CN1686351A - Medicine for treating gynecopathy inflammation and its production method - Google Patents

Abstract

The invention relates to a medicine for treating gynecological inflammation and a production method thereof, which comprises 7.2 to 17.2 parts of diamond thorn, verbena, Prunella vulgaris and Rosa japonica root, each accounting for 2.3 to 12.3 parts of Andrographis paniculata, Yanhusuo, Gonggongmu, Cyperus cyperus; angelica accounting for 0.5-10.4 parts of the total; made of Caulis Spatholobus accounting for 9.5-19.4 parts of the total. The production method is: crushing + oil extraction inclusion + alcohol extraction + water extraction to make thick Paste (part of Andrographis paniculata is extracted with ethanol or water, and the rest of Andrographis paniculata is crushed and then added and mixed) to make the medicine according to the requirements of pharmacy. The medicine of the present invention has the effects of clearing away heat and detoxifying, promoting blood circulation and removing blood stasis, promoting qi circulation and relieving pain, and is effective for patients with endometritis, adnexitis, and pelvic inflammatory disease belonging to stasis toxin syndrome, qi stagnation and blood stasis syndrome, and gynecological inflammation of damp-heat stagnation type. Good therapeutic effect. Clinical trials have proved that the drug is safe and reliable, and no obvious adverse reactions and toxic side effects have been found.

Description

A kind of medicine for treating gynecological inflammation and its production method

technical field

The invention relates to a medicine for treating gynecological inflammation, in particular to a medicine for treating endometritis, adnexitis, pelvic inflammatory disease belonging to blood stasis syndrome, qi stagnation and blood stasis syndrome, and damp-heat stasis type gynecological inflammation and its production method .

Background technique

Gynecological inflammation refers to the inflammation of female internal genitalia and its surrounding connective tissue and pelvic peritoneum, which can be divided into acute and chronic types. Ovarian inflammation, pelvic connective tissue inflammation, and pelvic peritonitis, among which salpingo-oophoritis is the most common, can lead to inflammation when the body's immune function declines, endocrine changes, or exogenous pathogenic bacteria invade. Endometritis is an inflammation caused by pathogens invading through the detachment surface of the placenta and spreading to the decidual layer of the uterus, which mostly occurs in uterine surgery, abortion and postpartum; Adhesion and periovarian inflammation occurs. The above inflammations are often aggravated after fatigue, after sexual intercourse, during defecation, and before and after menstruation.

There are many treatises on the treatment of gynecological inflammation in traditional Chinese medicine in my country, and many traditional Chinese medicine prescriptions for the treatment of gynecological inflammation are also recorded. Modern TCM theories are also fully summarizing, excavating and utilizing ancient TCM theories. Many scientific treatises have also proposed a large number of TCM methods and medicines for treating gynecological inflammation, which have played a better guiding role in TCM treatment of gynecological inflammation. Over the past few years, some pharmaceutical companies and Chinese medicine research institutes have also launched some Chinese patent medicines for treating gynecological inflammation, but some of these Chinese patent medicines are expensive and unacceptable to patients, and some are not very targeted and have unsatisfactory curative effects. Therapeutic effect.

Contents of the invention

The object of the present invention is to provide a Chinese patent medicine with strong pertinence to gynecological inflammation, remarkable curative effect, uncomplicated prescription and moderate price and its production method.

In the long-term medical practice, starting from the traditional medical theory of the motherland, the inventor screened dozens of traditional Chinese medicine prescriptions after years of research, compared them repeatedly, selected some medicines from them and formulated prescriptions, and carried out pharmacodynamics, pharmacology, etc. , and clinical research experiments, and finally invented a Chinese patent medicine with good curative effect, wide range of drug sources, moderate price, advanced and feasible production technology. The main active ingredients and weight content of the raw materials are as follows:

Diamond thorn 4.2～17.2 Verbena 4.2～17.2 Andrographis 2.3～12.3 Angelica 0.5～10.4 Millipede 6.5～19.4

Corydalis 2.3～12.3 Prunella vulgaris 4.2～17.2 Gonggong wood 2.3～12.3 Golden cherry root 4.2～17.2 Cyperus 2.3～12.3

Above-mentioned Chinese medicine can find its another name, Latin name and place of origin, usage from " Chinese Pharmacopoeia " and other Chinese medicine handbooks, in order to understand the mechanism of the present invention's disease treatment, now to the effect of each flavor Chinese medicine in the prescription and its effect in the prescription The description is as follows: Verbena and Andrographis paniculata can clear away heat and detoxify, cool blood and disperse blood stasis, diuresis and detumescence, and they are the king medicine together; Diamond thorn, Prunella vulgaris, and Gonglaomu are combined together as the minister medicine, which can help the king medicine to clear away heat and inflammation, relieve dampness and stop belt, The effect of dispelling blood stasis and eliminating symptoms; Angelica, Spatholobus Spatholobus and Rosa Rosa root together have the functions of nourishing the liver and kidney, solidifying essence, nourishing blood and regulating menstruation, dispelling stasis and reducing inflammation, taking into account the basics, mobilizing the body's immunity, and synergizing with monarch and minister medicines to achieve heat-clearing, The effect of removing dampness and removing blood stasis. Corydalis Corydalis and Rhizoma Rhizoma Cyperi soothe the liver, promote Qi and relieve pain. All medicines share the effect of clearing heat and dampness, nourishing blood and regulating menstruation, promoting blood circulation and removing blood stasis, promoting qi circulation and relieving pain.

The optimum mass fraction content of Chinese medicine composition of the present invention is:

Diamond thorn 6~12 Verbena 6~12 Andrographis 4~8 Angelica 3~6 Millipede 8~16

Corydalis 4～8 Prunella vulgaris 6～12 Gongluomu 4～8 Golden Cherry Root 8～16 Fragrance Attachment 4～8

The composition of Chinese medicine composition of the present invention and quality optimum content also can adopt following proportioning (weight part):

Diamond thorn 3.35 Verbena 3.35 Andrographis 2 Angelica 1.5 Millipede 4

Corydalis 2 Prunella vulgaris 3.35 Gonggong wood 2 Golden cherry root 4 Fragrance Attached 2

The above-mentioned composition can be used as a prescription for treating gynecological inflammation in a traditional Chinese medicine hospital, and can be taken by decocting soup for patients; it is more suitable for modern pharmaceutical companies to extract its active ingredients and make capsules, tablets, granules, sustained-release capsules, soft capsules, dripping pills, Any pharmaceutical dosage form such as oral liquid, the specific production method is as follows:

1. The production method of capsules:

(1) Take 7/25 of the total amount of Andrographis paniculata, pulverize it into fine powder with superfine pulverization technology, and sterilize it with high-pressure steam at 100°C-120°C for 30-60 minutes to obtain intermediate product A;

(2) Angelica and Rhizoma Cyperi, add 3 to 8 times the amount of water, extract the volatile oil with steam distillation for 2 to 4 hours, collect the oily distillate (medicine residue and alcohol extraction process), separate, take the volatile oil, and use β-cyclopaste Fine clathrate, after drying, weigh to obtain the intermediate product B; the distilled aqueous solution C for future use; dregs D is handed over to the alcohol extraction process.

(3) Add 3 to 8 times the amount of 45% to 75% ethanol to the dregs D and extract under reflux for 2 to 4 hours, filter the extract, recover the ethanol from the filtrate and concentrate to obtain thick ointment E.

(4) Add 3 to 8 times the amount of water to the above alcohol-extracted medicinal residues and the remaining Andrographis paniculata and Vajra thorn, Verbena, Millae Spatholobus, Corydalis Corydalis, Prunella vulgaris, Gonglaomu, and Rosa japonica root, and heat and extract twice , 1 to 3 hours each time to obtain the water extraction part F.

(5) Mix C, E and F, add intermediate product A, dry, and pulverize into fine powder to obtain intermediate product dry cream powder G.

(6) Take the intermediate product dry cream powder G, granulate, dry, add intermediate product B and appropriate amount of auxiliary materials, mix evenly, pack into capsules, pack in aluminum foil, and pack separately to obtain finished capsules.

Or produce as follows:

(1) Take 7/25 of the total amount of Andrographis paniculata, pulverize it into fine powder with superfine pulverization technology, and sterilize it with high-pressure steam at 100°C-120°C for 30-60 minutes to obtain intermediate product A;

(2) Angelica and Rhizoma Cyperi, add 3 to 8 times the amount of water, extract the volatile oil with steam distillation for 2 to 4 hours, collect the oily distillate (medicine residue and alcohol extraction process), separate, take the volatile oil, and use β-cyclopaste Fine clathrate, after drying, weigh to obtain the intermediate product B; the distilled aqueous solution C for future use; dregs D is handed over to the alcohol extraction process.

(3) Add 3-8 times the amount of 45-75% ethanol to reflux extraction for 2-4 hours with the dregs D, andrographis paniculata, gonglaoji, and verbena, then filter the extract, recover the ethanol and concentrate the filtrate to obtain thick ointment E. The slag F is handed over to the water extraction process.

(4) Add 3 to 8 times the amount of water together with King Kong thorn, Spatholobus Spatholobus, Corydalis Corydalis, Prunella vulgaris, and Rosaceae root, then add the above-mentioned medicinal residue F after alcohol extraction, heat and extract twice, 1 to 3 hours each time , to obtain the water extraction part G.

(5) Mix C, E and G, add intermediate product A, dry, and pulverize into fine powder to obtain intermediate product dry cream powder H.

(6) Take the dry cream powder H of the intermediate product, granulate it, dry it, add the intermediate product B and appropriate amount of auxiliary materials, mix evenly, pack into capsules, pack in aluminum foil, and pack separately to obtain finished capsules.

The adjuvant mentioned above is magnesium stearate, or other adjuvants that meet international and national standards, and the addition amount is 0.3-1% of the dry granules.

2, the production method of soft capsule:

(1) Add 3 to 8 times the amount of water to Chinese angelica and incense, extract the volatile oil by steam distillation for 2 to 4 hours, collect the oily distillate (drug residue alcohol extraction process), separate, take the volatile oil, and wrap it with β-cyclodextrin Combined, dried, and weighed to obtain an intermediate product A; the distilled aqueous solution B is ready for use; the dregs C is handed over to the alcohol extraction process.

(2) Add 3-8 times the amount of 45-75% ethanol to reflux extraction for 2-4 hours together with Andrographis paniculata, Gonglaojia, and Verbena. Slag E is handed over to the water extraction process.

(3) Add 3 to 8 times the amount of water together with King Kong thorn, Spatholobus Spatholobus, Corydalis Corydalis, Prunella vulgaris, and Rosaceae root, then add the above-mentioned medicinal residue E after alcohol extraction, and heat and extract twice, 1 to 3 hours each time , to obtain the water extraction part F.

(4) B, D and F are mixed and concentrated, dried and pulverized into fine powder to obtain the intermediate product dry cream powder G.

(5) Take the intermediate product dry extract powder G and A, vegetable oil, and beeswax to make a suspension H at a ratio of 1:1:0.02, prepare a rubber with a ratio of gelatin:glycerin:water of 1:0.35:0.9, and then mix the mixture Suspension H is filled and compressed into soft capsules, shaped at a temperature below 25°C, washed with ethanol to remove the oil layer on the surface of the soft capsules, dried at a temperature below 25°C, and taken out to obtain the finished soft capsules.

3. Production method of sustained-release capsules:

(1) Add 3 to 8 times the amount of water to Chinese angelica and incense, extract the volatile oil by steam distillation for 2 to 4 hours, collect the oily distillate (drug residue alcohol extraction process), separate, take the volatile oil, and wrap it with β-cyclodextrin Combined, dried, and weighed to obtain an intermediate product A; the distilled aqueous solution B is ready for use; the dregs C is handed over to the alcohol extraction process.

(2) Add 3-8 times the amount of 45-75% ethanol to reflux extraction for 2-4 hours together with Andrographis paniculata, Gonglaojia, and Verbena. Slag E is handed over to the water extraction process.

(3) Add 3 to 8 times the amount of water together with King Kong thorn, Spatholobus Spatholobus, Corydalis Corydalis, Prunella vulgaris, and Rosaceae root, then add the above-mentioned medicinal residue E after alcohol extraction, and heat and extract twice, 1 to 3 hours each time , to obtain the water extraction part F.

(4) B, D and F are mixed and concentrated, dried and pulverized into fine powder to obtain the intermediate product dry cream powder G.

(5) According to the total amount of the dry extract powder G and A of the intermediate product, add 0.5% to 5% of spermaceti or other blocker coating, and make slow-release pellets for 2, 4, 6, and 8 hours respectively. The pellets are distinguished by different colors, mixed evenly, put into empty capsules, packed into boxes or hot-pressed into aluminum-plastic plates to obtain finished sustained-release capsules.

4. The production method of dropping pills:

(1) Add 3 to 8 times the amount of water to Chinese angelica and incense, extract the volatile oil by steam distillation for 24 hours, collect the oil-containing distillate (drug residue alcohol extraction process), separate, take the volatile oil, and clathrate it with β-cyclodextrin, After drying, weigh to obtain the intermediate product A; the distilled aqueous solution B for future use; and the dregs C to be handed over to the alcohol extraction process.

(2) Add 3-8 times the amount of 45-75% ethanol to reflux extraction for 2-4 hours together with Andrographis paniculata, Gonglaojia, and Verbena. Slag E is handed over to the water extraction process.

(3) Add 3 to 8 times the amount of water together with King Kong thorn, Spatholobus Spatholobus, Corydalis Corydalis, Prunella vulgaris, and Rosaceae root, then add the above-mentioned medicinal residue E after alcohol extraction, and heat and extract twice, 1 to 3 hours each time , to obtain the water extraction part F.

(4) B, D and F are mixed and concentrated, dried and pulverized into fine powder to obtain the intermediate product dry cream powder G.

(5) Heat and melt polyethylene glycol 6000, then add the intermediate products A and G, stir well, transfer to the dropping pill device, keep it sealed at 86°C, and use 10°C~15°C liquid paraffin or other liquids as coolants , dripping at a speed of 50 drops/min to obtain finished pills.

5. Production method of tablet:

(1) Take 7/25 of the total amount of Andrographis paniculata, pulverize it into fine powder, and sterilize it with high-pressure steam at 100°C-120°C for 30-60 minutes to obtain intermediate product A;

(2) Add 3 to 8 times the amount of water to angelica and cypress, extract the volatile oil by steam distillation for 2 to 4 hours, collect the oily distillate (drug residue alcohol extraction process), separate, take the volatile oil, and wrap it with β-cyclodextrin combined, dried, and weighed to obtain an intermediate product B ₁ ; the distilled aqueous solution C ₁ is ready for use; and the dregs D ₁ are handed over to the alcohol extraction process.

(3) Add 3 to 8 times the amount of 45 to 75% ethanol to the dregs D ₁ for reflux extraction for 2 to 4 hours, filter the extract, recover the ethanol from the filtrate and concentrate to obtain a thick ointment E ₁ .

(4) Add 3 to 8 times the amount of water to the above alcohol-extracted medicinal residues and the remaining Andrographis paniculata and Vajra thorn, Verbena, Millae Spatholobus, Corydalis Corydalis, Prunella vulgaris, Gonglaomu, and Rosa japonica root, and heat and extract twice , each time for 1-3 hours to obtain the water-extracted fraction F ₁ .

(5) Mix C ₁ , E ₁ and F ₁ , add intermediate product A, dry, and pulverize into fine powder to obtain intermediate product dry cream powder G ₁ .

(6) Take the dry cream powder _G1 of the intermediate product, granulate it, dry it, add _B1 and mix with appropriate amount of auxiliary materials, press into tablets, coat with sugar or film, and pack to obtain finished tablets.

6. Production method of granules:

(1) Add 3 to 8 times the amount of water to Chinese angelica and incense, extract the volatile oil by steam distillation for 2 to 4 hours, collect the oily distillate (drug residue alcohol extraction process), separate, take the volatile oil, and wrap it with β-cyclodextrin Combined, dried, and weighed to obtain an intermediate product A; the distilled aqueous solution B is ready for use; the dregs C is handed over to the alcohol extraction process.

(2) Add 3-8 times the amount of 45-75% ethanol to reflux extraction for 2-4 hours together with Andrographis paniculata, Gonglaojia, and Verbena. Slag E.

(3) Add 3 to 8 times the amount of water together with King Kong thorn, Spatholobus Spatholobus, Corydalis Corydalis, Prunella vulgaris, and Rosaceae root, then add the above-mentioned medicinal residue E after alcohol extraction, and heat and extract twice, 1 to 3 hours each time , to obtain the water extraction part F.

(4) B, D and F are mixed and concentrated, dried and pulverized into fine powder to obtain the intermediate product dry cream powder G.

(5) Take the intermediate product dry paste powder G and mix with appropriate amount of auxiliary materials, granulate, dry, mix with A, pack separately, and obtain finished granules.

7. Production method of oral liquid:

(1) Angelica and Rhizoma Cyperi, add 3 to 8 times the amount of water, extract the volatile oil by steam distillation for 2 to 4 hours, collect the oily distillate, separate to obtain the volatile oil B ₃ ; the distilled aqueous solution C ₃ for later use; dregs D ₃ Transfer to the alcohol extraction process.

(2) Add 3 to 8 times the amount of 45 to 75% ethanol to the medicinal dregs D ₃ for reflux extraction for 2 to 4 hours, filter the extract, recover the ethanol from the filtrate to obtain the alcohol extraction fraction E ₃ .

(3) Add 3 to 8 times the amount of water to the above-mentioned medicinal residue after alcohol extraction, Andrographis paniculata, Vajra thorn, Verbena, Caulis Spatholobus, Corydalis Corydalis, Prunella vulgaris, Gonglaomu, and Rosa Radix, and heat and extract twice, each After 1-3 hours, the water-extracted fraction F ₃ is obtained.

(4) Mix and concentrate C ₃ , E ₃ and F ₃ to obtain an intermediate product liquid extract G3 with a relative density of 1.05-1.20/55-60°C.

(5) Mix intermediate products B ₃ and G ₃ with appropriate amount of syrup or honey, sterilize and fill to obtain finished oral liquid.

Other dosage forms such as pills, ointments, buccal tablets, etc. can be prepared with reference to the Pharmacopoeia or traditional Chinese medicine preparation methods.

The extraction method of the above-mentioned traditional Chinese medicine composition provides oil extraction inclusion + alcohol extraction + water extraction. In addition to oil extraction inclusion + alcohol extraction + water extraction, microwave, ultrasonic extraction, carbon dioxide supercritical extraction or other traditional Chinese medicines can also be used. Extraction methods of preparations, these extraction methods have been reported in scientific and technological literature, pharmaceutical companies can use extraction methods according to specific actual conditions, the purpose is to extract the active ingredients in the medicinal materials of the drug composition, and make it into any dosage form in medicine. available to patients.

How to use:

Capsules, 3 times a day, 4 capsules each time, 0.37 grams per capsule;

Soft capsules, orally, 2 capsules at a time, 3 times a day;

Sustained-release capsules, oral, 2 capsules at a time, 1-2 times a day, 0.7 grams per capsule;

Dropping pills, orally, 10 capsules at a time, 3 times a day;

Granules, 2 times a day, 1 bag each time, 8 grams per bag;

Tablets, 3 times a day, 6 tablets each time, 0.45 grams per tablet;

Oral solution, 3 times a day, 10ml each time.

Compared with the prior art, the present invention's outstanding substantive features and remarkable progress are:

Under the guidance of the theory of traditional Chinese medicine, the present invention optimizes the above-mentioned traditional Chinese medicines, adds scientific compatibility and preparation, makes each medicine cooperate with each other, and can ensure the overall effect of the reasonable prescription of the product and the exertion of the medicine effect to the greatest extent, and all the medicines are used in combination to achieve a good result. Clearing heat and dampness, nourishing blood and regulating menstruation, promoting blood circulation and removing blood stasis, promoting qi circulation and relieving pain.

1. Through clinical verification, the present invention has antibacterial, anti-inflammatory and analgesic effects: when the dilution of this product is 1:160, it has a killing effect on Staphylococcus aureus; It can kill cocci, anaerobic streptococcus and Escherichia coli; when the dilution ratio is 1:10, it can kill Neisseria gonorrhoeae for 20 minutes; it can kill rat paw swelling caused by carrageenan and auricle caused by croton oil Swelling, granulation tissue hyperplasia caused by cotton balls, and peritonitis caused by acetic acid all have obvious inhibitory effects, and can also increase the pain threshold of hot plate reactions in mice and reduce the number of writhing reactions in mice.

2. The raw materials are easy to obtain, the formula is scientific, the production technology is advanced, the operability is strong, the product price is moderate, and it is suitable for industrial production.

3. The production process adopts the corresponding sterilization methods of crushing, oil extraction and inclusion, alcohol extraction, and water mentioning. The oil extraction and inclusion ensures the extraction and preservation of the volatile oil of the active ingredients of Angelica and Rhizoma Cyperi, and the steps of alcohol extraction (effective extraction of Andrographis paniculata ingredients such as esters, etc.; glycosides of verbena, etc.; alkaloids, tannins, etc. of Gonggong wood; active ingredients of angelica and Cyperus volatile oil, etc.), so the product has high content of active ingredients, high bioavailability, and is not easy to deteriorate. long.

4. The production technology is advanced and the operability is strong. In the production, according to the properties of the active ingredients and preparation requirements of various traditional Chinese medicines, international advanced pharmaceuticals such as ultrafine pulverization technology, multi-effect decompression technology, spray drying technology, and three-dimensional mixing technology are successively adopted. technology and equipment.

5. The results of acute toxicity study and long-term toxicity study of the product of the present invention show that it is safe to use the product of the present invention according to the intended daily dose and course of treatment.

Detailed ways

The following are embodiments of the invention:

Example 1

Weigh the following traditional Chinese medicine ingredients (unit: g)

Diamond thorn 3.35 Verbena 3.35 Andrographis 2 Angelica 1.5 Millipede 4

Corydalis 2 Prunella vulgaris 3.35 Gonggong wood 2 Golden cherry root 4 Fragrance Attached 2

Its production process is:

(1) Take 7/25 of Andrographis paniculata total amount, pulverize it into fine powder with superfine pulverization technology, sterilize with 110 DEG C of high-pressure steam for 45 minutes, obtain intermediate product A;

(2) Add 8 times the amount of water to angelica and incense, soak for 1 hour, extract the volatile oil by steam distillation for 4 hours, collect the oily distillate (drug residue and alcohol extraction process), separate, take the volatile oil, and wrap it with β-cyclodextrin Combined, dried, and weighed to obtain an intermediate product B; the distilled aqueous solution C is set aside; the dregs D is handed over to the alcohol extraction process.

(3) Add 3 times the amount of 50% ethanol to the medicinal dregs D and extract under reflux for 4 hours, filter the extract, recover ethanol from the filtrate and concentrate to obtain a thick ointment E.

(4) Add 5 times the amount of water to the above-mentioned medicinal residue after alcohol extraction, together with the remaining Andrographis paniculata and Vajra thorn, Verbena, Millae Spatholobus, Corydalis Corydalis, Prunella vulgaris, Gonglaomu, and Rosa japonica root, soak for 1 hour, and heat to extract Twice, 2 hours each time, to obtain the water extraction part F.

(5) Mix C, E and F, add intermediate product A, dry, and pulverize into fine powder to obtain intermediate product dry cream powder G.

(6) Take the intermediate product dry cream powder G, granulate, dry, add intermediate product B and appropriate amount of auxiliary materials, mix evenly, pack into capsules, pack in aluminum foil, pack separately, and obtain the finished product. The product name is "Jinxiang Capsule".

Example 2

Weigh the following traditional Chinese medicine ingredients (unit: g)

Diamond thorn 7 Verbena 7 Andrographis 4 Angelica 3 Caulis Spatholobus 8

Corydalis 4 Prunella vulgaris 7 Gonggong wood 4 Golden cherry root 8 Fragrant attachment 4

Its production process is:

(1) Take 7/25 of Andrographis paniculata total amount, pulverize it into fine powder with superfine pulverization technology, and sterilize with 120 DEG C of high-pressure steam for 30 minutes to obtain intermediate product A;

(2) Add 3 times the amount of water to angelica and incense, soak for 1 hour, extract the volatile oil by steam distillation for 3 hours, collect the oily distillate (drug residue and alcohol extraction process), separate, take the volatile oil, and wrap it with β-cyclodextrin Combined, dried, and weighed to obtain an intermediate product B; the distilled aqueous solution C is set aside; the dregs D is handed over to the alcohol extraction process.

(3) Medicinal dregs D, andrographis paniculata, gonglaozhi, and verbena were extracted with 3 times the amount of 75% ethanol under reflux for 2 hours, the extract was filtered, and the filtrate recovered ethanol and concentrated to obtain thick ointment E, and medicinal dregs F were handed over to the water extraction process .

(4) Combine Vajra thorn, Spatholobus Spatholobus, Corydalis Corydalis, Prunella vulgaris, and Rosaceae root together, add 4 times the amount of water, soak for 1 hour, then add the above-mentioned medicinal residue F after alcohol extraction, heat and extract twice, 2.5 hours each time , to obtain the water extraction part G.

(5) Mix C, E and G, add intermediate product A, dry, and pulverize into fine powder to obtain intermediate product dry cream powder H.

(6) Take the dry paste powder H of the intermediate product, granulate it, dry it, add the intermediate product B and mix it with appropriate amount of auxiliary materials, pack it into capsules, pack it in aluminum foil, and pack it separately to obtain the finished product, the product name is "Jinxiang Capsule".

Example 3

Weigh the following traditional Chinese medicine ingredients (unit: g)

Vajra thorn9 Verbena 9 Andrographis 6 Angelica 4 Spathiphyllum 12

Corydalis 6 Prunella vulgaris 9 Gonggong wood 6 Golden cherry root 12 Fragrance Attached 6

Its production process is:

(1) Take 7/25 of Andrographis paniculata total amount, pulverize it into fine powder with superfine pulverization technology, and sterilize with 120 DEG C of high-pressure steam for 30 minutes to obtain intermediate product A;

(2) Angelica and Rhizoma Cyperi, add 6 times the amount of water, soak for 1 hour, extract the volatile oil with steam distillation for 2 hours, collect the oily distillate (drug residue and alcohol extraction process), separate, take the volatile oil, and use β-cyclopaste Fine clathrate, after drying, weigh to obtain the intermediate product B; the distilled aqueous solution C for future use; dregs D is handed over to the alcohol extraction process.

(3) Add 6 times the amount of 60% ethanol to the medicinal dregs D and extract under reflux for 3 hours, filter the extract, recover ethanol from the filtrate and concentrate to obtain a thick ointment E.

(4) Add 6 times the amount of water to the above-mentioned medicinal residue after alcohol extraction, together with the remaining Andrographis paniculata and Vajra thorn, Verbena, Millae Spatholobus, Corydalis Corydalis, Prunella vulgaris, Gonglaomu, and Rosa japonica root, soak for 1 hour, and heat to extract Twice, 3 hours each time, to obtain the water extraction part F.

(5) Mix C, E and F, add intermediate product A, dry, and pulverize into fine powder to obtain intermediate product dry cream powder G.

(6) Take the intermediate product dry cream powder G, granulate, dry, add intermediate product B and appropriate amount of auxiliary materials, mix evenly, pack into capsules, pack in aluminum foil, pack separately, and obtain the finished product. The product name is "Jinxiang Capsule".

Example 4

Weigh the following traditional Chinese medicine ingredients (unit: g)

Diamond thorn 12 Verbena 12 Andrographis 8 Angelica 6 Spathiphyllum 16

Corydalis 8 Prunella vulgaris 12 Gonggong wood 8 Golden cherry root 16 Fragrance with 8

Its production process is:

(1) Take 7/25 of Andrographis paniculata total amount, pulverize it into fine powder with superfine pulverization technology, sterilize with 115 ℃ of high-pressure steam for 60 minutes, obtain intermediate product A;

(2) Angelica and Rhizoma Cyperi, add 6 times the amount of water, soak for 1 hour, extract the volatile oil with steam distillation for 2 hours, collect the oily distillate (drug residue and alcohol extraction process), separate, take the volatile oil, and use β-cyclopaste Fine clathrate, after drying, weigh to obtain the intermediate product B; the distilled aqueous solution C for future use; dregs D is handed over to the alcohol extraction process.

(3) Herbal dregs D, andrographis paniculata, gonglaozhi, and verbena were added together with 6 times the amount of 60% ethanol for reflux extraction for 3 hours, the extract was filtered, and the filtrate was recovered with ethanol and concentrated to obtain thick ointment E, and herbal dregs F were handed over to the water extraction process .

(4) Add diamond thorn, Spatholobus Spatholobus, Corydalis Corydalis, Prunella vulgaris, and Rosaceae root together, add 6 times the amount of water, soak for 1 hour, then add the above-mentioned medicinal residue F after alcohol extraction, heat and extract twice, 3 hours each time , to obtain the water extraction part G.

(5) Mix C, E and G, add intermediate product A, dry, and pulverize into fine powder to obtain intermediate product dry cream powder H.

(6) Take the dry paste powder H of the intermediate product, granulate it, dry it, add the intermediate product B and mix it with appropriate amount of auxiliary materials, pack it into capsules, pack it in aluminum foil, and pack it separately to obtain the finished product, the product name is "Jinxiang Capsule".

Example 5

Weigh the following traditional Chinese medicine ingredients (unit: g)

Diamond thorn 3.35 Verbena 3.35 Andrographis 2 Angelica 1.5 Millipede 4

Corydalis 2 Prunella vulgaris 3.35 Gonggong wood 2 Golden cherry root 4 Fragrance Attached 2

Its production process is:

(1) Add 4 times the amount of water to angelica and incense, soak for 1 hour, extract the volatile oil by steam distillation for 3.5 hours, collect the oily distillate (drug residue and alcohol extraction process), separate, take the volatile oil, and wrap it with β-cyclodextrin Combined, dried, and weighed to obtain an intermediate product A; the distilled aqueous solution B is ready for use; the dregs C is handed over to the alcohol extraction process.

(2) Medicinal dregs C, andrographis paniculata, gonglaozhi, and verbena are added together with 4 times the amount of 65% ethanol for reflux extraction for 4 hours, the extract is filtered, and the filtrate is recovered with ethanol and concentrated to obtain thick ointment D, and medicinal dregs E is handed over to the water extraction process .

(3) Put Vajra thorn, Spatholobus Spatholobus, Corydalis Corydalis, Prunella vulgaris, and Rosaceae root together, add 4 times the amount of water, soak for 1 hour, then add the above-mentioned medicinal residue E after alcohol extraction, heat and extract twice, 2.5 hours each time , to obtain the water extraction part F.

(4) B, D and F are mixed and concentrated, dried and pulverized into fine powder to obtain the intermediate product dry cream powder G.

(5) Take the intermediate product dry extract powder G and A, vegetable oil, and beeswax to make a suspension H at a ratio of 1:1:0.02, prepare a rubber with a ratio of gelatin:glycerin:water of 1:0.35:0.9, and then mix the mixture Suspension H is filled and pressed into soft capsules, shaped below 25°C, washed with ethanol to remove the oil layer on the surface of the soft capsules, dried below 25°C, and taken out to obtain a finished product, which is named "Jinxiang Soft Capsules".

Example 6

Weigh the following traditional Chinese medicine ingredients (unit: g)

Diamond thorn 7 Verbena 7 Andrographis 3.8 Angelica 3.1 Millipede 8.3

Corydalis 4.1 Prunella vulgaris 7.1 Gonggong wood 4.2 Golden cherry root 8.1 Fragrance with 4.2

Its production process is:

(1) Add 8 times the amount of water to angelica and incense, soak for 1 hour, extract the volatile oil by steam distillation for 3 hours, collect the oily distillate (medicine residue and alcohol extraction process), separate, take the volatile oil, and wrap it with β-cyclodextrin Combined, dried, and weighed to obtain an intermediate product A; the distilled aqueous solution B is for use; the dregs C is handed over to the alcohol extraction process.

(2) Medicinal dregs C, andrographis paniculata, gonglaozhi, and verbena are added together with 4 times the amount of 55% ethanol for reflux extraction for 2 hours, the extract is filtered, and the filtrate is recovered with ethanol and concentrated to obtain thick ointment D, and medicinal dregs E is handed over to the water extraction process .

(3) Put Vajra thorn, Spatholobus Spatholobus, Corydalis Corydalis, Prunella vulgaris, and Rosaceae root together, add 7 times the amount of water, soak for 1 hour, then add the above-mentioned medicinal residue E after alcohol extraction, heat and extract twice, 1.5 hours each time , to obtain the water extraction part F.

(4) B, D and F are mixed and concentrated, dried, and pulverized into fine powder to obtain dry cream powder G, an intermediate product.

(5) Take the intermediate product dry extract powder G and A, vegetable oil, and beeswax to make a suspension H at a ratio of 1:1:0.02, prepare a rubber with a ratio of gelatin:glycerin:water of 1:0.35:0.9, and then mix the mixture Suspension H is filled and compressed into soft capsules, shaped below 25°C, washed with ethanol to remove the oil layer on the surface of the soft capsules, dried below 25°C, and taken out to obtain the finished product, which is named "Jinxiang Soft Capsules".

Example 7

Weigh the following traditional Chinese medicine ingredients (unit: g)

Diamond thorn 6.8 Verbena 6.7 Andrographis 3.9 Angelica 2.9 Millipede 8.1

Corydalis 3.8 Prunella vulgaris 6.7 Gonggong wood 4 Golden cherry root 8 Fragrance with 4

Its production process is:

(1) Add 5 times the amount of water to angelica and incense, soak for 1 hour, extract the volatile oil by steam distillation for 4 hours, collect the oily distillate (drug residue and alcohol extraction process), separate, take the volatile oil, and wrap it with β-cyclodextrin Combined, dried, and weighed to obtain an intermediate product A; the distilled aqueous solution B is ready for use; the dregs C is handed over to the alcohol extraction process.

(2) Medicinal dregs C, andrographis paniculata, gonglaozhi, and verbena are added together with 8 times the amount of 65% ethanol for reflux extraction for 2 hours, the extract is filtered, and the filtrate is recovered with ethanol and concentrated to obtain thick ointment D, and medicinal dregs E is handed over to the water extraction process .

(3) Put Vajra thorn, Spatholobus Spatholobus, Corydalis Corydalis, Prunella vulgaris, and Rosaceae root together, add 4 times the amount of water, soak for 1 hour, then add the above-mentioned medicinal residue E after alcohol extraction, heat and extract twice, 2.5 hours each time , to obtain the water extraction part F.

(4) B, D and F are mixed and concentrated, dried and pulverized into fine powder to obtain the intermediate product dry cream powder G.

(5) Take the intermediate product dry extract powder G and A, vegetable oil, and beeswax to make a suspension H at a ratio of 1:1:0.02, prepare a rubber with a ratio of gelatin:glycerin:water of 1:0.35:0.9, and then mix the mixture Suspension H is filled and pressed into soft capsules, shaped below 25°C, washed with ethanol to remove the oil layer on the surface of the soft capsules, dried below 25°C, and taken out to obtain a finished product, which is named "Jinxiang Soft Capsules".

Example 8

Weigh the following traditional Chinese medicine ingredients (unit: g)

Diamond thorn 33 Verbena 33 Andrographis paniculata 20 Angelica 16 Spatholobus 41

Corydalis 21 Prunella vulgaris 33 Gonggong wood 20 Golden cherry root 40 Fragrance Attached to 19

Its production process is:

(1) Add 3 times the amount of water to angelica and incense, soak for 1 hour, extract the volatile oil by steam distillation for 2 hours, collect the oily distillate (medicine residue and alcohol extraction process), separate, take the volatile oil, and wrap it with β-cyclodextrin Combined, dried, and weighed to obtain an intermediate product A; the distilled aqueous solution B is ready for use; the dregs C is handed over to the alcohol extraction process.

(2) Medicinal dregs C, andrographis paniculata, gonglaozhi, and verbena were extracted by adding 3 times the amount of 65% ethanol under reflux for 3 hours, the extract was filtered, and the filtrate recovered ethanol and concentrated to obtain thick ointment D, and medicinal dregs E were handed over to the water extraction process .

(3) Put Vajra thorn, Spatholobus Spatholobus, Corydalis Corydalis, Prunella vulgaris, and Rosaceae root together, add 8 times the amount of water, soak for 1 hour, then add the above-mentioned medicinal residue E after alcohol extraction, heat and extract twice, 3 hours each time , to obtain the water extraction part F.

(4) B, D and F are mixed and concentrated, dried and pulverized into fine powder to obtain the intermediate product dry cream powder G.

(5) According to the total amount of the dry extract powder G and A of the intermediate product, add 0.5% to 5% of spermaceti or other blocker coating, and make slow-release pellets for 2, 4, 6, and 8 hours respectively. The small pills are distinguished by different colors, mixed evenly, put into empty capsules, packed into boxes or hot-pressed into aluminum-plastic plates, and the finished product is obtained. The product name is "Jinxiang sustained-release capsule" or "Slow-release Jinxiang capsule".

Example 9

Weigh the following traditional Chinese medicine ingredients (unit: g)

Diamond thorn 3.35 Verbena 3.35 Andrographis 2 Angelica 1.5 Millipede 4

Corydalis 2 Prunella vulgaris 3.35 Gonggong wood 2 Golden cherry root 4 Fragrance Attached 2

Its production process is:

(1) Add 7 times the amount of water to angelica and incense, soak for 1 hour, extract the volatile oil with steam distillation for 3 hours, collect the oily distillate (medicine residue and alcohol extraction process), separate, take the volatile oil, and wrap it with β-cyclodextrin Combined, dried, and weighed to obtain an intermediate product A; the distilled aqueous solution B is ready for use; the dregs C is handed over to the alcohol extraction process.

(2) Medicinal dregs C, andrographis paniculata, gonglaojiao, and verbena were extracted with 7 times the amount of 70% ethanol under reflux for 2 hours, the extract was filtered, and the filtrate recovered ethanol and concentrated to obtain thick ointment D, and medicinal dregs E was handed over to the water extraction process .

(3) Put Vajra thorn, Spatholobus Spatholobus, Corydalis Corydalis, Prunella vulgaris, and Rosaceae root together, add 5 times the amount of water, soak for 1 hour, then add the above-mentioned medicinal residue E after alcohol extraction, heat and extract twice, 1.5 hours each time , to obtain the water extraction part F.

(4) B, D and F are mixed and concentrated, dried and pulverized into fine powder to obtain the intermediate product dry cream powder G.

(5) According to the total amount of the dry extract powder G and A of the intermediate product, add 0.5% to 5% of spermaceti or other blocker coating, and make slow-release pellets for 2, 4, 6, and 8 hours respectively. The small pills are distinguished by different colors, mixed evenly, put into empty capsules, packed into boxes or hot-pressed into aluminum-plastic plates, and the finished product is obtained. The product name is "Jinxiang sustained-release capsule" or "Slow-release Jinxiang capsule".

Example 10

Weigh the following traditional Chinese medicine ingredients (unit: g)

Vajra thorn 33.5 Verbena 33.5 Andrographis 20 Angelica 15 Spatholobus 41

Corydalis 21 Prunella vulgaris 33.5 Gonggong wood 21 Golden cherry root 41 Fragrance Attached to 21

Its production process is:

(1) Add 8 times the amount of water to angelica and incense, soak for 1 hour, extract the volatile oil by steam distillation for 4 hours, collect the oily distillate (drug residue and alcohol extraction process), separate, take the volatile oil, and wrap it with β-cyclodextrin Combined, dried, and weighed to obtain an intermediate product A; the distilled aqueous solution B is ready for use; the dregs C is handed over to the alcohol extraction process.

(2) Medicinal dregs C, andrographis paniculata, gonglaozhi, and verbena are added together with 8 times the amount of 55% ethanol for reflux extraction for 3.5 hours, the extract is filtered, and the filtrate is recovered with ethanol and concentrated to obtain thick ointment D, and medicinal dregs E is handed over to the water extraction process .

(3) Put Vajra thorn, Spatholobus Spatholobus, Corydalis Corydalis, Prunella vulgaris, and Rosaceae root together, add 5 times the amount of water, soak for 1 hour, then add the above-mentioned medicinal residue E after alcohol extraction, heat and extract twice, 2.5 hours each time , to obtain the water extraction part F.

(4) B, D and F are mixed and concentrated, dried and pulverized into fine powder to obtain the intermediate product dry cream powder G.

(5) According to the total amount of the dry extract powder G and A of the intermediate product, add 0.5% to 5% of spermaceti or other blocker coating, and make slow-release pellets for 2, 4, 6, and 8 hours respectively. The small pills are distinguished by different colors, mixed evenly, put into empty capsules, packed into boxes or hot-pressed into aluminum-plastic plates, and the finished product is obtained. The product name is "Jinxiang sustained-release capsule" or "Slow-release Jinxiang capsule".

Example 11

Weigh the following traditional Chinese medicine ingredients (unit: g)

Diamond thorn 35 Verbena 35 Andrographis paniculata 21 Angelica 16 Spatholobus 42

Corydalis 22 Prunella vulgaris 35 Gonggong wood 22 Golden cherry root 43 Fragrance Attached to 22

Its production process is:

(1) Add 4 times the amount of water to angelica and incense, soak for 1 hour, extract the volatile oil with steam distillation for 2.5 hours, collect the oily distillate (drug residue and alcohol extraction process), separate, take the volatile oil, and wrap it with β-cyclodextrin Combined, dried, and weighed to obtain an intermediate product A; the distilled aqueous solution B is ready for use; the dregs C is handed over to the alcohol extraction process.

(2) Medicinal dregs C, andrographis paniculata, gonglaozhi, and verbena were extracted with 3 times the amount of 70% ethanol under reflux for 2.5 hours, the extract was filtered, and the filtrate was recovered with ethanol and concentrated to obtain thick ointment D, and medicinal dregs E was handed over to the water extraction process .

(3) Put Vajra thorn, Spatholobus Spatholobus, Corydalis Corydalis, Prunella vulgaris, and Rosaceae root together, add 7 times the amount of water, soak for 1 hour, then add the above-mentioned medicinal residue E after alcohol extraction, heat and extract twice, 1.5 hours each time , to obtain the water extraction part F.

(4) B, D and F are mixed and concentrated, dried and pulverized into fine powder to obtain the intermediate product dry cream powder G.

(5) Heat and melt polyethylene glycol 6000, then add the intermediate products A and G, stir well, transfer to the dropping pill device, keep it sealed at 86°C, and use 10°C~15°C liquid paraffin or other liquids as coolants , drop system with 50 drops/minute speed, get finished product, product name is " Jinxiang dripping pill ".

Example 12

Weigh the following traditional Chinese medicine ingredients (unit: g)

Diamond thorn 6.7 Verbena 6.7 Andrographis 4 Angelica 3 Millipede 8

Corydalis 4 Prunella vulgaris 6.7 Gonggong wood 4 Golden cherry root 8 Fragrance Attached to 4

Its production process is:

(1) Add 4 times the amount of water to angelica and incense, soak for 1 hour, extract the volatile oil with steam distillation for 2.5 hours, collect the oily distillate (drug residue and alcohol extraction process), separate, take the volatile oil, and wrap it with β-cyclodextrin Combined, dried, and weighed to obtain an intermediate product A; the distilled aqueous solution B is ready for use; the dregs C is handed over to the alcohol extraction process.

(2) Medicinal dregs C, andrographis paniculata, gonglaozhi, and verbena are added together with 4 times the amount of 60% ethanol for reflux extraction for 3.5 hours, the extract is filtered, and the filtrate is recovered with ethanol and concentrated to obtain thick ointment D, and medicinal dregs E is handed over to the water extraction process .

(3) Put Vajra thorn, Spatholobus Spatholobus, Corydalis Corydalis, Prunella vulgaris, and Rosaceae root together, add 4 times the amount of water, soak for 1 hour, then add the above-mentioned medicinal residue E after alcohol extraction, heat and extract twice, 2.5 hours each time , to obtain the water extraction part F.

(4) B, D and F are mixed and concentrated, dried and pulverized into fine powder to obtain the intermediate product dry cream powder G.

(5) Heat and melt polyethylene glycol 6000, then add the intermediate products A and G, stir well, transfer to the dropping pill device, keep it sealed at 86°C, and use 10°C~15°C liquid paraffin or other liquids as coolants , drop system with 50 drops/minute speed, get finished product, product name is " Jinxiang dripping pill ".

Example 13

Weigh the following traditional Chinese medicine ingredients (unit: g)

Diamond thorn 3.35 Verbena 3.35 Andrographis 2 Angelica 1.5 Millipede 4

Corydalis 2 Prunella vulgaris 3.35 Gonggong wood 2 Golden cherry root 4 Fragrance Attached 2

Its production process is:

(1) Add 7 times the amount of water to angelica and incense, soak for 1 hour, extract the volatile oil with steam distillation for 3 hours, collect the oily distillate (medicine residue and alcohol extraction process), separate, take the volatile oil, and wrap it with β-cyclodextrin Combined, dried, and weighed to obtain an intermediate product A; the distilled aqueous solution B is ready for use; the dregs C is handed over to the alcohol extraction process.

(2) Medicinal dregs C, andrographis paniculata, gonglaozhi, and verbena are added together with 5 times the amount of 65% ethanol for reflux extraction for 2 hours, the extract is filtered, and the filtrate is recovered with ethanol and concentrated to obtain thick ointment D, and medicinal dregs E is handed over to the water extraction process .

(3) Put Vajra thorn, Spatholobus Spatholobus, Corydalis Corydalis, Prunella vulgaris, and Rosaceae root together, add 7 times the amount of water, soak for 1 hour, then add the above-mentioned medicinal residue E after alcohol extraction, heat and extract twice, 1.5 hours each time , to obtain the water extraction part F.

(4) B, D and F are mixed and concentrated, dried and pulverized into fine powder to obtain the intermediate product dry cream powder G.

(5) Heat and melt polyethylene glycol 6000, then add the intermediate products A and G, stir well, transfer to the dropping pill device, keep it sealed at 86°C, and use 10°C~15°C liquid paraffin or other liquids as coolants , drop system with 50 drops/minute speed, get finished product, product name is " Jinxiang dripping pill ".

Example 14

Weigh the following traditional Chinese medicine ingredients (unit: g)

Diamond thorn 11 Verbena 11 Andrographis 7 Angelica 5 Spathiphyllum 14

Corydalis 7 Prunella vulgaris 11 Gonggong wood 7 Golden cherry root 14 Fragrance Attached to 7

Its production process is:

(1) Take 7/25 of Andrographis paniculata total amount and pulverize into fine powder, sterilize with 115 DEG C of high-pressure steam for 40 minutes, obtain intermediate product _A1 ;

(2) Add 5 times the amount of water to angelica and incense, soak for 1 hour, extract the volatile oil by steam distillation for 3 hours, collect the oily distillate (drug residue and alcohol extraction process), separate, take the volatile oil, and wrap it with β-cyclodextrin combined, dried, and weighed to obtain an intermediate product B ₁ ; the distilled aqueous solution C ₁ is ready for use; and the dregs D ₁ are handed over to the alcohol extraction process.

(3) Medicinal dregs D ₁ and the remaining Andrographis paniculata, Verbena Herb, and Gonglaojiao plus 5 times the amount of 60% ethanol were refluxed for 4 hours, the extract was filtered, and the filtrate was recovered with ethanol and concentrated to obtain a thick ointment E ₁ .

(4) Add 8 times the amount of water to the above-mentioned alcohol-extracted medicinal residues together with King Kong thorn, Spatholobus Spatholobus, Corydalis Corydalis, Prunella vulgaris, and Rosaceae root, soak for 1 hour, heat and extract twice, each time for 3 hours, to obtain water Mention part _F1 .

(5) Mix C ₁ , E ₁ and F ₁ , add intermediate product A, dry, and pulverize into fine powder to obtain intermediate product dry cream powder G ₁ .

(6) Take the dry cream powder _G1 of the intermediate product, granulate, dry, add _B1 and mix with appropriate amount of auxiliary materials, press into tablets, coat with sugar or film, pack, and obtain the finished product, the product name is "Jinxiang Tablet".

Example 15

Weigh the following traditional Chinese medicine ingredients (unit: g)

Diamond thorn 3.35 Verbena 3.35 Andrographis 2 Angelica 1.5 Millipede 4

Corydalis 2 Prunella vulgaris 3.35 Gonggong wood 2 Golden cherry root 4 Fragrance Attached 2

Its production process is:

(1) Take 7/25 of Andrographis paniculata total amount and pulverize into fine powder, sterilize with 120 DEG C of high-pressure steam for 30 minutes, obtain intermediate product _A1 ;

(2) Add 5 times the amount of water to angelica and incense, soak for 1 hour, extract the volatile oil by steam distillation for 2.5 hours, collect the oily distillate (drug residue and alcohol extraction process), separate, take the volatile oil, and wrap it with β-cyclodextrin combined, dried, and weighed to obtain the intermediate product B ₁ ; the distilled aqueous solution C ₁ for future use; and the dregs D ₁ to be handed over to the alcohol extraction process.

(3) Add 4 times the amount of 50% ethanol to the dregs D ₁ and extract under reflux for 3.5 hours, filter the extract, recover ethanol from the filtrate and concentrate to obtain a thick ointment E ₁ .

(4) Add 7 times the amount of water to the above-mentioned alcohol-extracted medicinal residues and the remaining Andrographis paniculata and Vajra thorn, Verbena, Millae Spatholobus, Corydalis Corydalis, Prunella vulgaris, Gonglaomu, and Rosa japonica root, soak for 1 hour, and heat to extract Two times, 2.5 hours each time, to obtain the water-extracted fraction F ₁ .

(5) Mix C ₁ , E ₁ and F ₁ , add intermediate product A, dry, and pulverize into fine powder to obtain intermediate product dry cream powder G1.

(6) Take the dry cream powder _G1 of the intermediate product, granulate, dry, add _B1 and mix with appropriate amount of auxiliary materials, press into tablets, coat with sugar or film, pack, and obtain the finished product, the product name is "Jinxiang Tablet".

Example 16

Weigh the following traditional Chinese medicine ingredients (unit: g)

Diamond thorn 35 Verbena 34 Andrographis paniculata 21 Angelica 14 Caulis Spatholobus 41

Corydalis 20 Prunella vulgaris 33 Gonggong wood 23 Golden cherry root 42 Fragrance Attached to 19

Its production process is:

(1) Take 7/25 of Andrographis paniculata total amount and pulverize into fine powder, sterilize with high-pressure steam at 115 DEG C for 50 minutes to obtain intermediate product _A1 ;

(2) Add 4 times the amount of water to angelica and incense, soak for 1 hour, extract the volatile oil by steam distillation for 4 hours, collect the oily distillate (drug residue and alcohol extraction process), separate, take the volatile oil, and wrap it with β-cyclodextrin combined, dried, and weighed to obtain an intermediate product B ₁ ; the distilled aqueous solution C ₁ is ready for use; and the dregs D ₁ are handed over to the alcohol extraction process.

(3) Add 4 times the amount of 70% ethanol to the dregs D ₁ and extract under reflux for 4 hours, filter the extract, recover ethanol from the filtrate and concentrate to obtain a thick ointment E ₁ .

(4) Add 5 times the amount of water to the above-mentioned medicinal residue after alcohol extraction, together with the remaining Andrographis paniculata and Vajra thorn, Verbena, Millae Spatholobus, Corydalis Corydalis, Prunella vulgaris, Gonglaomu, and Rosa japonica root, soak for 1 hour, and heat to extract Two times, 2 hours each time, to obtain the water-extracted fraction F ₁ .

(5) Mix C ₁ , E ₁ and F ₁ , add intermediate product A, dry, and pulverize into fine powder to obtain intermediate product dry cream powder G ₁ .

(6) Take the dry cream powder _G1 of the intermediate product, granulate, dry, add _B1 and mix with appropriate amount of auxiliary materials, press into tablets, coat with sugar or film, pack, and obtain the finished product, the product name is "Jinxiang Tablet".

Example 17

Weigh the following traditional Chinese medicine ingredients (unit: g)

Diamond thorn 3.35 Verbena 3.35 Andrographis 2 Angelica 1.5 Millipede 4

Corydalis 2 Prunella vulgaris 3.35 Gonggong wood 2 Golden cherry root 4 Fragrance Attached 2

Its production process is:

(1) Add 5 times the amount of water to angelica and incense, soak for 1 hour, extract the volatile oil by steam distillation for 2 hours, collect the oily distillate (medicine residue and alcohol extraction process), separate, take the volatile oil, and wrap it with β-cyclodextrin Combined, dried, and weighed to obtain an intermediate product A; the distilled aqueous solution B is ready for use; the dregs C is handed over to the alcohol extraction process.

(2) Medicinal dregs C, andrographis paniculata, gonglaozhi, and verbena were extracted with 7 times the amount of 60% ethanol under reflux for 2.5 hours, the extract was filtered, and the filtrate was recovered with ethanol and concentrated to obtain thick ointment D and medicinal dregs E.

(3) Put Vajra thorn, Spatholobus Spatholobus, Corydalis Corydalis, Prunella vulgaris, and Rosaceae root together, add 7 times the amount of water, soak for 1 hour, then add the above-mentioned medicinal residue E after alcohol extraction, heat and extract twice, 1 hour each time , to obtain the water extraction part F.

(4) B, D and F are mixed and concentrated, dried and pulverized into fine powder to obtain the intermediate product dry cream powder G.

(5) Take the intermediate product dry paste powder G and mix with appropriate amount of auxiliary materials, granulate, dry, mix with A, pack separately, and obtain the finished product, the product name is "Jinxiang Granules".

Example 18

Weigh the following traditional Chinese medicine ingredients (unit: g)

Vajra thorn 30 Verbena 31 Andrographis 19 Angelica 14 Milletanus 39

Corydalis 18 Prunella vulgaris 31 Gonggong wood 18 Golden cherry root 38 Fragrance Attached to 18

Its production process is:

(1) Add 3 times the amount of water to angelica and incense, soak for 1 hour, extract the volatile oil by steam distillation for 2 hours, collect the oily distillate (medicine residue and alcohol extraction process), separate, take the volatile oil, and wrap it with β-cyclodextrin Combined, dried, and weighed to obtain an intermediate product A; the distilled aqueous solution B is ready for use; the dregs C is handed over to the alcohol extraction process.

(2) Medicinal dregs C, andrographis paniculata, gonglaozhi, and verbena were extracted with 3 times the amount of 70% ethanol under reflux for 2 hours, the extract was filtered, and the filtrate was recovered with ethanol and concentrated to obtain thick ointment D and medicinal dregs E.

(3) Put Vajra thorn, Spatholobus Spatholobus, Corydalis Corydalis, Prunella vulgaris, and Rosaceae root together, add 4 times the amount of water, soak for 1 hour, then add the above-mentioned medicinal residue E after alcohol extraction, heat and extract twice, 3 hours each time , to obtain the water extraction part F.

(4) B, D and F are mixed and concentrated, dried and pulverized into fine powder to obtain the intermediate product dry cream powder G.

(5) Take the intermediate product dry paste powder G and mix with appropriate amount of auxiliary materials, granulate, dry, mix with A, pack separately, and obtain the finished product, the product name is "Jinxiang Granules".

Example 19

Weigh the following traditional Chinese medicine ingredients (unit: g)

Diamond thorn 6.7 Verbena 6.8 Andrographis 3.9 Angelica 2.9 Millipede 7.9

Corydalis 3.8 Prunella vulgaris 6.6 Gonggong wood 3.9 Golden cherry root 8.1 Fragrance with 3.8

Its production process is:

(1) Add 4 times the amount of water to angelica and incense, soak for 1 hour, extract the volatile oil by steam distillation for 3 hours, collect the oily distillate (drug residue and alcohol extraction process), separate, take the volatile oil, and wrap it with β-cyclodextrin Combined, dried, and weighed to obtain an intermediate product A; the distilled aqueous solution B is ready for use; the dregs C is handed over to the alcohol extraction process.

(2) Medicinal dregs C, andrographis paniculata, gonglaozhi, and verbena were extracted with 4 times the amount of 55% ethanol under reflux for 2 hours, the extract was filtered, and the filtrate was recovered with ethanol and concentrated to obtain thick ointment D and medicinal dregs E.

(3) Put Vajra thorn, Spatholobus Spatholobus, Corydalis Corydalis, Prunella vulgaris, and Rosaceae root together, add 5 times the amount of water, soak for 1 hour, then add the above-mentioned medicinal residue E after alcohol extraction, heat and extract twice, 2.5 hours each time , to obtain the water extraction part F.

(4) B, D and F are mixed and concentrated, dried and pulverized into fine powder to obtain the intermediate product dry cream powder G.

(5) Take the intermediate product dry paste powder G and mix with appropriate amount of auxiliary materials, granulate, dry, mix with A, pack separately, and obtain the finished product, the product name is "Jinxiang Granules".

Example 20

Weigh the following traditional Chinese medicine ingredients (unit: g)

Diamond thorn 168 Verbena 168 Andrographis paniculata 100 Angelica 75 Millipede 200

Yanhusuo 100 Prunella vulgaris 168 Gonggong wood 100 Golden cherry root 200 Fragrance Attached 100

Its production process is:

(1) Add 5 times the amount of water to Chinese angelica and incense, soak for 1 hour, extract the volatile oil by steam distillation for 4 hours, collect the oily distillate, separate to obtain volatile oil _B3 ; the distilled aqueous solution _C3 for subsequent use; dregs _D3 hand over Alcohol extraction process.

(2) Add 4 times the amount of 60% ethanol to the medicinal dregs D ₃ for reflux extraction for 2 hours, filter the extract, recover ethanol from the filtrate to obtain the alcohol-extracted fraction E ₃ .

(3) Combine the above alcohol-extracted medicinal residues with Andrographis paniculata, Vajra thorn, Verbena, Caulis Spatholobus, Corydalis Corydalis, Prunella vulgaris, Gonglaomu, and Rosa japonica root, add 4 times the amount of water, soak for 1 hour, and heat and extract twice , 1 hour each time to obtain the water-extracted fraction F ₃ .

(4) Mix and concentrate C ₃ , E ₃ and F ₃ to obtain an intermediate product liquid extract G ₃ with a relative density of 1.05-1.20/55-60°C.

(5) Take the intermediate products B ₃ and G ₃ and mix them with an appropriate amount of syrup or honey, sterilize and fill to obtain a finished product, the product name is "Jinxiang Oral Liquid".

Example 21

Weigh the following traditional Chinese medicine ingredients (unit: g)

Diamond thorn 3.35 Verbena 3.35 Andrographis 2 Angelica 1.5 Millipede 4

Corydalis 2 Prunella vulgaris 3.35 Gonggong wood 2 Golden cherry root 4 Fragrance Attached 2

Its production process is:

(1) Angelica sinensis and Cyperus cyperi, add 4 times the amount of water, soak for 1 hour, extract the volatile oil by steam distillation for 2 hours, collect the oily distillate, separate to obtain volatile oil _B3 ; distilled aqueous solution _C3 for subsequent use; dregs D ₃ Transfer to the alcohol extraction process.

(2) Add 7 times the amount of 60% ethanol to the medicinal dregs D ₃ for reflux extraction for 2 hours, filter the extract, recover ethanol from the filtrate to obtain the alcohol-extracted fraction E ₃ .

(3) Combine the above alcohol-extracted medicinal residues with Andrographis paniculata, Vajra thorn, Verbena, Caulis Spatholobus, Corydalis Corydalis, Prunella vulgaris, Gonglaomu, and Rosa japonica root, add 5 times the amount of water, soak for 1 hour, and heat and extract twice , 2 hours each time to obtain the water-extracted fraction F ₃ .

(4) Mix and concentrate C ₃ , E ₃ and F ₃ to obtain an intermediate product liquid extract G ₃ with a relative density of 1.05-1.20/55-60°C.

(5) Take the intermediate products B ₃ and G ₃ and mix them with an appropriate amount of syrup or honey, sterilize and fill to obtain a finished product, the product name is "Jinxiang Oral Liquid".

Example 22

Weigh the following traditional Chinese medicine ingredients (unit: g)

Vajra thorn 40 Verbena 40 Andrographis 22 Angelica 16 Spatholobus 43

Corydalis 22 Prunella vulgaris 40 Gonggong wood 21 Golden cherry root 44 Fragrance Attached to 23

Its production process is:

(1) Radix Angelicae Sinensis and Rhizoma Cyperi, add 5 times the amount of water, soak for 1 hour, extract the volatile oil by steam distillation for 3 hours, collect the oily distillate, separate to get the volatile oil _B3 ; the distilled aqueous solution _C3 for subsequent use; dregs D ₃ Transfer to the alcohol extraction process.

(2) Medicinal dregs D ₃ and the remaining Andrographis paniculata, Verbena, and Gongluomu plus 5 times the amount of 60% ethanol were refluxed and extracted for 4 hours, the extract was filtered, and the filtrate was recovered with ethanol and concentrated to obtain a thick ointment E ₃ .

(3) Add 6 times the amount of water to the above alcohol-extracted medicinal residues together with King Kong thorn, Spatholobus Spatholobus, Corydalis Corydalis, Prunella vulgaris, and Rosa japonica root, soak for 1 hour, heat and extract twice, each time for 1.5 hours, to obtain water Mention part _F3 .

(4) Mix and concentrate C ₃ , E ₃ and F ₃ to obtain an intermediate product liquid extract G ₃ with a relative density of 1.05-1.20/55-60°C.

(5) Take the intermediate products B ₃ and G ₃ and mix them with an appropriate amount of syrup or honey, sterilize and fill to obtain a finished product, the product name is "Jinxiang Oral Liquid".

Following is the clinical research report of the present invention:

The medicine of the present invention entrusts three provincial and municipal hospitals to carry out clinical verification, and the working steps and experimental results are as follows:

clinical information:

1. General information:

There were 115 cases in the Jinxiang Capsule group (hereinafter referred to as the treatment group) and 69 cases in the Jinji Capsule group (hereinafter referred to as the control group), of which 2 cases were unmarried, all had a history of pregnancy abortion, and the rest were married women. See the attached table for the age and number of cases in each group.

2. Diagnosis, classification and case selection

(1) Symptoms: Pain in the lower abdomen or lower back, accompanied by lower abdominal swelling and lumbosacral pain, often aggravated before and after menstruation, fatigue, after intercourse, and during defecation, accompanied by low-grade fever, abnormal leukorrhea, and irregular menstruation , lumps, and even cause infertility.

(2) Gynecological examination: The uterus is often in a posterior position, with limited mobility or adhesions. In salpingitis, cords can be touched on one or both sides, and there is mild tenderness; Or there is flaky thickening and tenderness on both sides; or a mass is felt on one or both sides of the pelvic cavity.

(3) Syndrome classification: select stasis toxin internal knot syndrome and qi stagnation and blood stasis syndrome as the observation objects.

Syndrome of blood stasis and toxin internal stagnation can be seen in low-grade fever ups and downs, dull pain or swelling in the lower abdomen, lumbosacral pain, aggravated before or during menstruation and after fatigue, irregular menstruation, profuse profuse discharge, thick yellow vaginal discharge, yellow urine and dry stool, tongue quality Red, yellow and greasy fur, slippery and rapid pulse.

Qi stagnation and blood stasis syndrome see less abdominal pain such as acupuncture or long-term dull pain, the pain does not move, or accompanied by low back pain, irregular menstruation, menstrual color purple and black with lumps, increased leucorrhea, dizziness and fatigue, dark purple tongue with ecchymosis, fur White, astringent or deep pulse.

3. Observation method

Block random, experimental control, and double-blind observation were adopted. The treatment group used Jinxiang Capsules, and the control group took Jinji Capsules. The administration method was 4 capsules each time, 3 times a day, with warm water for 4 weeks. The appearance, dosage and packaging of the two groups of medicines are exactly the same, only the number codes on the labels of the medicine bottles are used to show the difference. Before taking the medicine, give the patient a routine physical examination, routine blood test, leucorrhea smear and other tests (those with leucorrhea examination showing mold, trichomonas or gonorrhea infection are not subject to observation), and follow up once a week after taking the medicine. No other anti-inflammatory and antibacterial drugs (including topical drugs) were used during the observation period.

4. Curative effect evaluation standard

(1) Recovery in the near future: symptoms, signs and gynecological examination all returned to normal, and witness scores decreased by more than 91%;

(2) Significant effect: Signs and symptoms and gynecological examination are significantly improved, and witness points are reduced by more than 61%-90%;

(3) Improvement: Symptoms and signs and gynecological examination are all relieved, and witness points are reduced by 31%-60%;

(4) Ineffective: no improvement after treatment, and the witness points decreased by less than 30%.

5. Results

(1) The treatment group and the control group had significant differences in witness points before and after treatment in patients with pelvic inflammatory disease of each syndrome type (P<0.01), indicating that the two drugs had a significant improvement effect on the symptoms and signs of patients with pelvic inflammatory disease of the above syndrome types; the treatment group Compared with the control group, there was no significant difference in curative effect of each syndrome type (P>0.05). In the treatment group of 115 cases, 69 cases of lower abdominal tenderness, increased leucorrhea or yellow odor, thickened attachments and adhesions were significantly relieved or disappeared, with a marked recovery rate of 60.0% and a total effective rate of 92.17%; 69 cases in the control group, with a marked recovery rate of 60.87 %, the total effective rate was 91.30%, and there was no significant difference in curative effect between the two groups (P>0.05).

(2) Comparison of curative effects of the two syndromes in the treatment group: stasis of toxin internal stagnation syndrome was slightly better than Qi stagnation and blood stasis syndrome, but there was no significant significance (R _{stasis mold} < R _{blood stasis} , U = 0.75, P > 0.05).

(3) Results of vaginal secretion examination: 51 cases of WBC were positive (1-3+) in the treatment group before treatment, 19 cases were positive (1-3+) in the control group, and 10 cases and 6 cases turned negative after treatment, respectively. Those who did not turn negative also improved significantly (P<0.01), and there was no significant difference between the two groups (X ² =0.55, P>0.05). Before treatment, 16 cases of pus balls in the treatment group were positive (1 to 2+), and 7 cases in the control group were positive (1 to 2+). ² = 0.03, P > 0.05).

(4) Changes in blood picture: before treatment, blood WBC increased in the treatment group and the control group in 14 cases and 3 cases, respectively, and after treatment, it returned to normal in 13 cases and 2 cases, respectively. There was a significant difference between the two groups (X ² =4.96, P <0.01), the treatment group was better than the control group.

6. Toxic and side effects

Among the 115 cases in the treatment group, 5 cases felt mild discomfort in the chest or upper abdomen after taking the medicine, which may be caused by capsule retention in the esophagus when individual patients took the capsule dosage form; 1 case in the control group also developed symptoms; Cases of mild dryness of the oropharynx. No obvious toxic side effects were found.

7. Conclusion

A total of 115 cases of pelvic inflammatory disease with syndrome of blood stasis and blood stasis were observed and treated with Jinxiang Capsules. The results showed that the drug can significantly improve the symptoms of pelvic inflammatory disease, and has the effects of clearing heat and detoxification, promoting blood circulation and removing blood stasis, promoting qi and relieving pain, and It can make the blood WBC rise caused by the above-mentioned syndrome type pelvic inflammatory disease return to normal, and at the same time, it can obviously improve the abnormal vaginal discharge. The results also show that it is safe, has no obvious toxic and side effects, and has good clinical application value.

8. Typical cases

Example 1 Tang X, 31 years old, married, lives at No. 227 Huaqiang Road, Nanning City. He came to the hospital for treatment on December 14, 1993 due to abdominal pain and lumbosacral pain for more than a month. The uterine body and adnexa were tender and tender, the leucorrhea was moderately yellow in color, leucorrhea smear WBC+++, blood WBC9.6×10 ⁹ /L, N76 %, pale red tongue, thin yellow fur, thready pulse, total witness score of 6 points, diagnosed as chronic pelvic inflammatory disease stasis toxin syndrome, taking Jinxiang Capsules 4 capsules each time, 3 times a day, after 3 weeks The above symptoms were obviously relieved, and all of them disappeared after 4 weeks. Leucorrhea WBC±, blood WBC6.0×10 ⁹ /L, N65%, no tenderness in the uterine body and appendages, and the curative effect was judged as recovery in the near future.

Case 2 Tian, 37 years old, lived in the Guangxi Water and Electricity Department, pregnant with 4 births, went to the doctor on October 12, 1993, and complained of unbearable pain in the lower abdomen, accompanied by lumbosacral pain, chills and cold limbs, leukorrhagia increased for nearly half a year, syndrome differentiation It is pelvic inflammatory disease of qi stagnation and blood stasis syndrome, the posterior position of the uterus is often poorly moved, tenderness +++, the tissue on the right side of the uterus is slightly thickened, tenderness +++, after taking Jinxiang Capsules for 4 weeks, all symptoms disappeared, gynecological The basin detector was normal and recovered recently.

Attached table: Analysis of clinical efficacy of Jinxiang Capsules Syndromes group Number of cases before and after integral difference curative effect Comparison of curative effect between groups A and B X±SD t-value recently recovered markedly effective get better invalid Efficient internal stasis A 70 4.20±2.233.89± 15.76 ^* 10 33 twenty one 6 91.43% R _B > R _A U = 0.35P > 0.05 B 37 1.70 13.93 ^* 4 17 14 2 94.59% Qi stagnation and blood stasis A 45 4.69±2.34 13.44 ^* 2 twenty four 16 3 93.33% R _B > R _A U = 0.46P > 0.05 B 32 4.63±2.08 12.58 ^* 2 19 7 4 87.50%

Note: *-P<0.01, A--treatment group, B--control group.

summary

The above clinical data revealed:

1. The medicine of the present invention has the effects of clearing heat and detoxifying, promoting blood circulation and removing blood stasis, promoting qi circulation and relieving pain, and has therapeutic effect on patients with pelvic inflammatory disease with stagnation of toxin and internal stagnation of qi and blood stasis.

2. The medicine of the present invention treats 115 patients with gynecological inflammation, the total effective rate is 92.17%, and the curative effect is slightly better than 91.30% of Jinji Capsule, thereby reaching the ultimate goal of the present invention.

3. This product is safe and reliable, and no obvious adverse reactions and side effects were found in 115 cases during the observation period.

Claims (10)

1. A medicine for treating gynecological inflammation, characterized in that the components and weight percentages of its main active raw materials are as follows: Diamond thorn 7.2~17.2; Verbena 7.2~17.2; Andrographis 2.3~12.3; Angelica 0.5~10.4; Corydalis 2.3~12.3; Prunella vulgaris 7.2~17.2; Gonggongmu 2.3~12.3; Rosa chinensis 7.2~17.2; Cyperus cyperus 2.3~12.3. 2. A medicine for treating gynecological inflammation as claimed in claim 1, characterized in that: the ingredients and quality of the traditional Chinese medicine composition are as follows: Diamond thorn 3.35 Verbena 3.35 Andrographis 2 Angelica 1.5 Millipede 4 Corydalis 2 Prunella vulgaris 3.35 Gonggong wood 2 Golden cherry root 4 Fragrance Attached 2 3. A method for producing a medicine for treating gynecological inflammation according to claims 1 to 2, characterized in that capsules are produced according to the following method: (1) Take 7/25 of the total amount of Andrographis paniculata, pulverize it into fine powder with superfine pulverization technology, and sterilize it with high-pressure steam at 100°C-120°C for 30-60 minutes to obtain intermediate product A; (2) Angelica and Rhizoma Cyperi, add 3 to 8 times the amount of water, extract the volatile oil with steam distillation for 2 to 4 hours, collect the oily distillate (medicine residue and alcohol extraction process), separate, take the volatile oil, and use β-cyclopaste Fine clathrate, after drying, weigh to obtain the intermediate product B; the distilled aqueous solution C for future use; dregs D is handed over to the alcohol extraction process. (3) Add 3 to 8 times the amount of 45% to 75% ethanol to the dregs D and extract under reflux for 2 to 4 hours, filter the extract, recover the ethanol from the filtrate and concentrate to obtain thick ointment E. (4) Add 3 to 8 times the amount of water to the above alcohol-extracted medicinal residues and the remaining Andrographis paniculata and Vajra thorn, Verbena, Millae Spatholobus, Corydalis Corydalis, Prunella vulgaris, Gonglaomu, and Rosa japonica root, and heat and extract twice , 1 to 3 hours each time to obtain the water extraction part F. (5) Mix C, E and F, add intermediate product A, dry, and pulverize into fine powder to obtain intermediate product dry cream powder G. (6) Take the dry cream powder G of the intermediate product, granulate, dry, add the intermediate product B and mix with appropriate amount of auxiliary materials, pack into capsules, pack in aluminum and plastic, and pack separately to obtain the finished capsule, the product name is "Jinxiang Capsule". Or produce as follows: (1) Take 7/25 of the total amount of Andrographis paniculata, pulverize it into fine powder with superfine pulverization technology, and sterilize it with high-pressure steam at 100°C-120°C for 30-60 minutes to obtain intermediate product A; (2) Angelica and Rhizoma Cyperi, add 3 to 8 times the amount of water, extract the volatile oil with steam distillation for 2 to 4 hours, collect the oily distillate (medicine residue and alcohol extraction process), separate, take the volatile oil, and use β-cyclopaste Fine clathrate, after drying, weigh to obtain the intermediate product B; the distilled aqueous solution C for future use; dregs D is handed over to the alcohol extraction process. (3) Add 3-8 times the amount of 45-75% ethanol to reflux extraction for 2-4 hours with the dregs D, andrographis paniculata, gonglaoji, and verbena, then filter the extract, recover the ethanol and concentrate the filtrate to obtain thick ointment E. The slag F is handed over to the water extraction process. (4) Add 3 to 8 times the amount of water together with King Kong thorn, Spatholobus Spatholobus, Corydalis Corydalis, Prunella vulgaris, and Rosaceae root, then add the above-mentioned medicinal residue F after alcohol extraction, heat and extract twice, 1 to 3 hours each time , to obtain the water extraction part G. (5) Mix C, E and G, add intermediate product A, dry, and pulverize into fine powder to obtain intermediate product dry cream powder H. (6) Take the intermediate product dry cream powder H to granulate, dry, add the intermediate product B and appropriate amount of auxiliary materials, mix evenly, pack into capsules, pack in aluminum and plastic, and pack separately to obtain the finished capsule, the product name is "Jinxiang Capsule". 4. A method for producing a medicine for treating gynecological inflammation as claimed in claims 1 to 2, characterized in that soft capsules are produced according to the following method: (1) Add 3 to 8 times the amount of water to Chinese angelica and incense, extract the volatile oil by steam distillation for 2 to 4 hours, collect the oily distillate (drug residue alcohol extraction process), separate, take the volatile oil, and wrap it with β-cyclodextrin Combined, dried, and weighed to obtain an intermediate product A; the distilled aqueous solution B is ready for use; the dregs C is handed over to the alcohol extraction process. (2) Add 3-8 times the amount of 45-75% ethanol to reflux extraction for 2-4 hours together with Andrographis paniculata, Gonglaojia, and Verbena. Slag E is handed over to the water extraction process. (3) Add 3 to 8 times the amount of water together with King Kong thorn, Spatholobus Spatholobus, Corydalis Corydalis, Prunella vulgaris, and Rosaceae root, then add the above-mentioned medicinal residue E after alcohol extraction, and heat and extract twice, 1 to 3 hours each time , to obtain the water extraction part F. (4) B, D and F are mixed and concentrated, dried and pulverized into fine powder to obtain the intermediate product dry cream powder G. (5) Take the intermediate product dry extract powder G and A, vegetable oil, and beeswax to make a suspension H at a ratio of 1:1:0.02, prepare a rubber with a ratio of gelatin:glycerin:water of 1:0.35:0.9, and then mix the mixture Suspension H is filled and pressed into soft capsules, set at a temperature below 25°C, wash off the oil layer on the surface of the soft capsules with ethanol, dry at a temperature below 25°C, and take it out. The product name is "Jinxiang Soft Capsules". 5. A method for producing a medicine for treating gynecological inflammation as claimed in claims 1 to 2, characterized in that the slow-release capsules are produced according to the following method: (1) Add 3 to 8 times the amount of water to Chinese angelica and incense, extract the volatile oil by steam distillation for 2 to 4 hours, collect the oily distillate (drug residue alcohol extraction process), separate, take the volatile oil, and wrap it with β-cyclodextrin Combined, dried, and weighed to obtain an intermediate product A; the distilled aqueous solution B is ready for use; the dregs C is handed over to the alcohol extraction process. (2) Add 3-8 times the amount of 45-75% ethanol to reflux extraction for 2-4 hours together with Andrographis paniculata, Gonglaojia, and Verbena. Slag E is handed over to the water extraction process. (3) Add 3 to 8 times the amount of water together with King Kong thorn, Spatholobus Spatholobus, Corydalis Corydalis, Prunella vulgaris, and Rosaceae root, then add the above-mentioned medicinal residue E after alcohol extraction, and heat and extract twice, 1 to 3 hours each time , to obtain the water extraction part F. (4) B, D and F are mixed and concentrated, dried and pulverized into fine powder to obtain the intermediate product dry cream powder G. (5) According to the total amount of the dry extract powder G and A of the intermediate product, add 0.5% to 5% of spermaceti or other blocker coating, and make slow-release pellets for 2, 4, 6, and 8 hours respectively. The small pills are distinguished by different colors, mixed evenly, put into empty capsules, packed into boxes or hot-pressed into aluminum-plastic plates, and the finished product is obtained. The product name is "Jinxiang sustained-release capsule" or "Slow-release Jinxiang capsule". 6, a kind of production method of the medicine for treating gynecological inflammation as claimed in claim 1～2, it is characterized in that drop pill is produced according to the following method: (1) Add 3 to 8 times the amount of water to Chinese angelica and incense, extract the volatile oil by steam distillation for 24 hours, collect the oil-containing distillate (drug residue alcohol extraction process), separate, take the volatile oil, and clathrate it with β-cyclodextrin, After drying, weigh to obtain the intermediate product A; the distilled aqueous solution B for future use; and the dregs C to be handed over to the alcohol extraction process. (2) Add 3-8 times the amount of 45-75% ethanol to reflux extraction for 2-4 hours together with Andrographis paniculata, Gonglaojia, and Verbena. Slag E is handed over to the water extraction process. (3) Add 3 to 8 times the amount of water together with King Kong thorn, Spatholobus Spatholobus, Corydalis Corydalis, Prunella vulgaris, and Rosaceae root, then add the above-mentioned medicinal residue E after alcohol extraction, and heat and extract twice, 1 to 3 hours each time , to obtain the water extraction part F. (4) B, D and F are mixed and concentrated, dried and pulverized into fine powder to obtain the intermediate product dry cream powder G. (5) Heat and melt polyethylene glycol 6000, then add the intermediate products A and G, stir well, transfer to the dropping pill device, keep it sealed at 86°C, and use 10°C~15°C liquid paraffin or other liquids as coolants , dripping at a speed of 50 drops/minute, to obtain the product name "Jinxiang Dropping Pills". 7. A production method of the medicine for treating gynecological inflammation according to claims 1-2, characterized in that the tablet is produced according to the following method: (1) Take 7/25 of the total amount of Andrographis paniculata, pulverize it into fine powder, and sterilize it with high-pressure steam at 100°C-120°C for 30-60 minutes to obtain intermediate product A; (2) Add 3 to 8 times the amount of water to angelica and cypress, extract the volatile oil by steam distillation for 2 to 4 hours, collect the oily distillate (drug residue alcohol extraction process), separate, take the volatile oil, and wrap it with β-cyclodextrin Combined, dried, and weighed to obtain an intermediate product B; the distilled aqueous solution C is set aside; the dregs D is handed over to the alcohol extraction process. (3) Add 3 to 8 times the amount of 45 to 75% ethanol to the dregs D and extract under reflux for 2 to 4 hours, filter the extract, recover the ethanol from the filtrate and concentrate to obtain thick ointment E. (4) Add 3 to 8 times the amount of water to the above alcohol-extracted medicinal residues and the remaining Andrographis paniculata and Vajra thorn, Verbena, Millae Spatholobus, Corydalis Corydalis, Prunella vulgaris, Gonglaomu, and Rosa japonica root, and heat and extract twice , 1 to 3 hours each time to obtain the water extraction part F. (5) Mix C, E and F, add intermediate product A, dry, and pulverize into fine powder to obtain intermediate product dry cream powder G. (6) Take the intermediate product dry cream powder G, granulate, dry, add B and mix with appropriate amount of auxiliary materials, compress into tablets, coat with sugar or film, pack, and obtain finished tablets, the product name is "Jinxiang Tablets". 8. A production method of the medicine for treating gynecological inflammation according to claims 1-2, characterized in that the granules are produced according to the following method: (1) Add 3 to 8 times the amount of water to Chinese angelica and incense, extract the volatile oil by steam distillation for 2 to 4 hours, collect the oily distillate (drug residue alcohol extraction process), separate, take the volatile oil, and wrap it with β-cyclodextrin Combined, dried, and weighed to obtain an intermediate product A; the distilled aqueous solution B is ready for use; the dregs C is handed over to the alcohol extraction process. (2) Add 3-8 times the amount of 45-75% ethanol to reflux extraction for 2-4 hours together with Andrographis paniculata, Gonglaojia, and Verbena. Slag E. (3) Add 3 to 8 times the amount of water together with King Kong thorn, Spatholobus Spatholobus, Corydalis Corydalis, Prunella vulgaris, and Rosaceae root, then add the above-mentioned medicinal residue E after alcohol extraction, and heat and extract twice, 1 to 3 hours each time , to obtain the water extraction part F. (4) B, D and F are mixed and concentrated, dried and pulverized into fine powder to obtain the intermediate product dry cream powder G. (5) Take the intermediate product dry paste powder G and mix with appropriate amount of auxiliary materials, granulate, dry, mix with A, and pack separately to obtain the finished granules, the product name is "Jinxiang Granules". 9. A production method of the medicine for treating gynecological inflammation according to claims 1-2, characterized in that the oral liquid is produced according to the following method: (1) Angelica and Rhizoma Cyperi, add 3 to 8 times the amount of water, extract the volatile oil by steam distillation for 2 to 4 hours, collect the oily distillate, separate to obtain the volatile oil B ₃ ; the distilled aqueous solution C ₃ for later use; dregs D ₃ Transfer to the alcohol extraction process. (2) Add 3 to 8 times the amount of 45 to 75% ethanol to the medicinal dregs D ₃ for reflux extraction for 2 to 4 hours, filter the extract, recover the ethanol from the filtrate to obtain the alcohol extraction fraction E ₃ . (3) Add 3 to 8 times the amount of water to the above-mentioned medicinal residue after alcohol extraction, Andrographis paniculata, Vajra thorn, Verbena, Caulis Spatholobus, Corydalis Corydalis, Prunella vulgaris, Gonglaomu, and Rosa Radix, and heat and extract twice, each After 1-3 hours, the water-extracted fraction F ₃ is obtained. (4) Mix and concentrate C ₃ , E ₃ and F ₃ to obtain an intermediate product liquid extract G ₃ with a relative density of 1.05-1.20/55-60°C. (5) Take the intermediate products B ₃ and G ₃ and mix them with an appropriate amount of syrup or honey, sterilize and fill to obtain the finished oral liquid, the product name is "Jinxiang Oral Liquid". 10. The medicine for treating gynecological inflammation according to claims 1-2, its dosage forms also include pills, ointments and other dosage forms mentioned in pharmacy, prepared according to pharmacopoeia or traditional Chinese medicine pharmacy.