CN1238028C - Method for preparing capsule of six drugs containing rehmannine - Google Patents
Method for preparing capsule of six drugs containing rehmannine Download PDFInfo
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- CN1238028C CN1238028C CN 03135286 CN03135286A CN1238028C CN 1238028 C CN1238028 C CN 1238028C CN 03135286 CN03135286 CN 03135286 CN 03135286 A CN03135286 A CN 03135286A CN 1238028 C CN1238028 C CN 1238028C
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- thick paste
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- fructus corni
- poria
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Abstract
The present invention discloses a new method for preparing a Liuwei Dihuang capsule. The Liuwei Dihuang capsule is prepared by that six kinds of medicines are processed, mixed, dried and pulverized into medicinal powder, auxiliary material is added into the medicinal powder, and then the medicinal powder is filled into capsules. The present invention is characterized in that in the technology of processing the medicines, 1/7 to 2/3 prescription quantity of tuckahoe is pulverized into fine powder, the residual tuckahoe is decocted and concentrated into thick paste; asiatic cornelian cherry fruits are extracted and concentrated into thick paste; tree peony bark is distilled to collect crystals; prepared rehmannia roots, Chinese yams, water plantains, medicinal dregs after the tree peony bark is distilled and medicinal dregs obtained after the asiatic cornelian cherry fruits are extracted are decocted, ontained medicinal liquid is separated and purified through Large-porous adsorption resin columns to collect eluent, and the eluent is extracted into thick paste; possibly, the prepared rehmannia roots, the Chinese yams, the water plantains, the medicinal dregs obtained after the tree peony bark is distilled and the medicinal dregs obtained after the asiatic cornelian cherry fruits are extracted are decocted, and decoction liquid is directly concentrated into thick paste. The present invention has the advantages that by the technology, residual agricultural chemicals and heavy metal impurities are reduced, the purity of the medicine is greatly improved, effective ingredients of each granule of medicines are raised, the dosage of the medicines which are taken at a time is reduced, and medicinal effect is obviously raised.
Description
Technical field
The present invention relates to a kind of preparation method of LIUWEIDIHUANG JIAONANG.
Background technology
LIUWEI DIHUANG WAN side comes across the Song dynasty the earliest, is by Qian Shi the Eastern Han Dynasty to be cured shenqi pill in the holy Zhang Zhongjing " Medical Treasures of the Golden Chamber ", deducts Radix Aconiti Lateralis Preparata, Ramulus Cinnamomi, easily Radix Rehmanniae is that Radix Rehmanniae Preparata forms.The successive dynasties document is all put down in writing LIUWEI DIHUANG WAN and is made up of Radix Rehmanniae Preparata, Fructus Corni, dried Rhizoma Dioscoreae, Rhizoma Alismatis, Cortex Moutan, Poria, and implication one is made up of the Six-element medicine, and the one, bitter sweet hot degree of saltiness Six-element is various in the side.Radix Rehmanniae Preparata in the side: sweet in the mouth, slightly warm in nature, have nourishing YIN and supplementing blood, beneficial essence is filled out the function of marrow.Cure mainly the hepatic and renal YIN deficiency, soreness of the waist and knees, hectic fever hectic fever due to YIN-deficiency, the night sweat seminal emission, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, severe palpitation, menoxenia, metrostaxis, dizzy, tinnitus, early whitening of beard and hair; Fructus Corni: sour-puckery flavor, slightly warm in nature has liver and kidney tonifying, the function of essence astringing and desertion stemming.Cure mainly vertigo and tinnitus, soreness of waist and knee joint, sexual impotence, seminal emission, the enuresis, frequent micturition, bleeding not during menses, menorrhagia, big apogee sweating, weak body and prostration, the palpitation with a distress feeling of having a guilty conscience, the asthma of suffering from a deficiency of the kidney is had loose bowels just before dawn, quenches one's thirst; Rhizoma Dioscoreae: sweet in the mouth, property is flat, has the spleen reinforcing nourishing the stomach, the lung benefiting that promotes the production of body fluid, the kidney invigorating relates to smart function.Cure mainly diarrhea due to hypofunction of the spleen, the lack of appetite edema, cough and asthma due to lung deficiency, emission due to deficiency of the kidney, leukorrhagia, frequent micturition, deficiency-heat is quenched one's thirst.Rhizoma Alismatis: sweet in the mouth, cold in nature, have promoting diuresis to eliminate damp pathogen, treating stranguria function expels the heat-evil.Cure mainly dysuria, the edema distension, the oliguria of having loose bowels, phlegm retention is dizzy, the wet pain of pyretic stranguria, seminal emission, hyperlipemia.Cortex Moutan: bitter in the mouth, suffering, cold nature, have clearing away heat and cooling blood, control the blood function of reducing phlegm.Cure mainly maculae caused by violent heat pathogen, haematemesis blood nosebleed, night fever abating at dawn, lossless hectic fever due to YIN-deficiency, amenorrhea dysmenorrhea, carbuncle sore tumefacting virus, the tumbling down pain of injury.Poria: sweet in the mouth, light, property are flat, have promoting diuresis to eliminate damp pathogen, the function of spleen invigorating mind calming.Cure mainly the edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, loose stool diarrhea, irritability, palpitation with fear insomnia.LIUWEI DIHUANG WAN by above-mentioned Six-element medicine compatibility is formed has the function of enriching yin and nourishing kidney, cures mainly the deficiency of the liver and kindey that occurs in all chronic disease processes, damage of kidney-YIN, soreness of the waist and knees, dribbling urination, tooth shakes, and has a dizzy spell Hiccough and deaf, forgetful dreaminess, night sweat seminal emission, feverish sensation in the palms and soles, low grade fever after being ill, quench one's thirst osteopyrexia and fever, diseases such as dryness of the tongue pharyngalgia.Go through first, bright, clear each generation development, become the famous prescription of enriching yin and nourishing kidney.Modern existing multiple dosage form is used in clinical, as pill, granule, tablet, oral liquid, soft extract and capsule etc.
Existing LIUWEIDIHUANG JIAONANG, the prescription of employing is:
Radix Rehmanniae Preparata 176g, Cortex Moutan 66g, Rhizoma Dioscoreae 88g, Fructus Corni 88g, Rhizoma Alismatis 66g, Poria 66g.
Its preparation method is with the Cortex Moutan in the above Six-element, Fructus Corni, Poria, is ground into fine powder, sieves, and is mixed: all the other Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Rhizoma Alismatis three flavors, decoct with water three times, first and second time each 2 hours is 1 hour for the third time, collecting decoction filters, and filtrate is condensed into cream; With above-mentioned powder mixes, drying is pulverized, and adds appropriate amount of auxiliary materials, is mixed, and incapsulates, and makes 1000 promptly again.Function with cure mainly: enriching yin and nourishing kidney.Be used for damage of kidney-YIN, dizziness and tinnitus, soreness of the waist and knees, osteopyrexia and fever, the sweating due to debility seminal emission is quenched one's thirst.Oral: one time 8, a twice-daily, every powder charge 0.3g.
The shortcoming of this capsule preparation method thereof is: be used as medicine because a large amount of medical materials are directly pulverized, its pesticide residues, beavy metal impurity residual quantity are higher, influence drug effect; Manufactured goods take one time 8, taking dose is big, and every effective ingredient is lower, is unfavorable for the patient.
Summary of the invention
The objective of the invention is to: provide a kind of no pesticide and beavy metal impurity residual, pastille purity height, every pharmaceutically active ingredient height, it is little once to take pharmaceutical quantities, the preparation method of the LIUWEIDIHUANG JIAONANG that drug effect is high.
The objective of the invention is to realize by the enforcement following technical proposals:
A kind of preparation method of LIUWEIDIHUANG JIAONANG comprises the treatment process to Radix Rehmanniae Preparata 1408g, Cortex Moutan 528g, Rhizoma Dioscoreae 704g, Fructus Corni 704g, Rhizoma Alismatis 528g and each medicine of Poria 528g; Close that medicine mixes, dry, the technology that is ground into fine powder; And mixed powder adds adjuvant filling capsule technology; In each medicine treatment process: the Poria powder that includes the 1/7-2/3 amount is broken into fine powder, the Poria decocting and concentrating of surplus is become the technology of thick paste; With Cortex Moutan with steam distillation, handle distillate and make the technology that is ground into fine powder after crystalline solid, the drying; Handle the technology that Fructus Corni obtains its extracting solution, recovery ethanol and the Fructus Corni active component is condensed into thick paste with 50-90%7 alcohol with backflow or percolation; And to directly concentrating after the decoction of Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Rhizoma Alismatis, Cortex Moutan medicinal residues and Fructus Corni medicinal residues or through the technology of macroporous adsorptive resins separation and purification; Close that medicine mixes, dry, the technology that is ground into fine powder, be meant with Poria fine powder, thick paste that surplus Poria decocting and concentrating becomes, thick paste that the Fructus Corni extracting solution is condensed into, to the treatment process gained thick paste of Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Rhizoma Alismatis, Cortex Moutan medicinal residues and Fructus Corni medicinal residues mix mutually, dry, the technology that is ground into fine powder; Described mixed powder adds adjuvant and loads capsule technology, be meant the Poria fine powder that will make, thick paste that surplus Poria decocting and concentrating becomes, thick paste that the Fructus Corni extracting solution is condensed into, to the treatment process gained thick paste of Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Rhizoma Alismatis, Cortex Moutan medicinal residues and Fructus Corni medicinal residues mix mutually, dry, the fine powder that is ground into, starch, the dextrin mixed into 5-50% incapsulate again, or the dimension crystalline cellulose of mixing into 5-30% incapsulates, or mixes the technology that the micropowder silica gel into 0.1-4% incapsulates; It is characterized in that: in each medicine treatment process, with Cortex Moutan with steam distillation, handle the crystalline solid that distillate is made, by after the cold drying it being ground into fine powder.
The invention has the advantages that: eliminated residual pesticide and beavy metal impurity by above-mentioned technology, improved pharmaceutical purity greatly, improved every the effective elements of the medicine content, made and once take pharmaceutical quantities and reduce, drug effect but is improved significantly.
Description of drawings
Fig. 1 is preparation technology's flow chart of LIUWEIDIHUANG JIAONANG of the present invention
The specific embodiment
Embodiment 1:
[prescription] Radix Rehmanniae Preparata 1408g Cortex Moutan 528g Rhizoma Dioscoreae 704g
Fructus Corni 704g Rhizoma Alismatis 528g Poria 528g.
[method for making] above Six-element is got Poria 350g and is ground into fine powder, and Fructus Corni adds the alcohol reflux secondary, and each 1 hour, filter, medicinal residues are standby, and filtrate recycling ethanol is concentrated into the thick paste shape; The Cortex Moutan steam distillation, distillate makes crystallization, and is standby; Three flavors such as aqueous solution after the distillation and Cortex Moutan medicinal residues, Fructus Corni medicinal residues, residue Poria and all the other Radix Rehmanniae Preparata decoct with water three times, and each 1 hour, filter, merging filtrate is concentrated into the thick paste shape; Add above-mentioned Poria fine powder and Fructus Corni thick paste, mixing, cold drying is ground into fine powder, adds above-mentioned Cortex Moutan extract and appropriate amount of auxiliary materials, and mixing incapsulates, and makes 2000.
[character] this product is a capsule, and content is that light brown is to brown powder or granule; Bitter in the mouth, little acid.
Every of [assay] this product contains Fructus Corni with ursolic acid (C
30H
18O
3) meter, must not be less than 0.6mg (0.3g/ grain).
[function with cure mainly] enriching yin and nourishing kidney are used for damage of kidney-YIN, dizziness and tinnitus, and soreness of the waist and knees, osteopyrexia and fever, the night sweat seminal emission is quenched one's thirst.
[usage and consumption] is oral, one time 1 (0.3g/ grain) or one time 2 (0.6g/ grain), a twice-daily.
[storage] sealing.
Embodiment 2:
[prescription] Radix Rehmanniae Preparata 1408g Cortex Moutan 528g Rhizoma Dioscoreae 704g
Fructus Corni 704g Rhizoma Alismatis 528g Poria 528g.
[method for making] above Six-element is got Poria 110g and is ground into fine powder, and tail over part and decoct with water three times with the residue Poria, each 30 minutes, filter, merging filtrate is concentrated into the thick paste shape; The Fructus Corni ethanol percolation is collected percolate, and medicinal residues are standby, and filtrate recycling ethanol is concentrated into the thick paste shape; The Cortex Moutan steam distillation, and adding 1mol/L hydrochloric acid solution makes crystallization in the distillate of collecting, and filters, crystallization washes with water, and cold drying is ground into fine powder; Three flavors such as aqueous solution after the distillation and Cortex Moutan medicinal residues, Fructus Corni medicinal residues and all the other Radix Rehmanniae Preparata decoct with water three times, each 1 hour, filter, merging filtrate by the macroporous adsorptive resins separation and purification, is used 70% ethanol elution, collect eluent, reclaim ethanol, be concentrated into the thick paste shape, add above-mentioned Poria thick paste, Fructus Corni thick paste and Poria fine powder, mix, drying under reduced pressure is ground into fine powder, adds above-mentioned Cortex Moutan extract crystallization fine powder and appropriate amount of auxiliary materials, mixing, incapsulate, make 1000, promptly.
[character] this product is a capsule, and content is that light brown is to brown powder or granule; Bitter in the mouth, little acid.
Every of [assay] this product contains Fructus Corni with ursolic acid (C
30H
48O
3) meter, must not be less than 0.6mg (0.3g/ grain).
[function with cure mainly] enriching yin and nourishing kidney are used for damage of kidney-YIN, dizziness and tinnitus, and soreness of the waist and knees, osteopyrexia and fever, the night sweat seminal emission is quenched one's thirst.
[usage and consumption] is oral, one time 1 (0.3g/ grain) or one time 2 (0.6g/ grain), a twice-daily.
[storage] sealing.
Embodiment 3:
[prescription] Radix Rehmanniae Preparata 1408g Cortex Moutan 528g Rhizoma Dioscoreae 704g
Fructus Corni 704g Rhizoma Alismatis 528g Poria 528g.
[method for making] above Six-element is got Poria 110g and is ground into fine powder, and tail over part and decoct with water three times with the residue Poria, each 30 minutes, filter, merging filtrate is concentrated into the thick paste shape; Fructus Corni adds the alcohol reflux secondary, and each 1 hour, filter, medicinal residues are standby, and filtrate recycling ethanol is concentrated into the thick paste shape; The Cortex Moutan steam distillation, and adding 1mol/L hydrochloric acid solution makes crystallization in the distillate of collecting, and filters, crystallization washes with water, and cold drying is ground into fine powder; Aqueous solution after the distillation and Cortex Moutan medicinal residues, decoct with water three times by Fructus Evodiae medicinal residues and all the other Radix Rehmanniae Preparata etc. three flavor, each 1 hour, filter, merging filtrate by the macroporous adsorptive resins separation and purification, is used 70% ethanol elution, collect eluent, reclaim ethanol, be concentrated into the thick paste shape, add above-mentioned Poria thick paste, Fructus Corni thick paste and Poria fine powder, mix, drying under reduced pressure is ground into fine powder, adds above-mentioned Cortex Moutan extract crystallization fine powder and appropriate amount of auxiliary materials, mixing, incapsulate, make 1000, promptly.
[character] this product is a capsule, and content is that light brown is to brown powder or granule; Bitter in the mouth, little acid.
Every of [assay] this product contains Fructus Corni with ursolic acid (C
30H
48O
3) meter, must not be less than 0.6mg (0.3g/ grain).
[function with cure mainly] enriching yin and nourishing kidney are used for damage of kidney-YIN, dizziness and tinnitus, and soreness of the waist and knees, osteopyrexia and fever, the night sweat seminal emission is quenched one's thirst.
[usage and consumption] is oral, one time 1 (0.3g/ grain) or one time 2 (0.6g/ grain), a twice-daily.
[storage] sealing.
Claims (1)
1, a kind of preparation method of LIUWEIDIHUANG JIAONANG, comprise treatment process to Radix Rehmanniae Preparata 1408g, Cortex Moutan 528g, Rhizoma Dioscoreae 704g, Fructus Corni 704g, Rhizoma Alismatis 528g and each medicine of Poria 528g, close that medicine mixes, dry, the technology that is ground into fine powder, and mixed powder adds adjuvant and loads capsule technology; In each medicine treatment process: the Poria powder that includes the 1/7-2/3 amount is broken into fine powder, the Poria decocting and concentrating of surplus is become the technology of thick paste; With Cortex Moutan with steam distillation, handle distillate and make the technology that crystalline solid, drying are ground into fine powder; Handle the technology that Fructus Corni obtains its extracting solution, recovery ethanol and the Fructus Corni active component is condensed into thick paste with 50-95% ethanol with backflow or percolation; And to directly concentrating after the decoction of Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Rhizoma Alismatis, Cortex Moutan medicinal residues and Fructus Corni medicinal residues or through the technology of macroporous adsorptive resins separation and purification; Close that medicine mixes, dry, the technology that is ground into fine powder, be meant with Poria fine powder, thick paste that surplus Poria decocting and concentrating becomes, thick paste that the Fructus Corni extracting solution is condensed into, to the treatment process gained thick paste of Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Rhizoma Alismatis, Cortex Moutan medicinal residues and Fructus Corni medicinal residues mix mutually, dry, the technology that is ground into fine powder; Described mixed powder adds adjuvant and loads capsule technology, be meant the Poria fine powder that will make, thick paste that surplus Poria decocting and concentrating becomes, thick paste that the Fructus Corni extracting solution is condensed into, to the treatment process gained thick paste of Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Rhizoma Alismatis, Cortex Moutan medicinal residues and Fructus Corni medicinal residues mix mutually, dry, the fine powder that is ground into, starch, the dextrin mixed into 5-50% incapsulate again, or the dimension crystalline cellulose of mixing into 5-30% incapsulates, or mixes the technology that the micropowder silica gel into 0.1-4% incapsulates; It is characterized in that: in each medicine treatment process, the crystalline solid with Cortex Moutan is made with steam distillation, processing distillate after cold drying, is ground into fine powder with it.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03135286 CN1238028C (en) | 2003-06-25 | 2003-06-25 | Method for preparing capsule of six drugs containing rehmannine |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03135286 CN1238028C (en) | 2003-06-25 | 2003-06-25 | Method for preparing capsule of six drugs containing rehmannine |
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| CN1513514A CN1513514A (en) | 2004-07-21 |
| CN1238028C true CN1238028C (en) | 2006-01-25 |
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| CN 03135286 Expired - Lifetime CN1238028C (en) | 2003-06-25 | 2003-06-25 | Method for preparing capsule of six drugs containing rehmannine |
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Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104000994A (en) * | 2014-06-06 | 2014-08-27 | 余中华 | Preparation method of concentrated six-taste glutinous rehmannia capsule |
| CN115137786A (en) * | 2022-07-29 | 2022-10-04 | 吉林省民泰制药股份有限公司 | A capsule containing six ingredients with rehmanniae radix and its preparation method |
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- 2003-06-25 CN CN 03135286 patent/CN1238028C/en not_active Expired - Lifetime
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| CN1513514A (en) | 2004-07-21 |
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Granted publication date: 20060125 |