotec Ag | Improved medicinal aerosol formulation |
| GB0918150D0 (en) * | 2009-10-16 | 2009-12-02 | Jagotec Ag | Improved formulations |
| EP2500072A1 (en) * | 2011-03-15 | 2012-09-19 | LEK Pharmaceuticals d.d. | A novel process of residual solvent removal |
| MX376564B (es) * | 2011-07-08 | 2025-03-07 | Pfizer Ltd | Proceso para la preparación de la forma 1 del propionato de fluticasona. |
| CN103958744B (zh) * | 2011-07-14 | 2016-08-31 | 科瓦里斯股份有限公司 | 用于使用聚焦声制备纳米晶体组合物的系统和方法 |
| JP5848621B2 (ja) * | 2012-01-25 | 2016-01-27 | 浜松ホトニクス株式会社 | 薬物評価方法及び薬物評価装置 |
| US8765725B2 (en) | 2012-05-08 | 2014-07-01 | Aciex Therapeutics, Inc. | Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof |
| EP2847207B1 (en) | 2012-05-08 | 2019-03-27 | Nicox Ophthalmics, Inc. | Fluticasone propionate nanocrystals |
| US9815865B2 (en) | 2013-01-07 | 2017-11-14 | Nicox Ophthalmics, Inc. | Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof |
| EA201591415A1 (ru) | 2013-01-31 | 2016-01-29 | Просоникс Лимитед | Фармацевтические композиции, включающие многокомпонентные кристаллические частицы, подходящие для применения в ингаляционной терапии |
| WO2014137982A1 (en) | 2013-03-08 | 2014-09-12 | The Board Of Trustees Of The University Of Illinois | Ultrasonic method and apparatus for producing particles having a controlled size distribution |
| CN103977593B (zh) * | 2014-05-19 | 2017-01-04 | 中国工程物理研究院化工材料研究所 | 制备纳米共晶含能材料的方法及装置 |
| DE102021121631A1 (de) | 2021-08-20 | 2023-02-23 | Dionex Softron Gmbh | Mischanordnung |
| WO2026004845A1 (ja) * | 2024-06-25 | 2026-01-02 | 株式会社カネカ | 連続析出による固体物の製造方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4930820B1 (es) * | 1966-02-10 | 1974-08-16 | ||
| US3749318A (en) * | 1971-03-01 | 1973-07-31 | E Cottell | Combustion method and apparatus burning an intimate emulsion of fuel and water |
| JPS5756031A (en) | 1980-09-19 | 1982-04-03 | Toshiba Corp | Ultrasonic emulsifier |
| JPS58163425A (ja) | 1982-03-25 | 1983-09-28 | Toshiba Corp | 超音波乳化装置 |
| US5032027A (en) | 1989-10-19 | 1991-07-16 | Heat Systems Incorporated | Ultrasonic fluid processing method |
| HUT59692A (en) * | 1990-11-15 | 1992-06-29 | Puetter Medice Chem Pharm | Process for producing complexes containing s/+/-phenyl-alkanoic acids and aminosugars |
| JP3178873B2 (ja) | 1991-12-20 | 2001-06-25 | 第一高周波工業株式会社 | 超音波を利用した液体混合方法 |
| US5471001A (en) * | 1994-12-15 | 1995-11-28 | E. I. Du Pont De Nemours And Company | Crystallization of adipic acid |
| JP3630834B2 (ja) | 1995-04-24 | 2005-03-23 | 株式会社リコー | 二種以上の樹脂原料液体の混合法及びその混合装置 |
| DE19712488A1 (de) * | 1997-03-25 | 1998-10-01 | Knoell Hans Forschung Ev | Steroidsulfamate, Verfahren zu ihrer Herstellung und Anwendung derselben |
| US20010023252A1 (en) * | 1998-07-02 | 2001-09-20 | Smithkline Beecham Plc | Novel compound |
| GB9828721D0 (en) * | 1998-12-24 | 1999-02-17 | Glaxo Group Ltd | Novel apparatus and process |
| DK1173265T3 (da) * | 1999-01-29 | 2006-04-10 | Bristol Myers Squibb Co | Apparat og fremgangsmåde til krystallisation med ultralydstråler |
-
2002
- 2002-01-22 GB GBGB0201400.9A patent/GB0201400D0/en not_active Ceased
-
2003
- 2003-01-20 TW TW092101276A patent/TW200302129A/zh unknown
- 2003-01-21 KR KR10-2004-7011260A patent/KR20040082395A/ko not_active Withdrawn
- 2003-01-21 IL IL16275103A patent/IL162751A0/xx unknown
- 2003-01-21 RU RU2004120549/15A patent/RU2004120549A/ru not_active Application Discontinuation
- 2003-01-21 MX MXPA04007073A patent/MXPA04007073A/es unknown
- 2003-01-21 AT AT03701533T patent/ATE312661T1/de not_active IP Right Cessation
- 2003-01-21 JP JP2003561752A patent/JP4408700B2/ja not_active Expired - Fee Related
- 2003-01-21 BR BR0306738-6A patent/BR0306738A/pt not_active Application Discontinuation
- 2003-01-21 CN CNA038025655A patent/CN1620333A/zh active Pending
- 2003-01-21 US US10/501,940 patent/US7384478B2/en not_active Expired - Fee Related
- 2003-01-21 PL PL03372897A patent/PL372897A1/xx unknown
- 2003-01-21 ES ES03701533T patent/ES2253656T3/es not_active Expired - Lifetime
- 2003-01-21 DE DE60302765T patent/DE60302765T2/de not_active Expired - Lifetime
- 2003-01-21 EP EP03701533A patent/EP1469938B1/en not_active Expired - Lifetime
- 2003-01-21 AR ARP030100169A patent/AR038200A1/es unknown
- 2003-01-21 WO PCT/EP2003/000558 patent/WO2003061816A1/en not_active Ceased
- 2003-01-21 CA CA002473059A patent/CA2473059A1/en not_active Abandoned
-
2004
- 2004-06-28 ZA ZA200405143A patent/ZA200405143B/en unknown
- 2004-06-28 IS IS7335A patent/IS7335A/is unknown
- 2004-07-19 CO CO04068635A patent/CO5611178A2/es not_active Application Discontinuation
- 2004-08-18 NO NO20043444A patent/NO20043444L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1469938A1 (en) | 2004-10-27 |
| JP4408700B2 (ja) | 2010-02-03 |
| ES2253656T3 (es) | 2006-06-01 |
| PL372897A1 (en) | 2005-08-08 |
| NO20043444L (no) | 2004-08-18 |
| KR20040082395A (ko) | 2004-09-24 |
| IS7335A (is) | 2004-06-28 |
| MXPA04007073A (es) | 2004-10-29 |
| RU2004120549A (ru) | 2005-05-10 |
| GB0201400D0 (en) | 2002-03-13 |
| DE60302765D1 (de) | 2006-01-19 |
| ZA200405143B (en) | 2005-12-28 |
| CN1620333A (zh) | 2005-05-25 |
| CA2473059A1 (en) | 2003-07-31 |
| EP1469938B1 (en) | 2005-12-14 |
| DE60302765T2 (de) | 2006-07-06 |
| ATE312661T1 (de) | 2005-12-15 |
| IL162751A0 (en) | 2005-11-20 |
| AR038200A1 (es) | 2005-01-05 |
| BR0306738A (pt) | 2004-12-28 |
| US20060096522A1 (en) | 2006-05-11 |
| TW200302129A (en) | 2003-08-01 |
| WO2003061816A1 (en) | 2003-07-31 |
| US7384478B2 (en) | 2008-06-10 |
| JP2005525216A (ja) | 2005-08-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Application withdrawn |