CN1698770A - Preparation method of coptis supernatant concentrated pill - Google Patents

Abstract

The invention discloses a method for preparing upper heat-removing concentrated pill with Chinese gold thread, wherein the nature of the different medicinal materials is taken into consideration, and the preparation consists of disintegrating, extracting volatile oil, boiling, concentrating, making pills and polishing, finally charging volatile oil, thus obtaining concentrated pills.

Description

Preparation method of coptis supernatant concentrated pill

technical field

The invention relates to a preparation process of concentrated traditional Chinese medicine pills. Specifically, it relates to a preparation method of coptis supernatant concentrated pills.

Background technique

Huanglian Shangqing Wan is used for clearing away heat and laxative, dispelling wind and relieving pain. It is a variety recorded in the 2000 edition of "Pharmacopoeia of the People's Republic of China". However, the traditional large honeyed pills have the disadvantages of large dosage and difficulty in swallowing. Concentrated pills are a better dosage form that can replace big honeyed pills.

Contents of the invention

The purpose of the present invention is to provide a preparation method of concentrated Huanglian Shangqing pills.

The prescription of Huanglian Shangqing Concentrated Pills in the present invention adopts the prescription of Huanglian Shangqing Pills recorded in "Pharmacopoeia of the People's Republic of China" 2000 edition, that is, the following parts by weight: 1 part of Coptis Rhizoma, 8 parts of Gardenia (Ginger), 8 parts of Forsythia 8 parts of Vitex (fried), 4 parts of Fangfeng, 8 parts of Schizonepeta, 8 parts of Angelica dahurica, 8 parts of Scutellaria baicalensis, 16 parts of chrysanthemum, 4 parts of mint, 32 parts of rhubarb (wine-roasted), Phellodendron cortex (wine-roasted) 4 parts, bellflower 8 parts, chuanxiong 4 parts, gypsum 8 parts, inula 2 parts, licorice 4 parts.

The preparation method of the coptis supernatant concentrated pill of the present invention adopts the following steps to complete:

a. Coptis chinensis, rhubarb, Angelica dahurica, Bellflower, Inula, Cortex Phellodendri, Fangfeng, and gardenia are combined and pulverized, passed through a 100-mesh sieve, coarse powder and fine powder are separated, fine powder accounts for 80-85% of the total weight, and gypsum is pulverized into Fine powder, pass through a 100 mesh sieve, combine the above fine powder, and mix well;

b. Forsythia, Ligusticum Chuanxiong, Schizonepeta, peppermint distilled to extract volatile oil;

c. Add the remaining chrysanthemum, Vitex, Scutellaria baicalensis, and licorice to the distilled medicinal residue, add the above-mentioned coarse powder, add water to decoct twice, combine the decoction, let stand, filter, and collect the filtrate;

d. The clear ointment with a relative density of 1.03 to 1.05 when the above medicinal liquid is concentrated to 70°C is used as pan-pill liquid;

e. Take the above-mentioned fine powder and pan-pill liquid pan-pill, dry, let cool, add volatile oil in airtight, mix well, and get ready.

In the method of the present invention, the eight medicinal materials such as Coptidis rhizome are ground into coarse powder and fine powder, and the weight of the fine powder is preferably 81.6% of the total weight. The above fine powder is then dried with a kang temperature of 50-70° C. to make the water content of the medicine 5%-8%.

In the method of the present invention, forsythia, Rhizoma Chuanxiong, Schizonepeta ear, Peppermint extract volatile oil and preferably use straight-through steam distillation. In the research, we found that the general method of extracting volatile oil is to add water to the drug, and then extract the volatile oil, but the amount of volatile oil extracted by this method is small. The volatile oil and water vapor enter the oil-water separator to collect until the volatile oil no longer increases, usually after 3 to 5 hours, so that the extracted volatile oil is more.

In the preparation method of the present invention, add the remaining chrysanthemum, vitex, scutellaria baicalensis and licorice four flavors to the medicinal dregs after distillation, add coarse powder, decoct twice, add 8 times of water for the first time and decoct for 2 hours, and add water for 6 times for the second time. Double the amount of decoction for 1.5 hours.

In the method of the present invention, the standing time of the decoction should be no less than 4 hours, otherwise the concentrated pan-pill liquid will not be clarified after being concentrated into a polishing liquid, which will easily cause bonding when polishing, the surface of the pellets will not be fine and smooth, and the color will be inconsistent.

The preparation method of the present invention is preferably polished with a polishing liquid after the pilling, and then polished once after adding volatile oil. The polishing liquid is prepared by taking 15% of the pilling liquid and concentrating it to 70 DEG C with a relative density of 1.06-1.08.

The method of the present invention takes the following steps when adding volatile oil: when the polishing pellets are heated to 30-40° C., add volatile oil, and seal it in an airtight container for 24 hours.

The method of the present invention selects part of medicinal materials to decoct, extract and condense into a clear cream as pan-pill liquid, and part of the medicine is crushed into fine powder, which is used as the carrier for adsorbing volatile oil and concentrated liquid, avoiding the use of starch, dextrin and sugar auxiliary materials, reducing the Reduced the volume of the pill, making it more convenient to take. At the same time, the method of heating when adding volatile oil and sealing it in a closed container makes the volatile oil absorb quickly and greatly reduces the loss of volatile oil components.

The advantages of the volatile oil adding process of the method of the present invention will be further illustrated below through a test example.

Process A: The volatile oil is clathrated with β-cyclodextrin and then added to the pellet mother, and dried at 50-70°C after panning the pellets.

Process B: volatile oil is added to hair balls (that is, unpolished balls), absorbed and then polished, and dried at 50-70°C.

Process C: volatile oil is added to the polishing solution, the hair balls are polished with the polishing solution, and dried at 50-70°C.

Process D: Process according to the invention.

Three batches of various process tests were carried out, adding 0.2ml of volatile oil per 100g of pellets, that is, the theoretical volatile oil content of the finished product was 0.2%, and the volatile oil content of the finished product was measured by the Pharmacopoeia volatile oil determination method, and the results are as follows: A B C D. The first batch, the second batch, the third batch, the average loss rate of the three batches % 0.160.130.140.0630 0.040.040.030.1680 0.030.030.030.1785 0.160.160.150.0420

From the experimental results, the loss of volatile oil in the preparation method of the present invention is the smallest. Process B and Process C lose most of the volatile oil of the two finished products. The reason is that after the volatile oil is added, there is a heating and drying process. Process A is better than Process B and Process C due to the protection of β-cyclodextrin, but the loss is higher than that of the present invention. The method, that is, the process D is larger, because part of the inclusion process will be lost, and the heating and drying of the pan pill will still lose part; in addition, β-CD and other solvents are needed in the inclusion process, which increases the cost and is relatively cumbersome.

Detailed ways

Example 1

Weigh 15g of Coptis chinensis, 120g of Gardenia (made from ginger), 120g of Forsythia, 120g of Vitex (fried), 60g of Fangfeng, 120g of Schizonepetae, 120g of Angelica dahurica, 120g of Scutellaria baicalensis, 240g of chrysanthemum, 60g of mint, rhubarb (wine-roasted) 480g, Cortex Phellodendri (wine fried) 60g, Campanulaceae 120g, Rhizoma Chuanxiong 60g, Gypsum 60g, Inula 30g, Licorice 60g.

a. Coptidis rhizome, rhubarb, Angelica dahurica, Platycodon grandiflorum, Inula, Cortex Phellodendron, Fangfeng, and gardenia are combined and pulverized, passed through a 100-mesh sieve to obtain 820g of fine powder, and the fine powder is dried on a kang at a temperature of 50-70°C to make the water content of the drug reach 5% to 8%, the coarse powder is separated; the gypsum is crushed into a fine powder, passed through a 100-mesh sieve, the above fine powder is combined, and mixed;

b. Four flavors of forsythia, chuanxiong, nepeta, and mint were steam-distilled for 4 hours to extract 2ml of volatile oil;

c. Add the remaining chrysanthemum, vitex, scutellaria baicalensis, and licorice to the dregs of the medicine, add the above coarse powder, add water to decoct twice, add 8 times the amount of water for 2 hours for the first time, add 6 times the amount of water for 1.5 hours for the second time, and combine Decoction, let stand for 5 hours, filter, and collect the filtrate;

d. When the above-mentioned filtrate is concentrated to 70° C., 680 ml of clear paste with a relative density of 1.03 to 1.05 is used as a pan-pill liquid; when 15% of the pan-pill liquid is concentrated to 70° C., the relative density is 1.06 to 1.08 to obtain a polishing liquid.

e. Take the above fine powder and pan-pill liquid pan-pill, polish with polishing liquid, dry, let cool, add volatile oil, heat to 30-40°C, mix well, seal it in a closed container for 24 hours, add volatile oil, and then polish , to get 1000g concentrated pellets. The concentrated pellets weigh 0.3 g per 10 pellets.

Claims (8)

1, a kind of preparation method of upper heat-removing concentrated pill with Chinese gold thread is characterized in that adopting following steps to make:

A. Rhizoma Coptidis, Radix Et Rhizoma Rhei, the Radix Angelicae Dahuricae, Radix Platycodonis, Flos Inulae, Cortex Phellodendri, Radix Saposhnikoviae, Fructus Gardeniae merge pulverizing, cross 100 mesh sieves, and coarse powder and fine powder split, and fine powder accounts for the 80-85% of gross weight, and Gypsum Fibrosum powder is broken into fine powder, cross 100 mesh sieves, and above-mentioned fine powder merges, mixing;

B. Fructus Forsythiae, Rhizoma Chuanxiong, Herba Schizonepetae, Herba Menthae distillating extracting oil;

C. the medicinal residues after the distillation add all the other Flos Chrysanthemis, Fructus Viticis, Radix Scutellariae, Radix Glycyrrhizae four flavors, add above-mentioned coarse powder, decoct with water secondary, and collecting decoction leaves standstill, and filter, and collect filtrate;

Relative density was 1.03～1.05 clear paste when d. above-mentioned medicinal liquid was concentrated into 70 ℃, as general ball liquid;

E. get above-mentioned fine powder and general ball liquid flooding ball, drying, put cold, airtight adding volatile oil, mixing, promptly.

2, according to the preparation method of claim 1, it is characterized in that fine powder adopts baking a heatable brick bed temperature to carry out drying for 50～70 ℃ after the pulverizing medicinal materials, make medicine water content 5%～8%.

3,, it is characterized in that the fine powder that Rhizoma Coptidis, Radix Et Rhizoma Rhei, the Radix Angelicae Dahuricae, Radix Platycodonis, Flos Inulae, Cortex Phellodendri, Radix Saposhnikoviae, Fructus Gardeniae are pulverized accounts for 81.6% of gross weight according to the preparation method of claim 1.

4,, it is characterized in that it is method distillation extraction 3-5 hour that adopts straight-through steam that Fructus Forsythiae, Rhizoma Chuanxiong, Herba Schizonepetae, Herba Menthae extract volatile oil according to the preparation method of claim 1.

5, according to the preparation method of claim 1, the medicinal residues after it is characterized in that distilling add all the other Flos Chrysanthemis, Fructus Viticis, Radix Scutellariae, Radix Glycyrrhizae four flavors, add coarse powder, decoct secondary, add water for the first time and decoct 2 hours for 8 times, add 6 times of amounts of water for the second time and decoct 1.5 hours.

6,, it is characterized in that the decocting liquid time of repose is no less than 4 hours according to the preparation method of claim 1.

7, according to the preparation method of claim 1, it is characterized in that polishing with polishing fluid behind the general ball, add volatile oil after, again polishing once, polishing fluid is that relative density is 1.06～1.08 when getting general ball liquid 15% and being concentrated into 70 ℃.

8, according to the preparation method of claim 1, take following steps when it is characterized in that adding volatile oil: after general ball, the polishing, add volatile oil, be heated to 30-40 ℃, in hermetic container airtight vexed 24 hours.