[go: up one dir, main page]

CO5271657A1 - Derivados de azaindol - Google Patents

Derivados de azaindol

Info

Publication number
CO5271657A1
CO5271657A1 CO01013156A CO01013156A CO5271657A1 CO 5271657 A1 CO5271657 A1 CO 5271657A1 CO 01013156 A CO01013156 A CO 01013156A CO 01013156 A CO01013156 A CO 01013156A CO 5271657 A1 CO5271657 A1 CO 5271657A1
Authority
CO
Colombia
Prior art keywords
azaindol
derivatives
mfi
jpeg
emi file
Prior art date
Application number
CO01013156A
Other languages
English (en)
Inventor
Wang Tao
B Wallace Owen
Zhang Zhongxing
Nicholas A Meanwell
John A Bender
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22675206&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO5271657(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of CO5271657A1 publication Critical patent/CO5271657A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Un compuesto de la fórmula I, o una sal farmacéuticamente aceptable del mismo, <EMI FILE="01013156_1" ID="1" IMF=JPEG >caracterizado porque: <EMI FILE="01013156_2" ID="2" IMF=JPEG > selecciona del grupo que consiste de: <EMI FILE="01013156_3" ID="3" IMF=JPEG >
CO01013156A 2000-02-22 2001-02-20 Derivados de azaindol CO5271657A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US18400400P 2000-02-22 2000-02-22

Publications (1)

Publication Number Publication Date
CO5271657A1 true CO5271657A1 (es) 2003-04-30

Family

ID=22675206

Family Applications (1)

Application Number Title Priority Date Filing Date
CO01013156A CO5271657A1 (es) 2000-02-22 2001-02-20 Derivados de azaindol

Country Status (31)

Country Link
US (1) US20020061892A1 (es)
EP (1) EP1257276B1 (es)
JP (1) JP3868814B2 (es)
KR (1) KR100496574B1 (es)
CN (1) CN1404392A (es)
AR (1) AR029469A1 (es)
AT (1) ATE314072T1 (es)
AU (2) AU2001232895B2 (es)
BR (1) BRPI0108485B1 (es)
CA (1) CA2400700C (es)
CO (1) CO5271657A1 (es)
CY (1) CY1107460T1 (es)
DE (1) DE60116260T2 (es)
DK (1) DK1257276T3 (es)
EG (1) EG24669A (es)
ES (1) ES2254367T3 (es)
HU (1) HU229992B1 (es)
IL (1) IL150734A0 (es)
MX (1) MXPA02008113A (es)
MY (1) MY128458A (es)
NO (1) NO323564B1 (es)
NZ (1) NZ520317A (es)
PE (1) PE20020786A1 (es)
PL (1) PL357434A1 (es)
PT (1) PT1257276E (es)
RU (1) RU2259372C2 (es)
TR (1) TR200201961T2 (es)
TW (1) TWI293629B (es)
UY (1) UY26593A1 (es)
WO (1) WO2001062255A1 (es)
ZA (1) ZA200206073B (es)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2387981T3 (es) * 2001-02-02 2012-10-05 Bristol-Myers Squibb Company Composición y actividad antiviral de derivados de piperazina azaindoloxoacética sustituidos
US20040110785A1 (en) * 2001-02-02 2004-06-10 Tao Wang Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives
US20030207910A1 (en) * 2001-02-02 2003-11-06 Tao Wang Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives
US6825201B2 (en) * 2001-04-25 2004-11-30 Bristol-Myers Squibb Company Indole, azaindole and related heterocyclic amidopiperazine derivatives
US20030236277A1 (en) 2002-02-14 2003-12-25 Kadow John F. Indole, azaindole and related heterocyclic pyrrolidine derivatives
AU2003217604A1 (en) * 2002-02-23 2003-09-09 Bristol-Myers Squibb Company Method of treating hiv infection by preventing interaction of cd4 and gp120
US20040063744A1 (en) * 2002-05-28 2004-04-01 Tao Wang Indole, azaindole and related heterocyclic 4-alkenyl piperidine amides
US20050075364A1 (en) * 2003-07-01 2005-04-07 Kap-Sun Yeung Indole, azaindole and related heterocyclic N-substituted piperazine derivatives
AU2004308299B2 (en) 2003-12-19 2011-11-24 Plexxikon, Inc. Compounds and methods for development of Ret modulators
UA88297C2 (ru) * 2004-03-15 2009-10-12 Бристол-Майэрс Сквибб Компани Пиперазиновые пролекарства и замещенные пиперидиновые антивирусные средства
US7745625B2 (en) * 2004-03-15 2010-06-29 Bristol-Myers Squibb Company Prodrugs of piperazine and substituted piperidine antiviral agents
US20050252408A1 (en) * 2004-05-17 2005-11-17 Richardson H W Particulate wood preservative and method for producing same
UY28945A1 (es) 2004-06-09 2006-01-31 Glaxo Group Ltd Derivados de pirrolopiridina
US7498342B2 (en) 2004-06-17 2009-03-03 Plexxikon, Inc. Compounds modulating c-kit activity
US20060100209A1 (en) * 2004-11-09 2006-05-11 Chong-Hui Gu Formulations of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione
US20060100432A1 (en) * 2004-11-09 2006-05-11 Matiskella John D Crystalline materials of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione
US7183284B2 (en) * 2004-12-29 2007-02-27 Bristol-Myers Squibb Company Aminium salts of 1,2,3-triazoles as prodrugs of drugs including antiviral agents
US7601715B2 (en) 2005-06-22 2009-10-13 Bristol-Myers Squibb Company Process for preparing triazole substituted azaindoleoxoacetic piperazine derivatives and novel salt forms produced therein
KR20080035653A (ko) 2005-07-22 2008-04-23 프로제닉스 파머슈티컬스, 인코포레이티드 Ｈｉｖ―１ 감염 환자에서 바이러스 부하를 감소시키는방법
US7598380B2 (en) * 2005-08-03 2009-10-06 Bristol-Myers Squibb Company Method of preparation of azaindole derivatives
US7396830B2 (en) * 2005-10-04 2008-07-08 Bristol-Myers Squibb Company Piperazine amidines as antiviral agents
EP1966199B1 (en) * 2005-11-18 2010-10-20 F. Hoffmann-La Roche AG Azaindole-2-carboxamide derivatives
US7851476B2 (en) * 2005-12-14 2010-12-14 Bristol-Myers Squibb Company Crystalline forms of 1-benzoyl-4-[2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-YL)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-C]pyridin-3-YL]-1,2-dioxoethyl]-piperazine
US7807671B2 (en) * 2006-04-25 2010-10-05 Bristol-Myers Squibb Company Diketo-piperazine and piperidine derivatives as antiviral agents
WO2008063888A2 (en) 2006-11-22 2008-05-29 Plexxikon, Inc. Compounds modulating c-fms and/or c-kit activity and uses therefor
CN101679358B (zh) * 2007-06-18 2013-10-30 塞诺菲-安万特股份有限公司 作为p2y12拮抗剂的吡咯衍生物
MX2010000617A (es) 2007-07-17 2010-05-17 Plexxikon Inc Compuestos y metodos para modulacion de cinasa, e indicaciones de estos.
WO2009011912A1 (en) * 2007-07-18 2009-01-22 Bristol-Myers Squibb Company A composition for treating hiv comprising virus-like particles
WO2009095162A1 (en) 2008-01-31 2009-08-06 Sanofi-Aventis Cyclic azaindole-3-carboxamides, their preparation and their use as pharmaceuticals
US20100056540A1 (en) * 2008-09-04 2010-03-04 Bristol-Myers Squibb Company Stable pharmaceutical composition for optimized delivery of an hiv attachment inhibitor
AU2010232670B2 (en) 2009-04-03 2015-07-09 F. Hoffmann-La Roche Ag Propane- I-sulfonic acid {3- [5- (4 -chloro-phenyl) -1H-pyrrolo [2, 3-b] pyridine-3-carbonyl] -2, 4-difluoro-pheny l } -amide compositions and uses thereof
MA33975B1 (fr) 2009-11-06 2013-02-01 Plexxikon Inc Composés et méthodes de modulation des kinases et leurs indications d'emploi
WO2012075235A1 (en) 2010-12-02 2012-06-07 Bristol-Myers Squibb Company Alkyl amides as hiv attachment inhibitors
HUE040136T2 (hu) 2011-02-07 2019-02-28 Plexxikon Inc Vegyületek és eljárások kináz modulációra és azok indikációi
TWI558702B (zh) 2011-02-21 2016-11-21 普雷辛肯公司 醫藥活性物質的固態形式
ES2636312T3 (es) 2011-04-12 2017-10-05 VIIV Healthcare UK (No.5) Limited Derivados de tioamida, amidoxima y amidrazona como inhibidores de la fijación del VIH
US8664213B2 (en) 2011-08-29 2014-03-04 Bristol-Myers Squibb Company Spiro bicyclic diamine derivatives as HIV attachment inhibitors
US8835454B2 (en) 2011-08-29 2014-09-16 Bristol-Myers Squibb Company Fused bicyclic diamine derivatives as HIV attachment inhibitors
US9193725B2 (en) 2012-03-14 2015-11-24 Bristol-Meyers Squibb Company Cyclic hydrazine derivatives as HIV attachment inhibitors
US9150570B2 (en) 2012-05-31 2015-10-06 Plexxikon Inc. Synthesis of heterocyclic compounds
CN102746295B (zh) * 2012-06-20 2014-10-15 上海阿达玛斯试剂有限公司 4位取代-7-氮杂吲哚的制备方法
WO2014025852A1 (en) 2012-08-09 2014-02-13 Bristol-Myers Squibb Company Tricyclic alkene derivatives as hiv attachment inhibitors
EP2895471B1 (en) 2012-08-09 2016-11-23 VIIV Healthcare UK (No.5) Limited Piperidine amide derivatives as hiv attachment inhibitors
CN109528749B (zh) * 2017-09-22 2023-04-28 上海交通大学医学院附属瑞金医院 长链非编码rna-h19在制备治疗垂体瘤药物中的用途
WO2022076975A1 (en) 2020-10-05 2022-04-14 Enliven Therapeutics, Inc. 5- and 6-azaindole compounds for inhibition of bcr-abl tyrosine kinases
CN115368320B (zh) * 2020-11-24 2024-05-31 中国人民解放军海军军医大学 一类取代苯甲酰哌嗪类化合物及其应用
CN115855899B (zh) * 2022-11-24 2025-06-10 常熟理工学院 一种荧光探针检测二氧化硫衍生物的应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2099335C1 (ru) * 1989-12-28 1997-12-20 Дзе Апджон Компани Диароматические соединения
US5424329A (en) * 1993-08-18 1995-06-13 Warner-Lambert Company Indole-2-carboxamides as inhibitors of cell adhesion

Also Published As

Publication number Publication date
JP3868814B2 (ja) 2007-01-17
TR200201961T2 (tr) 2002-12-23
CA2400700A1 (en) 2001-08-30
BRPI0108485B1 (pt) 2016-08-23
NO323564B1 (no) 2007-06-11
DE60116260T2 (de) 2006-08-31
EP1257276A4 (en) 2004-10-27
NZ520317A (en) 2004-05-28
RU2002125494A (ru) 2004-03-20
HUP0301508A2 (hu) 2003-09-29
ZA200206073B (en) 2003-10-30
WO2001062255A1 (en) 2001-08-30
HK1052132A1 (en) 2003-09-05
KR100496574B1 (ko) 2005-06-22
EP1257276B1 (en) 2005-12-28
MY128458A (en) 2007-02-28
AR029469A1 (es) 2003-07-02
CA2400700C (en) 2010-10-26
ES2254367T3 (es) 2006-06-16
MXPA02008113A (es) 2003-01-28
RU2259372C2 (ru) 2005-08-27
UY26593A1 (es) 2001-09-28
KR20020073598A (ko) 2002-09-27
JP2003523392A (ja) 2003-08-05
NO20023981L (no) 2002-10-17
US20020061892A1 (en) 2002-05-23
DK1257276T3 (da) 2006-04-10
AU3289501A (en) 2001-09-03
PT1257276E (pt) 2006-05-31
EG24669A (en) 2010-04-11
CN1404392A (zh) 2003-03-19
HU229992B1 (en) 2015-04-28
PL357434A1 (en) 2004-07-26
HUP0301508A3 (en) 2004-08-30
IL150734A0 (en) 2003-02-12
NO20023981D0 (no) 2002-08-21
EP1257276A1 (en) 2002-11-20
PE20020786A1 (es) 2002-09-06
ATE314072T1 (de) 2006-01-15
BR0108485A (pt) 2003-04-22
DE60116260D1 (de) 2006-02-02
TWI293629B (es) 2008-02-21
CY1107460T1 (el) 2012-12-19
AU2001232895B2 (en) 2005-03-17

Similar Documents

Publication Publication Date Title
CO5271657A1 (es) Derivados de azaindol
CO5280060A1 (es) Aminoacidos biciclicos como agentes farmaceuticos
CO5690131A1 (es) Derivados de eter biarilico que presentan actividad como inhibidores de la recaptacion de monoaminas para el tratamiento de transtornos del snc
CO5251404A1 (es) Compuestos antibioticos de azalida
CO5160253A1 (es) Complejo de 1,4-benzodiazepinas sustituidas y sulfobutileter -7-ciclodextrina o 2-hidroxipropil-b-ciclodextrina .
CO5570109A1 (es) Compuestos de dihidropirimidina heterociclicos
PA8514401A1 (es) Nuevos derivados de piperazina
DOP2002000456A (es) Inhibidores de la alquin-aril fosfodiesterasa-4&#39;&#39;
CO5261589A1 (es) Compuestos heterociclicos, su produccion y su utilizacion
TR200200579T2 (tr) Amino-tirazolpiridin türevleri.
RU2000119792A (ru) Моносульфат азепептидного производного и содержащая его фармацевтическая композиция, ингибирующая вич-протеазу
AP1782A (en) Use of compounds ?-D or ?-L nucleoside for treating hepatitis C virus.
GEP20053692B (en) Substituted Alkylamine Derivatives and Methods of Use
ATE270817T1 (de) Fungizide
DK1200418T3 (da) Nematodicide trifluorbutener
SE0004245D0 (sv) Novel compounds and their use
CO5070569A1 (es) Compuesto de aminoazol o una sal farmaceuticamente aceptable del mismo y medicamento que los contienen
EA200200545A1 (ru) Онколитические комбинации для лечения рака
BR0109542A (pt) Derivados de imidazopirina alquilados
CO5271735A1 (es) Forma cristalina
ES2190422T3 (es) Antagonistas selectivos de receptores de adenosina a2b.
CO5261594A1 (es) Inhibidores de myt1 cinasa
CO5090837A1 (es) Derivados de 1,3,4-oxadiazolona
DE60112960D1 (de) Kondensierte pyridoindolderivate
CO5150166A1 (es) (s)-10, 11-dihidro-3[2-(5,6,7,8-tetrahidro-1,8-naftiridin -2-il)-etoxi]-5h-dibenzo [a,d] cicloheptano-10-acido acetico

Legal Events

Date Code Title Description
FC Application refused