CN1365738A - Nano tiger bone-papaya medicine and its preparing process - Google Patents
Nano tiger bone-papaya medicine and its preparing process Download PDFInfo
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- CN1365738A CN1365738A CN 01100695 CN01100695A CN1365738A CN 1365738 A CN1365738 A CN 1365738A CN 01100695 CN01100695 CN 01100695 CN 01100695 A CN01100695 A CN 01100695A CN 1365738 A CN1365738 A CN 1365738A
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- 239000003814 drug Substances 0.000 title claims abstract description 46
- 241000282376 Panthera tigris Species 0.000 title claims abstract description 28
- 238000000034 method Methods 0.000 title claims description 13
- 239000000463 material Substances 0.000 claims abstract description 19
- 239000000843 powder Substances 0.000 claims abstract description 11
- 241000208340 Araliaceae Species 0.000 claims abstract description 10
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims abstract description 10
- 235000003140 Panax quinquefolius Nutrition 0.000 claims abstract description 10
- 210000000988 bone and bone Anatomy 0.000 claims abstract description 10
- 235000008434 ginseng Nutrition 0.000 claims abstract description 10
- 238000001694 spray drying Methods 0.000 claims abstract description 5
- 229940079593 drug Drugs 0.000 claims description 20
- 241000125175 Angelica Species 0.000 claims description 9
- 241000213006 Angelica dahurica Species 0.000 claims description 9
- 241000903946 Clematidis Species 0.000 claims description 9
- 235000001287 Guettarda speciosa Nutrition 0.000 claims description 9
- 239000002775 capsule Substances 0.000 claims description 7
- 239000008187 granular material Substances 0.000 claims description 6
- 238000002347 injection Methods 0.000 claims description 6
- 239000007924 injection Substances 0.000 claims description 6
- 239000012528 membrane Substances 0.000 claims description 6
- 239000006187 pill Substances 0.000 claims description 6
- 239000002994 raw material Substances 0.000 claims description 6
- 239000002904 solvent Substances 0.000 claims description 5
- 239000012141 concentrate Substances 0.000 claims description 4
- 235000008504 concentrate Nutrition 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 4
- 230000008676 import Effects 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- 239000000443 aerosol Substances 0.000 claims description 3
- 239000006196 drop Substances 0.000 claims description 3
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000019634 flavors Nutrition 0.000 claims description 3
- 239000003094 microcapsule Substances 0.000 claims description 3
- 239000002674 ointment Substances 0.000 claims description 3
- 229940100688 oral solution Drugs 0.000 claims description 3
- 239000000829 suppository Substances 0.000 claims description 3
- 239000006188 syrup Substances 0.000 claims description 3
- 235000020357 syrup Nutrition 0.000 claims description 3
- 239000003826 tablet Substances 0.000 claims description 3
- 239000003390 Chinese drug Substances 0.000 claims 2
- 241001506304 Kadsura japonica Species 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 9
- 241000173529 Aconitum napellus Species 0.000 abstract 1
- 240000006432 Carica papaya Species 0.000 abstract 1
- 235000009467 Carica papaya Nutrition 0.000 abstract 1
- 229940023019 aconite Drugs 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 description 6
- 239000003795 chemical substances by application Substances 0.000 description 5
- 241001506371 Kadsura Species 0.000 description 4
- 210000003205 muscle Anatomy 0.000 description 4
- 239000002671 adjuvant Substances 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 206010062575 Muscle contracture Diseases 0.000 description 2
- 210000001367 artery Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
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- 239000006185 dispersion Substances 0.000 description 2
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- 210000003414 extremity Anatomy 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
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- 239000002086 nanomaterial Substances 0.000 description 2
- 239000011858 nanopowder Substances 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 230000002040 relaxant effect Effects 0.000 description 2
- 239000007962 solid dispersion Substances 0.000 description 2
- 210000002435 tendon Anatomy 0.000 description 2
- 210000003462 vein Anatomy 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 241000380450 Danaus melanippus Species 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
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- 230000002349 favourable effect Effects 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
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- 229940008173 papaya preparation Drugs 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
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- Medicinal Preparation (AREA)
Abstract
A nanometre tigerbone-papaya medicine is prepared from the nanometer powders of 13 Chinese medicinal materials including tiger bone, papaya, wild aconite root, ginseng, etc. through proportioning, microwave extracting, pressure reduction concentrating and supersonic-jet spray drying. Its grain fineness reaches 1200-1500 meshes and grain diameters are 0.1-200 nm. Its advantages are high biological utilization rate and high curative effect.
Description
The present invention relates to the nano tiger bone-papaya medicine of a kind of invigorating blood and dispelling wind, muscles and tendons relaxing to alleviate pain, the invention still further relates to the method for this medication preparation.
The tiger bone-papaya ball is a kind of classical Chinese patent medicine, mainly contains effects such as invigorating blood and dispelling wind, muscles and tendons relaxing to alleviate pain, is used for limbs pain, numb hand and foot, the contracture of muscle arteries and veins, weakness of the waist and knees that wind-cold damp pathogen causes, walks with difficulty.But traditional tiger bone-papaya ball disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano tiger bone-papaya medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano tiger bone-papaya medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nano tiger bone 4-12 part nanometer Os pardi 40-105 part nanometer Radix Clematidis 50-110 part
Nanometer Fructus Chaenomelis 50-110 part nanometer Caulis Piperis Kadsurae 50-110 part nanometer Caulis Sinomenii 50-110 part
Nanometer Radix Aconiti Kusnezoffii 20-60 part nanometer Radix Aconiti 20-60 part nanometer Radix Achyranthis Bidentatae 100-220 part
Nano angelica root 50-110 part nano Chinese angelica 50-110 part nano ginseng 6-14 part
Nanometer Rhizoma Chuanxiong 50-110 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nano tiger bone 6-10 part nanometer Os pardi 55-90 part nanometer Radix Clematidis 65-95 part
Nanometer Fructus Chaenomelis 65-95 part nanometer Caulis Piperis Kadsurae 65-95 part nanometer Caulis Sinomenii 65-95 part
Nanometer GEWU 30-50 part nanometer Radix Aconiti 30-50 part nanometer Radix Achyranthis Bidentatae 130-190 part
Nano angelica root 65-95 part nano Chinese angelica 65-95 part nano ginseng 8-12 part
Nanometer Rhizoma Chuanxiong 65-95 part
The optimum weight proportioning of medicine of the present invention is:
80 parts of 72 parts of nanometer Radix Clematidiss of 8 parts of nanometer Os pardis of nano tiger bone
80 parts of 80 parts of nanometer Caulis Sinomeniis of 80 parts of nanometer Caulis Piperis Kadsuraes of nanometer Fructus Chaenomelis
160 parts of 40 parts of nanometer Radix Achyranthis Bidentataes of 40 parts of nanometer Radix Aconitis of nanometer Radix Aconiti Kusnezoffii
10 parts of 80 parts of nano ginsengs of 80 parts of nano Chinese angelicas of nano angelica root
80 parts of nanometer Rhizoma Chuanxiongs
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since nano material special construction---material grains size is less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get tiger bone-papaya preparation nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano tiger bone-papaya medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common tiger bone-papaya pill material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nano tiger bone-papaya medicine etc. is had no precedent in the past.
Treatment of conditions such as pharmaceutical preparation of the present invention can be used for limbs pain, numb hand and foot, the contracture of muscle arteries and veins, weakness of the waist and knees that wind-cold damp pathogen causes, walk with difficulty, clinical efficacy significantly is better than traditional tiger bone-papaya ball.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
80 parts of 72 parts of nanometer Radix Clematidiss of 8 parts of nanometer Os pardis of nano tiger bone
80 parts of 80 parts of nanometer Caulis Sinomeniis of 80 parts of nanometer Caulis Piperis Kadsuraes of nanometer Fructus Chaenomelis
160 parts of 40 parts of nanometer Radix Achyranthis Bidentataes of 40 parts of nanometer Radix Aconitis of nanometer Radix Aconiti Kusnezoffii
10 parts of 80 parts of nano ginsengs of 80 parts of nano Chinese angelicas of nano angelica root
80 parts of nanometer Rhizoma Chuanxiongs
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
80 parts of 72 parts of nanometer Radix Clematidiss of 8 parts of nanometer Os pardis of nano tiger bone
80 parts of 80 parts of nanometer Caulis Sinomeniis of 80 parts of nanometer Caulis Piperis Kadsuraes of nanometer Fructus Chaenomelis
160 parts of 40 parts of nanometer Radix Achyranthis Bidentataes of 40 parts of nanometer Radix Aconitis of nanometer Radix Aconiti Kusnezoffii
10 parts of 80 parts of nano ginsengs of 80 parts of nano Chinese angelicas of nano angelica root
80 parts of nanometer Rhizoma Chuanxiongs
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make the nano tiger bone-papaya powder needle injection, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
80 parts of 72 parts of nanometer Radix Clematidiss of 8 parts of nanometer Os pardis of nano tiger bone
80 parts of 80 parts of nanometer Caulis Sinomeniis of 80 parts of nanometer Caulis Piperis Kadsuraes of nanometer Fructus Chaenomelis
160 parts of 40 parts of nanometer Radix Achyranthis Bidentataes of 40 parts of nanometer Radix Aconitis of nanometer Radix Aconiti Kusnezoffii
10 parts of 80 parts of nano ginsengs of 80 parts of nano Chinese angelicas of nano angelica root
80 parts of nanometer Rhizoma Chuanxiongs
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make the nano tiger bone-papaya membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part, back or affected part.
Claims (6)
1, a kind of nano tiger bone-papaya medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nano tiger bone 4-12 part nanometer Os pardi 40-105 part nanometer Radix Clematidis 50-110 part
Nanometer Fructus Chaenomelis 50-110 part nanometer Caulis Piperis Kadsurae 50-110 part nanometer Caulis Sinomenii 50-110 part
Nanometer Radix Aconiti Kusnezoffii 20-60 part nanometer Radix Aconiti 20-60 part nanometer Radix Achyranthis Bidentatae 100-220 part
Nano angelica root 50-110 part nano Chinese angelica 50-110 part nano ginseng 6-14 part
Nanometer Rhizoma Chuanxiong 50-110 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano tiger bone-papaya medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nano tiger bone 6-10 part nanometer Os pardi 55-90 part nanometer Radix Clematidis 65-95 part
Nanometer Fructus Chaenomelis 65-95 part nanometer Caulis Piperis Kadsurae 65-95 part nanometer Caulis Sinomenii 65-95 part
Nanometer Radix Aconiti Kusnezoffii 30-50 part nanometer Radix Aconiti 30-50 part nanometer Radix Achyranthis Bidentatae 130-190 part
Nano angelica root 65-95 part nano Chinese angelica 65-95 part nano ginseng 8-12 part
Nanometer Rhizoma Chuanxiong 65-95 part
3, nano tiger bone-papaya medicine according to claim 1, wherein the weight proportion of each nano raw material is:
80 parts of 72 parts of nanometer Radix Clematidiss of 8 parts of nanometer Os pardis of nano tiger bone
80 parts of 80 parts of nanometer Caulis Sinomeniis of 80 parts of nanometer Caulis Piperis Kadsuraes of nanometer Fructus Chaenomelis
160 parts of 40 parts of nanometer Radix Achyranthis Bidentataes of 40 parts of nanometer Radix Aconitis of nanometer Radix Aconiti Kusnezoffii
10 parts of 80 parts of nano ginsengs of 80 parts of nano Chinese angelicas of nano angelica root
80 parts of nanometer Rhizoma Chuanxiongs
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano tiger bone-papaya medicines.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano tiger bone-papaya medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100695 CN1365738A (en) | 2001-01-17 | 2001-01-17 | Nano tiger bone-papaya medicine and its preparing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100695 CN1365738A (en) | 2001-01-17 | 2001-01-17 | Nano tiger bone-papaya medicine and its preparing process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1365738A true CN1365738A (en) | 2002-08-28 |
Family
ID=4651803
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01100695 Pending CN1365738A (en) | 2001-01-17 | 2001-01-17 | Nano tiger bone-papaya medicine and its preparing process |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1365738A (en) |
-
2001
- 2001-01-17 CN CN 01100695 patent/CN1365738A/en active Pending
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