CN1365790A - Nano medicine 'Shenrong Baifeng' and its preparing process - Google Patents
Nano medicine 'Shenrong Baifeng' and its preparing process Download PDFInfo
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Abstract
A nanometre medicine "Shenrong Baifeng" is prepared from the nanometre powders of 18 Chinese medicinal materials including ginseng, pilose antler, pilose asiabell root, Chinese angelica root, etc. through proportioning, microwave extracting, pressure reduction concentrating and supersonic-jet spray drying. Its grain fineness reaches 1200-1500 meshes and grain diameters are 0.1-200 nm. Its advantages are high biological utilization rate and high curative effect.
Description
The present invention relates to the nano medicine ' Shenrong Baifeng ' of a kind of blood yiqi, menstruction regulating and pain relieving, tonifying kidney for preventing miscarriage, the invention still further relates to the method for this medication preparation.
The Shenrong Baifeng ball is a kind of classical Chinese patent medicine, mainly contain enhancing immunity, resisting fatigue, resisting oxygen lack, the stripped heart rate that slows down, increase coronary flow, suppress that isolated uterine shrinks, promotes the 17-hydroxy-11-dehydrocorticosterone effect, makes high whole blood contrast viscosity, all obviously effects such as reduction of low whole blood contrast viscosity, plasma viscosity, be used for menoxenia, abdominal pain in menstruation, menometrorrhagia premature labor, insufficiency of vital energy and blood, also be used for habitual abortion, dysfunctional uterine hemorrhage, infertility, sexual disorder, spermatozoon deficiency of development, aplastic anemia, chronic nephritis etc.But traditional Shenrong Baifeng ball disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano medicine ' Shenrong Baifeng ' of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano medicine ' Shenrong Baifeng '.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nano ginseng 4-15 part nano-antler 6-18 part nanometer Radix Codonopsis 30-60 part
Nano Chinese angelica 35-70 part nanometer Radix Rehmanniae Preparata 40-120 part nano astragalus 30-55 part
Nanometer Radix Paeoniae Alba 30-55 part nanometer Rhizoma Chuanxiong 20-55 part nanometer Rhizoma Corydalis 15-40 part
Nanometer Semen Trigonellae 20-40 part nanometer Radix Dipsaci 20-45 part nanometer Rhizoma Atractylodis Macrocephalae 20-45 part
Nano cyperus tuber 20-45 part nanometer Fructus Amomi 15-40 part nanometer motherwort 25-60 part
Nanometer Radix Scutellariae 20-45 part nanometer Herba Taxilli 10-40 part nanometer Radix Glycyrrhizae Preparata 20-45 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nano ginseng 5-10 part nano-antler 8-15 part nanometer Radix Codonopsis 35-50 part
Nano Chinese angelica 40-60 part nanometer Radix Rehmanniae Preparata 50-100 part nano astragalus 35-45 part
Nanometer Radix Paeoniae Alba 35-50 part nanometer Rhizoma Chuanxiong 25-45 part nanometer Rhizoma Corydalis 20-30 part
Nanometer Semen Trigonellae 25-30 part nanometer Radix Dipsaci 25-35 part nanometer Rhizoma Atractylodis Macrocephalae 25-35 part
Nano cyperus tuber 25-35 part nanometer Fructus Amomi 20-30 part nanometer motherwort 30-50 part
Nanometer Radix Scutellariae 25-35 part nanometer Herba Taxilli 15-30 part nanometer Radix Glycyrrhizae Preparata 25-35 part
The optimum weight proportioning of medicine of the present invention is:
40 parts of 9.4 parts of nanometer Radix Codonopsis of 8.2 parts of nano-antlers of nano ginseng
39 parts of 77.5 parts of nano astragalus of 39 parts of nanometer Radix Rehmanniae Preparata of nano Chinese angelica
23 parts of 30 parts of nanometer Rhizoma Corydalis of 39 parts of nanometer Rhizoma Chuanxiongs of the nanometer Radix Paeoniae Alba
30 parts of 30 parts of nanometer Rhizoma Atractylodis Macrocephalaes of 30 parts of nanometer Radix Dipsacis of nanometer Semen Trigonellae
39 parts of 23 parts of nanometer motherworts of 31 parts of nanometer Fructus Amomis of nano cyperus tuber
30 parts of 21 parts of nanometer Radix Glycyrrhizae Preparatas of 30 parts of nanometer Herba Taxillis of nanometer Radix Scutellariae
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get the 'Shenrong Baifeng ' nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano medicine ' Shenrong Baifeng ' is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common Shenrong Baifeng pill material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200mm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nano medicine ' Shenrong Baifeng ' etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for gynaecopathias such as menoxenia, menorrhagia, dysmenorrhea, amenorrhea, chronic active hepatitis, and thrombocytopenia, treatment of conditions such as aplastic anemia, clinical efficacy significantly is better than traditional Shenrong Baifeng ball.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
40 parts of 9.4 parts of nanometer Radix Codonopsis of 8.2 parts of nano-antlers of nano ginseng
39 parts of 77.5 parts of nano astragalus of 39 parts of nanometer Radix Rehmanniae Preparata of nano Chinese angelica
23 parts of 30 parts of nanometer Rhizoma Corydalis of 39 parts of nanometer Rhizoma Chuanxiongs of the nanometer Radix Paeoniae Alba
30 parts of 30 parts of nanometer Rhizoma Atractylodis Macrocephalaes of 30 parts of nanometer Radix Dipsacis of nanometer Semen Trigonellae
39 parts of 23 parts of nanometer motherworts of 31 parts of nanometer Fructus Amomis of nano cyperus tuber
30 parts of 21 parts of nanometer Radix Glycyrrhizae Preparatas of 30 parts of nanometer Herba Taxillis of nanometer Radix Scutellariae
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
40 parts of 9.4 parts of nanometer Radix Codonopsis of 8.2 parts of nano-antlers of nano ginseng
39 parts of 77.5 parts of nano astragalus of 39 parts of nanometer Radix Rehmanniae Preparata of nano Chinese angelica
23 parts of 30 parts of nanometer Rhizoma Corydalis of 39 parts of nanometer Rhizoma Chuanxiongs of the nanometer Radix Paeoniae Alba
30 parts of 30 parts of nanometer Rhizoma Atractylodis Macrocephalaes of 30 parts of nanometer Radix Dipsacis of nanometer Semen Trigonellae
39 parts of 23 parts of nanometer motherworts of 31 parts of nanometer Fructus Amomis of nano cyperus tuber
30 parts of 21 parts of nanometer Radix Glycyrrhizae Preparatas of 30 parts of nanometer Herba Taxillis of nanometer Radix Scutellariae
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make nanometer Shenrong Baifeng powder needle injection, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
40 parts of 9.4 parts of nanometer Radix Codonopsis of 8.2 parts of nano-antlers of nano ginseng
39 parts of 77.5 parts of nano astragalus of 39 parts of nanometer Radix Rehmanniae Preparata of nano Chinese angelica
23 parts of 30 parts of nanometer Rhizoma Corydalis of 39 parts of nanometer Rhizoma Chuanxiongs of the nanometer Radix Paeoniae Alba
30 parts of 30 parts of nanometer Rhizoma Atractylodis Macrocephalaes of 30 parts of nanometer Radix Dipsacis of nanometer Semen Trigonellae
39 parts of 23 parts of nanometer motherworts of 31 parts of nanometer Fructus Amomis of nano cyperus tuber
30 parts of 21 parts of nanometer Radix Glycyrrhizae Preparatas of 30 parts of nanometer Herba Taxillis of nanometer Radix Scutellariae
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make nanometer Shenrong Baifeng membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part, chest.
Claims (6)
1, a kind of nano medicine ' Shenrong Baifeng ' is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nano ginseng 4-15 part nano-antler 6-18 part nanometer Radix Codonopsis 30-60 part
Nano Chinese angelica 35-70 part nanometer Radix Rehmanniae Preparata 40-120 part nano astragalus 30-55 part
Nanometer Radix Paeoniae Alba 30-55 part nanometer Rhizoma Chuanxiong 20-55 part nanometer Rhizoma Corydalis 15-40 part
Nanometer Semen Trigonellae 20-40 part nanometer Radix Dipsaci 20-45 part nanometer Rhizoma Atractylodis Macrocephalae 20-45 part
Nano cyperus tuber 20-45 part nanometer Fructus Amomi 15-40 part nanometer motherwort 25-60 part
Nanometer Radix Scutellariae 20-45 part nanometer Herba Taxilli 10-40 part nanometer Radix Glycyrrhizae Preparata 20-45 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano medicine ' Shenrong Baifeng ' according to claim 1, wherein the weight proportion of each nano raw material is:
Nano ginseng 5-10 part nano-antler 8-15 part nanometer Radix Codonopsis 35-50 part
Nano Chinese angelica 40-60 part nanometer Radix Rehmanniae Preparata 50-100 part nano astragalus 35-45 part
Nanometer Radix Paeoniae Alba 35-50 part nanometer Rhizoma Chuanxiong 25-45 part nanometer Rhizoma Corydalis 20-30 part
Nanometer Semen Trigonellae 25-30 part nanometer Radix Dipsaci 25-35 part nanometer Rhizoma Atractylodis Macrocephalae 25-35 part
Nano cyperus tuber 25-35 part nanometer Fructus Amomi 20-30 part nanometer motherwort 30-50 part
Nanometer Radix Scutellariae 25-35 part nanometer Herba Taxilli 15-30 part nanometer Radix Glycyrrhizae Preparata 25-35 part
3, nano medicine ' Shenrong Baifeng ' according to claim 1, wherein the weight proportion of each nano raw material is:
40 parts of 9.4 parts of nanometer Radix Codonopsis of 8.2 parts of nano-antlers of nano ginseng
39 parts of 77.5 parts of nano astragalus of 39 parts of nanometer Radix Rehmanniae Preparata of nano Chinese angelica
23 parts of 30 parts of nanometer Rhizoma Corydalis of 39 parts of nanometer Rhizoma Chuanxiongs of the nanometer Radix Paeoniae Alba
30 parts of 30 parts of nanometer Rhizoma Atractylodis Macrocephalaes of 30 parts of nanometer Radix Dipsacis of nanometer Semen Trigonellae
39 parts of 23 parts of nanometer motherworts of 31 parts of nanometer Fructus Amomis of nano cyperus tuber
30 parts of 21 parts of nanometer Radix Glycyrrhizae Preparatas of 30 parts of nanometer Herba Taxillis of nanometer Radix Scutellariae
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano medicine ' Shenrong Baifeng 's.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano medicine ' Shenrong Baifeng 's; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20-30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01101989 CN1365790A (en) | 2001-01-18 | 2001-01-18 | Nano medicine 'Shenrong Baifeng' and its preparing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01101989 CN1365790A (en) | 2001-01-18 | 2001-01-18 | Nano medicine 'Shenrong Baifeng' and its preparing process |
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| Publication Number | Publication Date |
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| CN1365790A true CN1365790A (en) | 2002-08-28 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01101989 Pending CN1365790A (en) | 2001-01-18 | 2001-01-18 | Nano medicine 'Shenrong Baifeng' and its preparing process |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100399919C (en) * | 2005-07-15 | 2008-07-09 | 余内逊 | Method for preparing milk tablets contg. nano-antler and micron ants etc. with tonifying-Yang and eliminating-fatigue functions |
-
2001
- 2001-01-18 CN CN 01101989 patent/CN1365790A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100399919C (en) * | 2005-07-15 | 2008-07-09 | 余内逊 | Method for preparing milk tablets contg. nano-antler and micron ants etc. with tonifying-Yang and eliminating-fatigue functions |
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