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AR029343A1 - USO DE UN ANTAGONISTA DE NMDA DE BAJA AFINIDAD PARA EL TRATAMIENTO DE LA DEPRESIoN - Google Patents

USO DE UN ANTAGONISTA DE NMDA DE BAJA AFINIDAD PARA EL TRATAMIENTO DE LA DEPRESIoN

Info

Publication number
AR029343A1
AR029343A1 ARP000101292A ARP000101292A AR029343A1 AR 029343 A1 AR029343 A1 AR 029343A1 AR P000101292 A ARP000101292 A AR P000101292A AR P000101292 A ARP000101292 A AR P000101292A AR 029343 A1 AR029343 A1 AR 029343A1
Authority
AR
Argentina
Prior art keywords
low affinity
depression
treatment
nmda antagonist
affinity nmda
Prior art date
Application number
ARP000101292A
Other languages
English (en)
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of AR029343A1 publication Critical patent/AR029343A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Uso de un antagonista de NMDA, de baja afinidad, como agentes antidepresivos. Compuestos preferidos incluyen los compuestos de formula 1 en la cual R1 es piridilo, fenilo o 4-fluor fenilo, R2 es fenilo o 4-fluor fenilo; R3 es hidrogeno, alquilo C1-6 o metoxicarbonilo, R4 es hidrogeno o metilo; y R5 es hidrogeno o COCH2NH2, y las sales farmacéuticamente aceptables de los mismos.
ARP000101292A 1999-03-23 2000-03-22 USO DE UN ANTAGONISTA DE NMDA DE BAJA AFINIDAD PARA EL TRATAMIENTO DE LA DEPRESIoN AR029343A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9901077A SE9901077D0 (sv) 1999-03-23 1999-03-23 Novel use

Publications (1)

Publication Number Publication Date
AR029343A1 true AR029343A1 (es) 2003-06-25

Family

ID=20414989

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP000101292A AR029343A1 (es) 1999-03-23 2000-03-22 USO DE UN ANTAGONISTA DE NMDA DE BAJA AFINIDAD PARA EL TRATAMIENTO DE LA DEPRESIoN

Country Status (17)

Country Link
US (1) US6479553B1 (es)
EP (1) EP1162967A1 (es)
JP (1) JP4705717B2 (es)
KR (1) KR20010108368A (es)
CN (1) CN1160065C (es)
AR (1) AR029343A1 (es)
AU (1) AU774117B2 (es)
BR (1) BR0009225A (es)
CA (1) CA2359568A1 (es)
IL (1) IL145334A0 (es)
MX (1) MXPA01009448A (es)
MY (1) MY135916A (es)
NO (2) NO330550B1 (es)
NZ (1) NZ513148A (es)
SE (1) SE9901077D0 (es)
WO (1) WO2000056324A1 (es)
ZA (1) ZA200106859B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040122090A1 (en) * 2001-12-07 2004-06-24 Lipton Stuart A. Methods for treating neuropsychiatric disorders with nmda receptor antagonists
KR20070104480A (ko) * 2003-05-27 2007-10-25 포레스트 래보러토리즈, 인코포레이티드 우울증 및 그 밖의 기분장애의 치료를 위한 ｎｍｄａ수용체 길항제 및 선택적 세로토닌 재흡수 억제제의 배합물
AR046314A1 (es) 2003-11-05 2005-11-30 Merz Pharma Gmbh & Co Kgaa Composiciones que comprenden ciclohexilaminas y aminoadamantanos
WO2005116657A2 (en) * 2004-05-24 2005-12-08 Universität Zu Köln Identification of ergothioneine transporter and therapeutic uses thereof
US20060002999A1 (en) 2004-06-17 2006-01-05 Forest Laboratories, Inc. Immediate release formulations of 1-aminocyclohexane compounds, memantine and neramexane
JP5025468B2 (ja) 2004-06-17 2012-09-12 メルツ・ファルマ・ゲゼルシヤフト・ミト・ベシュレンクテル・ハフツング・ウント・コンパニー・コマンデイトゲゼルシヤフト・アウフ・アクティーン メマンチン又はネラメキサンの直接圧縮によって製造された、飲用に適した即効型錠剤
US8039009B2 (en) * 2004-06-17 2011-10-18 Forest Laboratories Holdings Limited Modified release formulations of memantine oral dosage forms
US7619007B2 (en) 2004-11-23 2009-11-17 Adamas Pharmaceuticals, Inc. Method and composition for administering an NMDA receptor antagonist to a subject
CA2588296A1 (en) 2004-11-24 2006-06-01 Neuromolecular Pharmaceuticals, Inc. Composition comprising an nmda receptor antagonist and levodopa and use thereof for treating neurological disease
MX2007012374A (es) 2005-04-06 2008-02-22 Adamas Pharmaceuticals Inc Metodos y composiciones para el tratamiento de condiciones relacionadas con cns.
AU2006259619A1 (en) * 2005-06-16 2006-12-28 Forest Laboratories, Inc. Modified and immediate release memantine bead formulation
US20080008743A1 (en) * 2006-07-06 2008-01-10 Forest Laboratories Holdings Limited Orally Dissolving Formulations of Memantine
WO2009151498A2 (en) * 2008-03-28 2009-12-17 Forest Laboratories Holdings Limited Memantine formulations
EP2138173A1 (en) 2008-06-26 2009-12-30 Merz Pharma GmbH & Co.KGaA Pharmaceutical compositions comprising aminoadamantane derivatives
PE20120249A1 (es) * 2008-12-24 2012-04-19 Astrazeneca Ab Compuestos etanaminicos
JP5885668B2 (ja) 2009-12-02 2016-03-15 アダマス ファーマシューティカルズ， インコーポレイテッド アマンタジン組成物および使用方法
JP2015501652A (ja) * 2011-12-14 2015-01-19 アストラゼネカ・アクチエボラーグＡｓｔｒａｚｅｎｅｃａ Ａｋｔｉｅｂｏｌａｇ Ｇａｂｒ−ａ２診断
WO2014204933A1 (en) 2013-06-17 2014-12-24 Adamas Pharmaceuticals, Inc. Amantadine compositions and methods of use
EP3564234B1 (en) * 2013-11-05 2021-09-29 AstraZeneca AB Nmda antagonist prodrugs

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL84305A (en) * 1987-02-06 1992-01-15 Fisons Corp 2-aminoacetamide derivatives
US5206248A (en) * 1992-03-27 1993-04-27 Smith Richard A Method for reducing emotional lability
ATE163925T1 (de) * 1992-04-03 1998-03-15 Astra Ab Enantiomere 1-phenyl-2-(2-pyridinyl)ethylamin für die behandlung neurodegenerativer störungen
EP0869122B1 (en) 1997-03-31 2002-12-04 Korea Research Institute Of Chemical Technology Quinolinic sulfide derivatives acting as NMDA receptor antagonists and process for preparation thereof

Also Published As

Publication number Publication date
AU4156100A (en) 2000-10-09
CN1344157A (zh) 2002-04-10
NO20101069L (no) 2001-09-06
JP2002539256A (ja) 2002-11-19
IL145334A0 (en) 2002-06-30
ZA200106859B (en) 2002-11-20
JP4705717B2 (ja) 2011-06-22
NO330550B1 (no) 2011-05-16
KR20010108368A (ko) 2001-12-07
NO20014345D0 (no) 2001-09-06
WO2000056324A1 (en) 2000-09-28
NO20014345L (no) 2001-09-06
NZ513148A (en) 2003-10-31
US6479553B1 (en) 2002-11-12
SE9901077D0 (sv) 1999-03-23
CA2359568A1 (en) 2000-09-28
MXPA01009448A (es) 2002-08-06
BR0009225A (pt) 2001-12-26
MY135916A (en) 2008-07-31
AU774117B2 (en) 2004-06-17
CN1160065C (zh) 2004-08-04
EP1162967A1 (en) 2001-12-19

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal