CN1368329A - Nano medicine 'Xiaoer Zhuhuang' and its preparing process - Google Patents
Nano medicine 'Xiaoer Zhuhuang' and its preparing process Download PDFInfo
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- CN1368329A CN1368329A CN 01103618 CN01103618A CN1368329A CN 1368329 A CN1368329 A CN 1368329A CN 01103618 CN01103618 CN 01103618 CN 01103618 A CN01103618 A CN 01103618A CN 1368329 A CN1368329 A CN 1368329A
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- zhuhuang
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- 239000008675 zhuhuang Substances 0.000 title claims abstract description 14
- 239000003814 drug Substances 0.000 title claims description 45
- 238000000034 method Methods 0.000 title claims description 13
- 239000000463 material Substances 0.000 claims abstract description 20
- 241000219061 Rheum Species 0.000 claims abstract description 10
- 235000009411 Rheum rhabarbarum Nutrition 0.000 claims abstract description 10
- 239000000843 powder Substances 0.000 claims abstract description 9
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 5
- 238000001694 spray drying Methods 0.000 claims abstract description 5
- 229940079593 drug Drugs 0.000 claims description 18
- 210000000582 semen Anatomy 0.000 claims description 18
- 239000011049 pearl Substances 0.000 claims description 11
- 206010004542 Bezoar Diseases 0.000 claims description 9
- 241000675108 Citrus tangerina Species 0.000 claims description 9
- 244000247747 Coptis groenlandica Species 0.000 claims description 9
- 235000002991 Coptis groenlandica Nutrition 0.000 claims description 9
- 229920002892 amber Polymers 0.000 claims description 9
- 239000002775 capsule Substances 0.000 claims description 7
- 239000008187 granular material Substances 0.000 claims description 6
- 238000002347 injection Methods 0.000 claims description 6
- 239000007924 injection Substances 0.000 claims description 6
- 239000012528 membrane Substances 0.000 claims description 6
- 239000006187 pill Substances 0.000 claims description 6
- 239000002994 raw material Substances 0.000 claims description 6
- 239000000284 extract Substances 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- 239000012141 concentrate Substances 0.000 claims description 4
- 235000008504 concentrate Nutrition 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 4
- 230000008676 import Effects 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- 239000000443 aerosol Substances 0.000 claims description 3
- 239000006196 drop Substances 0.000 claims description 3
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000019634 flavors Nutrition 0.000 claims description 3
- 239000003094 microcapsule Substances 0.000 claims description 3
- 239000002674 ointment Substances 0.000 claims description 3
- 229940100688 oral solution Drugs 0.000 claims description 3
- 239000000829 suppository Substances 0.000 claims description 3
- 239000006188 syrup Substances 0.000 claims description 3
- 235000020357 syrup Nutrition 0.000 claims description 3
- 239000003826 tablet Substances 0.000 claims description 3
- 239000003390 Chinese drug Substances 0.000 claims 2
- 244000080767 Areca catechu Species 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 9
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 abstract 1
- 229940116229 borneol Drugs 0.000 abstract 1
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 abstract 1
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 description 7
- 239000003795 chemical substances by application Substances 0.000 description 5
- 241000202755 Areca Species 0.000 description 4
- 206010010904 Convulsion Diseases 0.000 description 4
- 230000036461 convulsion Effects 0.000 description 4
- 239000002671 adjuvant Substances 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 206010010774 Constipation Diseases 0.000 description 2
- 206010011224 Cough Diseases 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 206010016825 Flushing Diseases 0.000 description 2
- 208000007101 Muscle Cramp Diseases 0.000 description 2
- 206010030302 Oliguria Diseases 0.000 description 2
- 206010037660 Pyrexia Diseases 0.000 description 2
- 208000037656 Respiratory Sounds Diseases 0.000 description 2
- 208000005392 Spasm Diseases 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 201000006549 dyspepsia Diseases 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 230000000968 intestinal effect Effects 0.000 description 2
- 239000002086 nanomaterial Substances 0.000 description 2
- 239000011858 nanopowder Substances 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 238000010926 purge Methods 0.000 description 2
- 206010037833 rales Diseases 0.000 description 2
- 239000007962 solid dispersion Substances 0.000 description 2
- 230000002936 tranquilizing effect Effects 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
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- Medicinal Preparation (AREA)
Abstract
A nanometre (0.1-200 nm) emdicine "Xiaoer Zhuhuang" is prepared from the nanometre powders of 10 Chinese medicinal materials including rhu barb, pearl, borneol, etc. through proportioning, microwave extracting, pressure reduction concentrating and supersonic-jet spray drying. Its grain fineness reaches 1200-1500 meshes and grain diameters are 0.1-200 nm. Its advantages are high biological utilization rate and high curative effect.
Description
The present invention relates to the nano medicine ' Xiaoer Zhuhuang ' of a kind of pathogenic fire purging intestinal stasis relieving, tranquillizing the mind by relieving convulsion, the invention still further relates to the method for this medication preparation.
Children's's Zhu Huang San is a kind of classical Chinese patent medicine, mainly contains effects such as pathogenic fire purging intestinal stasis relieving, tranquillizing the mind by relieving convulsion, is used for children's's dyspepsia and holds flushed face and red lips, fever of the body uneasiness, cough rale, oliguria with reddish urine, constipation, the convulsion with spasms that heat causes under the arm.But traditional children's's Zhu Huang San absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano medicine ' Xiaoer Zhuhuang ' of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano medicine ' Xiaoer Zhuhuang '.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nano rhubarb 200-450 part nanometer Semen Pharbitidis 40-90 part nanometer Semen Arecae 200-400 part
The tangerine 100-250 part of nanometer coptis 60-150 part nanorize nano-pearl 1-5 part
Nano bezoar 10-25 part nano amber 40-90 part nanometer Cinnabaris 100-200 part
Nanometer Borneolum Syntheticum 20-45 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nano rhubarb 250-350 part nanometer Semen Pharbitidis 50-80 part nanometer Semen Arecae 250-350 part
The tangerine 120-180 part of nanometer coptis 70-120 part nanorize nano-pearl 1-2 part
Nano bezoar 12-18 part nano amber 50-80 part nanometer Cinnabaris 120-180 part
Nanometer Borneolum Syntheticum 25-35 part
The optimum weight proportioning of medicine of the present invention is:
300 parts of 60 portions of nanometer Semen Arecaes of 300 parts of nanometer Semen Pharbitidiss of nano rhubarb
1.5 parts of the tangerine 150 parts of nano-pearls of 90 parts of nanorize of nanometer coptis
150 parts in 60 parts of nanometer Cinnabaris of 15 parts of nano ambers of nano bezoar
30 parts of nanometer Borneolum Syntheticums
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with hypersonic velocity instantaneous jet drying.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get the 'Xiaoer Zhuhuang ' nano powder with hypersonic velocity instantaneous jet drying;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano medicine ' Xiaoer Zhuhuang ' is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common children's's Zhu Huang San preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the novel form that pill, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nano medicine ' Xiaoer Zhuhuang ' etc. had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for children's's dyspepsia and holds flushed face and red lips, fever of the body uneasiness, the treatment of conditions such as rale, oliguria with reddish urine, constipation, convulsion with spasms of coughing that heat causes under the arm, and clinical efficacy significantly is better than traditional children's's Zhu Huang San.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
300 parts of 60 portions of nanometer Semen Arecaes of 300 parts of nanometer Semen Pharbitidiss of nano rhubarb
1.5 parts of the tangerine 150 parts of nano-pearls of 90 parts of nanorize of nanometer coptis
150 parts in 60 parts of nanometer Cinnabaris of 15 parts of nano ambers of nano bezoar
30 parts of nanometer Borneolum Syntheticums
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
300 parts of 60 portions of nanometer Semen Arecaes of 300 parts of nanometer Semen Pharbitidiss of nano rhubarb
1.5 parts of the tangerine 150 parts of nano-pearls of 90 parts of nanorize of nanometer coptis
150 parts in 60 parts of nanometer Cinnabaris of 15 parts of nano ambers of nano bezoar
30 parts of nanometer Borneolum Syntheticums
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make nano children's pearl bloom needle injection, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
300 parts of 60 portions of nanometer Semen Arecaes of 300 parts of nanometer Semen Pharbitidiss of nano rhubarb
1.5 parts of the tangerine 150 parts of nano-pearls of 90 parts of nanorize of nanometer coptis
150 parts in 60 parts of nanometer Cinnabaris of 15 parts of nano ambers of nano bezoar
30 parts of nanometer Borneolum Syntheticums
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make the yellow membrane of nano children's pearl, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part, back, chest.
Claims (6)
1, a kind of nano medicine ' Xiaoer Zhuhuang ' is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nano rhubarb 200-450 part nanometer Semen Pharbitidis 40-90 part nanometer Semen Arecae 200-400 part
The tangerine 100-250 part of nanometer coptis 60-150 part nanorize nano-pearl 1-5 part
Nano bezoar 10-25 part nano amber 40-90 part nanometer Cinnabaris 100-200 part
Nanometer Borneolum Syntheticum 20-45 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano medicine ' Xiaoer Zhuhuang ' according to claim 1, wherein the weight proportion of each nano raw material is:
Nano rhubarb 250-350 part nanometer Semen Pharbitidis 50-80 part nanometer Semen Arecae 250-350 part
The tangerine 120-180 part of nanometer coptis 70-120 part nanorize nano-pearl 1-2 part
Nano bezoar 12-18 part nano amber 50-80 part nanometer Cinnabaris 120-180 part
Nanometer Borneolum Syntheticum 25-35 part
3, nano medicine ' Xiaoer Zhuhuang ' according to claim 1, wherein the weight proportion of each nano raw material is:
300 parts of 60 portions of nanometer Semen Arecaes of 300 parts of nanometer Semen Pharbitidiss of nano rhubarb
1.5 parts of the tangerine 150 parts of nano-pearls of 90 parts of nanorize of nanometer coptis
150 parts in 60 parts of nanometer Cinnabaris of 15 parts of nano ambers of nano bezoar
30 parts of nanometer Borneolum Syntheticums
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano medicine ' Xiaoer Zhuhuang 's.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano medicine ' Xiaoer Zhuhuang 's; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01103618 CN1368329A (en) | 2001-02-05 | 2001-02-05 | Nano medicine 'Xiaoer Zhuhuang' and its preparing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01103618 CN1368329A (en) | 2001-02-05 | 2001-02-05 | Nano medicine 'Xiaoer Zhuhuang' and its preparing process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1368329A true CN1368329A (en) | 2002-09-11 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01103618 Pending CN1368329A (en) | 2001-02-05 | 2001-02-05 | Nano medicine 'Xiaoer Zhuhuang' and its preparing process |
Country Status (1)
| Country | Link |
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| CN (1) | CN1368329A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105748727A (en) * | 2014-12-19 | 2016-07-13 | 天津中新药业集团股份有限公司乐仁堂制药厂 | Traditional Chinese medicinal composition for reducing phlegm and reliving coughs, and preparation method thereof |
-
2001
- 2001-02-05 CN CN 01103618 patent/CN1368329A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105748727A (en) * | 2014-12-19 | 2016-07-13 | 天津中新药业集团股份有限公司乐仁堂制药厂 | Traditional Chinese medicinal composition for reducing phlegm and reliving coughs, and preparation method thereof |
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| WD01 | Invention patent application deemed withdrawn after publication |