CN1366894A - Nano lung-clearing anti-inflammatory preparation medicine and preparation method thereof - Google Patents
Nano lung-clearing anti-inflammatory preparation medicine and preparation method thereof Download PDFInfo
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- CN1366894A CN1366894A CN 01102033 CN01102033A CN1366894A CN 1366894 A CN1366894 A CN 1366894A CN 01102033 CN01102033 CN 01102033 CN 01102033 A CN01102033 A CN 01102033A CN 1366894 A CN1366894 A CN 1366894A
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- 239000003814 drug Substances 0.000 title claims abstract description 46
- 238000002360 preparation method Methods 0.000 title claims abstract description 21
- 230000003110 anti-inflammatory effect Effects 0.000 title claims description 20
- 239000000463 material Substances 0.000 claims abstract description 20
- 238000000034 method Methods 0.000 claims abstract description 13
- XOJVHLIYNSOZOO-SWOBOCGESA-N Arctiin Chemical compound C1=C(OC)C(OC)=CC=C1C[C@@H]1[C@@H](CC=2C=C(OC)C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O)=CC=2)C(=O)OC1 XOJVHLIYNSOZOO-SWOBOCGESA-N 0.000 claims abstract description 10
- 239000002994 raw material Substances 0.000 claims abstract description 7
- 241000361919 Metaphire sieboldi Species 0.000 claims abstract description 5
- 238000001694 spray drying Methods 0.000 claims abstract description 5
- 210000000582 semen Anatomy 0.000 claims description 27
- 229940079593 drug Drugs 0.000 claims description 20
- 206010004542 Bezoar Diseases 0.000 claims description 9
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 claims description 9
- 239000000843 powder Substances 0.000 claims description 9
- 239000002775 capsule Substances 0.000 claims description 7
- 239000008187 granular material Substances 0.000 claims description 6
- 238000002347 injection Methods 0.000 claims description 6
- 239000007924 injection Substances 0.000 claims description 6
- 239000012528 membrane Substances 0.000 claims description 6
- 239000006187 pill Substances 0.000 claims description 6
- 241001108921 Asclepias asperula Species 0.000 claims description 5
- 241001233061 earthworms Species 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- 241000282817 Bovidae Species 0.000 claims description 4
- 239000012141 concentrate Substances 0.000 claims description 4
- 235000008504 concentrate Nutrition 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 4
- 230000008676 import Effects 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- 239000000443 aerosol Substances 0.000 claims description 3
- 239000006196 drop Substances 0.000 claims description 3
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000019634 flavors Nutrition 0.000 claims description 3
- 239000003094 microcapsule Substances 0.000 claims description 3
- 229940100688 oral solution Drugs 0.000 claims description 3
- 239000000829 suppository Substances 0.000 claims description 3
- 239000006188 syrup Substances 0.000 claims description 3
- 235000020357 syrup Nutrition 0.000 claims description 3
- 239000002674 ointment Substances 0.000 claims description 2
- 239000003826 tablet Substances 0.000 claims description 2
- 239000003390 Chinese drug Substances 0.000 claims 2
- 241000208843 Arctium Species 0.000 abstract 1
- 241000218671 Ephedra Species 0.000 abstract 1
- 229910052602 gypsum Inorganic materials 0.000 abstract 1
- 239000010440 gypsum Substances 0.000 abstract 1
- 238000000874 microwave-assisted extraction Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 8
- 239000003795 chemical substances by application Substances 0.000 description 6
- 206010006451 bronchitis Diseases 0.000 description 5
- 208000006673 asthma Diseases 0.000 description 4
- 206010006458 Bronchitis chronic Diseases 0.000 description 3
- 206010011224 Cough Diseases 0.000 description 3
- 206010044302 Tracheitis Diseases 0.000 description 3
- 239000002671 adjuvant Substances 0.000 description 3
- 208000007451 chronic bronchitis Diseases 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 206010062717 Increased upper airway secretion Diseases 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 239000003172 expectorant agent Substances 0.000 description 2
- 230000003419 expectorant effect Effects 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000002086 nanomaterial Substances 0.000 description 2
- 239000011858 nanopowder Substances 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 208000026435 phlegm Diseases 0.000 description 2
- 230000002685 pulmonary effect Effects 0.000 description 2
- 239000007962 solid dispersion Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 206010057190 Respiratory tract infections Diseases 0.000 description 1
- 206010046306 Upper respiratory tract infection Diseases 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 230000000954 anitussive effect Effects 0.000 description 1
- 229940124584 antitussives Drugs 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical compound C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
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- Medicinal Preparation (AREA)
Abstract
The present invention discloses a nano Qingfei Xiaoyan preparation medicine. It is made up by using 8 Chinese medicinal materials of nano ephedra, nano gypsum, nano earthworm, nano arctium, nano tingli and others as raw material through the processes of microwave extraction, reduced pressure concentration and supersonic jet spray drying. Its grain fineness is up to 1200-1500 meshes, grain size is 0.1-200 nm, in which most of grain size is less than 100 nm.
Description
The present invention relates to a kind of removing heat from the lung and dissipating phlegm, relieving cough and asthma, cure mainly the nano lung-clearing anti-inflammatory preparation medicine of thermal images such as cough with asthma expectorant due to tracheitis, bronchitis, chronic bronchitis, the pulmonary infection is thick, the invention still further relates to the method for this medication preparation.
The lung-clearing anti-inflammatory ball is a kind of classical Chinese patent medicine, and effect such as mainly contain antiinflammatory, antitussive, eliminate the phlegm, relieving asthma is used for thermal images such as cough with asthma expectorant due to tracheitis, bronchitis, chronic bronchitis, the pulmonary infection is thick.But traditional lung-clearing anti-inflammatory ball disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano lung-clearing anti-inflammatory preparation medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano lung-clearing anti-inflammatory preparation medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Herba Ephedrae 50-500 part nanometer Gypsum Fibrosum 100-500 part nanometer earthworm 100-500 part
Nanometer Fructus Arctii 100-500 part nanometer Semen Lepidii (Semen Descurainiae) 100-500 part nano bezoar 1-10 part
Nanometer Semen Armeniacae Amarum 100-500 part nano antelope horn 20-80 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Herba Ephedrae 100-300 part nanometer Gypsum Fibrosum 150-400 part nanometer earthworm 200-400 part
Nanometer Fructus Arctii 200-400 part nanometer Semen Lepidii (Semen Descurainiae) 150-400 part nano bezoar 3-8 part
Nanometer Semen Armeniacae Amarum 150-400 part nano antelope horn 30-70 part
The optimum weight proportioning of medicine of the present invention is:
300 parts of 250 parts of nanometer earthworms of 200 parts of nanometer Gypsum Fibrosum of nanometer Herba Ephedrae
5 parts of 250 parts of nano bezoars of 300 parts of nanometer Semen Lepidii (Semen Descurainiae)s of nanometer Fructus Arctii
50 parts of 260 parts of nano antelope horns of nanometer Semen Armeniacae Amarum
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, blue or green agent, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get the lung-clearing anti-inflammatory preparation nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano lung-clearing anti-inflammatory preparation medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common lung-clearing anti-inflammatory pill material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nano lung-clearing anti-inflammatory preparation medicine etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for the acute tracheitis that upper respiratory tract infection causes, treatment of conditions such as chronic bronchitis acute reaction, and clinical efficacy significantly is better than traditional lung-clearing anti-inflammatory ball.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
300 parts of 250 parts of nanometer earthworms of 200 parts of nanometer Gypsum Fibrosum of nanometer Herba Ephedrae
5 parts of 250 parts of nano bezoars of 300 parts of nanometer Semen Lepidii (Semen Descurainiae)s of nanometer Fructus Arctii
50 parts of 260 parts of nano antelope horns of nanometer Semen Armeniacae Amarum
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
300 parts of 250 parts of nanometer earthworms of 200 parts of nanometer Gypsum Fibrosum of nanometer Herba Ephedrae
5 parts of 250 parts of nano bezoars of 300 parts of nanometer Semen Lepidii (Semen Descurainiae)s of nanometer Fructus Arctii
50 parts of 260 parts of nano antelope horns of nanometer Semen Armeniacae Amarum
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make the nano lung-clearing anti-inflammatory powder needle injection, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
300 parts of 250 parts of nanometer earthworms of 200 parts of nanometer Gypsum Fibrosum of nanometer Herba Ephedrae
5 parts of 250 parts of nano bezoars of 300 parts of nanometer Semen Lepidii (Semen Descurainiae)s of nanometer Fructus Arctii
50 parts of 260 parts of nano antelope horns of nanometer Semen Armeniacae Amarum
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make the nano lung-clearing anti-inflammatory membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: back, chest.
Claims (6)
1, a kind of nano lung-clearing anti-inflammatory preparation medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Herba Ephedrae 50-500 part nanometer Gypsum Fibrosum 100-500 part nanometer earthworm 100-500 part
Nanometer Fructus Arctii 100-500 part nanometer Semen Lepidii (Semen Descurainiae) 100-500 part nano bezoar 1-10 part
Nanometer Semen Armeniacae Amarum 100-500 part nano antelope horn 20-80 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano lung-clearing anti-inflammatory preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Herba Ephedrae 100-300 part nanometer Gypsum Fibrosum 150-400 part nanometer earthworm 200-400 part
Nanometer Fructus Arctii 200-400 part nanometer Semen Lepidii (Semen Descurainiae) 150-400 part nano bezoar 3-8 part
Nanometer Semen Armeniacae Amarum 150-400 part nano antelope horn 30-70 part
3, nano lung-clearing anti-inflammatory preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
300 parts of 250 parts of nanometer earthworms of 200 parts of nanometer Gypsum Fibrosum of nanometer Herba Ephedrae
5 parts of 250 parts of nano bezoars of 300 parts of nanometer Semen Lepidii (Semen Descurainiae)s of nanometer Fructus Arctii
50 parts of 260 parts of nano antelope horns of nanometer Semen Armeniacae Amarum
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano lung-clearing anti-inflammatory preparation medicines.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano lung-clearing anti-inflammatory preparation medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01102033 CN1366894A (en) | 2001-01-22 | 2001-01-22 | Nano lung-clearing anti-inflammatory preparation medicine and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01102033 CN1366894A (en) | 2001-01-22 | 2001-01-22 | Nano lung-clearing anti-inflammatory preparation medicine and preparation method thereof |
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| Publication Number | Publication Date |
|---|---|
| CN1366894A true CN1366894A (en) | 2002-09-04 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01102033 Pending CN1366894A (en) | 2001-01-22 | 2001-01-22 | Nano lung-clearing anti-inflammatory preparation medicine and preparation method thereof |
Country Status (1)
| Country | Link |
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| CN (1) | CN1366894A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1314418C (en) * | 2003-12-23 | 2007-05-09 | 天津中新药业集团股份有限公司达仁堂制药厂 | Medicine for clearing away lung-heat, eliminating phaegn, reliveing cough and asthma and its preparing method |
| CN102706984A (en) * | 2012-07-03 | 2012-10-03 | 天津中新药业集团股份有限公司达仁堂制药厂 | Method for determining ephedrine hydrochloride content in lung-clearing inflammation pill by high-performance liquid phase |
-
2001
- 2001-01-22 CN CN 01102033 patent/CN1366894A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1314418C (en) * | 2003-12-23 | 2007-05-09 | 天津中新药业集团股份有限公司达仁堂制药厂 | Medicine for clearing away lung-heat, eliminating phaegn, reliveing cough and asthma and its preparing method |
| CN102706984A (en) * | 2012-07-03 | 2012-10-03 | 天津中新药业集团股份有限公司达仁堂制药厂 | Method for determining ephedrine hydrochloride content in lung-clearing inflammation pill by high-performance liquid phase |
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