CN1364545A - Nano Xiaoqinglong medicine and its preparing method - Google Patents
Nano Xiaoqinglong medicine and its preparing method Download PDFInfo
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- CN1364545A CN1364545A CN 01100812 CN01100812A CN1364545A CN 1364545 A CN1364545 A CN 1364545A CN 01100812 CN01100812 CN 01100812 CN 01100812 A CN01100812 A CN 01100812A CN 1364545 A CN1364545 A CN 1364545A
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- 239000003814 drug Substances 0.000 title claims abstract description 47
- 238000000034 method Methods 0.000 title claims description 13
- 239000000463 material Substances 0.000 claims abstract description 20
- 241000758794 Asarum Species 0.000 claims abstract description 10
- 239000002994 raw material Substances 0.000 claims abstract description 7
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims abstract description 5
- 238000001694 spray drying Methods 0.000 claims abstract description 5
- 229940079593 drug Drugs 0.000 claims description 20
- 239000000843 powder Substances 0.000 claims description 10
- 239000002775 capsule Substances 0.000 claims description 7
- 238000002347 injection Methods 0.000 claims description 6
- 239000007924 injection Substances 0.000 claims description 6
- 239000012528 membrane Substances 0.000 claims description 6
- 241000202807 Glycyrrhiza Species 0.000 claims description 5
- 239000008187 granular material Substances 0.000 claims description 5
- 239000006187 pill Substances 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- 239000012141 concentrate Substances 0.000 claims description 4
- 235000008504 concentrate Nutrition 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 4
- 230000008676 import Effects 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- 239000000443 aerosol Substances 0.000 claims description 3
- 239000006196 drop Substances 0.000 claims description 3
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000019634 flavors Nutrition 0.000 claims description 3
- 239000003094 microcapsule Substances 0.000 claims description 3
- 239000002674 ointment Substances 0.000 claims description 3
- 239000000829 suppository Substances 0.000 claims description 3
- 239000006188 syrup Substances 0.000 claims description 3
- 235000020357 syrup Nutrition 0.000 claims description 3
- 239000003826 tablet Substances 0.000 claims description 3
- 229940100688 oral solution Drugs 0.000 claims description 2
- 239000003390 Chinese drug Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 abstract description 9
- 238000002360 preparation method Methods 0.000 abstract description 8
- 244000037364 Cinnamomum aromaticum Species 0.000 abstract 1
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 abstract 1
- 241000218671 Ephedra Species 0.000 abstract 1
- 244000273928 Zingiber officinale Species 0.000 abstract 1
- 235000006886 Zingiber officinale Nutrition 0.000 abstract 1
- 235000008397 ginger Nutrition 0.000 abstract 1
- 238000000874 microwave-assisted extraction Methods 0.000 abstract 1
- 230000000704 physical effect Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 239000002671 adjuvant Substances 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 206010011224 Cough Diseases 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 208000006673 asthma Diseases 0.000 description 2
- 206010006451 bronchitis Diseases 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
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- 239000002086 nanomaterial Substances 0.000 description 2
- 239000011858 nanopowder Substances 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 239000007962 solid dispersion Substances 0.000 description 2
- 206010006458 Bronchitis chronic Diseases 0.000 description 1
- 201000006306 Cor pulmonale Diseases 0.000 description 1
- 201000005702 Pertussis Diseases 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 208000004186 Pulmonary Heart Disease Diseases 0.000 description 1
- 206010037423 Pulmonary oedema Diseases 0.000 description 1
- 206010039085 Rhinitis allergic Diseases 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 210000004404 adrenal cortex Anatomy 0.000 description 1
- 201000010105 allergic rhinitis Diseases 0.000 description 1
- 230000003266 anti-allergic effect Effects 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 208000007451 chronic bronchitis Diseases 0.000 description 1
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- 230000002500 effect on skin Effects 0.000 description 1
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- 230000034659 glycolysis Effects 0.000 description 1
- 206010022000 influenza Diseases 0.000 description 1
- 208000030603 inherited susceptibility to asthma Diseases 0.000 description 1
- 230000004199 lung function Effects 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 210000005259 peripheral blood Anatomy 0.000 description 1
- 239000011886 peripheral blood Substances 0.000 description 1
- 208000008423 pleurisy Diseases 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 208000005333 pulmonary edema Diseases 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
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- Medicinal Preparation (AREA)
Abstract
The nano Xiaoqinglong medicine is prepared with nano ephedra, nano cassia twig, nano Radix Paeoniae Alba, nano dry ginger, nano asarum and other three kinds of nano Chinese medicinal materials in certain proportion as raw material. The new medicine preparation has a grain fineness of 1200-1500 mesh, grain size of 0.1-200 nm, mostly below 100 nm, and new physical property. It is prepared through microwave extraction, decompressing concentration, spray drying in supersonic jet and other steps. It has high biological utilization and obvious treating effect.
Description
The present invention relates to a kind of cold expelling that induces sweat, warm cold retained fluid, cough-relieving flush end, cure mainly affection of exogenous wind-cold, in the cut off the water nano Xiaoqinglong medicine of drink, the invention still further relates to the method for this medication preparation.
Little Green Dragon electuary is a kind of classical Chinese patent medicine, mainly contains and relievings asthma, antiallergic, expansion peripheral blood vessel, the rising skin temperature improves adrenal cortex function and lung function, to hemorheological influence, promote effects such as erythrocyte glycolysis, be used for affection of exogenous wind-cold, in the drink of cutting off the water.But traditional little Green Dragon electuary disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano Xiaoqinglong medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano Xiaoqinglong medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Herba Ephedrae 60-140 part nanometer Ramulus Cinnamomi 60-140 part nanometer Radix Paeoniae Alba 60-140 part
Nanometer Rhizoma Zingiberis 60-140 part nanometric Herbra Asarum 28-72 part nanometer Radix Glycyrrhizae 60-140 part
Nanometer Rhizoma Pinelliae Preparatum 85-115 part nanometer Fructus Schisandrae Chinensis 60-140 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Herba Ephedrae 80-120 part nanometer Ramulus Cinnamomi 80-120 part nanometer Radix Paeoniae Alba 80-120 part
Nanometer Rhizoma Zingiberis 80-120 part nanometric Herbra Asarum 40-60 part nanometer Radix Glycyrrhizae 80-120 part
Nanometer Rhizoma Pinelliae Preparatum 120-180 part nanometer Fructus Schisandrae Chinensis 80-120 part
The optimum weight proportioning of medicine of the present invention is:
100 parts of 100 parts of nanometer Radix Paeoniae Albas of 100 parts of nanometer Ramulus Cinnamomi of nanometer Herba Ephedrae
100 parts in 50 parts of nanometer Radix Glycyrrhizaes of 100 parts of nanometric Herbra Asarums of nanometer Rhizoma Zingiberis
100 parts of 150 parts of nanometer Fructus Schisandrae Chinensis of nanometer Rhizoma Pinelliae Preparatum
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get the Xiaoqinglong nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano Xiaoqinglong medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common little Green Dragon electuary preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that powder, tablet, suppository, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup of nano Xiaoqinglong medicine etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for bronchial asthma, acute/chronic bronchitis, pneumonia, pertussis, chronic cough, flu, allergic rhinitis, and pleuritis, pulmonary edema, pulmonary heart disease, treatment of conditions such as ophthalmic, clinical efficacy significantly is better than traditional little Green Dragon electuary.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
100 parts of 100 parts of nanometer Radix Paeoniae Albas of 100 parts of nanometer Ramulus Cinnamomi of nanometer Herba Ephedrae
100 parts in 50 parts of nanometer Radix Glycyrrhizaes of 100 parts of nanometric Herbra Asarums of nanometer Rhizoma Zingiberis
100 parts of 150 parts of nanometer Fructus Schisandrae Chinensis of nanometer Rhizoma Pinelliae Preparatum
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
100 parts of 100 parts of nanometer Radix Paeoniae Albas of 100 parts of nanometer Ramulus Cinnamomi of nanometer Herba Ephedrae
100 parts in 50 parts of nanometer Radix Glycyrrhizaes of 100 parts of nanometric Herbra Asarums of nanometer Rhizoma Zingiberis
100 parts of 150 parts of nanometer Fructus Schisandrae Chinensis of nanometer Rhizoma Pinelliae Preparatum
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make the little Green Dragon powder needle injection of nanometer, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Be equipped with nano raw material by preceding method:
100 parts of 100 parts of nanometer Radix Paeoniae Albas of 100 parts of nanometer Ramulus Cinnamomi of nanometer Herba Ephedrae
100 parts in 50 parts of nanometer Radix Glycyrrhizaes of 100 parts of nanometric Herbra Asarums of nanometer Rhizoma Zingiberis
100 parts of 150 parts of nanometer Fructus Schisandrae Chinensis of nanometer Rhizoma Pinelliae Preparatum
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make the little Green Dragon membrane of nanometer, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: back, chest.
Claims (6)
1, a kind of nano Xiaoqinglong medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Herba Ephedrae 60-140 part nanometer Ramulus Cinnamomi 60-140 part nanometer Radix Paeoniae Alba 60-140 part
Nanometer Rhizoma Zingiberis 60-140 part nanometric Herbra Asarum 28-72 part nanometer Radix Glycyrrhizae 60-140 part
15 parts of nanometer Fructus Schisandrae Chinensis of nanometer Rhizoma Pinelliae Preparatum 85-1 60-140 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano Xiaoqinglong medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Herba Ephedrae 80-120 part nanometer Ramulus Cinnamomi 80-120 part nanometer Radix Paeoniae Alba 80-120 part
Nanometer Rhizoma Zingiberis 80-120 part nanometric Herbra Asarum 40-60 part nanometer Radix Glycyrrhizae 80-120 part
Nanometer Rhizoma Pinelliae Preparatum 120-180 part nanometer Fructus Schisandrae Chinensis 80-120 part
3, nano Xiaoqinglong medicine according to claim 1, wherein the weight proportion of each nano raw material is:
100 parts of 100 parts of nanometer Radix Paeoniae Albas of 100 parts of nanometer Ramulus Cinnamomi of nanometer Herba Ephedrae
100 parts in 50 parts of nanometer Radix Glycyrrhizaes of 100 parts of nanometric Herbra Asarums of nanometer Rhizoma Zingiberis
100 parts of 150 parts of nanometer Fructus Schisandrae Chinensis of nanometer Rhizoma Pinelliae Preparatum
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano Xiaoqinglong medicines.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano Xiaoqinglong medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100812 CN1364545A (en) | 2001-01-11 | 2001-01-11 | Nano Xiaoqinglong medicine and its preparing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100812 CN1364545A (en) | 2001-01-11 | 2001-01-11 | Nano Xiaoqinglong medicine and its preparing method |
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| Publication Number | Publication Date |
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| CN1364545A true CN1364545A (en) | 2002-08-21 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01100812 Pending CN1364545A (en) | 2001-01-11 | 2001-01-11 | Nano Xiaoqinglong medicine and its preparing method |
Country Status (1)
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| CN (1) | CN1364545A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102552837A (en) * | 2010-12-27 | 2012-07-11 | 江西济民可信集团有限公司 | Preparation method of xiaoqinglong mixture |
| CN116889601A (en) * | 2023-07-05 | 2023-10-17 | 广西中医药大学 | Magnolia flower traditional Chinese medicine composition, particle preparation method and application |
-
2001
- 2001-01-11 CN CN 01100812 patent/CN1364545A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102552837A (en) * | 2010-12-27 | 2012-07-11 | 江西济民可信集团有限公司 | Preparation method of xiaoqinglong mixture |
| CN116889601A (en) * | 2023-07-05 | 2023-10-17 | 广西中医药大学 | Magnolia flower traditional Chinese medicine composition, particle preparation method and application |
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