CN1371274A - Cosmetic composition - Google Patents

Abstract

According to the present invention there is provided a cosmetic composition comprising: (a) at least one quaternary ammonium agent; and (b) at least one sunscreen active. The compositions of the present invention give sun protection benefits with low tackiness or stickiness. Moreover, the compositions of the present invention can give good skin care benefits with low levels of negatives such as greasiness, stickiness or tack.

Description

cosmetic composition

Technical field

The present invention relates to a cosmetic composition. In particular, the present invention relates to a cosmetic composition that provides good moisturization, hydration, skin feel, skin softness and/or skin smoothness benefits and protects the skin from UV rays.

Background technique

The skin is made up of several layers of cells that cover and protect the keratin and collagen fibers that form the backbone of the skin structure. The outermost of these cell layers, called the stratum corneum, is known to consist of 25nm protein bundles surrounded by an 8nm thick cell layer. Anionic surfactants and organic solvents generally penetrate the stratum corneum membrane and disrupt the integrity of the skin by degreasing (ie, removing lipids from the stratum corneum). This disruption of the topographical structure of the skin surface results in roughness, which eventually leads to the interaction of surfactants or solvents with keratin, causing irritation. Many people's skin suffers from this damage every day. In addition, the skin can be damaged by environmental factors such as exposure to cold air or wind, mechanical friction, immersion in water, etc. However, the most common forms of environmentally induced skin damage are associated with exposure to ultraviolet radiation, especially that emitted by the sun. Therefore, need a kind of method that alleviates or improves this injury.

In the prior art, compositions have been formulated which claim to help the stratum corneum maintain its barrier and water-retaining functions in optimum condition, despite the detrimental effects the skin may encounter during cleansing, work and play. Desirable properties of such compositions are that they have good skin feel, water retention, moisturizing, absorbency and/or rub-in characteristics. Compositions of the prior art attempt to achieve these properties through the use of one or more "skin care benefit ingredients". For example, one method of imparting high moisturization to the skin is to include in the composition a polyol humectant material such as glycerin. However, skin care compositions that are high in polyols and are therefore highly moisturizing can be perceived by consumers as sticky or sticky when applied to the skin. Another means of imparting desired skin benefits to the skin is to incorporate emollients such as polyol carboxylates into skin care compositions. However, such compositions can be detrimental in terms of skin feel (ie they feel very greasy on the skin) and have poor rubbing, absorbency and residual properties.

It has also now been discovered that there is a direct relationship between the amount of skin care benefit ingredient used and the efficacy of the composition to provide the benefit to the skin. In fact, however, the higher the content of skin beneficial ingredients, the higher the risk of adverse effects associated with them. Thus, until now, there has been a need to balance the benefits of compositions comprising high levels of skin benefit ingredients with the adverse effects associated with such high levels. Therefore, there is a need to contain high levels of skin benefit ingredients and thus provide high moisturization and hydration as well as provide outstanding skin feel, skin softness and skin smoothness benefits, but exhibit low levels of associated adverse effects such as greasiness, stickiness or sticky compositions.

Quaternary ammonium ingredients are known for use in cosmetic compositions. See eg WO-A-99/27904, WO-A-96/32089 and EP-A-789,076. Skin care compositions are also disclosed in US-A-5,804,205 which claim to provide a high level of moisturisation without leaving a "sticky" or "sticky" residue. The composition contains a quaternary ammonium compound with two alkyl groups of 16-22 carbon atoms, a moisturizing agent and non-irritating hydrophobic microspheres with an average particle diameter of less than 50 μm. The hydrophobic polymeric microspheres are said to significantly reduce the "stickiness" associated with high humectant levels. The compositions of US-A-5,804,205 may also contain low levels of emollients such as petrolatum or mineral oil.

Substances which bring about protection against sun damage are also known for use in cosmetic compositions. See, for example, EP-A-992455, EP-A-953336, WO-A-97/29735 and US-A-5989529, all of which disclose sunscreen compositions. However, prior art compositions can often feel sticky when applied and make it difficult to spread the sunscreen active.

It has now surprisingly been found that compositions comprising at least one quaternary ammonium ingredient and a sunscreen active provide smooth, even application of the sunscreen active and have low adverse effects associated therewith. Furthermore, the compositions of the present invention can contain high levels of skin benefit ingredients to provide good benefits such as skin feel, skin softness and skin smoothness, but exhibit low levels of adverse effects such as greasy, sticky or sticky.

While not wishing to be bound by any theory, it is believed that the quaternary ammonium ingredients of the present invention are able to vesicle the sunscreen actives and facilitate their deposition on the skin, thereby ensuring that they are more evenly applied to the skin without the usual Stickiness/stickiness associated with this composition. In addition, it is also believed that the quaternary ammonium ingredients of the present invention are capable of vesicularizing any humectants and promoting their deposition on the skin. The result is an even, smooth application of the moisturizer to the skin with minimal stickiness/stickiness. Furthermore, it is believed that the quaternary ammonium ingredients of the present invention are capable of emulsifying the emollient to ensure more even application of the emollient to the skin with minimal greasiness/stickiness/stickiness. Quaternary ammonium ingredients help reduce the loss of sunscreen and/or moisturizers/emollients from the skin due to environmental factors such as water or friction. Furthermore, it is believed that the quaternary ammonium ingredients themselves confer skin care benefits such as good moisturization, good skin feel, good skin softness.

Summary of Invention

The invention provides a cosmetic composition comprising:

(a) at least one quaternary ammonium ingredient; and

(b) at least one sunscreen active.

The compositions of the present invention provide sun protection benefits with low stickiness or stickiness. Furthermore, the compositions of the present invention are capable of delivering good skin care benefits with low levels of adverse effects such as greasy, sticky or sticky feel.

Detailed description of the invention

The compositions of the present invention comprise at least one quaternary ammonium ingredient and at least one sunscreen active. These ingredients will be described in detail below.

The compositions of the invention can be used for any suitable purpose. In particular, the compositions of the invention are suitable for topical application to the skin. Specifically, the skin care compositions may be in the form of creams, lotions, gels, and the like. Preferably, the cosmetic composition of the present invention is in the form of an oil-in-water emulsion comprising one or more oily phases in a continuous aqueous phase, each oily phase containing a single oily component or oily components in miscible or homogeneous form mixtures, but the different oil phases contain different substances or mixtures of substances from each other.

The compositions of the invention preferably comprise vesicles. Preferably, the vesicles comprise a quaternary ammonium compound and a sunscreen active.

Preferably, the compositions of the present invention contain less than 10% by weight, preferably less than 5% by weight, more preferably less than 3% by weight, more preferably 0% by weight of anionic surfactant.

The compositions of the present invention are preferably formulated to have a viscosity of at least about 1,000 mPa.s, preferably from about 1,000 to about 300,000 mPa.s, more preferably from about 2,500 to about 250,000 mPa.s, especially from about 5,000 to about 200,000 mPa.s (26.8°C, net phase, product of Brookfield DV-II+spindle CP52/CP41). Quaternary Ammonium Ingredients

The compositions of the present invention must contain at least one quaternary ammonium ingredient. Various quaternary ammonium ingredients suitable for use in cosmetic compositions are suitable for use herein. As used herein, the term "quaternary ammonium component" means a compound or mixture of compounds containing a quaternary nitrogen atom which is substituted with one or more, preferably two, moieties containing 6 or more carbon atoms. Preferred quaternary ammonium components for use in the present invention are selected from those wherein the quaternary nitrogen is substituted with two moieties each containing 10 or more, preferably 12 or more, carbon atoms. Highly preferred quaternary ammonium components for use herein are those that form vesicles in polar solvents, which can be detected by microscopic analysis (polarized light microscopy using a Nikon Eclipse E800 microscope at a 60X magnification factor). The term "vesicle" as used herein refers to one or more bilayers arranged in a closed, generally spherical geometry, said bilayers comprising the quaternary ammonium component described below.

Preferably the compositions of the present invention contain at least 0.01% by weight, more preferably at least 0.1% by weight, still more preferably at least 1% by weight, even more preferably at least 3% by weight of quaternary ammonium ingredients.

Preferred quaternary ammonium ingredients for use in the present invention are selected from:

(a) quaternary ammonium compound shown in general formula (I):

wherein R ₁ and R ₂ are independently C ₁ -C ₄ alkyl or C ₁ -C ₄ hydroxyalkyl or a hydrogen atom. _R3 and _R4 are independently an alkyl or alkenyl group containing from about 8 to about 22 carbon atoms. X ^- is a salt-forming anion compatible with quaternary ammonium compounds and other adjuvant ingredients.

Preferred quaternary ammonium compounds of _this type are quaternary ammonium compounds of general formula (I), wherein R and _R are methyl or hydroxyethyl, and R _{and R} are Straight-chain or branched chain alkyl or alkenyl of carbon atoms.

(b) quaternary ammonium compounds shown in general formula (II) or (III):

和

wherein each R unit is independently selected from H, branched or linear C ₁ -C ₆ alkyl, branched _or linear C ₁ -C ₆ hydroxyalkyl and mixtures thereof, preferably methyl and hydroxy Ethyl; each R ₆ unit is independently a linear or branched C ₁₁ -C ₂₂ alkyl, a linear or branched C ₁₁ -C ₂₂ alkenyl, and mixtures thereof; X ^- is a skin care active Anion compatible with ingredients and adjuvant ingredients; m is 1-4, preferably 2; n is 1-4, preferably 2, and Q is a carbonyl unit selected from:

and

Wherein R ₇ is H, C ₁ -C ₄ alkyl, C ₁ -C ₄ hydroxyalkyl and mixtures thereof.

In the above examples of quaternary ammonium compounds, the unit -QR ₆ contains a fatty acyl unit typically derived from a triglyceride source. The source of triglycerides is preferably derived from tallow, partially hydrogenated tallow, lard, partially hydrogenated lard, vegetable oils and/or partially hydrogenated vegetable oils, such as canola oil, safflower oil, peanut oil, rapeseed oil, Sunflower oil, corn oil, soybean oil, tall oil, rice bran oil, etc., and mixtures of these oils.

The counter ion ^X in the above compound can be any compatible anion, preferably an anion of a strong acid, such as chloride, bromide, methylsulfate, ethylsulfate, sulfate, nitrate, etc., more preferably chlorine ion or methylsulfate. The anion can also, but not preferably, be double charged, in which case ^X- represents a half group.

The preferred quaternary ammonium compound of the present invention is diester and/or diamide quaternary ammonium compound (DEQA) as shown in general formula (II), diester and diamide, wherein carbonyl Q is selected from: and

Tallow, canola oil, and palm oil are convenient and economical sources of fatty acyl units suitable for use as _R units in the present invention.

The counterion X ^- can be chloride, bromide, methylsulfate, formate, sulfate, nitrate, and mixtures thereof. In practice the anion X is only present as a counterion to the positively charged quaternary ammonium compound. Limitation to specific anions is not considered within the scope of the present invention.

Where diesters are specified in the present invention, the normally present mono- and triesters brought about during the preparation are to be included.

(c) quaternary ammonium compounds shown in general formula (IV) or (V):

Wherein R ₉ is a C ₁₅ -C ₂₁ acyclic aliphatic hydrocarbon group, and R ₁₀ is a C ₁ -C ₆ alkyl or alkenyl group.

Such ammonium compounds have a pKa value of no more than about 4 and can impart a cationic charge upon dispersion in an aqueous solution, provided that the pH of the final composition does not exceed about 6.

(d) quaternary ammonium compounds shown in general formula (VI) or (VII):

wherein R ₉ and R ₁₀ are as defined above, and R ₁₁ is selected from C ₁ -C ₄ alkyl and hydroxyalkyl.

The counterion X ^- can be chloride, bromide, methylsulfate, formate, sulfate, nitrate, and mixtures thereof. In practice the anion X is only present as a counterion to the positively charged quaternary ammonium compound. It is not considered within the scope of the present invention to be limited to a particular anion.

(e) quaternary ammonium compounds shown in general formula (VIII) or (IX):

Wherein, n is 1-6, R ₉ is selected from C ₁₅ -C ₂₁ acyclic aliphatic hydrocarbon groups, and R ₁₂ is C ₁ -C ₄ alkyl and hydroxyalkyl.

Such ammonium compounds (VIII) have a pKa value not exceeding about 4 and can generate cationic charges in situ when dispersed in an aqueous solution, provided that the pH of the final composition does not exceed about 6.

The counterion X ⁻ (IX) can be chloride, bromide, methylsulfate, formate, sulfate, nitrate, and mixtures thereof. In practice the anion X is only present as a counterion to the positively charged quaternary ammonium compound. It is not intended that the scope of the present invention be limited to a particular anion.

(f) diquaternary ammonium compound shown in general formula (X), (XI), (XII) or (XIII):

wherein R ₅ , R ₆ , Q, n and X ^- are as defined in the above general formulas (II) and (III), R ₁₃ is selected from C ₁ -C ₆ alkylene, preferably ethylene, and z 0-4.

(g) Mixtures of the above quaternary ammonium compounds.

Preferred quaternary ammonium ingredients for use in the present invention are those described in section (b) above. Specifically, diester and/or diamide quaternary ammonium (DEQA) compounds represented by the above general formula (II) are preferred. Preferred diesters for use in the present invention are those represented by the general formula (II) in which R ₅ , R ₆ , and X ^- are as previously described, and Q is those represented by the following formula:

Preferred diamides for use in the present invention are those represented by the general formula (II) in which R ₅ , R ₆ and X ^- are as previously described, and Q is those represented by the following formula:

Examples of preferred quaternary ammonium compounds suitable for use in the compositions of the present invention are: N,N-bis(lowerucanoyl-oxy-ethyl)-N,N-dimethylammonium chloride, N,N-di (Canolanoyl-oxy-ethyl)-N-methyl, N-(2-hydroxyethyl)ammonium methylsulfate, N,N-di(canolanoyl-oxy-ethyl)- N-methyl, N-(2-hydroxyethyl)ammonium chloride and mixtures thereof. Particularly preferred for use in the present invention is N,N-bis(lowerucanoyl-oxy-ethyl)-N-methyl,N-(2-hydroxyethyl)ammonium methylsulfate.

While it is preferred that the quaternary ammonium compound be derived from a "canolyl" fatty acyl group, other examples of suitable quaternary ammonium compounds may be derived from other compounds wherein "canolyl" in the above examples may be substituted by Fatty acyl: "tallowoyl, cocoyl, palmityl, lauroyl, oleoyl, ricinoleoyl, stearoyl, palmityl" substitutions, which correspond to the glycerol from which these fatty acyl units are derived sources of triesters. These alternative fatty acyl sources may contain fully saturated, or preferably at least partially unsaturated chains. sunscreen

A second essential ingredient of the compositions of the present invention is that they contain at least one sunscreen active. These sunscreen actives include organic compounds and their salts as well as inorganic particulate materials. While not wishing to be bound by theory, it is believed that sunscreens protect the skin from ultraviolet radiation by one or more of the following mechanisms, including absorbing, scattering and reflecting ultraviolet light. Non-limiting examples of these sunscreens are disclosed in: US Patent 5,087,445 (Haffey et al., issued February 11, 1992); US Patent 5,073,372 (Turner et al., issued December 17, 1991); US Patent 5,073,371 (Turner et al. et al., authorized on December 17, 1991); U.S. Patent 5,160,731 (Sabatelli et al., authorized on November 3, 1992); U.S. Patent 5,138,089 (Sabatelli, authorized on August 11, 1992); August 20, 1991); U.S. Patent 4,999,186 (Sabatelli et al., March 12, 1991); U.S. Patent 4,937,370 (Sabatelli, June 26, 1990); and Segarin et al. Technology" (Cosmetics Science and Technology, Chapter VIII, page 189 below). Preferred sunscreens are selected from the group consisting of: 2-ethylhexyl p-methoxycinnamate, octyl salicylate, octocrylene, hydroxymethoxybenzophenone, N,N-dimethylaminobenzene 2-ethylhexyl formate, p-aminobenzoic acid, 2-phenyl-benzimidazole-5-sulfonic acid, homomenthyl salicylate, diethanolamine p-methoxycinnamate, 4,4'-methoxy Base-tert-butyldibenzoylmethane, 4-isopropyldibenzoylmethane, 3-(4-methylbenzylidene)camphor, 3-benzylidenecamphor, 4-N,N-dimethyl Ester of aminobenzoic acid and 2,4-dihydroxybenzophenone, ester of 4-N,N-dimethylaminobenzoic acid and 2-hydroxy-4-(2-hydroxyethoxy)benzophenone, 4- Ester of N,N-dimethylaminobenzoic acid and 4-hydroxydibenzoylmethane, ester of 4-N,N-dimethylaminobenzoic acid and 4-(2-hydroxyethoxy)dibenzoylmethane , 4-N, N-bis(2-ethylhexyl)-aminobenzoic acid and 2,4-dihydroxybenzophenone ester, 4-N,N-bis(2-ethylhexyl)aminobenzoic acid and Esters of 2-hydroxy-4-(2-hydroxyethoxy)benzophenone, esters of 4-N,N-bis(2-ethylhexyl)aminobenzoic acid and 4-hydroxydibenzoylmethane, 4 -Ester of N,N-di(2-ethylhexyl)aminobenzoic acid and 4-(2-hydroxyethoxy)dibenzoylmethane, 4-N,N-(2-ethylhexyl)methyl Ester of aminobenzoic acid and 2,4-dihydroxybenzophenone, 4-N,N-(2-ethylhexyl)methylaminobenzoic acid and 2-hydroxy-4-(2-hydroxyethoxy)di Esters of benzophenone, esters of 4-N,N-(2-ethylhexyl)methylaminobenzoic acid and 4-hydroxydibenzoylmethane, 4-N,N-(2-ethylhexyl)methyl Esters of aminobenzoic acid and 4-(2-hydroxyethoxy)dibenzoylmethane, titanium dioxide, zinc oxide, iron oxide and mixtures thereof.

More preferred sunscreens for use in the compositions of the present invention are selected from the group consisting of: N,N-dimethyl-p-aminobenzoic acid 2-ethylhexyl, p-methoxycinnamic acid 2-ethylhexyl, cyandiphenyl Octyl Acrylate, Octyl Salicylate, High Menthyl Salicylate, p-Aminobenzoic Acid, Hydroxymethoxybenzophenone, 2-Phenylbenzimidazole-5-sulfonic Acid, p-Methoxycinnamic Acid Di Ethanolamine, 4,4'-methoxy-tert-butyldibenzoylmethane, 4-isopropyldibenzoylmethane, 3-(4-methylbenzylidene)camphor, 3-benzylidenecamphor , esters of 4-N,N-(2-ethylhexyl)methylaminobenzoic acid and 4-(2-hydroxyethoxy)dibenzoylmethane, titanium dioxide, zinc oxide, iron oxide and mixtures thereof.

The exact amount of sunscreen that can be used will vary depending on the sunscreen chosen and the Sun Protection Factor (SPF) value to be achieved. SPF is often used to measure the photoprotective effect of sunscreens against skin erythema. See Federal Register, Vol. 43, No. 166, pp. 38206-38269, August 25, 1978. However, the compositions according to the invention preferably comprise from 0.01 to 20%, more preferably from 0.1 to 10%, by weight of sunscreen active ingredient. optional ingredients

The compositions of the present invention may contain various optional ingredients suitable to impart more acceptable cosmetic or aesthetic properties to the compositions of the present invention, or to provide additional in-use benefits. These common optional ingredients are well known to those of ordinary skill in the art. These optional ingredients include a variety of ingredients suitable for use in cosmetics, such as CTFA International Cosmetic Ingredient Dictionary and Handbook, 7th Edition, Wenninger and McEwen, eds. (Cosmetic, Toiletry and Fragrance Association, Inc., Washington, D.C., 1997)). Some non-limiting examples of these optional ingredients are listed below. Skin Benefits

It is particularly preferred that the compositions of the invention comprise skin benefit ingredients. As used herein, the term "skin benefit ingredient" refers to any compound or mixture of compounds that, for example, imparts moisturizing, protective, skin feel, skin softness and/or skin smoothness benefits to the skin. Preferred skin benefit ingredients for use herein are humectants, emollients, and mixtures thereof. Preferably, the compositions of the present invention comprise emollients and humectants.

Preferably, the compositions of the present invention comprise at least 1% by weight of skin benefit ingredient. More preferably, the compositions of the present invention comprise from 2% to 70%, preferably from 5% to 60%, more preferably from 10% to 55% by weight of a skin benefit ingredient. moisturizer

A particularly preferred optional ingredient for use in the compositions of the present invention is a humectant. As used herein, the term "humectant" refers to a substance that imparts moisture retention benefits to the skin. Preferably the compositions of the present invention comprise at least 1% by weight, more preferably at least 5% by weight, still more preferably at least 10% by weight, still more preferably at least 20% by weight of humectant.

A wide variety of humectants suitable for use in cosmetic compositions are suitable for use in the present invention. Non-limiting examples of humectants suitable for use in the present invention are disclosed in WO 98/22085, WO 98/18444 and WO 97/01326. Preferred humectants for use in the present invention are selected from, but not limited to, amino acids and their derivatives, such as proline and arginine aspartate, 1,3-butanediol, propylene glycol and water, and sea pine Codium tomentosum extract, collagen amino acid or peptide, creatinine, diglycerin, biopolysaccharide-1 (biosaccharide-1), glucosamine salt, glucuronate, glutamate, polyethylene glycol Glyceryl ethers (e.g. glycerol ethoxylate 20), glycerin, glycerol monopropoxylate, glycogen, hexanediol, honey and its extracts or derivatives, hydrogenated starch hydrolysates, hydrolyzed mucopolysaccharides, inositol, horn Proteoaminoglycans, urea, LAREX A-200 (available from Larex), glycosaminoglycans, methoxy PEG-10, methylgluceth-10 and -20 (both available from Amerchol in Edison, NJ), methyl Glucose, 3-methyl-1,3-butanediol, N-acetylglucosamine salt, polyethylene glycol and its derivatives (such as PEG15 butanediol, PEG4, PEG5 pentaerythritol, PEG6, PEG8, PEG9) , pentaerythritol, 1,2-pentanediol, PPG-1 glyceryl ether, PPG-9, 2-pyrrolidone-5-carboxylic acid and its salts such as glyceryl PCA, sugar isomers, SEACARE (available from Secma), silk Glutin, silk amino acid, sodium acetyl hyaluronate, sodium hyaluronate, sodium polyaspartate, sodium polyglutamate, sorbeth20, sorbeth6, sugars and sugar alcohols, and their derivatives such as glucose, mannose and Polyglyceryl sorbitol, trehalose, triglycerin, trimethylolpropane, tris(hydroxymethyl)aminomethane salt, yeast extract, and mixtures thereof.

More preferably, the humectant used in the present invention is selected from the group consisting of glycerin, urea, butylene glycol, polyethylene glycol and derivatives thereof, and mixtures thereof. Even more preferably, the humectant used in the present invention is selected from the group consisting of glycerin, urea and mixtures thereof, especially glycerin. emollient

Another highly preferred optional ingredient in the compositions of the present invention is an emollient. Emollients are used to lubricate the skin, improve the smoothness and suppleness of the skin, prevent or relieve dryness of the skin, and/or protect the skin. A wide variety of suitable emollients are known and can be used in the present invention. Cosmetics, Science and Technology by Sagarin, 2nd ed., Vol. 1, pp. 32-43 (1972) contains many examples of materials suitable for use as emollients. Preferably the compositions of the present invention comprise greater than 1% by weight of emollient, more preferably at least 5% by weight, still more preferably at least 10% by weight of emollient.

Emollients preferably suitable for use herein are selected from:

i) straight and branched chain hydrocarbons containing from about 7 to about 40 carbon atoms, such as dodecane, squalane, petrolatum, cholesterol and their derivatives, hydrogenated polyisobutene, isohexadecane and _C7 -C ₄₀ isoparaffins (being C ₇ -C ₄₀ branched chain hydrocarbons).

ii) C ₁ -C ₃₀ alcohol esters of C ₁ -C ₃₀ carboxylic acids and C ₂ -C ₃₀ dicarboxylic acids, such as isononyl isononanoate, isopropyl myristate, myristyl propionate, hard Isopropyl fatty acid, behenyl behenate, dioctyl maleate, diisopropyl adipate, and diisopropyl dilinoleate.

iii) Mono-, diglycerides and triglycerides of C ₁ -C ₃₀ carboxylic acids and their ethoxylated derivatives. Suitable polyethylene glycol derivatives of glycerides include: PEG-20 Almond Glycerides, PEG-60 Almond Glycerides, PEG-11 Avocado Glycerides, PEG-6 Caprylic/Capric Glycerides, PEG-8 Caprylic/Capric Glycerides Glyceryl Caprate, PEG-20 Corn Glycerides, PEG-60 Corn Glycerides, PEG-60 Evening Primrose Oil Glycerides, PEG-7 Glyceryl Cocoate, PEG-30 Glyceryl Cocoate, PEG-40 Glyceryl Cocoate, PEG-78 Glyceryl Cocoate, PEG-80 Glyceryl Cocoate, PEG-12 Glyceryl Dioleate, PEG-15 Glyceryl Isostearate, PEG-20 Glyceryl Isostearate, PEG-30 Glyceryl Isostearate, PEG-75 Cocoa Butter Glycerides, PEG-20 Hydrogenated Palm Glycerides, PEG-70 Mango Glycerides, PEG-13 Mink Glycerides, PEG -75 Bisporin Glycerides, PEG 10 Olive Glycerides, PEG-12 Palm Kernel Glycerides, PEG-45 Palm Kernel Glycerides, PEG-8 Glyceryl Laurate and PEG-30 Glyceryl Laurate ester. Mixtures of polyethylene glycol derivatives of glycerides may also be used in the present invention.

iv) Alkylene glycol esters of C ₁ -C ₃₀ carboxylic acids, such as ethylene glycol monoesters and diesters of C ₁ -C ₃₀ carboxylic acids, and propylene glycol monoesters and diesters, such as ethylene glycol distearate alcohol esters.

v) Organopolysiloxane oils. The organopolysiloxane oil can be a volatile, nonvolatile or a mixture of volatile and nonvolatile silicones. As used herein, the term "nonvolatile" refers to those polysiloxanes which are liquids at ambient conditions and have a flash point (at 1 atmosphere) of greater than or equal to about 100°C. The term "volatile" as used herein refers to all other silicone oils. Suitable organopolysiloxane oils can be selected from a wide variety of polysiloxanes spanning a wide range of volatilities and viscosities. Non-volatile polysiloxanes are preferred. Suitable polysiloxanes are disclosed in US Patent 5,069,897 (issued December 3, 1991). The organopolysiloxanes preferably used in the present invention are selected from the group consisting of polyalkylsiloxanes, alkyl-substituted polydimethylsiloxanes, dimethiconols, polyalkylarylsiloxanes alkanes and their mixtures. More preferred for use herein are polyalkylsiloxanes and cyclomethicones. Preferred among the polyalkylsiloxanes are polydimethylsiloxanes.

vi) Vegetable oils and hydrogenated vegetable oils. Examples of vegetable and hydrogenated vegetable oils include: safflower oil, castor oil, coconut oil, cottonseed oil, menhaden oil, palm kernel oil, palm oil, peanut oil, soybean oil, rapeseed oil, linseed oil, rice bran oil, pine oil, sesame oil , sunflower oil, partially hydrogenated and fully hydrogenated forms of oils from the above sources, and mixtures thereof.

vii) Animal fats and fats, such as cod liver oil, lanolin and its derivatives, such as acetylated lanolin and isopropyl lanolate. Lanolin oil is preferred.

viii) Also C ₄ -C ₂₀ alkyl ethers of polypropylene glycol, C ₁ -C ₂₀ carboxylic acid esters of polypropylene glycol and di-C ₈ -C ₃₀ alkyl ethers can be used, examples include PPG-14 butyl ether , PPG-15 stearyl ether, dioctyl ether, dodecyl octyl ether and mixtures thereof.

ix) Polyol carboxylic acid esters.

x) Mixtures of the above ingredients.

Preferred emollients for use in the compositions of the present invention are selected from the group consisting of dodecane, squalane, cholesterol and its derivatives, isohexadecane, isononyl isononanoate, petrolatum, lanolin and its derivatives. plant, safflower oil, castor oil, coconut oil, cottonseed oil, palm kernel oil, palm oil, peanut oil, soybean oil, polyol carboxylic acid esters, and mixtures thereof. More preferred emollients for use herein are selected from polyol carboxylic acid esters, petrolatum, and mixtures thereof.

These esters are derived from a sugar or polyol moiety and one or more carboxylic acid moieties. Depending on the acids and sugars from which the esters are composed, these esters can be in liquid or solid form at room temperature. Examples of liquid esters include: glucose tetraoleate, glucose tetraester of (unsaturated) soy fatty acid, mannose tetraester of mixed soy fatty acid, galactose tetraester of oleic acid, arabic acid tetraester of linoleic acid Sugar tetraester, xylose tetralinoleate, galactose pentaoleate, sorbitan tetraoleate, unsaturated soybean oil fatty acid sorbitan hexaester, xylitol pentaoleate, sucrose tetraoleate , sucrose pentaoleate, sucrose hexaoleate, sucrose heptaoleate, sucrose octaoleate and mixtures thereof. Examples of solid esters include: sorbitan hexaester, wherein the carboxylate moiety is palm oleic acid ester and arachidic acid ester in a molar ratio of 1:2; raffinose octaester, wherein the carboxylate moiety is 1:3 linoleate and behenate; maltose heptaester, wherein the esterified carboxylic acid moiety is sunflower fatty acid and behenate in a molar ratio of 3:4; octaester of sucrose, wherein the esterified carboxylic acid moiety is oleate and behenate in a molar ratio of 2:6; and octaester of sucrose wherein the esterified carboxylic acid moiety is laurate in a molar ratio of 1:3:4 , linoleate and behenate. The preferred solid material is sucrose polyester, wherein the degree of esterification is 7-8, wherein the fatty acid moieties are C ₁₈ mono- and/or di-unsaturated acids and behenic acid, wherein the unsaturated acids and behenic acid The molar ratio of alkanoic acid is 1:7-3:5. A particularly preferred solid sugar polyester is the octaester of sucrose having about 7 behenic fatty acid moieties and about 1 oleic acid moiety in the molecule. Other materials include cottonseed oil or soybean oil fatty acid sucrose esters. These esters are also disclosed in U.S. Patent 2,831,854; U.S. Patent 4,005,196 (Jandacek, authorized on January 25, 1977); April 26, 1994); U.S. Patent 5,306,515 (Letton et al., April 26, 1994); U.S. Patent 5,305,514 (Letton et al., April 26, 1994); U.S. Patent 4,797,300 (Jandacek et al., issued January 10, 1989); US Patent 3,963,699 (Rizzi et al., issued June 15, 1976); US Patent 4,518,772 (Volpenhein, issued May 21, 1985); and US Patent 4,517,360 (Volpenhein, 1985 authorized on May 21).

Fatty acid polyol esters suitable for use in the present invention can be prepared by various methods known to those of ordinary skill in the art. These methods include transesterification of polyols with methyl, ethyl, or glycerol fatty acid esters using various catalysts; acylation of polyols with fatty acid chlorides; acylation of polyols with fatty acid anhydrides; Acylation of polyols. See, for example, US Patent 2,831,854; US Patent 4,005,196 (Jandacek, issued January 25, 1977).

A particularly preferred material is that which has the INCI designation polysucrose cottonseedoleate. Other Skin Benefits

Other skin benefit ingredients may be employed in the compositions of the present invention. Examples of other skin benefit ingredients that may be used in the compositions of the present invention include:

(a) vitamin compounds

Vitamin compounds, their precursors and their derivatives may be included in the compositions of the present invention. These vitamin compounds can be in natural or synthetic form. Suitable vitamin compounds include vitamin A (e.g., beta-carotene, retinoic acid, retinol, retinoids, retinyl palmitate, retinyl propionate, etc.), vitamin B (such as niacin, niacinamide, riboflavin, pantothenic acid, etc.), vitamin C (such as ascorbic acid, etc.), vitamin D (such as ergosterol, ergocalciferol, cholecalciferol, etc.), vitamin E (such as acetic acid tocopherol, etc.) and vitamin K (eg, vitamin K, menadione, tuberculosis naphthoquinone, etc.) compounds. A preferred vitamin compound for use in the compositions of the present invention is a vitamin _B3 compound. Vitamin _B3 compounds are particularly useful for regulating skin condition as described in WO-A-97/39733. If vitamin compounds are used, the compositions of the present invention preferably comprise from about 0.01% by weight to about 50% by weight, more preferably from about 0.1% by weight to about 10% by weight, still more preferably from about 0.5 % (weight) to about 5% (weight) of vitamin _B3 compounds.

The term "vitamin _B3 compound" used in the present invention refers to a compound represented by the following formula:

Wherein R is -CONH ₂ (ie nicotinamide), -COOH (ie nicotinic acid) or -CH ₂ OH (ie nicotinylalcohol); derivatives thereof; and salts of the above compounds.

Examples of derivatives of the aforementioned vitamin _B3 compounds include: niacin esters, including non-vasodilatory esters of niacin; niacinamide, nicotinyl alcohol esters of carboxylic acids, niacin N-oxide, and niacinamide N-oxide thing.

Examples of suitable vitamin _B3 compounds are well known in the art and are commercially available from various sources such as Sigma Chemical Company (St. Louis, MO); ICN Biomedical Company (Irvin, CA) and Aldrich Chemical Company ( Milwaukee, WI).

The vitamin compound may be added in substantially pure form, or as an extract obtained by suitable physical and/or chemical isolation from a natural source such as a plant. (b) Anti-wrinkle and anti-skin atrophy active ingredients

Examples of anti-wrinkle and anti-skin atrophy active ingredients that may be used in the compositions of the present invention include: lactic acid and its derivatives; retinoic acid and its derivatives (e.g., cis and trans); retinol; retinyl Esters; Niacinamide; Salicylic acid and its derivatives; Sulfur-containing D and L amino acids and their derivatives and salts, especially N-acetyl derivatives, a preferred example of which is N-acetyl-L-cysteine amino acids; thiols such as ethanethiol; hydroxy acids; phytic acid; lipoic acid; (c) Antimicrobial and antifungal active ingredients

Examples of antimicrobial and antifungal active ingredients that may be used in the compositions of the present invention include: beta-lactams, quinolones, ciprofloxacin, norfloxacin, tetracycline, erythromycin, butylamine Kanamycin, 2,4,4'-trichloro-2'-hydroxydiphenyl ether, 3,4,4'-trichloro-N-carbanilide, phenoxyethanol, phenoxypropanol , phenoxyisopropanol, doxycycline, capreomycin, chlorhexidine, chlortetracycline, oxytetracycline, clindamycin, ethambutol (ethambutol), hexyl isethionate Amidine, metronidazole, pentamidine, gentamicin, kanamycin, lincomycin, methacycline, urotropine, minocycline, neomycin erythromycin, netilmicin, paromomycin, streptomycin, tobramycin, miconazole, tetracycline hydrochloride, erythromycin, erythromycin zinc, odorless erythromycin, erythromycin stearate, Amikacin sulfate, doxycycline hydrochloride, capreomycin sulfate, chlorhexidine gluconate, chlorhexidine hydrochloride, chlortetracycline hydrochloride, oxytetracycline hydrochloride, clincomycin hydrochloride, ethambutol hydrochloride , metronidazole hydrochloride, pentamidine hydrochloride, gentamicin sulfate, kanamycin sulfate, lincomycin hydrochloride (lineomycin), methacycline hydrochloride, urotropine hippurate, mendelidine ( methenamine mandelate), minocycline hydrochloride, neomycin sulfate, netilmicin sulfate, paromomycin sulfate, streptomycin sulfate, tobramycin sulfate, miconazole hydrochloride, amanfadine hydrochloride ), amanfadine sulfate, octopyrone, chloroxylenol, nystatin, tolnaftate, zinc pyrithione, and clotrimazole. polar solvent

Polar solvents may also be included in the compositions of the present invention. Any polar solvent suitable for use in cosmetic compositions may be used in the present invention. However, the polarity of the polar solvent should be sufficient to promote the formation of vesicles in the present invention. A preferred polar solvent for use in the compositions of the present invention is water.

The composition of the present invention preferably contains 10% (weight)-90% (weight), more preferably 20% (weight)-80% (weight), still more preferably 30% (weight)-60% (weight) polar solvents. thickener

The compositions of the invention preferably contain a thickener. Any thickener suitable for use in cosmetic compositions can be used in the present invention. Preferred thickeners are selected from nonionic water soluble polymers, fatty alcohols and mixtures thereof. Suitable nonionic polymers include such water-soluble polymers as cellulose ethers (e.g., hydroxybutylmethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, ethylhydroxyethylcellulose, hydrophobically Modified hydroxyethyl cellulose and hydroxyethyl cellulose), poly(oxyethylene), polyvinyl alcohol, polyvinylpyrrolidone, hydroxypropyl guar gum, amylose (amulose), hydroxyethyl linear Starch (amylose), starch and starch derivatives. Suitable fatty alcohols are high molecular weight, non-volatile primary alcohols having the general formula:

RCH ₂ OH

Wherein R is C _8-20 alkyl. They can be obtained from natural oils or fats by reducing the -COOH carboxyl groups in fatty acids to hydroxyl functional groups. Alternatively, fatty alcohols of the same or similar structure can be prepared by conventional synthetic methods known in the art. Suitable fatty alcohols include: docosanol, C ₉ -C ₁₁ alcohols, C ₁₂ -C ₁₃ alcohols, C ₁₂ -C ₁₅ alcohols, C ₁₂ -C ₁₆ alcohols, C ₁₄ -C ₁₅ alcohols, octanol, Cetyl/Stearyl Alcohol, Coco Alcohol, Decyl Alcohol, Isocetyl Alcohol, Isostearyl Alcohol, Lauryl Alcohol, Oleyl Alcohol, Palm Kernel Alcohol, Stearyl Alcohol, Cetyl Alcohol, Tallow Alcohol, Tridecyl Alcohol or myristyl alcohol, but not limited to these. other optional ingredients

The compositions used in the methods of the present invention can contain various other optional components. These additional components should be pharmaceutically acceptable. Non-limiting examples of ingredients suitable for use in the compositions of the present invention, classified by function, include: abrasives, absorbents, anti-acne actives, anti-caking agents, anti-dandruff agents, antiperspirants, antioxidants, anti-acne Viral active ingredients, artificial tanning active ingredients and accelerators, biological additives, bleaching agents, bleach activators, brighteners, builders, buffers, chelating agents, chemical additives, coloring agents, cosmetic ingredients, cleaning agents, Astringents for cosmetics, bactericides for cosmetics, denaturants, deodorants, peeling active ingredients, depilatory agents, medicinal astringents, dyes, transfection agents, enzymes, topical analgesics, foaming agents, flavoring agents, Film formers, fragrance components, insect repellants, antifungal agents, non-steroidal anti-inflammatory active ingredients, sunscreens, oxidation dyes, oxidizing agents, insecticidal ingredients, pH regulators such as citric acid, pH buffers, pharmaceutical active ingredients , plasticizers, preservatives, free radical scavengers, skin or hair or nail bleaching agents, skin or hair or nail conditioners, skin or hair or nail penetration enhancers, stabilizers, surfactants, surface conditioners, reducing additives, temperature depressants, viscosity regulators and warming agents such as heating zeolites. Aesthetic components suitable for use here are: colorants, essential oils and skin healing agents. Other optional materials suitable for use herein include: Pigments. Pigments suitable for use in the compositions of the present invention may be organic and/or inorganic components. Also within the scope of the term pigment are low-pigmentation or low-gloss substances, such as matte finishing agents, and light scattering agents. Examples of suitable pigments are iron oxides, iron oxides acyl glutamate, titanium dioxide, ultramarine blue, D&C dyes, cochineal and mixtures thereof. Preparation steps

Preferably the compositions of the present invention are prepared in such a way that the quaternary ammonium compound can form vesicles. Preferably, the vesicles also contain a humectant. Preferably, the vesicles also contain an emollient. Still more preferably, said vesicles comprise sunscreen actives. To ensure optimum performance characteristics, it is preferred that the compositions of the present invention are prepared by:

(i) intermixing all or part of the quaternary ammonium ingredient with the humectant, water-soluble sunscreen active, water-soluble skin care active (if included) and preferably also a polar solvent at a temperature above the melting point of the quaternary ammonium ingredient;

(ii) the mixture is optionally vigorously stirred;

(iii) In a separate container, an emulsion is prepared by mixing the oily phase containing the emollient, the associated thickener (so long as said thickener is oil-soluble) at a temperature above the melting point of the quaternary ammonium ingredient, ), the oil-soluble sunscreen active, and any remaining quaternary ammonium ingredients. Prepare the aqueous phase separately. Water, associated thickeners (so long as said thickeners are water soluble) and other remaining water soluble ingredients are heated to the same temperature as the oil phase.

(iv) The temperature of the oil phase and the water phase of the emulsion is approximately balanced, and then the water phase is combined with the oil phase under stirring conditions.

(v) When preparing the emulsion, the mixture prepared in step (i) is added to the above emulsion with stirring.

Instructions

The cosmetic compositions according to the invention can be used in conventional manner for the care of the skin. An effective amount of the composition, usually from about 0.1 gram to about 50 grams, preferably from about 1 gram to about 20 grams, is applied to wet or dry, preferably wet, skin. Application of the composition generally involves rubbing the composition on the skin, usually with the hands and fingers. The composition is then left on the skin, or, preferably, the skin is rinsed.

Therefore, a preferred method of caring for the skin comprises the following steps:

(a) applying an effective amount of the cosmetic composition to the skin,

(b) Rinse the skin.

A preferred aspect of the invention relates to the above method comprising applying the composition to dry skin prior to applying the composition to wet skin. Therefore, preferred methods include:

(i) applying an effective amount of the cosmetic composition to dry skin;

(ii) rinsing the skin under a shower;

(iii) reusing said composition; and

(iv) Rinse again.

Most damage to human skin results from repeated exposure of the skin to surfactant-containing compositions during cleansing. It has now been found that this damage can be alleviated using the methods of the present invention. Another preferred method therefore includes:

(i) cleansing the skin with a surfactant-containing composition;

(ii) rinsing the skin;

(iii) applying the composition of the invention to wet skin;

(iv) Rinse the skin.

It has also now been found that the compositions of the present invention are particularly useful when incorporated as part of a regular cleaning routine. Another preferred method therefore includes:

(i) applying to the skin a composition comprising:

(a) at least one quaternary ammonium compound;

(b) humectants; and

(ii) rinsing the skin;

(iii) Repeat steps (i) and (ii) within 48 hours.

The composition of the present invention may also be used to alleviate damage caused by exposure of the skin to ultraviolet radiation, damage caused by contact of the skin with water during swimming or similar water sports, damage caused by shaving or exfoliation, or damage caused by skin contact with the skin while bathing. Skin damage from water contact.

Example

The following examples serve to further illustrate preferred embodiments within the scope of the present invention. The examples listed are for illustration only and do not constitute any limitation of the invention, and there are many variations without departing from the spirit or scope of the invention. All ingredients are expressed in weight percent of active ingredient unless otherwise indicated. Example 1 2 3 4 5 6 7 8 9 10 11 12 13 %(weight) Quaternary ammonium ingredients (see notes) 3 3 3 3 3 3 3 3 3 3 3 3 3 A glycerin 32 32 32 32 32 32 32 - - - - - - A Urea - - - - - - - twenty two twenty two twenty two twenty two twenty two twenty two A Petrolatum - - 10 - 12 15 - - - 10 - 12 15 B Lanolin ¹ - - - 7.5 5 - 15 - - - 10 10 - B Coronet lanolin ¹ - - - - - - 5 - - - - - - B super sterol ester ¹ - - - - - - 5 - - - - - - B Sefa Cotton Oleate twenty one twenty one 12 12 - - - twenty one twenty one 12 12 - - B Dimethicone 10 cSt - 0.5 0.5 0.5 - 0.5 0.5 0.5 - - - 0.5 0.5 B Dimethicone 1000 centistokes - 1.0 1.0 1.0 - 1.0 1.0 1.0 - - - 1.0 1.0 B Cyclomethicone - 2.5 2.5 2.5 - 2.5 2.5 2.5 - - - 2.5 2.5 B Florasun PEG-10 ² - 2 - 2 - 3 - 1 - - 3 - - B Methylparaben 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 A Propylparaben 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 B Disodium EDTA 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 A sodium benzoate 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 B Nicotinamide 5 5 3 5 5 5 3 5 5 5 A panthenol 3 3 1 3 3 3 1 3 3 3 A tocopheryl acetate 2 2 0.5 2 2 2 0.5 2 2 2 B Retinyl Palmitate 0.1 - - - - - 0.05 - - 0.1 - - - B Parsol 1789 ³ 1 1 0.5 1 0.5 1 0.1 0.5 1 1 1 0.5 1 B Parsol MCX ³ 5 5 2.5 5 2.5 5 0.5 2.5 5 5 5 2.5 5 B citric acid 1 0.5 1 0.5 0.5 1 0.5 1 0.3 0.75 1 1 1 A salicylic acid - 0.5 - 0.5 0.5 - 0.5 - 0.7 - - - - A Triethanolamine 0.1 - - 0.1 0.1 - - - 0.1 - - 0.9 0.5 C sodium hydroxide - - 0.1 0.1 0.1 - - 0.1 - 0.1 - - C Polyquaternium-10 - - 1.0 - 0.5 - 0.6 - - - 0.5 B Polymer KG 30 ⁴ - 0.7 - 0.7 - - - 0.8 - - - B spices 0.5 0.5 0.5 0.5 0.5 - 0.5 0.5 0.5 0.5 0.5 0.5 0.5 E. cetyl alcohol 3 - - - 2.6 - - 2.2 - 2.2 - 2.5 - C stearyl alcohol 2 - - - 1.5 - - 3.2 - 1.1 - 1.6 - C Cetyl/Stearyl Alcohol - - 4 - 0.4 - - - 3.4 - - - 3.4 C Docosanol 2 - 2 - - - - 0.6 - 0.7 - - - C Natrosol 330 Plus 1 - - - 0.4 - - 0.7 0.6 - 0.5 0.25 C Natrosol 250HHR - - 1 - 0.3 - - - - 1.2 - - 0.3 C Jaguar HP 105 ⁵ - 1.2 - - - - - - - - 0.8 - - D. Jaguar C14S ⁵ - - - 1 - - - - - - - - - D. Jaguar C13S ⁵ - - - - - 1.2 - - - - - - - D. xanthan gum - - - - - - 2.0 - - - - - - D. Sodium chloride - - 0.1 - - - 0.5 0.2 - 0.3 - - - A water Appropriate amount Appropriate amount Appropriate amount Appropriate amount Appropriate amount Appropriate amount Appropriate amount Appropriate amount Appropriate amount Appropriate amount Appropriate amount Appropriate amount Appropriate amount A Example 14 15 16 17 18 19 20 twenty one twenty two twenty three twenty four 25 26 %(weight) Quaternary ammonium ingredients (see note) 8 8 8 8 8 8 8 8 8 8 8 8 8 A glycerin 32 32 32 32 32 32 32 - - - - - - A Urea - - - - - - - twenty two twenty two twenty two twenty two twenty two twenty two A Petrolatum - - 10 - 12 15 - - - 10 - 12 15 B Lanolin ¹ - - - 7.5 5 - 15 - - - 10 10 - B Coronet lanolin ¹ - - - - - - 5 - - - - - - B super sterol ester ¹ - - - - - - 5 - - - - - - B Sefa Cotton Oleate twenty one twenty one 12 12 - - - twenty one twenty one 12 12 - - B Dimethicone 10 cSt - 0.5 0.5 0.5 - 0.5 0.5 0.5 - - - 0.5 0.5 B Dimethicone 1000 centistokes - 1.0 1.0 1.0 - 1.0 1.0 1.0 - - - 1.0 1.0 B Cyclomethicone - 2.5 2.5 2.5 - 2.5 2.5 2.5 - - - 2.5 2.5 B Florasun PEG-10 ² - 2 - 2 - 3 - 1 - - 3 - - B Methylparaben 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 A Propylparaben 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 B Disodium EDTA 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 A sodium benzoate 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 B Nicotinamide 5 5 3 5 5 5 3 5 5 5 A panthenol 3 3 1 3 3 3 1 3 3 3 A tocopheryl acetate 2 2 0.5 2 2 2 0.5 2 2 2 B Retinyl Palmitate 0.1 - - - - 0.05 - - - - - - 0.1 B Parsol 1789 ³ 1 1 0.5 1 0.5 0.5 0.1 1 1 0.5 1 1 1 B Parsol MCX ³ 5 5 2.5 5 2.5 2.5 0.5 5 5 2.5 5 5 5 B citric acid 1 0.5 1 0.5 0.5 1 0.5 1 0.3 0.7 1 1 1 A salicylic acid - 0.5 - 0.5 0.5 - 0.5 - 0.7 - - - - A Triethanolamine 0.1 - - 0.1 0.1 - - - 0.1 - - 0.9 0.5 C sodium hydroxide - - 0.1 0.1 0.1 - - 0.1 - 0.1 - - - C Polyquaternium-10 - - 1.0 - 0.5 - 0.6 - - - 0.5 B Polymer KG 30 ⁴ - 0.7 - 0.7 - - - 0.8 - - - B spices 0.5 0.5 0.5 0.5 0.5 - 0.5 0.5 0.5 0.5 0.5 0.5 0.5 E. cetyl alcohol 3 - - - 2.6 - - 2.2 - 2.2 - 2.5 - C stearyl alcohol 2 - - - 1.5 - - 3.2 - 1.1 - 1.6 - C Cetyl/Stearyl Alcohol - - 4 - 0.4 - - - 3.4 - - - 3.4 C Docosanol 2 - 2 - - - - 0.6 - 0.7 - - - C Natrosol 330 Plus 1 - - - 0.4 - - 0.7 0.6 - 0.5 0.25 C Natrosol 250HHR - - 1 - 0.3 - - - - 1.2 - - 0.3 C Jaguar HP 105 ⁵ - 1.2 - - - - - - - - 0.8 - - D. Jaguar C14S ⁵ - - - 1 - - - - - - - - - D. Jaguar C13S ⁵ - - - - - 1.2 - - - - - - - D. xanthan gum - - - - - - 2.0 - - - - - - D. Sodium chloride - - 0.1 - - - 0.5 0.2 - 0.3 - - - A water Appropriate amount Appropriate amount Appropriate amount Appropriate amount Appropriate amount Appropriate amount Appropriate amount Appropriate amount Appropriate amount Appropriate amount Appropriate amount Appropriate amount Appropriate amount A Example 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 %(weight) Quaternary ammonium ingredients (see note) 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 A glycerin 15 16 twenty two 9 8 9 - 32 32 32 32 32 32 32 32 A Propylene Glycol - 16 - - - 5 12 - - - - - - - - A Butanediol - - 8 8 - 8 12 - - - - - - - - A Urea - - - 12 - 2 9 - - - - - - - - A Petrolatum - - 10 - 12 15 - - 4 7.5 - 12 5 - 6 B Lanolin ¹ - - - 7.5 7.5 - 15 - 3.5 - 3 - - - - B Coronet lanolin ¹ - - - - - - - - 7 - 6.7 - - 6 - B super sterol ester ¹ - - - - - - - - 3.5 - 6.5 - 3 6 3 B Isohexadecane - - - - - - - - - 5 - 3 - - 3 B Isononyl isononanoate - - - - - - - - - 3 - 5 - - - B Sefa Cotton Oleate twenty one twenty one 12 12 - - - 13 - 8 - - 8 12 10 B Sefa behenate - - - - - - - 9 - - 3 - 5 - - B Dimethicone 10 cSt - 0.5 0.5 0.5 - 0.5 0.5 0.5 - - - 0.5 0.5 - - B Dimethicone 1000 centistokes - 1.0 1.0 1.0 - 1.0 1.0 1.0 - - - 1.0 1.0 - - B Cyclomethicone - 2.5 2.5 2.5 - 2.5 2.5 2.5 - - - 2.5 2.5 - - B Florasun PEG-10 ² - 2 - 2 - 3 - 1 - - 3 - - 2.5 - B Methylparaben 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 A Propylparaben 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 B Disodium EDTA 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 A sodium benzoate 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 B Nicotinamide 3 5 5 5 5 5 3 3 5 5 5 3 A panthenol 1 3 3 3 3 3 1 1 3 3 3 1 A tocopheryl acetate 0.5 2 2 2 2 2 0.5 0.5 2 2 2 0.5 B Retinyl Palmitate - - - 0.1 - 0.05 - - 0.1 - - - - - - B Parsol 1789 ³ 0.5 1 1 1 0.5 0.5 1 0.5 1 1 1 - 0.1 1 0.5 B Parsol MCX ³ 2.5 5 5 5 2.5 2.5 5 2.5 5 5 5 - 0.5 5 2.5 B citric acid 1 0.5 1 0.5 0.5 1 0.5 1 0.3 0.75 1 1 1 1 - A salicylic acid - 0.5 - 0.5 0.5 - 0.5 - 0.7 - - - - - 0.5 A Triethanolamine 0.1 - - 0.1 0.1 - - - 0.1 - - 0.9 0.5 - - C sodium hydroxide - - 0.1 0.1 0.1 - - 0.1 - 0.1 - - - - 0.6 C Polyquaternium-10 - - - 1.0 - - 0.5 - 0.6 - - - 0.5 1.0 - B Polymer KG 30 ⁴ - 0.7 - - 0.7 - - - 0.8 - - - - 0.8 B spices 0.5 0.5 0.5 0.5 0.5 - 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 E. cetyl alcohol 3 - - - 2.6 - - 2.2 - 2.2 - 2.5 - - 3.2 C stearyl alcohol 2 - - - 1.5 - - 3.2 - 1.1 - 1.6 - - 2.6 C Cetyl/Stearyl Alcohol - - 4 - 0.4 - - - 3.4 - - - 3.4 - - C Docosanol 2 - 2 - - - - 0.6 - 0.7 - - - - 0.2 C Natrosol 330 Plus 1 - - 0.4 - - 0.7 0.6 - - 0.5 0.25 - 0.6 C Natrosol 250 HHR - - 1 - 0.3 - - - - 1.2 - - 0.3 - - C Jaguar HP 105 ⁵ - 1.2 - - - - - - - - 0.8 - - - - D. Jaguar C14S ⁵ - - - 1 - - - - - - - - - - - D. Jaguar C13S ⁵ - - - - - 1.2 - - - - - - - 0.8 - D. xanthan gum - - - - - - 3.0 - - - - - - - - D. Sodium chloride - - 0.1 - - - 0.5 0.2 - 0.3 - - - 0.2 0.1 A water Appropriate amount Appropriate amount Appropriate amount Appropriate amount Appropriate amount Appropriate amount Appropriate amount Appropriate amount Appropriate amount Appropriate amount Appropriate amount Appropriate amount Appropriate amount Appropriate amount Appropriate amount A Example 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 %(weight) Quaternary ammonium ingredients (see note) 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 A glycerin 15 16 twenty two 9 8 9 - 32 32 32 32 32 32 32 32 A Propylene Glycol - 16 - - - 5 12 - - - - - - - - A Butanediol - - 8 8 - 8 12 - - - - - - - - A Urea - - - 12 - 2 9 - - - - - - - - A Petrolatum - - 10 - 12 15 - - 4 7.5 - 12 5 - 6 B Lanolin ¹ - - - 7.5 7.5 - 15 - 3.5 - 3 - - - - B Coronet lanolin ¹ - - - - - - - - 7 - 6.7 - - 6 - B super sterol ester ¹ - - - - - - - - 3.5 - 6.5 - 3 6 3 B Isohexadecane - - - - - - - - - 5 - 3 - - 3 B Isononyl isononanoate - - - - - - - - - 3 - 5 - - - B Sefa Cotton Oleate twenty one twenty one 12 12 - - - 13 - 8 - - 8 12 10 B Sefa behenate - - - - - - - 9 - - 3 - 5 - - B Dimethicone 10 cSt - 0.5 0.5 0.5 - 0.5 0.5 0.5 - - - 0.5 0.5 - - B Dimethicone 1000 centistokes - 1.0 1.0 1.0 - 1.0 1.0 1.0 - - - 1.0 1.0 - - B Cyclomethicone - 2.5 2.5 2.5 - 2.5 2.5 2.5 - - - 2.5 2.5 - - B Florasun PEG-10 ² - 2 - 2 - 3 - 1 - - 3 - - 2.5 - B Methylparaben 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 A Propylparaben 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 B Disodium EDTA 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 A sodium benzoate 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 B Nicotinamide 3 5 5 5 5 5 3 3 5 5 5 3 A panthenol 1 3 3 3 3 3 1 1 3 3 3 1 A tocopheryl acetate 0.5 2 2 2 2 2 0.5 0.5 2 2 2 0.5 B Retinyl Palmitate - - - - - - - - 0.05 - - 0.1 - - - B Parsol 1789 ³ 1 1 0.5 1 0.5 1 1 0.5 1 0.5 1 1 0.1 1 1 B Parsol MCX ³ 5 5 2.5 5 2.5 5 5 2.5 5 2.5 5 5 0.5 5 5 B citric acid 1 0.5 1 0.5 0.5 1 0.5 1 0.3 0.7 1 1 1 1 - A salicylic acid - 0.5 - 0.5 0.5 - 0.5 - 0.7 - - - - - 0.5 A Triethanolamine 0.1 - - 0.1 0.1 - - - 0.1 - - 0.9 0.5 - - C sodium hydroxide - - 0.1 0.1 0.1 - - 0.1 - 0.1 - - - - 0.6 C Polyquaternium-10 - - - 1.0 - - 0.5 - 0.6 - - - 0.5 1.0 - B Polymer KG 30 ⁴ - 0.7 - - 0.7 - - - - 0.8 - - - - 0.8 B spices 0.5 0.5 0.5 0.5 0.5 - 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 E. cetyl alcohol 3 - - - 2.6 - - 2.2 - 2.2 - 2.5 - - 3.2 C stearyl alcohol 2 - - - 1.5 - - 3.2 - 1.1 - 1.6 - - 2.6 C Cetyl/Stearyl Alcohol - - 4 - 0.4 - - - 3.4 - - - 3.4 - - C Docosanol 2 - 2 - - - - 0.6 - 0.7 - - - - 0.2 C Natrosol 330 Plus 1 - - 0.4 - - 0.7 0.6 - - 0.5 0.25 - 0.6 C Natrosol 250 HHR - - 1 - 0.3 - - - - 1.2 - - 0.3 - - C Jaguar HP 105 ⁵ - 1.2 - - - - - - - - 0.8 - - - - D. Jaguar C14S ⁵ - - - 1 - - - - - - - - - - - D. Jaguar C13S ⁵ - - - - - 1.2 - - - - - - - 0.8 - D. xanthan gum - - - - - - 3.0 - - - - - - - - D. Sodium chloride - - 0.1 - - - 0.5 0.2 - 0.3 - - - 0.2 0.1 A water Appropriate amount Appropriate amount Appropriate amount Appropriate amount Appropriate amount Appropriate amount Appropriate amount Appropriate amount Appropriate amount Appropriate amount Appropriate amount Appropriate amount Appropriate amount Appropriate amount Appropriate amount A

1: Purchased from Croda

2: Purchased from Floratech, AZ, USA

3: Purchased from Hoffman La Roche, NJ, USA

4: Purchased from Amerchol, NJ, USA

5: Purchased from Rhodia, NJ, USA Notes

In embodiment 1,4,7,9,17,20,22,24,28,36,38,47,49,53,56, the quaternary ammonium compound used

The compound is distearyldimethylammonium chloride, available from Goldschmidt under the trade name Varisoft

TA100

Examples 2, 3, 5, 6, 8, 10, 15, 16, 18, 19, 21, 23, 26, 27, 31, 33, 34, 35, 37,

41, 45, 46, 48, 50, 51, 52, 54, 55, the quaternary ammonium compound used is N, N-di(lowerucic acid

Brassinoyl-oxy-ethyl)-N-methyl, N-(2-hydroxyethyl)ammonium methylsulfate was purchased from Goldschmidt,

The trade name is Rewoquat V3620.

In Example 11, the quaternary ammonium compound used is N, N-bis(lowerucinoyl-oxygen-ethyl

base)-N-methyl, N-(2-hydroxyethyl)ammonium methylsulfate, purchased from Goldschmidt under the trade name

Rewoquat WE18

In Example 12, the quaternary ammonium compound used is N, N-di(lowerucicanoyl-oxygen-ethyl

base)-N-methyl, N-(2-hydroxyethyl)ammonium chloride, available from Goldschmidt, development material (WE25)

In Example 13, the quaternary ammonium compound used is methyl bis (hydrogenated tallow amido ethyl) (2-

Hydroxyethyl) ammonium methyl sulfate, purchased from Goldschmidt, trade name is Varisoft 110

In Example 14, the quaternary ammonium compound used is methyl bis(tallowamidoethyl) (2-hydroxyethyl)

Ammonium methylsulfate available from Goldschmidt under the tradename Varisoft 222

In Example 25, the quaternary ammonium compound used is methyl-1-tallowoyl ethyl-2-tallow imidazoline,

Purchased from Goldschmidt, Development Materials

In Example 29, the quaternary ammonium compound used is methyl-1-tallowamidoethyl-2-tallow

Oxazoline, purchased from Goldschmidt, Development Materials

In Example 30, the quaternary ammonium compound used is methyl-1-tallowoyl ethyl-2-tallow imidazoline

Onium methylsulfate, available from Goldschmidt,

In Example 32, the quaternary ammonium compound used is methyl-1-tallowamidoethyl-2-tallow

Azolinium methylsulfate available from Goldschmidt under the trade names Varisoft 475, Varisoft 445

In Example 39, the quaternary ammonium compound used is N, N-dimethyl-N-(canolacoyl-

Oxy-ethyl)-N-(canolaloylamidoethyl)amine was purchased from Kao.

In Example 40, the quaternary ammonium compound used is N, N-dimethyl-N (canolanoyl-

Oxy-ethyl)-N-(canolaloylamidoethyl)ammonium methylsulfate was purchased from Kao

In Example 42, the quaternary ammonium compound used is N, N'-bis(2-tallowoyloxyethyl)-N, N,

N', N'-tetramethylene diammonium dichloride, disclosed in U.S. Patent 4728337, U.S. Patent 4721512,

Available from Ciba-Geigy in US Patent 4906413

In Example 43, the quaternary ammonium compound used is N, N'-bis (2-lowerucinoyloxyethyl

base)-N,N'-dimethyl-N,N'-(2-hydroxyethyl)-1,6-hexane diammonium methyl sulfate, disclosed in

Goldschmidt-Witco patents EP0503155A1 and EP0803498

In embodiment 44, the quaternary ammonium compound used is made of fatty acid, two functional group (or functional group) acid

Reaction with triethanolamine followed by quaternization of dimeric and oligoester quaternary ammonium compounds

(quats), disclosed in WO98/49132 (Kao) and US Patent 5880289 (Henkel). The method is applicable to the examples including component C:

1. Premix 1: Mix the components of Group A above the conversion temperature of the selected quaternary ammonium compound, leaving the predetermined amount of quaternary ammonium compound and water unadded. The premix was stirred vigorously.

2. Premix 2: Combine the components of Groups B and C with the remaining quaternary ammonium compound not used in Premix 1 and water. Heat above the melting point of quaternary ammonium compounds and oils.

3. Mix premix 1 and 2, cool to 40°C, stir and add essence. Applicable to examples including Component D:

1. Premix 1: Mix the components of Group A above the conversion temperature of the selected quaternary ammonium compound, leaving the predetermined amount of water unadded. The premix was stirred vigorously.

2. Premix 2: Under agitation, combine the ingredients in Group D with the remaining water not used in Premix 1.

3. Combine the components of Premixes 1 and 2, and Groups B and E. Stir vigorously.

The compositions of the above examples provide good skin care benefits, such as good moisturization, good hydration, good skin feel, good skin softness and/or good skin smoothness, while having a low degree of adverse Effects such as greasiness, stickiness or stickiness.

Claims (10)

1. cosmetic composition, said composition comprises:

(a) at least a quaternary ammonium composition; With

(b) at least a sunscreen actives composition.

2. the compositions of claim 1, wherein said compositions also comprises a kind of skin protection beneficiating ingredient.

3. according to the compositions of aforementioned each claim, wherein said compositions also comprises the skin protection beneficiating ingredient that is selected from wetting agent, emollient and their mixture.

4. according to the compositions of aforementioned each claim; wherein sunscreen actives is selected from N; N-dimethyl-para-amino benzoic acid 2-Octyl Nitrite; p-methoxycinnamic acid 2-Octyl Nitrite; octocrylene; ethylhexyl salicylate; the high  ester of salicylic acid; para-amino benzoic acid; the hydroxyl methoxy benzophenone; 2-Phenylbenzimidazole-5-sulfonic acid; the p-methoxycinnamic acid diethanolamine; 4; 4 '-methoxyl group-tert-butyl group dibenzoyl methane; 4-isopropyl diphenyl formoxyl methane; 3-(4-methyl benzal) Camphora; the 3-benzylidene camphor; 4-N, the ester of N-(2-ethylhexyl) methylamino benzoic acid and 4-(2-hydroxyl-oxethyl) dibenzoyl methane; titanium dioxide; zinc oxide; ferrum oxide and composition thereof.

5. according to the compositions of aforementioned each claim, wherein said compositions also comprises 0.01%-20%, more preferably the sunscreen actives of 0.1%-10% weight.

6. according to the compositions of aforementioned each claim, wherein the quaternary ammonium composition is selected from general formula (II) or (III) those:

Each R wherein ₅The unit is independently selected from the C of H, side chain or straight chain ₁-C ₆The C of alkyl, side chain or straight chain ₁-C ₆Hydroxyalkyl and composition thereof, preferable methyl and ethoxy; Each R ₆The unit is straight or branched C independently ₁₁-C ₂₂Alkyl, straight or branched C ₁₁-C ₂₂Alkenyl and composition thereof; X ^-Be can be compatible with the adjuvant composition with the skin care active composition anion; M is 1-4, is preferably 2; N is 1-4, is preferably 2, and Q is selected from following carbonyl unit:

With

R wherein ₇Be H, C ₁-C ₄Alkyl, C ₁-C ₄Hydroxyalkyl and composition thereof.

7. according to the compositions of aforementioned each claim; wherein the quaternary ammonium composition is selected from N; N-two (canola acyl group-oxygen-ethyl)-N; N-alkyl dimethyl ammonium chloride, N; N-two (canola acyl group-oxygen-ethyl)-N-methyl; N-(2-ethoxy) methylsulfuric acid ammonium, N, N-two (canola acyl group-oxygen-ethyl)-N-methyl, N-(2-ethoxy) ammonium chloride and their mixture.

8. according to the compositions of aforementioned each claim, wherein compositions comprises vesicle, and described vesicle comprises quaternary ammonium compound and sunscreen actives.

9. according to the compositions of aforementioned each claim, wherein said compositions comprises and is less than 5%, preferably is less than 3%, the anion surfactant of preferred 0% weight.

10. the application of the described compositions of aforementioned each claim in nursing skin.