CN1366942A - Nano Chuanbei Luohan cough-relieving preparation medicine and preparation method - Google Patents
Nano Chuanbei Luohan cough-relieving preparation medicine and preparation method Download PDFInfo
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- CN1366942A CN1366942A CN 01102136 CN01102136A CN1366942A CN 1366942 A CN1366942 A CN 1366942A CN 01102136 CN01102136 CN 01102136 CN 01102136 A CN01102136 A CN 01102136A CN 1366942 A CN1366942 A CN 1366942A
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- chuanbei
- luohan
- cough
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- 239000003814 drug Substances 0.000 title claims abstract description 46
- 238000002360 preparation method Methods 0.000 title claims abstract description 22
- 206010011224 Cough Diseases 0.000 title claims description 24
- 239000000463 material Substances 0.000 claims abstract description 20
- 238000000034 method Methods 0.000 claims abstract description 13
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims abstract description 10
- 239000002994 raw material Substances 0.000 claims abstract description 7
- 241001092070 Eriobotrya Species 0.000 claims abstract description 6
- 235000009815 Momordica Nutrition 0.000 claims abstract description 6
- 241000218984 Momordica Species 0.000 claims abstract description 6
- 238000001694 spray drying Methods 0.000 claims abstract description 5
- 229940079593 drug Drugs 0.000 claims description 20
- 239000000843 powder Substances 0.000 claims description 10
- 241001644295 Fritillaria przewalskii Species 0.000 claims description 9
- 239000002775 capsule Substances 0.000 claims description 7
- 238000002347 injection Methods 0.000 claims description 6
- 239000007924 injection Substances 0.000 claims description 6
- 239000012528 membrane Substances 0.000 claims description 6
- 239000006187 pill Substances 0.000 claims description 6
- 239000008187 granular material Substances 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- 239000012141 concentrate Substances 0.000 claims description 4
- 235000008504 concentrate Nutrition 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 4
- 230000008676 import Effects 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- 239000000443 aerosol Substances 0.000 claims description 3
- 239000006196 drop Substances 0.000 claims description 3
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000019634 flavors Nutrition 0.000 claims description 3
- 239000003094 microcapsule Substances 0.000 claims description 3
- 239000002674 ointment Substances 0.000 claims description 3
- 229940100688 oral solution Drugs 0.000 claims description 3
- 239000000829 suppository Substances 0.000 claims description 3
- 239000006188 syrup Substances 0.000 claims description 3
- 235000020357 syrup Nutrition 0.000 claims description 3
- 239000003826 tablet Substances 0.000 claims description 3
- 239000003390 Chinese drug Substances 0.000 claims 2
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 abstract 1
- 235000009008 Eriobotrya japonica Nutrition 0.000 abstract 1
- 241000605372 Fritillaria Species 0.000 abstract 1
- 235000006751 Platycodon Nutrition 0.000 abstract 1
- 244000274050 Platycodon grandiflorum Species 0.000 abstract 1
- 229940041616 menthol Drugs 0.000 abstract 1
- 238000000874 microwave-assisted extraction Methods 0.000 abstract 1
- 229930189914 platycodon Natural products 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 8
- 239000003795 chemical substances by application Substances 0.000 description 5
- 239000002671 adjuvant Substances 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 201000009240 nasopharyngitis Diseases 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 206010062717 Increased upper airway secretion Diseases 0.000 description 2
- 206010006451 bronchitis Diseases 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 239000002086 nanomaterial Substances 0.000 description 2
- 239000011858 nanopowder Substances 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 208000026435 phlegm Diseases 0.000 description 2
- 239000007962 solid dispersion Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
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- Medicinal Preparation (AREA)
Abstract
The present invention discloses a nano chuanbei luohan Zhike preparation medicine. It is made up by using using the Chinese medicinal materials of nano sichuan fritillaria, nano loquat leaf, nano platycodon, nano menthol and nano grosvenor's momordica as raw material through the processes of microwave extraction, reduced pressure concentration and supersonic jet spray drying. Its grain fineness is up to 1200-1500 meshes, grain size is 0.1-200 nm, in which most of grain size is less than 100 nm.
Description
The present invention relates to a kind of lung heat clearing, cough-relieving, eliminate the phlegm, cure mainly the cough due to common cold, bronchitic nano Chuanbei Luohan cough-relieving preparation medicine, the invention still further relates to the method for this medication preparation.
The Chuanbei Luohan cough-relieving electuary is a kind of classical Chinese patent medicine, and effect such as mainly contain lung heat clearing, cough-relieving, eliminate the phlegm is used for the cough due to common cold, bronchitis.But traditional Chuanbei Luohan cough-relieving electuary absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano Chuanbei Luohan cough-relieving preparation medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano Chuanbei Luohan cough-relieving preparation medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
The female 20-55 part of nano Sichuan fritillary bulb nanometer Folium Eriobotryae 350-600 part nanometer Radix Platycodonis 80-200 part
Nanometer Mentholum 0.5-3 part nanometer Fructus Momordicae 8-25 part
The formula optimization weight proportion scope of medicine of the present invention is:
The female 25-45 part of nano Sichuan fritillary bulb nanometer Folium Eriobotryae 400-500 part nanometer Radix Platycodonis 100-180 part
Nanometer Mentholum 0.5-2 part nanometer Fructus Momordicae 10-20 part
The optimum weight proportioning of medicine of the present invention is:
130 parts of 435 parts of nanometer Radix Platycodoniss of the female 35 parts of nanometer Folium Eriobotryaes of nano Sichuan fritillary bulb
14 parts of 0.8 portion of nanometer Fructus Momordicaes of nanometer Mentholum
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity jet.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get the Chuanbei Luohan cough-relieving preparation nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano Chuanbei Luohan cough-relieving preparation medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common Chuanbei Luohan cough-relieving electuary preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the novel form that pill, powder, tablet, suppository, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nano Chuanbei Luohan cough-relieving preparation medicine etc. had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for treatment of conditions such as the cough due to common cold, bronchitis, and clinical efficacy significantly is better than traditional Chuanbei Luohan cough-relieving electuary.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
130 parts of 435 parts of nanometer Radix Platycodoniss of the female 35 parts of nanometer Folium Eriobotryaes of nano Sichuan fritillary bulb
14 parts of 0.8 portion of nanometer Fructus Momordicaes of nanometer Mentholum
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
130 parts of 435 parts of nanometer Radix Platycodoniss of the female 35 parts of nanometer Folium Eriobotryaes of nano Sichuan fritillary bulb
14 parts of 0.8 portion of nanometer Fructus Momordicaes of nanometer Mentholum
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make the nano Chuanbei Luohan cough-relieving powder needle injection, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
130 parts of 435 parts of nanometer Radix Platycodoniss of the female 35 parts of nanometer Folium Eriobotryaes of nano Sichuan fritillary bulb
14 parts of 0.8 portion of nanometer Fructus Momordicaes of nanometer Mentholum
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make the nano Chuanbei Luohan cough-relieving membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: back, chest.
Claims (6)
1, a kind of nano Chuanbei Luohan cough-relieving preparation medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
The female 20-55 part of nano Sichuan fritillary bulb nanometer Folium Eriobotryae 350-600 part nanometer Radix Platycodonis 80-200 part
Nanometer Mentholum 0.5-3 part nanometer Fructus Momordicae 8-25 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano Chuanbei Luohan cough-relieving preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
The female 25-45 part of nano Sichuan fritillary bulb nanometer Folium Eriobotryae 400-500 part nanometer Radix Platycodonis 100-180 part
Nanometer Mentholum 0.5-2 part nanometer Fructus Momordicae 10-20 part
3, nano Chuanbei Luohan cough-relieving preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
130 parts of 435 parts of nanometer Radix Platycodoniss of the female 35 parts of nanometer Folium Eriobotryaes of nano Sichuan fritillary bulb
14 parts of 0.8 portion of nanometer Fructus Momordicaes of nanometer Mentholum
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano Chuanbei Luohan cough-relieving preparation medicines.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano Chuanbei Luohan cough-relieving preparation medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01102136 CN1366942A (en) | 2001-01-20 | 2001-01-20 | Nano Chuanbei Luohan cough-relieving preparation medicine and preparation method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01102136 CN1366942A (en) | 2001-01-20 | 2001-01-20 | Nano Chuanbei Luohan cough-relieving preparation medicine and preparation method |
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| Publication Number | Publication Date |
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| CN1366942A true CN1366942A (en) | 2002-09-04 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 01102136 Pending CN1366942A (en) | 2001-01-20 | 2001-01-20 | Nano Chuanbei Luohan cough-relieving preparation medicine and preparation method |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102120016A (en) * | 2011-02-22 | 2011-07-13 | 广西健丰药业有限公司 | Method for preparing Sichuan fritillary bulb and fructus momordicae cough relieving tablets |
| CN102119733A (en) * | 2010-12-27 | 2011-07-13 | 陈慧婷 | Formula and preparation method of grosvenoria peanut milk for preventing pharyngitis |
| CN103505621A (en) * | 2013-09-27 | 2014-01-15 | 张洋 | Cough relieving and sputum reducing syrup and preparation method thereof |
-
2001
- 2001-01-20 CN CN 01102136 patent/CN1366942A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102119733A (en) * | 2010-12-27 | 2011-07-13 | 陈慧婷 | Formula and preparation method of grosvenoria peanut milk for preventing pharyngitis |
| CN102119733B (en) * | 2010-12-27 | 2012-10-03 | 陈慧婷 | Formula of siraitia grosvenorii and peanut milk for preventing pharyngitis and preparation method thereof |
| CN102120016A (en) * | 2011-02-22 | 2011-07-13 | 广西健丰药业有限公司 | Method for preparing Sichuan fritillary bulb and fructus momordicae cough relieving tablets |
| CN102120016B (en) * | 2011-02-22 | 2013-04-10 | 广西健丰药业有限公司 | Method for preparing Sichuan fritillary bulb and fructus momordicae cough relieving tablets |
| CN103505621A (en) * | 2013-09-27 | 2014-01-15 | 张洋 | Cough relieving and sputum reducing syrup and preparation method thereof |
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