CN1365698A - Nano medicine 'Muxiang Fenqi' and its preparing process - Google Patents
Nano medicine 'Muxiang Fenqi' and its preparing process Download PDFInfo
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- CN1365698A CN1365698A CN 01100641 CN01100641A CN1365698A CN 1365698 A CN1365698 A CN 1365698A CN 01100641 CN01100641 CN 01100641 CN 01100641 A CN01100641 A CN 01100641A CN 1365698 A CN1365698 A CN 1365698A
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- 239000003814 drug Substances 0.000 title claims abstract description 46
- 238000000034 method Methods 0.000 title claims description 13
- 239000000463 material Substances 0.000 claims abstract description 20
- 239000000843 powder Substances 0.000 claims abstract description 11
- 235000016639 Syzygium aromaticum Nutrition 0.000 claims abstract description 10
- 244000223014 Syzygium aromaticum Species 0.000 claims abstract description 10
- 238000001694 spray drying Methods 0.000 claims abstract description 5
- 229940079593 drug Drugs 0.000 claims description 18
- 235000021419 vinegar Nutrition 0.000 claims description 18
- 239000000052 vinegar Substances 0.000 claims description 18
- 241000234653 Cyperus Species 0.000 claims description 9
- 210000000582 semen Anatomy 0.000 claims description 9
- 239000002775 capsule Substances 0.000 claims description 7
- 239000008187 granular material Substances 0.000 claims description 6
- 238000002347 injection Methods 0.000 claims description 6
- 239000007924 injection Substances 0.000 claims description 6
- 239000006187 pill Substances 0.000 claims description 6
- 239000002994 raw material Substances 0.000 claims description 6
- 239000000284 extract Substances 0.000 claims description 5
- 239000012528 membrane Substances 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- 239000012141 concentrate Substances 0.000 claims description 4
- 235000008504 concentrate Nutrition 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 4
- 239000010135 fructus aurantii immaturus Substances 0.000 claims description 4
- 230000008676 import Effects 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- 239000000443 aerosol Substances 0.000 claims description 3
- 239000006196 drop Substances 0.000 claims description 3
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000019634 flavors Nutrition 0.000 claims description 3
- 239000003094 microcapsule Substances 0.000 claims description 3
- 239000002674 ointment Substances 0.000 claims description 3
- 229940100688 oral solution Drugs 0.000 claims description 3
- 239000000829 suppository Substances 0.000 claims description 3
- 239000006188 syrup Substances 0.000 claims description 3
- 235000020357 syrup Nutrition 0.000 claims description 3
- 239000003826 tablet Substances 0.000 claims description 3
- 239000003390 Chinese drug Substances 0.000 claims 2
- 244000080767 Areca catechu Species 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 9
- 241001127714 Amomum Species 0.000 abstract 1
- 240000000513 Santalum album Species 0.000 abstract 1
- 235000008632 Santalum album Nutrition 0.000 abstract 1
- 235000013399 edible fruits Nutrition 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 description 6
- 238000002360 preparation method Methods 0.000 description 6
- 206010047700 Vomiting Diseases 0.000 description 5
- 230000008673 vomiting Effects 0.000 description 5
- 241000202755 Areca Species 0.000 description 4
- 206010000077 Abdominal mass Diseases 0.000 description 3
- 206010000087 Abdominal pain upper Diseases 0.000 description 3
- 206010003591 Ataxia Diseases 0.000 description 3
- 206010010947 Coordination abnormal Diseases 0.000 description 3
- 206010067171 Regurgitation Diseases 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 239000002671 adjuvant Substances 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 208000016290 incoordination Diseases 0.000 description 3
- 210000004185 liver Anatomy 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 210000000952 spleen Anatomy 0.000 description 3
- 210000002784 stomach Anatomy 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000002086 nanomaterial Substances 0.000 description 2
- 239000011858 nanopowder Substances 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 239000007962 solid dispersion Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
A nanometre medicine "Muxiang Fenqi" is prepared from the nanometre powders of 16 Chinese medicinal materials including aucklandia root, amomum fruit, clove, sandal wood, etc. through proportioning, microwave extracting, pressure reduction concentrating and supersonic-jet spray drying. Its grain fineness reaches 1200-1500 meshes and grain diameters are 0.1-200 nm. Its advantages are high biological utilization rate and high curative effect.
Description
The present invention relates to a kind of the chest stuffiness relieving relieving distension, preventing or arresting vomiting, cure mainly stagnation of QI due to depression of the liver, incoordination between the spleen and stomach, the chest and diaphragm painful abdominal mass is vexed, two side of body distensions, gastralgia is fallen full noisyly, and vomiting is felt sick, and the nano medicine ' Muxiang Fenqi ' of belch acid regurgitation the invention still further relates to the method for this medication preparation.
It is a kind of classical Chinese patent medicine that the Radix Aucklandiae divides the gas ball, mainly contains effects such as the chest stuffiness relieving relieving distension, preventing or arresting vomiting, is used for stagnation of QI due to depression of the liver, incoordination between the spleen and stomach, and the chest and diaphragm painful abdominal mass is vexed, two side of body distensions, gastralgia, it is noisy to fall to satisfy, and vomiting is felt sick, the belch acid regurgitation.Disintegrate is slower but traditional Radix Aucklandiae divides the gas ball, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano medicine ' Muxiang Fenqi ' of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano medicine ' Muxiang Fenqi '.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component;
Nanometer Radix Aucklandiae 120-300 part nanometer Fructus Amomi 25-80 part nano clove 25-80 part
Nanometer Lignum Santali Albi 25-80 part nano cyperus tuber (processed with vinegar) 300-550 part nanometer Herba Pogostemonis 35-80 part
Nanometer Pericarpium Citri Reticulatae 100-300 part nanometer Cortex Magnoliae Officinalis (Rhizoma Zingiberis Recens is processed) 250-600 part nanometer Fructus Aurantii Immaturus 100-350 part
Nanometer Fructus Amomi Rotundus 25-80 part nanometer Rhizoma Curcumae (processed with vinegar) 250-800 part nanometer Fructus Crataegi (stir-fry) 120-300 part
The nanometer Rhizoma Atractylodis Macrocephalae (parched with bran) 120-300 part nanometer Radix Et Rhizoma Nardostachyos 120-300 part nanometer Semen Arecae 60-150 part
Nanometer Radix Glycyrrhizae 60-150 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Radix Aucklandiae 150-250 part nanometer Fructus Amomi 40-60 part nano clove 40-60 part
Nanometer Lignum Santali Albi 40-60 part nano cyperus tuber (processed with vinegar) 350-450 part nanometer Herba Pogostemonis 40-60 part
Nanometer Pericarpium Citri Reticulatae 150-250 part nanometer Cortex Magnoliae Officinalis (Rhizoma Zingiberis Recens is processed) 300-500 part nanometer Fructus Aurantii Immaturus 150-250 part
Nanometer Fructus Amomi Rotundus 40-60 part nanometer Rhizoma Curcumae (processed with vinegar) 300-600 part nanometer Fructus Crataegi (stir-fry) 150-250 part
The nanometer Rhizoma Atractylodis Macrocephalae (parched with bran) 150-250 part nanometer Radix Et Rhizoma Nardostachyos 150-250 part nanometer Semen Arecae 80-120 part
Nanometer Radix Glycyrrhizae 80-120 part
The optimum weight proportioning of medicine of the present invention is:
48 parts of 48 parts of nano cloves of 192 parts of nanometer Fructus Amomis of the nanometer Radix Aucklandiae
48 parts of 384 parts of nanometer Herba Pogostemonis of 48 parts of nano cyperus tubers of nanometer Lignum Santali Albi (processed with vinegar)
192 parts of 384 parts of nanometer Fructus Aurantii Immaturuss of 192 parts of nanometer Cortex Magnoliae Officinalis of nanometer Pericarpium Citri Reticulatae (Rhizoma Zingiberis Recens is processed)
192 parts of 384 parts of nanometer Fructus Crataegis of 48 parts of nanometer Rhizoma Curcumae of nanometer Fructus Amomi Rotundus (processed with vinegar) (stir-fry)
96 parts of 192 portions of nanometer Semen Arecaes of 192 parts of nanometer Radix Et Rhizoma Nardostachyos of the nanometer Rhizoma Atractylodis Macrocephalae (parched with bran)
192 parts in nanometer Radix Glycyrrhizae
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The in the past granule of composition material, its size all star and material to the nanoscale development occurred now at micron or more than the millimeter magnitude.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%; Be small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour:
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get the 'Muxiang Fenqi ' nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano medicine ' Muxiang Fenqi ' is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, the common Radix Aucklandiae divides gas pill material to be micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nano medicine ' Muxiang Fenqi ' etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for stagnation of QI due to depression of the liver, incoordination between the spleen and stomach, and the chest and diaphragm painful abdominal mass is vexed, two side of body distensions, gastralgia, it is noisy to fall to satisfy, and vomiting is felt sick, treatment of conditions such as belch acid regurgitation, clinical efficacy significantly is better than traditional Radix Aucklandiae and divides the gas ball.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
48 parts of 48 parts of nano cloves of 192 parts of nanometer Fructus Amomis of the nanometer Radix Aucklandiae
48 parts of 384 parts of nanometer Herba Pogostemonis of 48 parts of nano cyperus tubers of nanometer Lignum Santali Albi (processed with vinegar)
192 parts of 384 parts of nanometer Fructus Aurantii Immaturuss of 192 parts of nanometer Cortex Magnoliae Officinalis of nanometer Pericarpium Citri Reticulatae (Rhizoma Zingiberis Recens is processed)
192 parts of 384 parts of nanometer Fructus Crataegis of 48 parts of nanometer Rhizoma Curcumae of nanometer Fructus Amomi Rotundus (processed with vinegar) (stir-fry)
96 parts of 192 portions of nanometer Semen Arecaes of 192 parts of nanometer Radix Et Rhizoma Nardostachyos of the nanometer Rhizoma Atractylodis Macrocephalae (parched with bran)
192 parts in nanometer Radix Glycyrrhizae
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
48 parts of 48 parts of nano cloves of 192 parts of nanometer Fructus Amomis of the nanometer Radix Aucklandiae
48 parts of 384 parts of nanometer Herba Pogostemonis of 48 parts of nano cyperus tubers of nanometer Lignum Santali Albi (processed with vinegar)
192 parts of 384 parts of nanometer Fructus Aurantii Immaturuss of 192 parts of nanometer Cortex Magnoliae Officinalis of nanometer Pericarpium Citri Reticulatae (Rhizoma Zingiberis Recens is processed)
192 parts of 384 parts of nanometer Fructus Crataegis of 48 parts of nanometer Rhizoma Curcumae of nanometer Fructus Amomi Rotundus (processed with vinegar) (stir-fry)
96 parts of 192 portions of nanometer Semen Arecaes of 192 parts of nanometer Radix Et Rhizoma Nardostachyos of the nanometer Rhizoma Atractylodis Macrocephalae (parched with bran)
192 parts in nanometer Radix Glycyrrhizae
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, making the nanometer Radix Aucklandiae, to divide gas powder needle injection, every injection content be the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
48 parts of 48 parts of nano cloves of 192 parts of nanometer Fructus Amomis of the nanometer Radix Aucklandiae
48 parts of 384 parts of nanometer Herba Pogostemonis of 48 parts of nano cyperus tubers of nanometer Lignum Santali Albi (processed with vinegar)
192 parts of 384 parts of nanometer Fructus Aurantii Immaturuss of 192 parts of nanometer Cortex Magnoliae Officinalis of nanometer Pericarpium Citri Reticulatae (Rhizoma Zingiberis Recens is processed)
192 parts of 384 parts of nanometer Fructus Crataegis of 48 parts of nanometer Rhizoma Curcumae of nanometer Fructus Amomi Rotundus (processed with vinegar) (stir-fry)
96 parts of 192 portions of nanometer Semen Arecaes of 192 parts of nanometer Radix Et Rhizoma Nardostachyos of the nanometer Rhizoma Atractylodis Macrocephalae (parched with bran)
192 parts in nanometer Radix Glycyrrhizae
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make the nanometer Radix Aucklandiae and divide the air film agent, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part.
Claims (6)
1, a kind of nano medicine ' Muxiang Fenqi ' is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Radix Aucklandiae 120-300 part nanometer Fructus Amomi 25-80 part nano clove 25-80 part
Nanometer Lignum Santali Albi 25-80 part nano cyperus tuber (processed with vinegar) 300-550 part nanometer Herba Pogostemonis 35-80 part
Nanometer Pericarpium Citri Reticulatae 100-300 part nanometer Cortex Magnoliae Officinalis (Rhizoma Zingiberis Recens is processed) 250-600 part nanometer Fructus Aurantii Immaturus 100-350 part
Nanometer Fructus Amomi Rotundus 25-80 part nanometer Rhizoma Curcumae (processed with vinegar) 250-800 part nanometer Fructus Crataegi (stir-fry) 120-300 part
The nanometer Rhizoma Atractylodis Macrocephalae (parched with bran) 120-300 part nanometer Radix Et Rhizoma Nardostachyos 120-300 part nanometer Semen Arecae 60-150 part
Nanometer Radix Glycyrrhizae 60-150 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano medicine ' Muxiang Fenqi ' according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Radix Aucklandiae 150-250 part nanometer Fructus Amomi 40-60 part nano clove 40-60 part
Nanometer Lignum Santali Albi 40-60 part nano cyperus tuber (processed with vinegar) 350-450 part nanometer Herba Pogostemonis 40-60 part
Nanometer Pericarpium Citri Reticulatae 150-250 part nanometer Cortex Magnoliae Officinalis (Rhizoma Zingiberis Recens is processed) 300-500 part nanometer Fructus Aurantii Immaturus 150-250 part
Nanometer Fructus Amomi Rotundus 40-60 part nanometer Rhizoma Curcumae (processed with vinegar) 300-600 part nanometer Fructus Crataegi (stir-fry) 150-250 part
The nanometer Rhizoma Atractylodis Macrocephalae (parched with bran) 150-250 part nanometer Radix Et Rhizoma Nardostachyos 150-250 part nanometer Semen Arecae 80-120 part
Nanometer Radix Glycyrrhizae 80-120 part
3, nano medicine ' Muxiang Fenqi ' according to claim 1, wherein the weight proportion of each nano raw material is:
48 parts of 48 parts of nano cloves of 192 parts of nanometer Fructus Amomis of the nanometer Radix Aucklandiae
48 parts of 384 parts of nanometer Herba Pogostemonis of 48 parts of nano cyperus tubers of nanometer Lignum Santali Albi (processed with vinegar)
192 parts of 384 parts of nanometer Fructus Aurantii Immaturuss of 192 parts of nanometer Cortex Magnoliae Officinalis of nanometer Pericarpium Citri Reticulatae (Rhizoma Zingiberis Recens is processed)
192 parts of 384 parts of nanometer Fructus Crataegis of 48 parts of nanometer Rhizoma Curcumae of nanometer Fructus Amomi Rotundus (processed with vinegar) (stir-fry)
96 parts of 192 portions of nanometer Semen Arecaes of 192 parts of nanometer Radix Et Rhizoma Nardostachyos of the nanometer Rhizoma Atractylodis Macrocephalae (parched with bran)
192 parts in nanometer Radix Glycyrrhizae
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano medicine ' Muxiang Fenqi 's.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano medicine ' Muxiang Fenqi 's; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100641 CN1365698A (en) | 2001-01-15 | 2001-01-15 | Nano medicine 'Muxiang Fenqi' and its preparing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100641 CN1365698A (en) | 2001-01-15 | 2001-01-15 | Nano medicine 'Muxiang Fenqi' and its preparing process |
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| Publication Number | Publication Date |
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| CN1365698A true CN1365698A (en) | 2002-08-28 |
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| CN 01100641 Pending CN1365698A (en) | 2001-01-15 | 2001-01-15 | Nano medicine 'Muxiang Fenqi' and its preparing process |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103142921A (en) * | 2013-03-07 | 2013-06-12 | 王玉兰 | Three-vanilla spirit |
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2001
- 2001-01-15 CN CN 01100641 patent/CN1365698A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103142921A (en) * | 2013-03-07 | 2013-06-12 | 王玉兰 | Three-vanilla spirit |
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