[go: up one dir, main page]

CO2018012506A2 - Composiciones farmacéuticas y regímenes de dosificación para el uso clínico de anticuerpos contra el antígeno 2 de las células dendríticas de la sangre - Google Patents

Composiciones farmacéuticas y regímenes de dosificación para el uso clínico de anticuerpos contra el antígeno 2 de las células dendríticas de la sangre

Info

Publication number
CO2018012506A2
CO2018012506A2 CONC2018/0012506A CO2018012506A CO2018012506A2 CO 2018012506 A2 CO2018012506 A2 CO 2018012506A2 CO 2018012506 A CO2018012506 A CO 2018012506A CO 2018012506 A2 CO2018012506 A2 CO 2018012506A2
Authority
CO
Colombia
Prior art keywords
dosage regimens
dendritic cells
antibodies against
pharmaceutical compositions
against antigen
Prior art date
Application number
CONC2018/0012506A
Other languages
English (en)
Inventor
Mark R H Krebs
David Dai
Shantanu Sule
Dania Rabah
David Martin
Original Assignee
Biogen Ma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogen Ma Inc filed Critical Biogen Ma Inc
Publication of CO2018012506A2 publication Critical patent/CO2018012506A2/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Se proporcionan formulaciones y regímenes de dosificación de anticuerpos contra el antígeno 2 de las células dendríticas de la sangre (BDCA2). Estas formulaciones y regímenes de dosificación se usan en el tratamiento de trastornos asociados al BDCA2 tales como el lupus eritematoso sistémico, lupus eritematoso cutáneo y lupus eritematoso discoide, así como el síndrome de liberación de citocinas.
CONC2018/0012506A 2016-04-28 2018-11-22 Composiciones farmacéuticas y regímenes de dosificación para el uso clínico de anticuerpos contra el antígeno 2 de las células dendríticas de la sangre CO2018012506A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662328959P 2016-04-28 2016-04-28
PCT/US2017/029802 WO2017189827A1 (en) 2016-04-28 2017-04-27 Pharmaceutical compositions and dosage regimens for clinical use of anti-blood dendritic cell antigen 2 antibodies

Publications (1)

Publication Number Publication Date
CO2018012506A2 true CO2018012506A2 (es) 2018-12-14

Family

ID=58672794

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2018/0012506A CO2018012506A2 (es) 2016-04-28 2018-11-22 Composiciones farmacéuticas y regímenes de dosificación para el uso clínico de anticuerpos contra el antígeno 2 de las células dendríticas de la sangre

Country Status (16)

Country Link
US (2) US20190284281A1 (es)
EP (1) EP3448425A1 (es)
JP (3) JP7045327B2 (es)
KR (5) KR102366547B1 (es)
CN (2) CN116850282A (es)
AU (2) AU2017258191B2 (es)
BR (1) BR112018072125A2 (es)
CA (1) CA3022116A1 (es)
CO (1) CO2018012506A2 (es)
EA (1) EA201892443A1 (es)
IL (2) IL262514B2 (es)
MA (1) MA44763A (es)
MX (3) MX2018012945A (es)
NZ (2) NZ747504A (es)
PH (1) PH12018502278A1 (es)
WO (1) WO2017189827A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA49962A (fr) * 2017-08-22 2020-07-01 Biogen Ma Inc Procédés de purification d'anticorps présentant des agrégats réduits à poids moléculaire élevé
EP4559485A3 (en) 2018-07-19 2025-08-06 Ichnos Sciences S.A. Liquid antibody formulation
KR200494676Y1 (ko) 2020-08-04 2021-12-01 (주) 티나인 버튼식 헤어 염색기
IL303279A (en) * 2020-12-03 2023-07-01 Biogen Ma Inc Methods of treating cutaneous lupus erythematosus and systemic lupus erythematosus
KR20230022786A (ko) 2021-08-09 2023-02-16 주식회사 인벤테라제약 생체 내 주입 후 대식세포에 의해 탐식 및/또는 대사분해되지 않은 상태로 신장을 통해 소변으로 배출되는 나노 구조물
TW202400652A (zh) * 2022-05-25 2024-01-01 大陸商映恩生物製藥（蘇州）有限公司 抗ｂｄｃａ２抗體及其用途
AU2023416592A1 (en) * 2022-12-28 2025-07-17 Duality Biologics (Shanghai) Co., Ltd. Anti-bdca2 antibody-drug conjugate and use thereof
WO2025067469A1 (zh) * 2023-09-28 2025-04-03 南京维立志博生物科技股份有限公司 Bdca2单克隆抗体及其和taci组成的融合蛋白及其方法和用途
CN118638234B (zh) * 2024-07-04 2025-10-14 杭州博之锐生物制药有限公司 抗bdca2抗体及其制备方法和应用
WO2026008012A1 (zh) * 2024-07-04 2026-01-08 杭州博之锐生物制药有限公司 抗bdca2抗体及其用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3178492A1 (en) * 2003-04-04 2017-06-14 Genentech, Inc. High concentration antibody and protein formulations
EP2928923B1 (en) * 2012-12-10 2020-01-22 Biogen MA Inc. Anti-blood dendritic cell antigen 2 antibodies and uses thereof

Also Published As

Publication number Publication date
US20250289895A1 (en) 2025-09-18
US20190284281A1 (en) 2019-09-19
KR102366547B1 (ko) 2022-02-23
CA3022116A1 (en) 2017-11-02
JP2024038308A (ja) 2024-03-19
MX2023008075A (es) 2023-07-18
IL262514B1 (en) 2025-08-01
JP2019520316A (ja) 2019-07-18
JP2022084782A (ja) 2022-06-07
BR112018072125A2 (pt) 2019-03-19
AU2024203240A1 (en) 2024-06-13
CN109475623B (zh) 2023-05-26
CN109475623A (zh) 2019-03-15
MX2025000037A (es) 2025-02-10
EA201892443A1 (ru) 2019-04-30
WO2017189827A1 (en) 2017-11-02
IL262514B2 (en) 2025-12-01
IL262514A (en) 2018-12-31
KR20240159012A (ko) 2024-11-05
EP3448425A1 (en) 2019-03-06
MA44763A (fr) 2019-03-06
NZ747504A (en) 2025-08-29
MX2018012945A (es) 2019-03-06
IL321561A (en) 2025-08-01
AU2017258191A1 (en) 2018-11-15
JP7045327B2 (ja) 2022-03-31
KR20190002563A (ko) 2019-01-08
NZ787392A (en) 2025-08-29
AU2017258191B2 (en) 2024-06-13
CN116850282A (zh) 2023-10-10
KR20240033168A (ko) 2024-03-12
KR20220028150A (ko) 2022-03-08
PH12018502278A1 (en) 2019-09-09
KR20250088784A (ko) 2025-06-17

Similar Documents

Publication Publication Date Title
CO2018012506A2 (es) Composiciones farmacéuticas y regímenes de dosificación para el uso clínico de anticuerpos contra el antígeno 2 de las células dendríticas de la sangre
CO2018003477A2 (es) Anticuerpos anti-pd1 y métodos de uso
CY1125326T1 (el) Προαιρετικως συντηγμενα ετεροκυκλυλο- υποκατεστημενα παραγωγα πυριμιδινης χρησιμα για τη θεραπευτικη αγωγη φλεγμονωδων, μεταβολικων, ογκολογικων και αυτοανοσων ασθενειων.
MX390014B (es) Compuestos de dinucleótidos cíclicos y métodos de uso.
CL2019000334A1 (es) Nuevos conjugados de anticuerpo y usos de los mismos (divisional solicitud 201502357)
CL2019000245A1 (es) Moduladores nmda espiro-lactam y métodos de uso de los mismos.
BR112016022814A8 (pt) composição farmacêutica e seu método de preparação, ácido nucleico, e dispositivo médico ou kit médico
AR110645A1 (es) Anticuerpos anti-hla-g y uso de los mismos
MX2018010032A (es) Formulaciones de antagonista de il-6 y sus usos.
MX391015B (es) Composiciones de nanoparticulas y usos de las mismas
UY37098A (es) Moduladores de ror-gamma
MX2018007288A (es) Anticuerpos neutralizantes para el virus de inmunodeficiencia humana.
AR092188A1 (es) ANTICUERPOS HUMANOS PARA GFRa3 Y METODOS PARA SU USO
CL2019000246A1 (es) Moduladores del receptor nmda espiro-lactam y uso de los mismos.
CL2019000248A1 (es) Moduladores del receptor nmda espiro-lactam y uso de los mismos
CL2019000249A1 (es) Moduladores del receptor nmda spiro-lactam y bis-spiro-lactam y uso de los mismos.
CL2015002835A1 (es) Nuevos derivados de piridina
MX386938B (es) Moduladores del receptor nmda espiro-lactam y uso de los mismos.
PH12019500949A1 (en) Ror-gamma modulators
BR112019010128A2 (pt) proteínas de ligação a antígeno anti-gitr e métodos de uso das mesmas
AR109279A1 (es) Anticuerpos anti plazomicina y métodos de uso de los mismos
PH12018502139A1 (en) Phosphaplatin liquid formulations
MX2017006491A (es) Composiciones y métodos para la modulación de la actividad at2r.
HK40054419A (en) Use of anti-cd137 antibody drug conjugate (adc) in allogeneic cell therapy
AR112928A1 (es) Composiciones y métodos para la administración de aav