CO4480031A1 - Derivados de acido quinolon- y naftiridoncarboxilico - Google Patents
Derivados de acido quinolon- y naftiridoncarboxilicoInfo
- Publication number
- CO4480031A1 CO4480031A1 CO95045988A CO95045988A CO4480031A1 CO 4480031 A1 CO4480031 A1 CO 4480031A1 CO 95045988 A CO95045988 A CO 95045988A CO 95045988 A CO95045988 A CO 95045988A CO 4480031 A1 CO4480031 A1 CO 4480031A1
- Authority
- CO
- Colombia
- Prior art keywords
- vinilo
- halogen
- atoms
- carbon
- represents hydrogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Cosmetics (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Luminescent Compositions (AREA)
Abstract
1. COMPUESTO DE LA FORMULA (I) T-Q (I) EN LA QUE Q SIGNIFICA UN RESTO DE LAS FORMULAS FIGURA 1 EN LAS QUE R1 REPRESENTA ALQUILO SUBSTITUIDO DADO EL CASO UNA O DOS VECES POR HALOGENO O HIDROXI CON 1 A 4 ATO- MOS DE CARBONO, ALQUNILO 2 A 4 ATOMOS DE CARBONO, CICLOALQUILO SUBSTITUIDO DADO EL CASO POR 1 o 2 ATOMOS DE FLUOR CON 3 A 6 ATOMOS DE CARBONO, BICI- CLO[1.1.1]PENT-1-ILO, 1,1-DIMETILPROPARGILO, 3- OXETANILO, METOXI, AMINO, METILAMINO, DIMETILAMI- NO, FENILO DADO EL CASO SUBSTITUIDO UNA O DOS VE- CES POR HALOGENO, AMINO O HIDROXI, R2 REPRESENTA HIDROXI, ALCOXI DADO EL CASO SUBSTI- TUIDO POR HIDROXI, METOXI, AMINO, DIMETILAMINO CON 1 A 3 ATOMOS DE CARBONO, BENCILOXI O (5-METIL-2- OXO-1,3-DIOXOL-4-IL)-METILOXI, ACETOXIMETILOXI PIVALOILOXIMETILOXI, 5-INDANOLILOXI, FTALIDINILO- XI, 3-ACETOXI-2-OXO-BUTILOXI, NITROMETILO O DIALCOXICARBONILMETILO CON 1 A 2 ATOMOS DE CARBONO EN CADA PARTE ALQUILO, R9 REPRESENTA HIDROGENO O ALQUILO DADO EL CASO SUBSTITUIDO POR METOXI, HIDROXI O HALOGENO CON 1 A 3 ATOMOS DE CARBONO, R11 REPRESENTA HIDROGENO, CH3 o CH2F, R1 REPRESENTA HALOGENO O NITRO, X2 REPRESENTA HIDROGENO, HALOGENO, AMINO, HIDROXI, METOXI, MERCAPTO, METILO, HALOGENOMETILO O VINILO, A REPRESENTA N o C-R7, EN LA QUE R7 REPRESENTA HIDROGENO, HALOGENO, CF3, OCH3, OCHF2, CH3, CN, CH=CH2 o C CH o TAMBIEN JUNTO CON R1 PUEDE FORMAR UN PUENTE DE LA ESTRUCTURA -*O-CH2-CH-CH3, *-S-CH2-CH2-, *S-CH2-CH-CH3, -*CH2-CH-CH-CH3 o -*C-CH2-N-R8, DONDE EL ATOMO MARCADO CON * ESTA ENLAZADO CON EL ATOMO DE CARBO- NO DE A Y EN LA QUE R8 SIGNIFICA HIDROGENO, METILO O FORMILO, Y D REPRESENTA N o C-R10, EN LA QUE R10 REPRESENTA HIDROGENO, HALOGENO, CF3, OCH3, OCHF2 o CH3 o TAMBIEN CON R9 PUEDE FORMAR UN PUEN- TE DE LA ESTRUCTURA -*O-CH2-NH-CH2-, -N(CH3)-CH2)-, -*N(C2H5)-CH2-, -*N(C-C3H5)-CH2- o -*S-CH-, DONDE EL ATOMO MARCADO CON * ESTA ENLAZA- DO CONEL ATOMO DE CARBONO DE D, Y T SIGNIFICA UN RESTO DE LA FORMULA FIGURA 2 EN LA QUE B REPRESENTA (CH2)m-NR3R4 o (CH2)m-OR5, EN LA QUE m REPRESENTA 0 o 1 R3 REPRESENTA HIDROGENO, METILO O ALCOXICARBONILO CON 1 A 4 ATOMOS DE CARBONO EN LA PARTE ALQUILO, R4 REPRESENTA HIDROGENO O METILO Y R5 REPRESENTA HIDROGENO O METILO Y R6 REPRESENTA HIDROGENO O METILO, Y SUS HIDRATOS Y SALES DE ADICION DE PACIDOS UTI- LIZABLES FARMACEUTICAMENTE ASI COMO LAS SALES ALCALINAS, TERREOALCALINAS, DE PLATA Y GUANIDINO DE LOS ACIDOS CARBOXILICOS QUE SIRVEN DE BASE.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4435479A DE4435479A1 (de) | 1994-10-04 | 1994-10-04 | Chinolon- und Naphthyridoncarbonsäure-Derivate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO4480031A1 true CO4480031A1 (es) | 1997-07-09 |
Family
ID=6529941
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO95045988A CO4480031A1 (es) | 1994-10-04 | 1995-10-03 | Derivados de acido quinolon- y naftiridoncarboxilico |
Country Status (40)
| Country | Link |
|---|---|
| US (1) | US5679689A (es) |
| EP (1) | EP0705828B1 (es) |
| JP (1) | JP3794737B2 (es) |
| KR (1) | KR100371883B1 (es) |
| CN (1) | CN1063747C (es) |
| AT (1) | ATE187171T1 (es) |
| AU (1) | AU697608B2 (es) |
| BG (1) | BG62965B1 (es) |
| CA (1) | CA2159547A1 (es) |
| CO (1) | CO4480031A1 (es) |
| CU (1) | CU22751A3 (es) |
| CZ (1) | CZ291616B6 (es) |
| DE (2) | DE4435479A1 (es) |
| DK (1) | DK0705828T3 (es) |
| DZ (1) | DZ1933A1 (es) |
| EE (1) | EE03443B1 (es) |
| ES (1) | ES2140599T3 (es) |
| FI (1) | FI954680L (es) |
| GR (1) | GR3032659T3 (es) |
| HR (1) | HRP950469B1 (es) |
| HU (1) | HUT73429A (es) |
| IL (2) | IL130921A (es) |
| MA (1) | MA23682A1 (es) |
| MY (1) | MY113196A (es) |
| NO (1) | NO307514B1 (es) |
| NZ (1) | NZ280129A (es) |
| PE (1) | PE29698A1 (es) |
| PL (1) | PL182812B1 (es) |
| PT (1) | PT705828E (es) |
| RO (1) | RO115261B1 (es) |
| RU (1) | RU2145604C1 (es) |
| SG (1) | SG38880A1 (es) |
| SI (1) | SI0705828T1 (es) |
| SK (1) | SK280877B6 (es) |
| SV (1) | SV1995000063A (es) |
| TN (1) | TNSN95099A1 (es) |
| TW (1) | TW364908B (es) |
| UA (1) | UA42797C2 (es) |
| YU (1) | YU63595A (es) |
| ZA (1) | ZA958296B (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4435479A1 (de) * | 1994-10-04 | 1996-04-11 | Bayer Ag | Chinolon- und Naphthyridoncarbonsäure-Derivate |
| DE19751948A1 (de) | 1997-11-24 | 1999-05-27 | Bayer Ag | Verfahren zur Herstellung von 8-Methoxy-Chinoloncarbonsäuren |
| US8163769B2 (en) * | 2002-03-12 | 2012-04-24 | Abbott Laboratories | Antibacterial compounds |
| EP1631570A1 (en) * | 2003-03-12 | 2006-03-08 | Abbott Laboratories | Naphthyridine derivatives as antibacterial agents |
| EP2097400B1 (en) | 2007-01-05 | 2013-07-03 | Daiichi Sankyo Company, Limited | Fused substituted aminopyrrolidine derivative |
| BR112022010112A2 (pt) * | 2019-11-28 | 2022-09-06 | Bayer Ag | Aminoquinolonas substituídas como inibidores de dgkalfa para ativação imunológica |
| KR102151969B1 (ko) * | 2019-12-11 | 2020-09-04 | 주식회사 지투비 | 투과도 가변창의 제조방법 및 그에 의해 제조된 투과도 가변창 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CS274601B2 (en) * | 1983-07-27 | 1991-09-15 | Dainippon Pharmaceutical Co | Method of 1,8-naphthyridine derivative production |
| JPH0262875A (ja) * | 1988-05-23 | 1990-03-02 | Wakunaga Pharmaceut Co Ltd | 新規イソインドリン誘導体 |
| CA2030217A1 (en) * | 1989-11-21 | 1991-05-22 | Jun Imose | Pyridone-carboxylic acid derivatives useful as veterinary medicines |
| JPH03181478A (ja) * | 1989-12-08 | 1991-08-07 | Banyu Pharmaceut Co Ltd | ピリドンカルボン酸誘導体 |
| JPH04253973A (ja) | 1990-04-20 | 1992-09-09 | Banyu Pharmaceut Co Ltd | ピリドンカルボン酸誘導体 |
| EP0516861A4 (en) * | 1990-12-27 | 1993-01-13 | Banyu Pharmaceutical Co., Ltd. | Pyridonecarboxylic acid derivative |
| DE4120646A1 (de) | 1991-06-22 | 1992-12-24 | Bayer Ag | 7-isoindolinyl-chinolon- und naphthyridoncarbonsaeure-derivate |
| DE4121214A1 (de) * | 1991-06-27 | 1993-01-14 | Bayer Ag | 7-azaisoindolinyl-chinolon- und -naphthyridoncarbonsaeure-derivate |
| DE4230804A1 (de) | 1992-09-15 | 1994-03-17 | Bayer Ag | 7-Isoindolinyl-chinolon- und -naphthyridon-Derivate |
| DE4329600A1 (de) | 1993-09-02 | 1995-03-09 | Bayer Ag | Pyrido [1,2,3-d,e] [1,3,4] benzoxadiazinderivate |
| JP2848538B2 (ja) * | 1994-02-04 | 1999-01-20 | 大日本製薬株式会社 | ２環性アミノ基で置換されたピリドンカルボン酸誘導体、そのエステルおよびその塩ならびにこれらの中間体たる２環性アミン |
| DE4435479A1 (de) * | 1994-10-04 | 1996-04-11 | Bayer Ag | Chinolon- und Naphthyridoncarbonsäure-Derivate |
-
1994
- 1994-10-04 DE DE4435479A patent/DE4435479A1/de not_active Withdrawn
-
1995
- 1995-09-11 HR HR950469A patent/HRP950469B1/xx not_active IP Right Cessation
- 1995-09-12 MY MYPI95002699A patent/MY113196A/en unknown
- 1995-09-21 PT PT95114839T patent/PT705828E/pt unknown
- 1995-09-21 ES ES95114839T patent/ES2140599T3/es not_active Expired - Lifetime
- 1995-09-21 SI SI9530332T patent/SI0705828T1/xx not_active IP Right Cessation
- 1995-09-21 DE DE59507324T patent/DE59507324D1/de not_active Expired - Fee Related
- 1995-09-21 EP EP95114839A patent/EP0705828B1/de not_active Expired - Lifetime
- 1995-09-21 DK DK95114839T patent/DK0705828T3/da active
- 1995-09-21 AT AT95114839T patent/ATE187171T1/de not_active IP Right Cessation
- 1995-09-22 RO RO95-01656A patent/RO115261B1/ro unknown
- 1995-09-26 SG SG1995001429A patent/SG38880A1/en unknown
- 1995-09-27 AU AU32919/95A patent/AU697608B2/en not_active Ceased
- 1995-09-27 US US08/534,369 patent/US5679689A/en not_active Expired - Fee Related
- 1995-09-28 YU YU63595A patent/YU63595A/sh unknown
- 1995-09-29 CA CA002159547A patent/CA2159547A1/en not_active Abandoned
- 1995-09-29 NZ NZ280129A patent/NZ280129A/en unknown
- 1995-09-29 TW TW084110152A patent/TW364908B/zh active
- 1995-10-02 FI FI954680A patent/FI954680L/fi unknown
- 1995-10-02 PL PL95310747A patent/PL182812B1/pl unknown
- 1995-10-02 KR KR1019950033650A patent/KR100371883B1/ko not_active Expired - Fee Related
- 1995-10-02 BG BG100041A patent/BG62965B1/bg unknown
- 1995-10-02 JP JP27617395A patent/JP3794737B2/ja not_active Expired - Fee Related
- 1995-10-02 MA MA24026A patent/MA23682A1/fr unknown
- 1995-10-02 IL IL13092195A patent/IL130921A/en unknown
- 1995-10-02 DZ DZ950115A patent/DZ1933A1/fr active
- 1995-10-02 TN TNTNSN95099A patent/TNSN95099A1/fr unknown
- 1995-10-02 IL IL11549295A patent/IL115492A/xx active IP Right Grant
- 1995-10-03 CZ CZ19952568A patent/CZ291616B6/cs not_active IP Right Cessation
- 1995-10-03 UA UA95104373A patent/UA42797C2/uk unknown
- 1995-10-03 CO CO95045988A patent/CO4480031A1/es unknown
- 1995-10-03 SK SK1238-95A patent/SK280877B6/sk unknown
- 1995-10-03 RU RU95117071/04A patent/RU2145604C1/ru not_active IP Right Cessation
- 1995-10-03 PE PE1995280648A patent/PE29698A1/es not_active Application Discontinuation
- 1995-10-03 HU HU9502888A patent/HUT73429A/hu unknown
- 1995-10-03 NO NO953931A patent/NO307514B1/no not_active IP Right Cessation
- 1995-10-03 ZA ZA958296A patent/ZA958296B/xx unknown
- 1995-10-03 EE EE9500069A patent/EE03443B1/xx not_active IP Right Cessation
- 1995-10-04 CU CU1995089A patent/CU22751A3/es unknown
- 1995-10-04 CN CN95102552A patent/CN1063747C/zh not_active Expired - Fee Related
- 1995-10-04 SV SV1995000063A patent/SV1995000063A/es not_active Application Discontinuation
-
2000
- 2000-02-14 GR GR20000400357T patent/GR3032659T3/el not_active IP Right Cessation
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