CN1364529A - Nano Sichuan fritillary bulb xueli medicine and its preparing method - Google Patents
Nano Sichuan fritillary bulb xueli medicine and its preparing method Download PDFInfo
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- CN1364529A CN1364529A CN 01100796 CN01100796A CN1364529A CN 1364529 A CN1364529 A CN 1364529A CN 01100796 CN01100796 CN 01100796 CN 01100796 A CN01100796 A CN 01100796A CN 1364529 A CN1364529 A CN 1364529A
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Abstract
Tha nano tendril-leaved fritillay bulb Xueli medicine is preapred with nano pear paste, nano tendril-leaved fritially bulb, nano lilyturf root, nano lily and nano coltsfoot flower in certain proportion as raw material. The new medicine preparation has a grain fineness of 1200-1500 mesh, grain size of 0.1-200 nm, mostly below 100 nm, and new physical property. It is prepared through microwave extraction, decompressing concentration, spray drying in supersonic jet and other steps. It has high biological utilization and obvious treating effect.
Description
The present invention relates to a kind of nourishing the lung to arrest cough, secretion replenishing and throat moistening cures mainly deficiency of YIN lung-heat, cough, and dyspnea with rapid and short breath, the nano Sichuan fritillary bulb xueli medicine of dryness of the mouth and throat the invention still further relates to the method for this medication preparation.
CHUANBEI XUELI GAO is a kind of classical Chinese patent medicine, mainly contains nourishing the lung to arrest cough, and effects such as secretion replenishing and throat moistening are used for deficiency of YIN lung-heat, cough, dyspnea with rapid and short breath, dryness of the mouth and throat.But traditional CHUANBEI XUELI GAO absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano Sichuan fritillary bulb xueli medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano Sichuan fritillary bulb xueli medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
The female 35-80 part of nanometer Fructus Pyri thin paste 300-500 part nano Sichuan fritillary bulb nanometer 70-150 Radix Ophiopogonis part
Nanometer Bulbus Lilii 35-70 part nanometer Flos Farfarae 15-40 part
The formula optimization weight proportion scope of medicine of the present invention is:
The female 40-60 part of nanometer Fructus Pyri thin paste 350-450 part nano Sichuan fritillary bulb nanometer 80-120 Radix Ophiopogonis part
Nanometer Bulbus Lilii 40-60 part nanometer Flos Farfarae 20-30 part
The optimum weight proportioning of medicine of the present invention is:
100 parts of 400 parts of nano Sichuan fritillary bulbs of nanometer Fructus Pyri thin paste female 50 parts of nanometer Radix Ophiopogonis
25 parts of 50 parts of nanometer Flos Farfaraees of nanometer Bulbus Lilii
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get the Sichuan fritillary bulb xueli nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano Sichuan fritillary bulb xueli medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common CHUANBEI XUELI GAO preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, oral solution of nano Sichuan fritillary bulb xueli medicine etc. had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for deficiency of YIN lung-heat, cough, and dyspnea with rapid and short breath, treatment of conditions such as dryness of the mouth and throat, clinical efficacy significantly is better than traditional CHUANBEI XUELI GAO.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
100 parts of 400 parts of nano Sichuan fritillary bulbs of nanometer Fructus Pyri thin paste female 50 parts of nanometer Radix Ophiopogonis
25 parts of 50 parts of nanometer Flos Farfaraees of nanometer Bulbus Lilii
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
100 parts of 400 parts of nano Sichuan fritillary bulbs of nanometer Fructus Pyri thin paste female 50 parts of nanometer Radix Ophiopogonis
25 parts of 50 parts of nanometer Flos Farfaraees of nanometer Bulbus Lilii
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make nano Sichuan fritillary bulb pear powder needle injection, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
100 parts of 400 parts of nano Sichuan fritillary bulbs of nanometer Fructus Pyri thin paste female 50 parts of nanometer Radix Ophiopogonis
25 parts of 50 parts of nanometer Flos Farfaraees of nanometer Bulbus Lilii
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make nano Sichuan fritillary bulb pear membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: back, chest.
Claims (6)
1, a kind of nano Sichuan fritillary bulb xueli medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
The female 35-80 part of nanometer Fructus Pyri thin paste 300-500 part nano Sichuan fritillary bulb nanometer 70-150 Radix Ophiopogonis part
Nanometer Bulbus Lilii 35-70 part nanometer Flos Farfarae 15-40 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano Sichuan fritillary bulb xueli medicine according to claim 1, wherein the weight proportion of each nano raw material is:
The female 40-60 part of nanometer Fructus Pyri thin paste 350-450 part nano Sichuan fritillary bulb nanometer 80-120 Radix Ophiopogonis part
Nanometer Bulbus Lilii 40-60 part nanometer Flos Farfarae 20-30 part
3, nano Sichuan fritillary bulb xueli medicine according to claim 1, wherein the weight proportion of each nano raw material is:
100 parts of 400 parts of nano Sichuan fritillary bulbs of nanometer Fructus Pyri thin paste female 50 parts of nanometer Radix Ophiopogonis
25 parts of 50 parts of nanometer Flos Farfaraees of nanometer Bulbus Lilii
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano Sichuan fritillary bulb xueli medicines.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano Sichuan fritillary bulb xueli medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100796 CN1364529A (en) | 2001-01-11 | 2001-01-11 | Nano Sichuan fritillary bulb xueli medicine and its preparing method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100796 CN1364529A (en) | 2001-01-11 | 2001-01-11 | Nano Sichuan fritillary bulb xueli medicine and its preparing method |
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| CN1364529A true CN1364529A (en) | 2002-08-21 |
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| CN 01100796 Pending CN1364529A (en) | 2001-01-11 | 2001-01-11 | Nano Sichuan fritillary bulb xueli medicine and its preparing method |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102266479A (en) * | 2010-06-02 | 2011-12-07 | 襄樊隆中药业有限责任公司 | Fritillary and snow pear particle and preparation method thereof |
| CN102266480A (en) * | 2010-06-02 | 2011-12-07 | 襄樊隆中药业有限责任公司 | Bulbus fritilariae snow pear capsules and preparation method thereof |
| CN104770866A (en) * | 2015-03-06 | 2015-07-15 | 云南中烟工业有限责任公司 | Aerosol precursor containing medical components of Chuanbei Xueli Extract and method for dispersing medical components in Chuanbei Xueli Extract into nanoscale fog drops |
-
2001
- 2001-01-11 CN CN 01100796 patent/CN1364529A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102266479A (en) * | 2010-06-02 | 2011-12-07 | 襄樊隆中药业有限责任公司 | Fritillary and snow pear particle and preparation method thereof |
| CN102266480A (en) * | 2010-06-02 | 2011-12-07 | 襄樊隆中药业有限责任公司 | Bulbus fritilariae snow pear capsules and preparation method thereof |
| CN102266480B (en) * | 2010-06-02 | 2013-05-01 | 襄樊隆中药业有限责任公司 | Bulbus fritilariae snow pear capsules and preparation method thereof |
| CN104770866A (en) * | 2015-03-06 | 2015-07-15 | 云南中烟工业有限责任公司 | Aerosol precursor containing medical components of Chuanbei Xueli Extract and method for dispersing medical components in Chuanbei Xueli Extract into nanoscale fog drops |
| CN104770866B (en) * | 2015-03-06 | 2016-08-24 | 云南中烟工业有限责任公司 | A kind of aerosol precursor comprising CHUANBEI XUELI GAO active ingredient and the method being dispersed into nanometer-sized mist droplets |
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