DE60112960D1 - Kondensierte pyridoindolderivate - Google Patents

Kondensierte pyridoindolderivate

Info

Publication number: DE60112960D1
Authority: DE; Germany
Prior art keywords: pyridoindol; condensed; derivatives; compounds; solvates
Prior art date: 2000-10-02
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE60112960T

Other languages

English (en)

Other versions

DE60112960T2 (de

Inventor

W Orme

Scott Sawyer

Alain Claude-Marie Daugan

Francoise Gellibert

Romain Luc Marie Gosmini

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Lilly Icos LLC

Original Assignee

Lilly Icos LLC

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-10-02

Filing date

2001-09-17

Publication date

2005-09-29

2001-09-17 Application filed by Lilly Icos LLC filed Critical Lilly Icos LLC

2005-09-29 Publication of DE60112960D1 publication Critical patent/DE60112960D1/de

2006-02-09 Application granted granted Critical

2006-02-09 Publication of DE60112960T2 publication Critical patent/DE60112960T2/de

2021-09-18 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Pulmonology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Vascular Medicine (AREA)
Reproductive Health (AREA)
Endocrinology (AREA)
Gynecology & Obstetrics (AREA)
Orthopedic Medicine & Surgery (AREA)
Ophthalmology & Optometry (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Pregnancy & Childbirth (AREA)
Pain & Pain Management (AREA)
Immunology (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

DE60112960T 2000-10-02 2001-09-17 Kondensierte pyridoindolderivate Expired - Lifetime DE60112960T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US23724000P	2000-10-02	2000-10-02
US237240P		2000-10-02
PCT/US2001/042173 WO2002028859A2 (en)	2000-10-02	2001-09-17	Condensed pyridoindole derivatives

Publications (2)

Publication Number	Publication Date
DE60112960D1 true DE60112960D1 (de)	2005-09-29
DE60112960T2 DE60112960T2 (de)	2006-02-09

Family

ID=22892892

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE60112960T Expired - Lifetime DE60112960T2 (de)	2000-10-02	2001-09-17	Kondensierte pyridoindolderivate

Country Status (10)

Country	Link
US (1)	US6838456B2 (de)
EP (1)	EP1335917B1 (de)
JP (1)	JP4220776B2 (de)
AT (1)	ATE302776T1 (de)
AU (1)	AU2002213419A1 (de)
CA (1)	CA2423308A1 (de)
DE (1)	DE60112960T2 (de)
ES (1)	ES2248399T3 (de)
MX (1)	MXPA03002909A (de)
WO (1)	WO2002028859A2 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2445189C (en)	2001-06-21	2009-02-17	Lilly Icos Llc	Carboline derivatives as pdev inhibitors
PT1572173E (pt)	2002-12-13	2010-05-10	Warner Lambert Co	Ligando alfa-2-delta para tratar sintomas do tracto urinário inferior
WO2005079808A1 (en)	2004-01-22	2005-09-01	Pfizer Limited	Triazole derivatives which inhibit vasopressin antagonistic activity
US7501438B2 (en) *	2006-07-07	2009-03-10	Forest Laboratories Holdings Limited	Pyridoimidazole derivatives
JP2009027396A (ja)	2007-07-19	2009-02-05	Riso Kagaku Corp	印刷装置
EP2476680B1 (de)	2008-01-11	2014-08-27	Albany Molecular Research, Inc.	(1-Azinon)-substituierte Pyrido-Indole
WO2010015585A1 (en) *	2008-08-05	2010-02-11	Nycomed Gmbh	6-benzyl-2,3,4,7-tetrahydro-indolo[2,3-c]quinoline compounds
WO2011003007A1 (en)	2009-07-01	2011-01-06	Albany Molecular Research, Inc.	Azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine mch-1 antagonists, methods of making, and use thereof
JP2012532144A (ja)	2009-07-01	2012-12-13	アルバニーモレキュラーリサーチ，インコーポレイテッド	アジノン置換アゼピノ［ｂ］インドールおよびピリド−ピロロ−アゼピンｍｃｈ−１拮抗薬、ならびにその作製方法および使用
WO2011003021A1 (en) *	2009-07-01	2011-01-06	Albany Molecular Research, Inc.	Azinone-substituted azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine mch-1 antagonists, methods of making, and use thereof
US8618299B2 (en)	2009-07-01	2013-12-31	Albany Molecular Research, Inc.	Azinone-substituted azapolycycle MCH-1 antagonists, methods of making, and use thereof
WO2012088124A2 (en)	2010-12-21	2012-06-28	Albany Molecular Research, Inc.	Tetrahydro-azacarboline mch-1 antagonists, methods of making, and uses thereof
WO2012088038A2 (en)	2010-12-21	2012-06-28	Albany Molecular Research, Inc.	Piperazinone-substituted tetrahydro-carboline mch-1 antagonists, methods of making, and uses thereof
TWI465454B (zh) *	2011-07-15	2014-12-21	Academia Sinica	４Ｈ－苯并［ｄ］吡咯［１，２－ａ］噻唑類及吲哚嗪［６，７－ｂ］吲哚衍生物之合成及其作為抗腫瘤醫療藥劑之用途
CN113024553B (zh) *	2021-03-16	2022-02-25	皖南医学院	三唑并四氢-β-咔啉衍生物及其制备方法和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3459758A (en) *	1967-11-09	1969-08-05	Searle & Co	9,10 - dihydro - 4h - pyrazolo(1',5':1,6)pyrido (3,4-b)indole - 2,3 - dicarboxylic acids and esters
GB9401090D0 (en)	1994-01-21	1994-03-16	Glaxo Lab Sa	Chemical compounds
GB9514465D0 (en)	1995-07-14	1995-09-13	Glaxo Lab Sa	Chemical compounds
GB9514473D0 (en)	1995-07-14	1995-09-13	Glaxo Lab Sa	Chemical compounds

2001
- 2001-09-17 WO PCT/US2001/042173 patent/WO2002028859A2/en not_active Ceased
- 2001-09-17 AU AU2002213419A patent/AU2002213419A1/en not_active Abandoned
- 2001-09-17 JP JP2002532442A patent/JP4220776B2/ja not_active Expired - Fee Related
- 2001-09-17 EP EP01981802A patent/EP1335917B1/de not_active Expired - Lifetime
- 2001-09-17 US US10/363,475 patent/US6838456B2/en not_active Expired - Fee Related
- 2001-09-17 CA CA002423308A patent/CA2423308A1/en not_active Abandoned
- 2001-09-17 ES ES01981802T patent/ES2248399T3/es not_active Expired - Lifetime
- 2001-09-17 MX MXPA03002909A patent/MXPA03002909A/es active IP Right Grant
- 2001-09-17 AT AT01981802T patent/ATE302776T1/de not_active IP Right Cessation
- 2001-09-17 DE DE60112960T patent/DE60112960T2/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
CA2423308A1 (en)	2002-04-11
ES2248399T3 (es)	2006-03-16
JP4220776B2 (ja)	2009-02-04
ATE302776T1 (de)	2005-09-15
EP1335917A2 (de)	2003-08-20
DE60112960T2 (de)	2006-02-09
WO2002028859A3 (en)	2002-09-12
JP2004510774A (ja)	2004-04-08
EP1335917B1 (de)	2005-08-24
MXPA03002909A (es)	2003-09-10
US6838456B2 (en)	2005-01-04
AU2002213419A1 (en)	2002-04-15
US20030207906A1 (en)	2003-11-06
WO2002028859A2 (en)	2002-04-11

Publication	Publication Date	Title
ATE302775T1 (de)	2005-09-15	Carbolinderivate
DE60121461D1 (de)	2006-08-24	Kondensierte pyridoindolderivate
ATE346067T1 (de)	2006-12-15	Carbolinderivate
DE60112306D1 (de)	2005-09-01	Kondensierte pyrazindionderivate als pde5 inhibitore
MXPA02012076A (es)	2003-06-06	Compuestos quimicos.
EA200300717A1 (ru)	2003-12-25	Гетероциклилиндазольные и -азаиндазольные соединения в качестве 5-гидрокситриптамин-6-лигандов
TR200200579T2 (tr)	2002-12-23	Amino-tirazolpiridin türevleri.
ATE416157T1 (de)	2008-12-15	Inhibitoren von integrin alpha-v-beta-6
DE60112960D1 (de)	2005-09-29	Kondensierte pyridoindolderivate
ATE333457T1 (de)	2006-08-15	Zyklische gmp-spezifische phosphodiesteraseinhibitoren
DE60121048D1 (de)	2006-08-03	PYRAZINOi1'2':1,6öPYRIDOi3,4-BöINDOLDERIVATE
DE60110124D1 (de)	2005-05-19	Kondensierte pyrazindionderivate als pde inhibitoren
DE60122559D1 (de)	2006-10-05	Indolderivate als pde5-inhibitoren
ATE259813T1 (de)	2004-03-15	Triazolopyrimidinderivate
DE60213798D1 (de)	2006-09-21	Carbolinderivate als pdev inhibitoren
MXPA03000887A (es)	2004-04-05	Derivados heterociclicos fusionados como inhibidores de fosfodiesterasa.
ATE360422T1 (de)	2007-05-15	Tetrazyklische verbindungen als pde5-inhibitoren
CY1105981T1 (el)	2011-04-06	Ενωσεις 5-πυριδυλ-1,3-αζολιου, μεθοδοι παρασκευης αυτων και χρηση αυτων
CY1110529T1 (el)	2015-04-29	Παρασκευη ν-υποκατεστημενων 2,7-διαλκυλο-4-υδροξυ-5-αμινο-8-αρυλοοκτανοϋλαμιδιων

Legal Events

Date	Code	Title	Description
2006-09-14	8364	No opposition during term of opposition