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CO5261589A1 - Compuestos heterociclicos, su produccion y su utilizacion - Google Patents

Compuestos heterociclicos, su produccion y su utilizacion

Info

Publication number
CO5261589A1
CO5261589A1 CO01027571A CO01027571A CO5261589A1 CO 5261589 A1 CO5261589 A1 CO 5261589A1 CO 01027571 A CO01027571 A CO 01027571A CO 01027571 A CO01027571 A CO 01027571A CO 5261589 A1 CO5261589 A1 CO 5261589A1
Authority
CO
Colombia
Prior art keywords
production
jpeg
formula
alkyl group
represented
Prior art date
Application number
CO01027571A
Other languages
English (en)
Inventor
Akihiro Tasaka
Hitaka Takenori
Matsutani Etsuya
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of CO5261589A1 publication Critical patent/CO5261589A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Un compuesto caracterizado por que está representado por la fórmula:<EMI FILE="01027571_1" ID="1" IMF=JPEG >en donde n es de valor 1 ó 2;R1 es un átomo halógeno o un grupo alquilo C1-2 opcionalmente halogenado;uno de R2 y R3 es un átomo de hidrógeno y el otro es un grupo representado por la fórmula:<EMI FILE="01027571_2" ID="2" IMF=JPEG >en donde n es 3 ó 4; R4 es un grupo alquilo C1-4 sustituido por 1 o 2 grupos hidroxilo, o una sal del mismo.
CO01027571A 2000-04-07 2001-04-06 Compuestos heterociclicos, su produccion y su utilizacion CO5261589A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2000106836 2000-04-07

Publications (1)

Publication Number Publication Date
CO5261589A1 true CO5261589A1 (es) 2003-03-31

Family

ID=18619943

Family Applications (1)

Application Number Title Priority Date Filing Date
CO01027571A CO5261589A1 (es) 2000-04-07 2001-04-06 Compuestos heterociclicos, su produccion y su utilizacion

Country Status (19)

Country Link
US (2) US6716863B2 (es)
EP (1) EP1268473A1 (es)
KR (1) KR20020028865A (es)
CN (1) CN1444582A (es)
AU (1) AU2001244726A1 (es)
BR (1) BR0109851A (es)
CA (1) CA2404760A1 (es)
CO (1) CO5261589A1 (es)
CZ (1) CZ20023264A3 (es)
EE (1) EE200200576A (es)
HU (1) HUP0300434A3 (es)
IL (1) IL152115A0 (es)
MX (1) MXPA02009621A (es)
NO (1) NO20024742L (es)
OA (1) OA12244A (es)
PE (1) PE20011178A1 (es)
PL (1) PL365787A1 (es)
SK (1) SK14132002A3 (es)
WO (1) WO2001077107A1 (es)

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HUP0103761A3 (en) * 1998-10-08 2002-11-28 Takeda Chemical Industries Ltd Compositions for retarding change of hormone-dependent cancer into hormone-independent cancer and their use
KR20050063747A (ko) * 2000-07-19 2005-06-28 다케다 야쿠힌 고교 가부시키가이샤 1-치환-1,2,3-트리아졸 유도체, 그 중간체, 및 이들의제조 방법
WO2002087616A1 (en) * 2001-04-25 2002-11-07 Takeda Chemical Industries, Ltd. Preventives for postoperative recurrence of premenopausal breast cancer
WO2002087619A1 (en) * 2001-04-27 2002-11-07 Takeda Chemical Industries, Ltd. Preventive/therapeutic method for cancer
WO2002087618A1 (en) * 2001-04-27 2002-11-07 Takeda Chemical Industries, Ltd. Preventive/therapeutic method for cancer
EP1424080B1 (en) * 2001-08-10 2011-02-16 Takeda Pharmaceutical Company Limited Gnrh agonist combination drugs
EP1439178A4 (en) * 2001-10-05 2005-11-16 Takeda Pharmaceutical Heterocyclic compounds, oxazole derivatives, process for their preparation and their use
US7812044B2 (en) 2001-11-13 2010-10-12 Takeda Pharmaceutical Company Limited Anticancer agents
AU2002349477A1 (en) * 2001-11-26 2003-06-10 Takeda Chemical Industries, Ltd. Bicyclic derivative, process for producing the same, and use
AU2003203170A1 (en) * 2002-01-17 2003-07-30 Takeda Chemical Industries, Ltd. Nitrogenous heterocyclic compounds, process for preparation of the same and use thereof
JP2006501147A (ja) 2002-04-25 2006-01-12 ユニバーシティー オブ コネティカット ヘルス センター 非ワクチン治療法の治療効果を改善するための熱ショックタンパク質の使用
EP1574215B1 (en) * 2002-12-16 2015-07-15 Kissei Pharmaceutical Co., Ltd. Solid drug for oral use
TW200505913A (en) * 2003-03-28 2005-02-16 Hoffmann La Roche Novel oxazole derivatives, their manufacture and use as pharmaceutical agents
TW200423931A (en) * 2003-04-30 2004-11-16 Hoffmann La Roche Novel aniline derivatives, their manufacture and use as pharmaceutical agents
US7247649B2 (en) * 2003-08-13 2007-07-24 Hoffmann-La Roche Inc. Oxazoles, their manufacture and use as pharmaceutical agents
US7259262B2 (en) * 2003-10-24 2007-08-21 Hoffmann-La Roche Inc. Arylazole derivatives, their manufacture and use as pharmaceutical agents
US20050186275A1 (en) * 2004-02-23 2005-08-25 Standard Chem. & Pharm. Co. Ltd. Sustained release tamsulosin formulations
TW200531688A (en) 2004-03-05 2005-10-01 Hoffmann La Roche Novel pentafluorosulfanyl compounds, their manufacture and use as pharmaceutical agents
TW200612914A (en) * 2004-03-05 2006-05-01 Hoffmann La Roche Novel oxidized thioether derivatives, their manufacture and use as pharmaceutical agents
TW200533346A (en) 2004-03-18 2005-10-16 Hoffmann La Roche Novel ether derivatives, their manufacture and use as pharmaceutical agents
RU2006138425A (ru) * 2004-04-02 2008-06-20 Ф.Хоффманн-Ля Рош Аг (Ch) Новый способ получения диазиновых производных
US7005526B2 (en) 2004-05-25 2006-02-28 Hoffmann-La Roche Inc. Thioether derivatives
US7163953B2 (en) 2004-05-25 2007-01-16 Hoffmann-La Roche Inc. Benzylether derivatives
US7618769B2 (en) * 2004-06-07 2009-11-17 Applied Materials, Inc. Textured chamber surface
US7288557B2 (en) 2004-09-21 2007-10-30 Hoffmann-La Roche Inc. Triazole derivatives
TW200616951A (en) 2004-09-22 2006-06-01 Hoffmann La Roche Indole derivatives, their manufacture and use as pharmaceutial agents
US20060069095A1 (en) * 2004-09-24 2006-03-30 Thomas Hofmeister Azole derivatives
US20060116407A1 (en) * 2004-11-22 2006-06-01 Birgit Bossenmaier Amide derivatives
TW200727900A (en) * 2005-07-27 2007-08-01 Yakult Honsha Kk Aqueous solution preparation containing camptothecins
US7429605B2 (en) * 2005-08-04 2008-09-30 Hoffmann-La Roche Inc. Phenylpyridine derivatives
EP1915370A1 (en) * 2005-08-08 2008-04-30 F.Hoffmann-La Roche Ag Pyrazole derivatives, their manufacture and their use as pharmaceutical agents
CA2622944A1 (en) * 2005-09-30 2007-04-12 F. Hoffmann-La Roche Ag Diazine azole derivatives, their manufacture and use as pharmaceutical agents
WO2008034579A1 (en) * 2006-09-20 2008-03-27 F. Hoffmann-La Roche Ag 2-heterocyclyl-5-phenoxymethylpyridine derivatives as anticancer agents
JPWO2008072634A1 (ja) 2006-12-12 2010-04-02 武田薬品工業株式会社 縮合複素環化合物
WO2008133102A1 (ja) 2007-04-20 2008-11-06 Daido Chemical Corporation 新規乾式固体分散体用基剤、該基剤を含有する固体分散体及び該分散体を含有する組成物
TW200944528A (en) 2008-03-12 2009-11-01 Takeda Pharmaceutical Fused heterocyclic compound
TW201016703A (en) * 2008-09-26 2010-05-01 Takeda Pharmaceutical Prevention and treatment of cancer with LKB1 non-expression (deletion or mutation)
TW201016704A (en) * 2008-09-26 2010-05-01 Takeda Pharmaceutical Prevention and treatment of cancer with RAS gene mutation
JP5663750B2 (ja) 2009-09-30 2015-02-04 株式会社サンギ 難溶性物質の水溶解性改善方法
EP2540286A4 (en) 2010-02-26 2015-05-27 Nisshin Kasei Co Ltd HARD CAPSULE AND METHOD OF PRODUCING THE SAME
WO2011153049A1 (en) 2010-06-02 2011-12-08 The Trustees Of The University Of Pennsylvania Methods and use of compounds that bind to her2/neu receptor complex
US9265739B2 (en) 2010-06-02 2016-02-23 The Trustees Of The University Of Pennsylvania Methods and use of compounds that bind to HER2/neu receptor complex
JP5909796B2 (ja) 2012-03-02 2016-04-27 株式会社サンギ 難溶性物質の水溶解性改善方法
WO2014050910A1 (ja) 2012-09-26 2014-04-03 武田薬品工業株式会社 固体粒子の製造方法
US9468681B2 (en) 2013-03-01 2016-10-18 California Institute Of Technology Targeted nanoparticles
WO2017003668A1 (en) 2015-07-01 2017-01-05 California Institute Of Technology Cationic mucic acid polymer-based delivery systems
EP3238711B1 (en) 2016-04-26 2023-07-12 Mitsubishi Chemical Corporation Base for solid dispersion, production method for solid dispersion using same, and solid dispersion
CA2995617A1 (en) * 2017-11-03 2019-05-03 Universite De Montreal Heterocyclic mitochondrial activity inhibitors and uses thereof
JP7483193B2 (ja) 2018-06-13 2024-05-15 カリフォルニア・インスティテュート・オブ・テクノロジー 血脳バリアを越えるためのナノ粒子とそれを用いた治療法
EP3903828A4 (en) 2018-12-21 2022-10-05 Daiichi Sankyo Company, Limited ANTIBODY-DRUG CONJUGATE AND KINAS INHIBITOR COMBINATION
JP7769388B2 (ja) 2019-12-12 2025-11-13 ティン セラピューティクス，インコーポレイテッド 聴覚損失の予防及び治療のための組成物及び方法
CN114217025B (zh) * 2021-12-17 2024-01-23 哈尔滨工业大学 评估空气质量浓度预测中气象数据对其影响的分析方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05506857A (ja) * 1990-04-16 1993-10-07 ローヌ―プーラン　ローラー　インターナショナル　（ホウルディングス）インコーポレイテッド Ｅｇｆレセプタチロシンキナーゼを阻害するスチリル―置換単環式および二環式複素アリール化合物
ATE338754T1 (de) * 1996-07-19 2006-09-15 Takeda Pharmaceutical Heterocyclische verbindungen, ihre herstellung und verwendung

Also Published As

Publication number Publication date
WO2001077107B1 (en) 2001-12-20
CN1444582A (zh) 2003-09-24
EE200200576A (et) 2004-06-15
NO20024742D0 (no) 2002-10-02
WO2001077107A1 (en) 2001-10-18
CA2404760A1 (en) 2001-10-18
MXPA02009621A (es) 2003-05-14
US6716863B2 (en) 2004-04-06
KR20020028865A (ko) 2002-04-17
HUP0300434A3 (en) 2004-11-29
IL152115A0 (en) 2003-05-29
EP1268473A1 (en) 2003-01-02
PE20011178A1 (es) 2001-11-19
PL365787A1 (en) 2005-01-10
US20040024035A1 (en) 2004-02-05
SK14132002A3 (sk) 2003-04-01
US20020173526A1 (en) 2002-11-21
CZ20023264A3 (cs) 2003-02-12
BR0109851A (pt) 2003-06-03
NO20024742L (no) 2002-11-25
WO2001077107A8 (en) 2003-02-13
OA12244A (en) 2006-05-10
HUP0300434A2 (hu) 2003-06-28
AU2001244726A1 (en) 2001-10-23

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