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CN1313769A - 含有COX－2抑制剂和iNOS抑制剂的药物组合 - Google Patents

含有COX－2抑制剂和iNOS抑制剂的药物组合 Download PDF

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Publication number
CN1313769A
CN1313769A CN99810007A CN99810007A CN1313769A CN 1313769 A CN1313769 A CN 1313769A CN 99810007 A CN99810007 A CN 99810007A CN 99810007 A CN99810007 A CN 99810007A CN 1313769 A CN1313769 A CN 1313769A
Authority
CN
China
Prior art keywords
piperidine
quinazoline
amine
spiro
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN99810007A
Other languages
English (en)
Chinese (zh)
Inventor
P·哈姆利
A·廷克尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of CN1313769A publication Critical patent/CN1313769A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN99810007A 1998-06-29 1999-06-23 含有COX－2抑制剂和iNOS抑制剂的药物组合 Pending CN1313769A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9802333-6 1998-06-29
SE9802333A SE9802333D0 (sv) 1998-06-29 1998-06-29 Novel combination

Publications (1)

Publication Number Publication Date
CN1313769A true CN1313769A (zh) 2001-09-19

Family

ID=20411898

Family Applications (1)

Application Number Title Priority Date Filing Date
CN99810007A Pending CN1313769A (zh) 1998-06-29 1999-06-23 含有COX－2抑制剂和iNOS抑制剂的药物组合

Country Status (22)

Country Link
US (1) US6248745B1 (is)
EP (1) EP1100505A1 (is)
JP (1) JP2002519324A (is)
KR (1) KR20010053252A (is)
CN (1) CN1313769A (is)
AU (1) AU4944799A (is)
BR (1) BR9911666A (is)
CA (1) CA2334515A1 (is)
CZ (1) CZ20004896A3 (is)
EE (1) EE200000766A (is)
ID (1) ID27394A (is)
IL (1) IL140022A0 (is)
IN (1) IN2000MU00721A (is)
IS (1) IS5794A (is)
MX (1) MXPA00012162A (is)
NO (1) NO20006559L (is)
PL (1) PL345028A1 (is)
SE (1) SE9802333D0 (is)
SK (1) SK18482000A3 (is)
TR (1) TR200003808T2 (is)
WO (1) WO2000000200A1 (is)
ZA (1) ZA200007076B (is)

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Also Published As

Publication number Publication date
IL140022A0 (en) 2002-02-10
NO20006559L (no) 2001-02-28
CZ20004896A3 (en) 2001-06-13
KR20010053252A (ko) 2001-06-25
JP2002519324A (ja) 2002-07-02
BR9911666A (pt) 2001-03-20
WO2000000200A1 (en) 2000-01-06
MXPA00012162A (es) 2001-05-01
EE200000766A (et) 2002-06-17
US6248745B1 (en) 2001-06-19
SK18482000A3 (sk) 2001-07-10
ZA200007076B (en) 2002-02-28
PL345028A1 (en) 2001-11-19
IN2000MU00721A (is) 2005-03-18
ID27394A (id) 2001-04-05
SE9802333D0 (sv) 1998-06-29
AU4944799A (en) 2000-01-17
IS5794A (is) 2000-12-27
NO20006559D0 (no) 2000-12-21
EP1100505A1 (en) 2001-05-23
TR200003808T2 (tr) 2001-06-21
CA2334515A1 (en) 2000-01-06

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