MX2022000242A - Anticuerpos contra ticagrelor y metodos de uso. - Google Patents
Anticuerpos contra ticagrelor y metodos de uso.Info
- Publication number
- MX2022000242A MX2022000242A MX2022000242A MX2022000242A MX2022000242A MX 2022000242 A MX2022000242 A MX 2022000242A MX 2022000242 A MX2022000242 A MX 2022000242A MX 2022000242 A MX2022000242 A MX 2022000242A MX 2022000242 A MX2022000242 A MX 2022000242A
- Authority
- MX
- Mexico
- Prior art keywords
- antibodies
- ticagrelor
- methods
- disclosure
- metabolites
- Prior art date
Links
- OEKWJQXRCDYSHL-FNOIDJSQSA-N ticagrelor Chemical compound C1([C@@H]2C[C@H]2NC=2N=C(N=C3N([C@H]4[C@@H]([C@H](O)[C@@H](OCCO)C4)O)N=NC3=2)SCCC)=CC=C(F)C(F)=C1 OEKWJQXRCDYSHL-FNOIDJSQSA-N 0.000 title abstract 3
- 229960002528 ticagrelor Drugs 0.000 title abstract 2
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/54—F(ab')2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/626—Diabody or triabody
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
La descripción proporciona en general anticuerpos y fragmentos de anticuerpos de unión a antígenos que se unen a ticagrelor y metabolitos de ticagrelor. La descripción proporciona también composiciones que comprenden los anticuerpos, moléculas de ácidos nucleicos que codifican los anticuerpos, métodos de tratar a un paciente, que comprende administrar los anticuerpos y métodos de producir y utilizar los anticuerpos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462058458P | 2014-10-01 | 2014-10-01 | |
| US201562114931P | 2015-02-11 | 2015-02-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2022000242A true MX2022000242A (es) | 2022-02-03 |
Family
ID=54238444
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2017004196A MX389103B (es) | 2014-10-01 | 2015-09-30 | Anticuerpos contra ticagrelor y métodos de uso. |
| MX2022000242A MX2022000242A (es) | 2014-10-01 | 2017-03-30 | Anticuerpos contra ticagrelor y metodos de uso. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2017004196A MX389103B (es) | 2014-10-01 | 2015-09-30 | Anticuerpos contra ticagrelor y métodos de uso. |
Country Status (12)
| Country | Link |
|---|---|
| US (5) | US9982061B2 (es) |
| EP (1) | EP3201235A1 (es) |
| JP (2) | JP6799530B2 (es) |
| KR (2) | KR102767586B1 (es) |
| CN (2) | CN106715473B (es) |
| AU (2) | AU2015326869B2 (es) |
| CA (1) | CA2963166C (es) |
| MX (2) | MX389103B (es) |
| NZ (1) | NZ730247A (es) |
| RU (1) | RU2021125449A (es) |
| TW (2) | TWI707870B (es) |
| WO (1) | WO2016050867A1 (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016050867A1 (en) * | 2014-10-01 | 2016-04-07 | Medimmune Limited | Antibodies to ticagrelor and methods of use |
| WO2018212556A1 (en) * | 2017-05-16 | 2018-11-22 | Cj Healthcare Corporation | A method for purifying an antibody or an antibody fragment thereof using affinity chromatography |
| CN107976497B (zh) * | 2017-11-23 | 2020-11-10 | 重庆华邦制药有限公司 | 替格瑞洛中间体1的合成反应程度测定方法及应用 |
| WO2020061465A1 (en) * | 2018-09-20 | 2020-03-26 | Phasebio Pharmaceuticals, Inc. | Methods of reversing ticagrelor activity |
| CN114432315B (zh) * | 2020-11-05 | 2025-02-11 | 华东师范大学 | 一种预防、治疗疼痛的化合物及其应用 |
| WO2022240754A2 (en) * | 2021-05-10 | 2022-11-17 | Phasebio Pharmaceuticals, Inc. | Pharmacokinetic & pharmacodynamic model for determining effective dose of anti-ticagrelor antibody |
| WO2026019858A1 (en) * | 2024-07-16 | 2026-01-22 | SFJ Pharma X, Inc. | Methods of reversing ticagrelor activity |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE768377T1 (de) | 1988-09-02 | 1998-01-02 | Dyax Corp | Herstellung und Auswahl von Rekombinantproteinen mit verschiedenen Bindestellen |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| JPH03154867A (ja) * | 1989-11-13 | 1991-07-02 | Teijin Ltd | １―メチルアデノシンの免疫学的測定方法，そのための測定試薬及び試薬キット |
| AU7247191A (en) | 1990-01-11 | 1991-08-05 | Molecular Affinities Corporation | Production of antibodies using gene libraries |
| US5780225A (en) | 1990-01-12 | 1998-07-14 | Stratagene | Method for generating libaries of antibody genes comprising amplification of diverse antibody DNAs and methods for using these libraries for the production of diverse antigen combining molecules |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| US5698426A (en) | 1990-09-28 | 1997-12-16 | Ixsys, Incorporated | Surface expression libraries of heteromeric receptors |
| DE69129154T2 (de) | 1990-12-03 | 1998-08-20 | Genentech, Inc., South San Francisco, Calif. | Verfahren zur anreicherung von proteinvarianten mit geänderten bindungseigenschaften |
| ATE269401T1 (de) | 1991-04-10 | 2004-07-15 | Scripps Research Inst | Bibliotheken heterodimerer rezeptoren mittels phagemiden |
| EP0590067A1 (en) | 1991-06-14 | 1994-04-06 | Xoma Corporation | Microbially-produced antibody fragments and their conjugates |
| DE69233782D1 (de) | 1991-12-02 | 2010-05-20 | Medical Res Council | Herstellung von Autoantikörpern auf Phagenoberflächen ausgehend von Antikörpersegmentbibliotheken |
| US5733743A (en) | 1992-03-24 | 1998-03-31 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
| AU696293B2 (en) | 1993-12-08 | 1998-09-03 | Genzyme Corporation | Process for generating specific antibodies |
| PT1231268E (pt) | 1994-01-31 | 2005-11-30 | Univ Boston | Bancos de anticorpos policlonais |
| US5516637A (en) | 1994-06-10 | 1996-05-14 | Dade International Inc. | Method involving display of protein binding pairs on the surface of bacterial pili and bacteriophage |
| US5739277A (en) | 1995-04-14 | 1998-04-14 | Genentech Inc. | Altered polypeptides with increased half-life |
| GB9601081D0 (en) | 1995-10-06 | 1996-03-20 | Cambridge Antibody Tech | Specific binding members for human transforming growth factor beta;materials and methods |
| JP2978435B2 (ja) | 1996-01-24 | 1999-11-15 | チッソ株式会社 | アクリロキシプロピルシランの製造方法 |
| US6277375B1 (en) | 1997-03-03 | 2001-08-21 | Board Of Regents, The University Of Texas System | Immunoglobulin-like domains with increased half-lives |
| TW530058B (en) | 1997-07-22 | 2003-05-01 | Astra Pharma Prod | Triazolo [4,5-d]pyrimidine compounos and their use and process for preparation |
| TWI229674B (en) * | 1998-12-04 | 2005-03-21 | Astra Pharma Prod | Novel triazolo[4,5-d]pyrimidine compounds, pharmaceutical composition containing the same, their process for preparation and uses |
| JP2004501642A (ja) | 2000-06-28 | 2004-01-22 | グライコフィ， インコーポレイテッド | 改変された糖タンパク質を生成するための方法 |
| EP1355919B1 (en) * | 2000-12-12 | 2010-11-24 | MedImmune, LLC | Molecules with extended half-lives, compositions and uses thereof |
| CA2482448C (en) | 2002-04-11 | 2014-07-08 | Medimmune Vaccines, Inc. | Preservation of bioactive materials by freeze dried foam |
| WO2003087335A2 (en) | 2002-04-11 | 2003-10-23 | Medimmune Vaccines, Inc. | Preservation of bioactive materials by spray drying |
| AU2003230908A1 (en) | 2002-04-11 | 2003-10-27 | Medimmune Vaccines, Inc. | Spray freeze dry of compositions for intranasal administration |
| US7923029B2 (en) | 2002-04-11 | 2011-04-12 | Medimmune Llc | Spray freeze dry of compositions for pulmonary administration |
| US7378110B2 (en) | 2002-12-17 | 2008-05-27 | Med Immune Vaccines, Inc. | High pressure spray-dry of bioactive materials |
| US8802820B2 (en) | 2004-11-12 | 2014-08-12 | Xencor, Inc. | Fc variants with altered binding to FcRn |
| US7884264B2 (en) | 2006-01-17 | 2011-02-08 | Biolex Therapeutics, Inc. | Compositions and methods for inhibition of fucosyltransferase and xylosyltransferase expression in duckweed plants |
| TWI391378B (zh) | 2006-03-16 | 2013-04-01 | Astellas Pharma Inc | 喹啉酮衍生物或其製藥學上可被容許之鹽 |
| MX2009001620A (es) * | 2006-08-11 | 2009-02-23 | Schering Corp | Anticuerpos para il-17a. |
| CL2007002668A1 (es) | 2006-09-20 | 2008-05-09 | Amgen Inc | Proteina de union a antigeno que se une al receptor de glucagon humano; acido nucleico que la codifica; metodo de produccion; composicion farmaceutica que la comprende; y su uso para tratar o prevenir la diabetes tipo 2. |
| EP1995309A1 (en) | 2007-05-21 | 2008-11-26 | Vivalis | Recombinant protein production in avian EBx® cells |
| KR20100058509A (ko) | 2007-07-31 | 2010-06-03 | 메디뮨 엘엘씨 | 다중특이적 에피토프 결합 단백질 및 이의 용도 |
| RU2013154741A (ru) | 2011-06-01 | 2015-07-20 | Астразенека Аб | Новый сокристалл тикагрелора |
| EP2729488A4 (en) | 2011-07-06 | 2015-01-14 | Medimmune Llc | PROCESS FOR PREPARING MULTIMANT POLYPEPTIDES |
| US9108951B2 (en) | 2011-10-14 | 2015-08-18 | Bristol-Myers Squibb Company | Substituted 5,6,7,8-tetrahydro-1,6-naphthyridines as factor XIa inhibitors |
| US9592297B2 (en) | 2012-08-31 | 2017-03-14 | Bayer Healthcare Llc | Antibody and protein formulations |
| US10363040B2 (en) | 2014-05-02 | 2019-07-30 | W. L. Gore & Associates, Inc. | Anastomosis devices |
| WO2016050867A1 (en) | 2014-10-01 | 2016-04-07 | Medimmune Limited | Antibodies to ticagrelor and methods of use |
| JP7110199B2 (ja) | 2016-12-23 | 2022-08-01 | ノバルティス アーゲー | 抗第ＸＩ／ＸＩａ因子抗体による処置法 |
| BR112019018022A2 (pt) | 2017-03-01 | 2020-06-02 | Medimmune Limited | Formulações de anticorpos monoclonais |
| WO2020061465A1 (en) | 2018-09-20 | 2020-03-26 | Phasebio Pharmaceuticals, Inc. | Methods of reversing ticagrelor activity |
| WO2022240754A2 (en) | 2021-05-10 | 2022-11-17 | Phasebio Pharmaceuticals, Inc. | Pharmacokinetic & pharmacodynamic model for determining effective dose of anti-ticagrelor antibody |
-
2015
- 2015-09-30 WO PCT/EP2015/072606 patent/WO2016050867A1/en not_active Ceased
- 2015-09-30 TW TW104132245A patent/TWI707870B/zh active
- 2015-09-30 KR KR1020237036037A patent/KR102767586B1/ko active Active
- 2015-09-30 RU RU2021125449A patent/RU2021125449A/ru unknown
- 2015-09-30 TW TW109133037A patent/TWI774071B/zh active
- 2015-09-30 EP EP15771960.0A patent/EP3201235A1/en active Pending
- 2015-09-30 AU AU2015326869A patent/AU2015326869B2/en active Active
- 2015-09-30 US US14/871,111 patent/US9982061B2/en active Active
- 2015-09-30 NZ NZ730247A patent/NZ730247A/en unknown
- 2015-09-30 CA CA2963166A patent/CA2963166C/en active Active
- 2015-09-30 JP JP2017517307A patent/JP6799530B2/ja active Active
- 2015-09-30 KR KR1020177011208A patent/KR102594117B1/ko active Active
- 2015-09-30 MX MX2017004196A patent/MX389103B/es unknown
- 2015-09-30 CN CN201580053771.XA patent/CN106715473B/zh active Active
- 2015-09-30 CN CN202111351203.1A patent/CN113956361B/zh active Active
-
2017
- 2017-03-30 MX MX2022000242A patent/MX2022000242A/es unknown
-
2018
- 2018-07-16 US US16/035,954 patent/US10954308B2/en active Active
- 2018-07-16 US US16/035,964 patent/US10487154B2/en active Active
-
2020
- 2020-09-18 JP JP2020157239A patent/JP7027502B2/ja active Active
-
2021
- 2021-02-16 US US17/176,624 patent/US11773186B2/en active Active
- 2021-07-27 AU AU2021209207A patent/AU2021209207B2/en active Active
-
2023
- 2023-08-17 US US18/451,751 patent/US12391768B2/en active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP4417263A3 (en) | Cd3 binding antibodies | |
| PH12016501644A1 (en) | Binding proteins and methods of use thereof | |
| PH12018502400A1 (en) | Anti-tim-3 antibodies and methods of use thereof | |
| WO2014004549A3 (en) | Anti-mesothelin binding proteins | |
| PH12018500684A1 (en) | Agonistic antibodies specifically binding human cd40 and methods of use | |
| PH12018500380A1 (en) | Anti-dll3 antibody drug conjugates and methods of use | |
| MX2021014735A (es) | Anticuerpos anti-cd166, anticuerpos anti-cd166 activables, y metodos de uso de los mismos. | |
| MX2022000242A (es) | Anticuerpos contra ticagrelor y metodos de uso. | |
| MY192999A (en) | Combination therapy of t cell activating bispecific antigen binding molecules and pd-1 axis binding antagonists | |
| EA201792413A1 (ru) | Антитела против cd71, активируемые антитела против cd71 и способы их применения | |
| GEP20227343B (en) | Anti-lag3 antibodies and antigen-binding fragments | |
| EP4631978A3 (en) | Humanized or chimeric cd3 antibodies | |
| EA201492101A1 (ru) | Антитела против fcrn | |
| MX341578B (es) | Tratamiento de la osteoartritis y del dolor. | |
| NZ707086A (en) | Anti-cd40 antibodies and methods of use | |
| MX2017004526A (es) | Terapia combinada de anticuerpos biespecificos especificos para fap y dr5 y agentes quimioterapeuticos. | |
| MX2015013166A (es) | Proteinas de union especificas duales dirigidas contra il-1 beta y/o il-17. | |
| PH12017500406A1 (en) | Novel anti-mfi2 antibodies and methods of use | |
| NZ717399A (en) | Antibodies against csf-1r | |
| MA40527A (fr) | Protéines de liaison à l'antigène se liant à wisp5 | |
| PH12016500753A1 (en) | Antibodies specific to fcrn | |
| MX2018006249A (es) | Nuevos anticuerpos anti-emr2 y metodos de uso. | |
| MX2018007817A (es) | Nuevos anticuerpos anti-mmp16 y metodos para su uso. | |
| MX2016014416A (es) | Anticuerpos anti-her3 que se unen a la horquilla beta de her3. | |
| MX2016014726A (es) | Proteinas de union al antigeno her1 que se unen a la beta-horquilla de her1. |