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CL2019000249A1 - Moduladores del receptor nmda spiro-lactam y bis-spiro-lactam y uso de los mismos. - Google Patents

Moduladores del receptor nmda spiro-lactam y bis-spiro-lactam y uso de los mismos.

Info

Publication number
CL2019000249A1
CL2019000249A1 CL2019000249A CL2019000249A CL2019000249A1 CL 2019000249 A1 CL2019000249 A1 CL 2019000249A1 CL 2019000249 A CL2019000249 A CL 2019000249A CL 2019000249 A CL2019000249 A CL 2019000249A CL 2019000249 A1 CL2019000249 A1 CL 2019000249A1
Authority
CL
Chile
Prior art keywords
spiro
lactam
nmda
modulators
bis
Prior art date
Application number
CL2019000249A
Other languages
English (en)
Inventor
Amin M Khan
Original Assignee
Aptinyx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aptinyx Inc filed Critical Aptinyx Inc
Publication of CL2019000249A1 publication Critical patent/CL2019000249A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

SE DESCRIBEN LOS COMPUESTOS QUE TIENEN POTENCIA EN LA MODULACIÓN DE ACTIVIDAD DEL RECEPTOR NMDA. TALES COMPUESTOS PUEDEN SER USADOS EN EL TRATAMIENTO DE AFECCIONES TALES COMO DEPRESIÓN Y TRASTORNOS RELACIONADOS. TAMBIÉN SE DESCRIBEN FORMULACIONES ADMINISTRADAS POR VÍA ORAL Y OTRAS FORMAS DE ADMINISTRACIÓN FARMACÉUTICAMENTE ACEPTABLES DE LOS COMPUESTOS, INCLUIDAS LAS FORMULACIONES INTRAVENOSAS.
CL2019000249A 2016-08-01 2019-01-30 Moduladores del receptor nmda spiro-lactam y bis-spiro-lactam y uso de los mismos. CL2019000249A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201662369534P 2016-08-01 2016-08-01

Publications (1)

Publication Number Publication Date
CL2019000249A1 true CL2019000249A1 (es) 2019-06-21

Family

ID=59593195

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2019000249A CL2019000249A1 (es) 2016-08-01 2019-01-30 Moduladores del receptor nmda spiro-lactam y bis-spiro-lactam y uso de los mismos.

Country Status (16)

Country Link
US (2) US11028095B2 (es)
EP (1) EP3490994B8 (es)
JP (1) JP2019527235A (es)
KR (1) KR102462288B1 (es)
CN (1) CN109661398B (es)
AU (1) AU2017306158B2 (es)
BR (1) BR112019001926A2 (es)
CL (1) CL2019000249A1 (es)
CO (1) CO2019000944A2 (es)
EA (1) EA201990425A1 (es)
ES (1) ES2979128T3 (es)
IL (1) IL264496B (es)
MX (1) MX383292B (es)
PE (1) PE20190502A1 (es)
SG (1) SG11201900546UA (es)
WO (1) WO2018026792A1 (es)

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CN109843889B (zh) 2016-08-01 2022-03-15 阿普廷伊克斯股份有限公司 螺-内酰胺nmda调节剂和使用其的方法
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JP2019527235A (ja) 2016-08-01 2019-09-26 アプティニックス インコーポレイテッド スピロ−ラクタム及びビス−スピロ−ラクタムｎｍｄａ受容体修飾因子及びその使用
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EP3490994B1 (en) 2024-02-07
CA3031562A1 (en) 2018-02-08
MX383292B (es) 2025-03-13
US11028095B2 (en) 2021-06-08
AU2017306158A1 (en) 2019-01-31
CN109661398A (zh) 2019-04-19
IL264496A (es) 2019-03-31
EP3490994C0 (en) 2024-02-07
EP3490994B8 (en) 2024-03-13
ES2979128T3 (es) 2024-09-24
IL264496B (en) 2022-09-01
PE20190502A1 (es) 2019-04-10
BR112019001926A2 (pt) 2019-08-06
WO2018026792A1 (en) 2018-02-08
CN109661398B (zh) 2022-07-05
MX2019001322A (es) 2019-09-11
AU2017306158B2 (en) 2021-10-14
US20200181159A1 (en) 2020-06-11
US20220098211A1 (en) 2022-03-31
KR102462288B1 (ko) 2022-11-01
EA201990425A1 (ru) 2019-08-30
CO2019000944A2 (es) 2019-02-08
KR20190037276A (ko) 2019-04-05
EP3490994A1 (en) 2019-06-05
JP2019527235A (ja) 2019-09-26
SG11201900546UA (en) 2019-02-27

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