CN1362209A - Nano bezoar medicine for treating upper respiratory tract infection and its preparation - Google Patents
Nano bezoar medicine for treating upper respiratory tract infection and its preparation Download PDFInfo
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- CN1362209A CN1362209A CN 01100708 CN01100708A CN1362209A CN 1362209 A CN1362209 A CN 1362209A CN 01100708 CN01100708 CN 01100708 CN 01100708 A CN01100708 A CN 01100708A CN 1362209 A CN1362209 A CN 1362209A
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- coptis
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- 239000003814 drug Substances 0.000 title claims abstract description 46
- 238000002360 preparation method Methods 0.000 title abstract description 8
- 206010004542 Bezoar Diseases 0.000 title 1
- 206010057190 Respiratory tract infections Diseases 0.000 title 1
- 206010046306 Upper respiratory tract infection Diseases 0.000 title 1
- 244000247747 Coptis groenlandica Species 0.000 claims abstract description 22
- 235000002991 Coptis groenlandica Nutrition 0.000 claims abstract description 22
- 239000000463 material Substances 0.000 claims abstract description 19
- 238000000034 method Methods 0.000 claims abstract description 12
- 235000009411 Rheum rhabarbarum Nutrition 0.000 claims abstract description 10
- 241000132446 Inula Species 0.000 claims abstract description 6
- 239000002994 raw material Substances 0.000 claims abstract description 6
- 238000001694 spray drying Methods 0.000 claims abstract description 5
- 241000555682 Forsythia x intermedia Species 0.000 claims abstract 2
- 229940079593 drug Drugs 0.000 claims description 20
- 241000628997 Flos Species 0.000 claims description 18
- 239000000843 powder Substances 0.000 claims description 10
- 235000001287 Guettarda speciosa Nutrition 0.000 claims description 9
- 241000972673 Phellodendron amurense Species 0.000 claims description 9
- 241001643642 Viticis Species 0.000 claims description 9
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 claims description 9
- 239000002775 capsule Substances 0.000 claims description 7
- 239000008187 granular material Substances 0.000 claims description 6
- 238000002347 injection Methods 0.000 claims description 6
- 239000007924 injection Substances 0.000 claims description 6
- 239000012528 membrane Substances 0.000 claims description 6
- 241000202807 Glycyrrhiza Species 0.000 claims description 5
- 241001180876 Saposhnikovia Species 0.000 claims description 5
- 241000207929 Scutellaria Species 0.000 claims description 5
- 239000006187 pill Substances 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- 239000012141 concentrate Substances 0.000 claims description 4
- 235000008504 concentrate Nutrition 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 4
- 230000008676 import Effects 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- 239000000443 aerosol Substances 0.000 claims description 3
- 239000006196 drop Substances 0.000 claims description 3
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000019634 flavors Nutrition 0.000 claims description 3
- 239000003094 microcapsule Substances 0.000 claims description 3
- 239000002674 ointment Substances 0.000 claims description 3
- 229940100688 oral solution Drugs 0.000 claims description 3
- 239000000829 suppository Substances 0.000 claims description 3
- 239000006188 syrup Substances 0.000 claims description 3
- 235000020357 syrup Nutrition 0.000 claims description 3
- 239000003826 tablet Substances 0.000 claims description 2
- 244000061520 Angelica archangelica Species 0.000 claims 3
- 244000299790 Rheum rhabarbarum Species 0.000 claims 3
- 239000003390 Chinese drug Substances 0.000 claims 2
- 244000111489 Gardenia augusta Species 0.000 claims 1
- 241000219061 Rheum Species 0.000 abstract description 7
- 235000006679 Mentha X verticillata Nutrition 0.000 abstract 1
- 235000002899 Mentha suaveolens Nutrition 0.000 abstract 1
- 235000001636 Mentha x rotundifolia Nutrition 0.000 abstract 1
- 238000000874 microwave-assisted extraction Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 8
- 241000125175 Angelica Species 0.000 description 6
- 239000003795 chemical substances by application Substances 0.000 description 5
- 241000555712 Forsythia Species 0.000 description 4
- 241000157835 Gardenia Species 0.000 description 4
- 239000002671 adjuvant Substances 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000002086 nanomaterial Substances 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 208000034579 Acute haemorrhagic conjunctivitis Diseases 0.000 description 2
- 206010014020 Ear pain Diseases 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 206010018286 Gingival pain Diseases 0.000 description 2
- 206010018291 Gingival swelling Diseases 0.000 description 2
- 201000007100 Pharyngitis Diseases 0.000 description 2
- 208000009205 Tinnitus Diseases 0.000 description 2
- 230000000202 analgesic effect Effects 0.000 description 2
- 208000002399 aphthous stomatitis Diseases 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 208000002173 dizziness Diseases 0.000 description 2
- 208000007176 earache Diseases 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000011858 nanopowder Substances 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 239000007962 solid dispersion Substances 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- 231100000886 tinnitus Toxicity 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 239000004035 construction material Substances 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
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- Medicinal Preparation (AREA)
Abstract
The present invention discloses a nano Huanglian-shangqing preparation medicine. It is made up by using 17 Chinese medicinal materials of nano coptis, nano rhubarb, nano forsythia, nano mint, nano inula flower and others as raw material through the processes of microwave extraction, reduced pressure concentration and supersonic jet spray drying. Its grain fineness is up to 1200-1500 meshes, grain size is 0.1-200 nm, in which most of grain size is less than 100 nm. Said medicine is high in biological utilization rate and obvious in therapeutic effect.
Description
The present invention relates to a kind of clearing away heat and loosing the bowels, the wind analgesic nanometer coptis Shangqing ' medicine that looses the invention still further relates to the method for this medication preparation.
Coptos bolus for clearing the upper heat is a kind of classical Chinese patent medicine, mainly contains infection, and is analgesic, calmness, and effects such as blood pressure lowering are used for part of the body cavity above the diaphragm housing the heart and lungs wind heat, dizziness, gingival swelling and pain, aphtha of the mouth and tongue, pharyngitis, otalgia tinnitus, epidemic hemorrhagic conjunctivitis is hard and dry, yellowish or reddish urine etc.But traditional coptos bolus for clearing the upper heat disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nanometer coptis Shangqing ' medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nanometer coptis Shangqing ' medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer coptis 3-7 part nano rhubarb 140-180 part nanometer Fructus Forsythiae 20-60 part
Nanometer Herba Menthae 10-30 part nanometer Flos Inulae 6-14 part nanometer Radix Scutellariae 20-60 part
Nanometer Herba Schizonepetae 20-60 part nanometer Fructus Gardeniae 20-60 part nanometer Radix Saposhnikoviae 10-30 part
Nanometer Gypsum Fibrosum 10-30 part nanometer Radix Platycodonis 20-60 part nano phellodendron bark 10-30 part
Nanometer Fructus Viticis 20-60 part nano angelica root 20-60 part nanometer Radix Glycyrrhizae 10-30 part
Nanometer Rhizoma Chuanxiong 10-30 part nanometer Flos Chrysanthemi 60-100 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer coptis 4-6 part nano rhubarb 150-170 part nanometer Fructus Forsythiae 30-50 part
Nanometer Herba Menthae 15-25 part nanometer Flos Inulae 8-12 part nanometer Radix Scutellariae 30-50 part
Nanometer Herba Schizonepetae 30-50 part nanometer Fructus Gardeniae 30-50 part nanometer Radix Saposhnikoviae 15-25 part
Nanometer Gypsum Fibrosum 15-25 part nanometer Radix Platycodonis 30-50 part nano phellodendron bark 15-25 part
Nanometer Fructus Viticis 30-50 part nano angelica root 30-50 part nanometer Radix Glycyrrhizae 15-25 part
Nanometer Rhizoma Chuanxiong 15-25 part nanometer Flos Chrysanthemi 70-90 part
The optimum weight proportioning of medicine of the present invention is:
40 parts of 160 parts of nanometer Fructus Forsythiaes of 5 parts of nano rhubarbs of nanometer coptis
40 parts of 10 parts of nanometer Radix Scutellariaes of 20 parts of nanometer Flos Inulaes of nanometer Herba Menthae
20 parts of 40 parts of nanometer Radix Saposhnikoviaes of 40 parts of nanometer Fructus Gardeniaes of nanometer Herba Schizonepetae
20 parts of 40 parts of nano phellodendron barks of 20 parts of nanometer Radix Platycodoniss of nanometer Gypsum Fibrosum
20 parts in 40 parts of nanometer Radix Glycyrrhizaes of 40 parts of nano angelica roots of nanometer Fructus Viticis
80 parts of 20 parts of nanometer Flos Chrysanthemis of nanometer Rhizoma Chuanxiong
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since the particle size of the special construction----material of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15%-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, add to concoct according to Chinese Pharmacopoeia one one of version in 2000 and be processed into the common Chinese decoction pieces
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get Rhizoma Coptidis Shangqing ' nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nanometer coptis Shangqing ' medicine is identical.
A kind of important feature of the present invention is, the made drug material of the present invention has reached nanoscale, common Rhizoma Coptidis Shangqing ' material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1-200nm, and the overwhelming majority can be crossed the 1200-1500 mesh sieve less than 100nm.
Another important feature of the present invention is, solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that powder, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of Rhizoma Coptidis Shangqing ' medicine etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for part of the body cavity above the diaphragm housing the heart and lungs wind heat, dizziness, gingival swelling and pain, aphtha of the mouth and tongue, pharyngitis, otalgia tinnitus, epidemic hemorrhagic conjunctivitis is hard and dry; yellowish or reddish urine, Chinese medical discrimination belong on the wind-fire attack, treatment such as excessive heat in SAN JIAO, clinical efficacy is significantly because traditional coptos bolus for clearing the upper heat.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment:
Prepare nano raw material by preceding method:
40 parts of 160 parts of nanometer Fructus Forsythiaes of 5 parts of nano rhubarbs of nanometer coptis
40 parts of 10 parts of nanometer Radix Scutellariaes of 20 parts of nanometer Flos Inulaes of nanometer Herba Menthae
20 parts of 40 parts of nanometer Radix Saposhnikoviaes of 40 parts of nanometer Fructus Gardeniaes of nanometer Herba Schizonepetae
20 parts of 40 parts of nano phellodendron barks of 20 parts of nanometer Radix Platycodoniss of nanometer Gypsum Fibrosum
20 parts in 40 parts of nanometer Radix Glycyrrhizaes of 40 parts of nano angelica roots of nanometer Fructus Viticis
80 parts of 20 parts of nanometer Flos Chrysanthemis of nanometer Rhizoma Chuanxiong
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1-0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano material by preceding method:
40 parts of 160 parts of nanometer Fructus Forsythiaes of 5 parts of nano rhubarbs of nanometer coptis
40 parts of 10 parts of nanometer Radix Scutellariaes of 20 parts of nanometer Flos Inulaes of nanometer Herba Menthae
20 parts of 40 parts of nanometer Radix Saposhnikoviaes of 40 parts of nanometer Fructus Gardeniaes of nanometer Herba Schizonepetae
20 parts of 40 parts of nano phellodendron barks of 20 parts of nanometer Radix Platycodoniss of nanometer Gypsum Fibrosum
20 parts in 40 parts of nanometer Radix Glycyrrhizaes of 40 parts of nano angelica roots of nanometer Fructus Viticis
80 parts of 20 parts of nanometer Flos Chrysanthemis of nanometer Rhizoma Chuanxiong
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make nanometer coptis supernatant powder needle injection, every injection content is the 5-20 milligram, and each consumption is that 1-2 props up, and use 1-3 every day.
Implement sharp 3:
Prepare nano raw material by preceding method:
40 parts of 160 parts of nanometer Fructus Forsythiaes of 5 parts of nano rhubarbs of nanometer coptis
40 parts of 10 parts of nanometer Radix Scutellariaes of 20 parts of nanometer Flos Inulaes of nanometer Herba Menthae
20 parts of 40 parts of nanometer Radix Saposhnikoviaes of 40 parts of nanometer Fructus Gardeniaes of nanometer Herba Schizonepetae
20 parts of 40 parts of nano phellodendron barks of 20 parts of nanometer Radix Platycodoniss of nanometer Gypsum Fibrosum
20 parts in 40 parts of nanometer Radix Glycyrrhizaes of 40 parts of nano angelica roots of nanometer Fructus Viticis
80 parts of 20 parts of nanometer Flos Chrysanthemis of nanometer Rhizoma Chuanxiong
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make nanometer coptis supernatant membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part, back, chest.
Claims (6)
1, a kind of nanometer coptis Shangqing ' medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made.
Nanometer coptis 3-7 part nano rhubarb 140-180 part nanometer Fructus Forsythiae 20-60 part
Nanometer Herba Menthae 10-30 part nanometer Flos Inulae 6-14 part nanometer Radix Scutellariae 20-60 part
Nanometer Herba Schizonepetae 20-60 part nanometer Fructus Gardeniae 20-60 part nanometer Radix Saposhnikoviae 10-30 part
Nanometer Gypsum Fibrosum 10-30 part nanometer Radix Platycodonis 20-60 part nano phellodendron bark 10-30 part
Nanometer Fructus Viticis 20-60 part nano angelica root 20-60 part nanometer Radix Glycyrrhizae 10-30 part
Nanometer Rhizoma Chuanxiong 10-30 part nanometer Flos Chrysanthemi 60-100 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nanometer coptis Shangqing ' medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer coptis 4-6 part nano rhubarb 150-170 part nanometer Fructus Forsythiae 30-50 part
Nanometer Herba Menthae 15-25 part nanometer Flos Inulae 8-12 part nanometer Radix Scutellariae 30-50 part
Nanometer Herba Schizonepetae 30-50 part nanometer Fructus Gardeniae 30-50 part nanometer Radix Saposhnikoviae 15-25 part
Nanometer Gypsum Fibrosum 15-25 part nanometer Radix Platycodonis 30-50 part nano phellodendron bark 15-25 part
Nanometer Fructus Viticis 30-50 part nano angelica root 30-50 part nanometer Radix Glycyrrhizae 15-25 part
Nanometer Rhizoma Chuanxiong 15-25 part nanometer Flos Chrysanthemi 70-90 part
3, nanometer coptis Shangqing ' medicine according to claim 1, wherein the weight proportion of each nano raw material is:
40 parts of 160 parts of nanometer Fructus Forsythiaes of 5 parts of nano rhubarbs of nanometer coptis
40 parts of 10 parts of nanometer Radix Scutellariaes of 20 parts of nanometer Flos Inulaes of nanometer Herba Menthae
20 parts of 40 parts of nanometer Radix Saposhnikoviaes of 40 parts of nanometer Fructus Gardeniaes of nanometer Herba Schizonepetae
20 parts of 40 parts of nano phellodendron barks of 20 parts of nanometer Radix Platycodoniss of nanometer Gypsum Fibrosum
20 parts in 40 parts of nanometer Radix Glycyrrhizaes of 40 parts of nano angelica roots of nanometer Fructus Viticis
80 parts of 20 parts of nanometer Flos Chrysanthemis of nanometer Rhizoma Chuanxiong
4, according to claim 1 or 2 or 3 described nanometer coptis Shangqing ' medicines, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nanometer coptis Shangqing ' medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100708 CN1362209A (en) | 2001-01-08 | 2001-01-08 | Nano bezoar medicine for treating upper respiratory tract infection and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100708 CN1362209A (en) | 2001-01-08 | 2001-01-08 | Nano bezoar medicine for treating upper respiratory tract infection and its preparation |
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| Publication Number | Publication Date |
|---|---|
| CN1362209A true CN1362209A (en) | 2002-08-07 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01100708 Pending CN1362209A (en) | 2001-01-08 | 2001-01-08 | Nano bezoar medicine for treating upper respiratory tract infection and its preparation |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100418556C (en) * | 2005-05-20 | 2008-09-17 | 太极集团重庆中药二厂 | Preparation method of coptis supernatant concentrated pill |
| CN103316154A (en) * | 2013-05-20 | 2013-09-25 | 回音必集团安徽制药有限公司 | Preparation method of Huanglian Shangqing tablets |
| CN104825779A (en) * | 2015-04-23 | 2015-08-12 | 刘德臻 | Traditional Chinese medicine oral aerosol |
| CN104906348A (en) * | 2015-06-11 | 2015-09-16 | 王淑霞 | Traditional Chinese medicine oral aerosol |
| CN105616754A (en) * | 2016-01-04 | 2016-06-01 | 成都富豪斯生物科技有限公司 | Pill medicine for treating wind-heat attacking upward syndrome and preparation method thereof |
-
2001
- 2001-01-08 CN CN 01100708 patent/CN1362209A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100418556C (en) * | 2005-05-20 | 2008-09-17 | 太极集团重庆中药二厂 | Preparation method of coptis supernatant concentrated pill |
| CN103316154A (en) * | 2013-05-20 | 2013-09-25 | 回音必集团安徽制药有限公司 | Preparation method of Huanglian Shangqing tablets |
| CN104825779A (en) * | 2015-04-23 | 2015-08-12 | 刘德臻 | Traditional Chinese medicine oral aerosol |
| CN104906348A (en) * | 2015-06-11 | 2015-09-16 | 王淑霞 | Traditional Chinese medicine oral aerosol |
| CN105616754A (en) * | 2016-01-04 | 2016-06-01 | 成都富豪斯生物科技有限公司 | Pill medicine for treating wind-heat attacking upward syndrome and preparation method thereof |
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