CO5540301A2 - Derivados sustituidos del 1-oxa-2,8-daza-espiro[4,5] dec-2-eno - Google Patents
Derivados sustituidos del 1-oxa-2,8-daza-espiro[4,5] dec-2-enoInfo
- Publication number
- CO5540301A2 CO5540301A2 CO03111723A CO03111723A CO5540301A2 CO 5540301 A2 CO5540301 A2 CO 5540301A2 CO 03111723 A CO03111723 A CO 03111723A CO 03111723 A CO03111723 A CO 03111723A CO 5540301 A2 CO5540301 A2 CO 5540301A2
- Authority
- CO
- Colombia
- Prior art keywords
- alkyl
- aryl
- heterocyclyl
- cycloalkyl
- represent
- Prior art date
Links
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 12
- 125000003118 aryl group Chemical group 0.000 abstract 7
- 125000000623 heterocyclic group Chemical group 0.000 abstract 6
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 5
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 4
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 abstract 3
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 1
- ZTUPVEXGISXGGN-UHFFFAOYSA-N 1-oxa-2,8-diazaspiro[4.5]dec-2-ene Chemical class C1C=NOC11CCNCC1 ZTUPVEXGISXGGN-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 150000003840 hydrochlorides Chemical class 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P1/12—Antidiarrhoeals
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P25/08—Antiepileptics; Anticonvulsants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/32—Alcohol-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P27/06—Antiglaucoma agents or miotics
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- A—HUMAN NECESSITIES
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- A61P27/16—Otologicals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
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- A—HUMAN NECESSITIES
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychology (AREA)
- Ophthalmology & Optometry (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Otolaryngology (AREA)
- Nutrition Science (AREA)
- Child & Adolescent Psychology (AREA)
Abstract
1.- Derivados sustituidos de 1-oxa-2,8-diaza-espiro[4.5]dec-2-eno con la fórmula general (I) en forma de sus racematos, sus estereoisómeros puros, en especial enantiómeros o diastereómeros, o en forma de mezclas de estereoisómeros, en especial de enantiómeros o diastereómeros, en cualquier relación de mezcla; en forma aislada o en forma de sus ácidos o sus bases, o en forma de sus sales, en especial de las sales fisiológicamente admisibles, y muy en especial se prefiere en forma de sus clorhidratos o en forma de sus solvatos, en especial de los hidratos;en dondeR1 y R2 son independientes entre sí y representan H, alquilo C1-18, cicloalquilo C3-10, (alquilo C1-12)-cicloalquilo C3-10, arilo, (alquilo C1-12)-arilo, heterociclilo, (alquilo C1-12)-heterociclilo o NH-C(=O)-arilo, en donde al menos uno de los grupos R1 y R2 no representa H,o bienlos dos juntos representan -(CR4R5)m-(CR6R7)n-Y-(CR8R9)p-(CR10R11)q- con cada uno de m, n, p y q = 0, 1, 2, 3, 4 o 5, con la condición de que cuando m n = 1 y p q = 1 , o bien representan -CH2-CH2-C(arilo)=CHCH2;R3 representa H, SO2R12 o COR13;R4, R5, R6, R7, R8, R9 R10 y R11 son independientes entre sí y representan H, alquilo C1-10, cicloalquilo C3-8, (alquilo C1-6)-cicloalquilo C3-8, arilo, (alquilo C1-6)-arilo, heterociclilo o C(=O)R14;Y representa CR15R16, NR17 u O;R12 y R13 son independientes entre sí y representan alquilo C1-10, cicloalquilo C3-10, (alquilo C1-6)-cicloalquilo C3-10, arilo, (alquilo C1-6)-arilo, heterociclilo, (alquilo C1-8)-heterociclilo o NR18R19;R14 representa H, alquilo C1-10, cicloalquilo C3-8, (alquilo C1-6)-cicloalquilo C3-8, arilo, (alquilo C1-6)-arilo, heterociclilo, (alquilo C1-6)-heterociclilo o OR20;R15 y R16 son independientes entre sí y representan H, alquilo C1-10, cicloalquilo C3-8, (alquilo C1-6)-cicloalquilo C3-8, arilo, (alquilo C1-6)-arilo, heterociclilo, (alquilo C1-6)-heterociclilo o C(=O)R21;R17 representa H, alquilo C1-10, cicloalquilo C3-8, (alquilo C1-6)-cicloalquilo C3-8, arilo, (alquilo C1-6)-arilo, heterociclilo, (alquilo C1-6)-heterociclilo o C(=O)R22; ...
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10130020A DE10130020A1 (de) | 2001-06-25 | 2001-06-25 | Substituierte 1-Oxa-2,8-diaza-spiro[4.5]dec-2-en-derivate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5540301A2 true CO5540301A2 (es) | 2005-07-29 |
Family
ID=7689008
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO03111723A CO5540301A2 (es) | 2001-06-25 | 2003-12-22 | Derivados sustituidos del 1-oxa-2,8-daza-espiro[4,5] dec-2-eno |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US8048890B2 (es) |
| EP (1) | EP1401841B1 (es) |
| JP (1) | JP4410554B2 (es) |
| KR (1) | KR100917112B1 (es) |
| CN (1) | CN1315840C (es) |
| AR (1) | AR036098A1 (es) |
| AT (1) | ATE302782T1 (es) |
| AU (1) | AU2002310768B2 (es) |
| BR (1) | BR0211053A (es) |
| CA (1) | CA2451859C (es) |
| CO (1) | CO5540301A2 (es) |
| CZ (1) | CZ20033432A3 (es) |
| DE (2) | DE10130020A1 (es) |
| DK (1) | DK1401841T3 (es) |
| EC (1) | ECSP034924A (es) |
| ES (1) | ES2245402T3 (es) |
| HU (1) | HU228774B1 (es) |
| IL (2) | IL159544A0 (es) |
| MX (1) | MXPA03012013A (es) |
| NO (1) | NO332217B1 (es) |
| NZ (1) | NZ530689A (es) |
| PE (1) | PE20030146A1 (es) |
| PL (1) | PL214290B1 (es) |
| PT (1) | PT1401841E (es) |
| RU (1) | RU2296128C2 (es) |
| SI (1) | SI1401841T1 (es) |
| SK (1) | SK287390B6 (es) |
| WO (1) | WO2003000699A1 (es) |
| ZA (1) | ZA200400489B (es) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10130020A1 (de) | 2001-06-25 | 2003-12-04 | Gruenenthal Gmbh | Substituierte 1-Oxa-2,8-diaza-spiro[4.5]dec-2-en-derivate |
| MXPA05001705A (es) * | 2002-08-14 | 2005-04-19 | Pharmacia & Upjohn Co Llc | Uso de reboxetina para el tratamiento de sofocos. |
| DE102004023635A1 (de) * | 2004-05-10 | 2006-04-13 | Grünenthal GmbH | Heteroarylsubstituierte Cyclohexyl-1,4-diamin-Derivate |
| DE102005016170A1 (de) * | 2005-04-07 | 2006-10-12 | Grünenthal GmbH | 4,5,6,7- Tetrahydro-isoxazolo(4,5c)pyridin-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln |
| DE102005044813A1 (de) | 2005-05-19 | 2007-10-04 | Grünenthal GmbH | Substituierte Spiro-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln |
| DE102005023784A1 (de) * | 2005-05-19 | 2006-11-30 | Grünenthal GmbH | Substituierte Spiro-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln |
| DE102005044814A1 (de) * | 2005-05-19 | 2006-11-23 | Grünenthal GmbH | Substituierte Sprio-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln |
| US9340558B2 (en) | 2007-11-02 | 2016-05-17 | Pain Therapeutics Inc. | Filamin a binding anti-inflammatory and analgesic |
| US8653068B2 (en) | 2009-10-30 | 2014-02-18 | Pain Therapeutics, Inc. | Filamin A binding anti-inflammatory and analgesic |
| US8614324B2 (en) * | 2008-10-31 | 2013-12-24 | Pain Therapeutics, Inc. | Filamin A binding anti-inflammatory and analgesic |
| US8580808B2 (en) * | 2009-10-30 | 2013-11-12 | Pain Therapeutic, Inc. | Filamin A-binding anti-inflammatory analgesic |
| US20100279996A1 (en) * | 2009-05-04 | 2010-11-04 | Lindsay Burns Barbier | Novel analgesic that binds filamin a |
| WO2010051476A1 (en) * | 2008-10-31 | 2010-05-06 | Pain Therapeutics, Inc. | Filamin a-binding anti-inflammatory analgesic |
| CN102361876B (zh) * | 2009-01-26 | 2015-02-04 | 以色列生物研究所 | 二环杂环螺环化合物 |
| US8580809B2 (en) * | 2009-10-30 | 2013-11-12 | Pain Therapeutics, Inc. | Filamin A-binding anti-inflammatory analgesic |
| US8822464B2 (en) | 2011-11-28 | 2014-09-02 | Boehringer Ingelheim International Gmbh | N-aryl-piperazine derivatives and their use as positive allosteric modulators of mGluR5 receptors |
| US8741892B2 (en) | 2011-12-05 | 2014-06-03 | Boehringer Ingelheim International Gmbh | Compounds |
| US8642774B2 (en) * | 2011-12-08 | 2014-02-04 | Boehringer Ingelheim International Gmbh | Compounds |
| US8846948B2 (en) | 2011-12-13 | 2014-09-30 | Boehringer Ingelheim International Gmbh | Compounds |
| US8796467B2 (en) | 2011-12-13 | 2014-08-05 | Boehringer Ingelheim International Gmbh | Compounds |
| US8937176B2 (en) | 2011-12-14 | 2015-01-20 | Boehringer Ingelheim International Gmbh | Compounds |
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| US8889677B2 (en) | 2012-01-17 | 2014-11-18 | Boehringer Ingellheim International GmbH | Substituted triazoles useful as mGlu5 receptor modulators |
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| US9433604B2 (en) | 2013-10-08 | 2016-09-06 | Pain Therapeutics Inc. | Method for inhibiting growth of cancer cells |
| KR20180097733A (ko) | 2016-01-13 | 2018-08-31 | 그뤼넨탈 게엠베하 | 3-(카복시메틸)-8-아미노-2-옥소-1,3-디아자-스피로-[4.5]-데칸 유도체 |
| TWI654181B (zh) | 2016-01-13 | 2019-03-21 | 歌林達有限公司 | ８－胺基－２－側氧基－１，３－二氮－螺－［４．５］－癸烷衍生物 |
| EP3722283A1 (en) | 2016-01-13 | 2020-10-14 | Grünenthal GmbH | 3-(carboxyethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives |
| PL3402781T3 (pl) | 2016-01-13 | 2020-09-21 | Grünenthal GmbH | Pochodne 3-((hetero-)arylo)-8-amino-2-okso-1,3-diazaspiro-[4.5]-dekanu |
| HRP20200837T1 (hr) | 2016-01-13 | 2020-08-07 | Grünenthal GmbH | Derivati 3-((hetero-)aril)-alkil-8-amino-2-okso-1,3-diaza-spiro-[4.5]-dekana |
| IL269896B (en) | 2017-04-12 | 2022-07-01 | Il Dong Pharma | Isoxazole derivatives as nuclear receptor agonists and their uses |
| CN109793713B (zh) * | 2019-03-26 | 2021-05-28 | 李世系 | 一种用于麻醉的短效催眠镇静的药物组合物及其注射剂制备方法及应用 |
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| NL127065C (es) * | 1964-04-22 | |||
| GB1227365A (es) * | 1968-07-29 | 1971-04-07 | ||
| JPH02164882A (ja) * | 1988-12-20 | 1990-06-25 | Yamanouchi Pharmaceut Co Ltd | スピロ化合物及びその中間体 |
| US5534520A (en) | 1990-04-10 | 1996-07-09 | Fisher; Abraham | Spiro compounds containing five-membered rings |
| US5073560A (en) * | 1990-07-20 | 1991-12-17 | Fisons Corporation | Spiro-isoxazolidine derivatives as cholinergic agents |
| DE4024415A1 (de) * | 1990-08-01 | 1992-02-06 | Hoechst Ag | Verfahren zur herstellung von 1-oxa-3,8-diaza-4-oxo-spiro-(4,5)decan- verbindungen |
| US5849736A (en) * | 1993-11-24 | 1998-12-15 | The Dupont Merck Pharmaceutical Company | Isoxazoline and isoxazole fibrinogen receptor antagonists |
| US5739336A (en) | 1995-06-23 | 1998-04-14 | Syntex (U.S.A.) Inc. | 1,3,8-triaza- and 3,8-diaza-1-oxaspiro 4,5! decane derivatives |
| DE19528472A1 (de) | 1995-08-03 | 1997-02-06 | Boehringer Ingelheim Kg | Neues Verfahren zur Herstellung von Norbenzomorphan einer Zwischenstufe bei Herstellung von pharmazeutisch wertvollen Benzomorphanderivaten, insbesondere von (-)-(1R,5S,S"R)-3'-Hydroxy-2-(2-methoxypropyl-)-5,9,9-trimethyl-6,7 benzomorphan |
| CA2233204A1 (en) | 1995-09-29 | 1997-04-03 | Joseph A. Jakubowski | Spiro compounds as inhibitors of fibrinogen-dependent platelet aggregation |
| ZA972195B (en) * | 1996-03-15 | 1998-09-14 | Du Pont Merck Pharma | Spirocycle integrin inhibitors |
| WO1997033887A1 (en) * | 1996-03-15 | 1997-09-18 | Du Pont Pharmaceuticals Company | Spirocycle integrin inhibitors |
| AU6780398A (en) | 1997-03-28 | 1998-10-22 | Du Pont Merck Pharmaceutical Company, The | Heterocyclic integrin inhibitor prodrugs |
| JP4818511B2 (ja) | 1998-11-18 | 2011-11-16 | ビーエーエスエフ ソシエタス・ヨーロピア | ２−アルキル−３−（４，５−ジヒドロイソオキサゾール−３−イル）ハロベンゼン類の製造方法 |
| KR20030000243A (ko) | 2001-06-22 | 2003-01-06 | 이 석 민 | 동물사료 제조방법 및 그에 적합한 기밀 플라스틱백발효용기 |
| DE10130020A1 (de) | 2001-06-25 | 2003-12-04 | Gruenenthal Gmbh | Substituierte 1-Oxa-2,8-diaza-spiro[4.5]dec-2-en-derivate |
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2001
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2002
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- 2002-06-21 CN CNB028166825A patent/CN1315840C/zh not_active Expired - Fee Related
- 2002-06-21 ES ES02735422T patent/ES2245402T3/es not_active Expired - Lifetime
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- 2002-06-21 SI SI200230221T patent/SI1401841T1/sl unknown
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